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Supartiningsih Supartiningsih

Program Studi D3 ANAFARMA, Universitas Sari Mutiara Indonesia

Author-ID : 3483809

Medicine & Pharmacology

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FORMULASI DAN EVALUASI SEDIAAN LIP BALM DENGAN PEWARNA EKSTRAK UBI JALAR UNGU (Ipomoea batatas (L.) Lamk.) Supartiningsih Supartiningsih; Elly Nurita Sitorus; Yosy Cinthya Eriwaty Silalahi; Khairunnisa Khairunnisa
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Lip balm is a cosmetic preparation with the main components such as wax, fat, and oil from natural or synthesized extracts with the aim of preventing dryness of the lips by increasing lip moisture and protecting the adverse effects of the environment on the lips. The use of purple sweet potato as a dye is because purple sweet potato (Ipomoea batatas (L.) Lamk.) has an attractive color, the color of purple sweet potato is due to the presence of anthocyanin pigments which are derivatives of flavonoid compounds which are generally soluble in polar solvents. This study aims to formulate and evaluate lip balm preparations using purple sweet potato extract at concentrations of 3%, 6%, 9%, and without using purple sweet potato extract. This research is experimental research. Lip balm preparations were made by adding purple sweet potato extract with various concentrations (F1) 3%, (F2) 6%, (F3) 9%, and blank formula (F0) as the basis for lip balm preparations without purple sweet potato extract. Evaluation of the preparation includes homogeneity test, stability test, smear test, adhesion test, spreadability test, and pH test. The test results showed that purple sweet potato extract can be formulated in lip balm preparations that have a homogeneous composition, have good smearing power, good adhesion F0 (1 minute), F1 (1 minute 3 seconds), F2 (1 minute 8 seconds). seconds), F3 (1 minute 11 seconds), spreadability (5-5.7cm), pH test on all preparations showed a pH that was in accordance with the pH of the skin. And obtained formula 3 is the best formula.

PENETAPAN KADAR VITAMIN C PADA DAUN JELATANG (Urtica dioica L.) DENGAN MENGGUNAKAN SPEKTROFOTOMETRI ULTRAVIOLET Zuhairiah Nasution; Siti Nurbaya; Supartiningsih Supartiningsih; Tiurma Sitompul
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Nettle leaf (Urtica dioica L) is the most widely known species in the genus Urtica and has many benefits for the community, one of which is to treat venereal diseases, kidney disorders, allergies, diabetes, anemia, and digestive tract diseases. Vitamins contained in nettle leaves that are useful for the body is vitamin C. Vitamin C has properties that are easily damaged by heat, and easily soluble in water. This study aims to determine the levels of vitamin C in young and old nettle leaves by an ultraviolet spectrophotometric method using Aquadest solvent and read a wavelength of 265 nm with a linear regression equation y= ax + b with a value of y= 0.0525 + 0.0618 with r = 0.9878 each treatment was replicated 6 times. Based on the results of the qualitative test experiment, it was stated that in nettle leaves there was vitamin C with iodine solution reagent, FeCl3, Fehling A&B, and obtained vitamin C levels in old nettle leaves 0.2526 mg/g and in young nettle leaves 0.2026 mg/g. So that the levels of vitamin C in old nettle leaves are higher than in young nettle leaves.

UJI AKTIVITAS EKSTRAK ETANOL BAWANG PUTIH (Alliumsativum L.)YANG DIHITAMKAN SEBAGAI ANTI INFLAMASI YANG DIINDUKSI OLEH KARAGENAN TERHADAP Mus musculus Dicky Yuswardi Wiratma; Kesaktian Manurung; Supartiningsih Supartiningsih; May Fransisca Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

One of the plants used as an alternative to traditional medicine is Garlic (Allium sativum L.). Garlic which is rich in organic organo sulfur compounds (amino acids and essential oils) in the form of allin has many benefits in treating various types of diseases. One of the processed forms of garlic is black garlic. Black garlic is a heating product from garlic that is heated at a temperature of 70oC with a relative humidity of 70-80%. This study aims to determine the use of black garlic as an anti-inflammatory, how to make black garlic and at what concentration black garlic has an anti-inflammatory effect. The method used in this research is a pure experimental method. The results of the %R measurement, the negative control group had the highest level of inflammation and the lowest was the black garlic extract group with a concentration of 60%. Meanwhile, in the %IR measurement, the black garlic extract group with a concentration of 60% had the greatest ability to block inflammation. From the tests that have been carried out, black garlic is obtained from heating results and the results of measuring the effectiveness of its anti-inflammatory activity, namely black garlic extract with a concentration of 60% have a better anti-inflammatory effect compared to other concentrations and diclofenac sodium.

PERBANDINGAN UJI AKTIVITAS ANTI DIABETES EKSTRAK ETANOL BUAH PARE (Momordicacharantia L.) DANDAUN LIDAH BUAYA (Aloe vera L.) PADA MENCIT JANTAN Erly Sitompul; Supartiningsih Supartiningsih; Samsia Yolanda Sari
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Diabetes is a non-communicable degenerative disease that will increase in number in the future. This is evidenced by the increasing incidence of diabetes every decade. Bitter gourd and aloe vera are an alternative in treating Diabetes Mellitus because these plants contain saponins, flavonoids, and polyphenols (strong antioxidants), as well as glycosides cucurbitacin, momordicin, and charantin that can lower blood sugar, saponins, flavonoids, and alkaloids. This study aims to determine secondary metabolite compounds, anti-diabetic activity, and the combination of aloe vera extract and bitter melon extract that has antidiabetic activity. The method used in this study is an experimental method, namely testing the antidiabetic effect of extracts obtained from ethanol of bitter melon and aloe vera leaves on alloxan-induced mice. The results obtained from the research are that the administration of aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group with the ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW showed a very good effect on reducing BGD. This means that aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group given ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW had good antidiabetic activity.

UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SENDOK (Plantago major L.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Adiansyah Adiansyah; Hapsah Junita Siregar
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Spoon leaves contain active ingredients, namely tannins, flavonoids, sterols, and polysaccharides. These compounds may be responsible for providing a hypoglycemic effect. This study aims to determine the characterization of the ethanol extract of spoon leaves in male white rats induced by alloxan. Diabetic rats were grouped into five treatment groups, each group consisted of 5 rats. Group I (CMC-Na suspension 0.5% w/v), group II (glibenclamide 0.45 mg/kg BW); Groups II, III, and IV (EEDS doses of 200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW) were taken orally for 15 consecutive days. Furthermore, the measurement of glucose levels was observed and measured with a glucometer on days 3, 5, 7, 9, 11, 13, and day 15. The results of the examination of simplicia characteristics showed that the water-soluble extract content was 13.47%, the ethanol-soluble extract content was 12.84%, the total ash content was 3.29%, and the acid insoluble ash content was 0.29%. The results of the analysis of the administration of EEDS showed a significant effect of reducing blood glucose levels in mice compared to the 1% CMC-Na control group. The best decrease in blood glucose levels on the 15th day was shown in the 600 mg/kg BW dose group. Statistical test results (a = 0.05) showed that EEDS at a dose of 400 mg/kg BW and a dose of 600 mg/kg BW were not significantly different from glibenclamide at a dose of 0.45 mg/kg BW.

PERBANDINGAN UJI AKTIVITAS ANTIDIABETES EKSTRAK DAUN LIDAH BUAYA DAN LIDAH MERTUA PADA MENCIT PUTIH JANTAN Erly Sitompul; Supartiningsih Supartiningsih; Rifka Gloria
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.531 KB)

Diabetes mellitus (DM) is a disease whose prevalence is increasing from year to year. This increase was accompanied by an increase in the cost of treatment and the number of complications. The use of traditional medicine is an alternative for the community to control blood sugar levels (KGD). Considering that synthetic drugs have various side effects, one of the medicinal plants used as traditional medicine is aloe vera leaf and mother-in-law's tongue leaf which contain flavonoid compounds, alkaloids, tannins, saponins, and steroids/triterpenoids. The purpose of this study was to determine the antidiabetic activity of aloe vera leaf extract and mother-in-law's tongue and to compare the activities of the two. The results of the analysis of the glucose tolerance ANOVA test showed a significant difference in the percentage reduction at 60, 90, and 120 minutes for all treatment preparations. The alloxan induction test showed a significant difference in the percentage decrease from days 3, 5, 7, 9, 11, 13, and 15. Based on these results, it can be concluded that Aloe Vera Leaf Ethanol Extract (EEDLB) and LidahMertua Leaf Ethanol Extract (EEDLM) with each dose of 150 and 200 mg/kg BW and the combination of the two gave antidiabetic activity against mice as well as differences in effectiveness between samples of aloe vera leaf and LidahMertua leaf as well as a single dose with a combination.

PEMBUATAN KERTAS RAMAH LINGKUNGAN KOMBINASI LIMBAH AMPAS TAHU DAN LIMBAH KULIT PISANG KEPOK DENGAN METODE PEMISAHAN ALKALISASI Eka Margaret Sinaga; Supartiningsih Supartiningsih; Elly Sitorus; Sriadiprastio Sriadiprastio
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Tofu dregs waste contains 30.4% cellulose content, while kepok banana peel has high cellulose content (60-65%), hemicellulose 6-8%, and lignin 5-10%. The purpose of this study was to determine the process of making natural paper from tofu dregs waste and kepok banana peel waste as an alternative raw material for wood substitutes and to find out the characteristics of natural paper produced from tofu waste fiber and kepok banana peel waste based on SNI 287:2010 (including test water content) and SNI 6588-1:2010 (including pH acidity test). Based on the results of research that has been carried out, the optimum composition in making paper from tofu dregs and kepok banana peels is 50:50% variation. The temperature and time of heating and the optimum concentration of sodium hydroxide solution was 120 oC for 90 minutes with sodium hydroxide solution concentration of 10.0%, pulp content of 46.45%, cellulose content of 53.3%, and lignin content of 46.67%. All levels obtained have met the requirements of SNI. Based on the FT-IR spectrum analysis, tofu dregs and kepok banana peels are suitable for use as raw materials for making paper because they contain cellulose. Based on the SEM analysis, the morphological surface structure, the tighter the fiber bonds, this proves that the diameter of the resulting fiber is very small, because the smaller the fiber diameter, the better the mechanical properties.

IDENTIFIKASI ANTALGIN DALAM JAMU PEGAL LINU SECARA KROMATOGRAFI LAPIS TIPIS Supartiningsih Supartiningsih; Eka Margaret Sinaga; Maringan Silitonga; Hotvera Marianis
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Traditional medicine is an ingredient or ingredient in the form of plant material, animal material, mineral material, preparation of extracts (galenic), or a mixture of these materials which have been used for generations. Jamu is traditional medicine, in general, herbal medicine cannot cure all kinds of diseases and its natural effect is not as fast as chemical drugs. Lately, medicinal chemicals are often added which are prohibited under the provisions of BPOM (Food and Drug Supervisory Agency). Antalgin is an analgesic-antipyretic and anti-inflammatory drug. Identification of antalgin in herbal aches and pains by thin layer chromatography aims to determine whether the herbal aches and pains circulating around Jalan Captain Muslim, Medan city contain levorphanoll drug chemicals or not. Antalgin identification in herbal pain relief was applied using Thin Layer Chromatography method with 60 F Silica gel stationary phase and chloroform-acetone-toluene (65: 25:10) mobile phase. From the results of identification by thin-layer chromatography (TLC) on herbal pain relief, it was found that the Rf value of the chromatogram spot on the levorphanol 0.16 reference standard was close to the sample Rf value (E) of 0.12. Based on the examination that has been carried out, it can be concluded that the positive herbal pain relief contains levorphanol drug chemicals so that the sample (E) tested does not meet the requirements.

FORMULASI SEDIAAN KRIM DEODORANT EKSTRAK ETANOL DAUN BELUNTAS (Plucea indica Less.) SEBAGAI PENCEGAH BAU BADAN Eka Margaret Sinaga; Supartiningsih Supartiningsih; Siti Maimunah; Nikmat Jayadi
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Beluntas is one of the plants that is often used as traditional medicine. Beluntas leaves have antimicrobial activity against various kinds of bacteria. This study aims to formulate Beluntas leaf extract (Plucea indica Less.) in the form of a deodorant cream that functions as a deterrent to body odor. The research method was carried out experimentally which included extract preparation, formulation using Beluntas leaf extract (Plucea indica Less.) with a concentration of 5%, 7.5%, 10%, preparation quality test, and hedonic test. The results of the formula The deodorant cream preparation can be used properly and can prevent sweating for 8 hours and the deodorant cream does not cause irritation and provides comfort when used, from formulas 1, 2, and 3, all the results are good to prevent sweating in the armpits but, the formula favored by the volunteers was formula 1 because the aroma was just right unlike formula 2, and formula 3 which had a slightly more pungent aroma, and similarly to the color in formula 1, the color was light green, unlike formula 2, and formula 3 which tended to be lighter in color. dark green. Beluntas leaf ethanol extract can be used to prevent body odor, and the extract can be used as a natural deodorant cream to prevent body odor.

ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Panal Sitorus; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Bernadetta R. Munthe
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux

Co-Authors Adiansyah Adiansyah Ahmad Ghazali Sofwan Ahmad Hafizullah Ritonga Barita Aritonang Bernadetta R. Munthe Cut Masyithah Thaib Devina Chandra Dicky Yuswardi Wiratma Eka M Sinaga Eka Margaret Sinaga Elly Nurita Sitorus Elly Sitorus Erly Sitompul Hapsah Junita Siregar Hotvera Marianis Jon Kenedy Marpaung Karnerius Harefa Kesaktian Manurung Khairunnisa Khairunnisa Maringan Silitonga May Fransisca Telaumbanua Naim Bahagia Nikmat Jayadi Panal Sitorus Pandapotan Nasution Rifka Gloria Samsia Yolanda Sari Sarah Lestari Sianipar, Artha Yuliana Siti Maimunah Siti Nurbaya Sriadiprastio Sriadiprastio Tiurma Sitompul Yosy Cinthya Eriwaty Silalahi Zuhairiah Nasution Zuhairiah Zuhairiah

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