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All Journal Jurnal Farmanesia

Yosy Cinthya Eriwaty Silalahi

Program Studi D3 ANAFARMA, Universitas Sari Mutiara Indonesia

Author-ID : 3483789

Medicine & Pharmacology

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SKRINING FITOKIMIA DAN UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL JAHE MERAH (Zingiber officinale Rosc. Var Rubrum) DAN EKSTRAK ETANOL JAHE PUTIH (Zingiber officinale Rosc. Var Officinarum) PADA MENCIT PUTIH JANTAN Siti Nurbaya; Yosy Cinthya Eriwaty Silalahi; Trionaldo Putra
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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One of the medicinal plants is ginger. The ginger plant has properties in overcoming pain, but it is not yet known how big the percentage of the strength of the analgesic activity of the ginger plant is. The components consisting of oleoresin are a complete picture of the content of ginger, namely essential oils and fixed oils consisting of gingerol, shagaol, and resin. Mice were divided into eight treatment groups (CMC 0.5%, Acetosal, EEJM (Red Ginger Ethanol Extract) 100, EEJM 200, EEJP (White Ginger Ethanol Extract) 100, EEJP 200, Combination 100, Combination 200). orally. Animals were induced with 3% acetic acid. Pain is characterized by the emergence of stretching which is indicated by the abdomen touching the base of the footing and both pairs of legs being pulled back. Observe stretching at intervals of every 10 minutes for 90 minutes. The characterization of red ginger rhizome simplicia and white ginger rhizome has met the requirements set by the Indonesian Herbal Pharmacopoeia. The results of phytochemical screening showed that simplicia and extracts from red and white ginger rhizome contained alkaloids and triterpenoids/steroids. The results showed that all treatment groups had an analgesic effect, which was not significantly different from the acetosal treatment (P>0.01). The highest analgesic power and effectiveness was seen in the EEJM 200mg/kg BW treatment group.

UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN BANGUN-BANGUN (Plectranthus amboinicus Lour.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Zuhairiah Zuhairiah; Yosy Cinthya Eriwaty Silalahi; Ariyanti Ariska
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Bangun-Bangun leaves contain phytochemical compounds such as phenolic compounds and flavonoids which have potential as antioxidant activity. This study aims to determine the antidiabetic activity of the ethanolic extract of Bangun-Bangun leaves on reducing blood glucose levels (KGD) of male white rats by using the glucose tolerance test method and the alloxan induction test. The study was conducted by grouping rats where each group consisted of 5 rats, the fasting KGD was measured. Then, a group I was given Na-CMC 1% BW, group II was given glibenclamide 0.45 mg/kg BW, group III was given EEDBB at a dose of 200 mg/kg BW, group IV was given EEDBB at a dose of 250 mg/kg BW and group V was given EEDBB dose of 300 mg/kg BW. In the glucose tolerance test, each group was given a 50% concentration of glucose solution. Furthermore, measurements of KGD were carried out at 30, 60, 90, and 120 minutes. In alloxan induction, 25 test animals weighing ±150-200 g that had been fasted were divided into 5 groups and then KGD was measured. The rats were then induced with a dose of 150 mg/kg BW of alloxan intraperitoneally. Diabetic rats were then given the test preparation orally for 15 consecutive days. Furthermore, glucose levels were measured on the 3rd, 5th, 7th, 9th, 11th, 13th, and 15th days. The results concluded that EEDBB can reduce blood glucose levels of male white rats induced by alloxan.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli, Shigella dysentriae, DAN Salmonella typhi Yosy Cinthya Eriwaty Silalahi; Realisni Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

One of the medicinal plants is the areca nut (Areca catechu L.) from the Arecae family which has the potential as an anticancer having antioxidant and antimutagenic, astringent, and anthelmintic effects. Areca nut seeds contain alkaloids, such as arekoline, arekolidine, arekain, guvakolin, guvasine and isoguvasine. This study aims to determine the characteristics of the betel nut (Areca catechu L.) simplicia, class of compounds, and the antibacterial activity of the ethanol extract of areca nut (Areca catechu L.) against the growth of Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria. The method used is the ethanol extract of areca nut (Areca catechu L.) obtained from the maceration process with 96% ethanol. The results of phytochemical screening showed that the ethanolic extract of areca nut (Areca catechu L.) contains a group of alkaloid compounds, tannins, flavonoids, saponins, and triterpenoids. The effect of giving young betel nut ethanol extract to Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria was indicated by the formation of an inhibition zone of optimum concentration. The ethanol extract of old betel nut against Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria was characterized by the formation of an optimum concentration inhibition zone. Based on the results, it can be concluded that the ethanol extract of areca nut (Areca catechu L.) has antibacterial activity against Escherichia coli, Shigella dysentriae, and Salmonella typhi.

FORMULASI DAN EVALUASI SEDIAAN LIP BALM DENGAN PEWARNA EKSTRAK UBI JALAR UNGU (Ipomoea batatas (L.) Lamk.) Supartiningsih Supartiningsih; Elly Nurita Sitorus; Yosy Cinthya Eriwaty Silalahi; Khairunnisa Khairunnisa
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Lip balm is a cosmetic preparation with the main components such as wax, fat, and oil from natural or synthesized extracts with the aim of preventing dryness of the lips by increasing lip moisture and protecting the adverse effects of the environment on the lips. The use of purple sweet potato as a dye is because purple sweet potato (Ipomoea batatas (L.) Lamk.) has an attractive color, the color of purple sweet potato is due to the presence of anthocyanin pigments which are derivatives of flavonoid compounds which are generally soluble in polar solvents. This study aims to formulate and evaluate lip balm preparations using purple sweet potato extract at concentrations of 3%, 6%, 9%, and without using purple sweet potato extract. This research is experimental research. Lip balm preparations were made by adding purple sweet potato extract with various concentrations (F1) 3%, (F2) 6%, (F3) 9%, and blank formula (F0) as the basis for lip balm preparations without purple sweet potato extract. Evaluation of the preparation includes homogeneity test, stability test, smear test, adhesion test, spreadability test, and pH test. The test results showed that purple sweet potato extract can be formulated in lip balm preparations that have a homogeneous composition, have good smearing power, good adhesion F0 (1 minute), F1 (1 minute 3 seconds), F2 (1 minute 8 seconds). seconds), F3 (1 minute 11 seconds), spreadability (5-5.7cm), pH test on all preparations showed a pH that was in accordance with the pH of the skin. And obtained formula 3 is the best formula.

ANALISA KADAR CEMARAN LOGAM MERKURI PADA IKAN SARDEN (Sardinella lemuru) KEMASAN KALENG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Yosy Cinthya Eriwaty Silalahi; Cut Masyithah Thaib; Siti Nurbaya
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Food packaging in cans is a food preservation technology using high-temperature sterilization. Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. This study aims to determine the levels of mercury contamination in canned sardines. The samples used in this study were 6 different brands of canned sardines. The method used to determine mercury (Hg) levels is qualitatively using color reagents and quantitatively using AAS (Atomic Absorption Spectrophotometry). The results obtained from 6 samples of canned sardines that were positive for heavy metal mercury (Hg) were indicated by the formation of orange color with KI reagent, yellow precipitate with NaOH, white precipitate with HCl. The wavelength used is 253.7 nm. The results showed that Brand A mercury 4.9814 ± 0.0301 mg/kg, Brand B 0.8757 ± 0.0308 mg/kg, Brand C 1.4899 ± 0 mg/kg, Brand D 1.4175 ± 0 mg/kg , Brand E 0.7527 ± 0 mg/kg, and Brand F 0.5270 ± 0 mg/kg. This study concludes that the mercury content in canned fish circulating in the Medan Brastagi Supermarket is above the maximum limit allowed by the National Standardization Agency (2016) in SNI 8222-2016, which is 0.5 mg/kg.

UJI AKTIVITAS EKSTRAK ETANOL DAUN SAWO MANILA (Manikara zapota L.) TERHADAP BAKTERI Bacillus cereus Kesaktian Manurung; Adiansyah Adiansyah; Yosy Cinthya Eriwaty Silalahi; Sry Hayati
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Sawo manila (Manikara zapota L.) merupakan salah satu bahan alam sebagai obat alternatif yang telah banyak dimanfaatkan oleh masyarakatnya juga untuk mengobati berbagai penyakit dan sawo merupakan tanaman dari family Sapotaceae yang digunakan dalam pengobatan tradisional. Ekstrak daun sawo manila mengandung alkaloid, tanin, flavonoid, dan saponin yang diketahui memiliki aktivitas antibakteri. Tujuan penulisan surat ini adalah untuk mengetahui aktivitas antibakteri sawo manila (Manikara zapota L.) terhadap bakteri Bacillus cereus. Penelitian ini menggunakan metode eksperimen, dengan metode ekstraksi maserasi dan metode chakra difusi untuk aktivitas antibakteri. Hasil penelitian menunjukkan bahwa simplisia memiliki kadar air 9,30%, larut dalam air 23,72%, kadar larut air ekstrak 31,15%, kadar abu total 1,11%, dan kadar ask tidak larut asam. 0,30%. Percobaan aktivitas anti bakteri ekstrak etanol daun sawo terhadap daya hambat bakteri bacillus cereus pada konsentrasi 20%, 40%, 60%, 80% dan 100% yaitu 12,62 mm, 15,0 mm, 15,74 mm, 16,9 mm , dan 18,78 mm, control positif menggunakan kotrimoksazol dan luas zona hambat 21,5 mm daun sawo manila dapat menghambat Bacillus cereus.

PEMERIKSAAN ZAT WARNA MERAH PADA MINUMAN BOTOL YANG BEREDAR DI SEKITAR JALAN KAPTEN MUSLIM MEDAN SECARA KROMATOGRAFI KERTAS Yosy Cinthya Eriwaty Silalahi; Dicky Yuswardi Wiratma; Artha Yuliana Sianipar
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Drinks are materials that are needed by living things, which are useful for survival. Therefore, many manufacturers are innovating with drinks, one of which is bottled drinks and adding colorants to drinks to attract buyers. The purpose of this study was to determine whether or not the use of red dye is not allowed in bottled drinks sold around Jalan Captain Muslim Medan. This study uses a descriptive method, namely by conducting examinations in the laboratory. Drinks that are red were taken as samples, namely as many as 5 samples. Samples were purified using wool absorption, followed by identification using paper chromatography compared with tables. The results of the observations showed that from the 5 samples tested, none of the bottled drinks containing red dye were prohibited.

FORMULASI KRIM ANTI-AGING DARI EKSTRAK KULIT BUAH JERUK LEMON (Citruslimon) Yosy Cinthya Eriwaty Silalahi; Zuhairiah Zuhairiah; Eka Margaret Sinaga; Isra Kristina Sitohang
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Anti-aging is a preparation that is useful for preventing or slowing down the effects of aging such as wrinkles, dark spots, rough skin, and enlarged pores. Lemon peel contains flavonoids, namely hesperidin which can prevent aging and can improve skin health. This study aims to formulate anti-aging cream preparations, test the anti-aging effect, and determine the best concentration of anti-aging cream from lemon peel extract. The concentration of lemon peel extract used as a cream ingredient are: 2.5%, 5%, 7.5%, 10%. The tests carried out were homogeneity test, determination of emulsion type, pH, stability observation, skin irritation test. The test was carried out for 4 weeks. The results showed that the anti-aging cream preparations produced were homogeneous and showed an o/w type. The pH test when the cream was made was: 6-7 and after 12 weeks of storage, it was: 5-7. Anti-aging cream preparations have shown a significant increase in skin effects after 1 week, 2 weeks, 3 weeks, and 4 weeks. F5 (10% cream) provides the best anti-aging effectiveness. Lemon peel extract can be formulated into an o/a cream preparation that is able to provide anti-aging effects on the skin. Formula 5 (F5) with a concentration of 10% lemon peel extract was the most.

PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL DAN EKSTRAK ETIL ASETAT DAUN JELATANG (Urticadioica L.) SECARA SPEKTROFOTOMETRI-VISIBLE Ahmad Gazali Sofwan; Yosy Cinthya Eriwaty Silalahi; Siti Nurbaya; Julianto Irawan
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Nettle (Urticadioica L.) is a dicotyledonous plant in the Urticaceae family. The nettle plant contains flavonoids. The parts of the nettle plant used as medicine are leaves, roots, and seed stotreatvene real diseases, kidney disorders, allergies, diabetes, anemia, and digestivetract diseases. Nettle leaves contain a lot of secondary metabolites which are active compounds. The purposeofthis study was to determine the appropriate solvent used to obtain nettle leaf extract (Urticadioica L.) withthehighest flavonoid contentfro methanol extract and ethylacetate extract. Determination of total flavonoid contentfrome than olextract and ethylacetate extract of nettle leafe quivalent to quercetin (Quercetin Equivalent (QE)) using aluminum chloridereagentat a wave lengthof 437 nm by Visible spectrophotometry. Base don there search conducted and determined by visible spectrophotometry, the total flavonoid content of nettle leafe than olextract using aluminum chloridereagent was 322.2494 ± 49.2828 mg QE/g extract, whilethe total flavonoid content of nettle leafe thylacetate extract using aluminum chloridereagent was 254,3651 ± 15,0245 mg QE/g extract, The right solventused to obtain nettle leaf extract (Urticadioica L.) with the highest flavonoid contentis ethanol solvent.

ANALISA KADAR CEMARAN MERKURI (Hg) PADA IKAN TUNA (Thunnus sp.) KEMASAN KALENG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Adiansyah Adiansyah; Yosy Cinthya Eriwaty Silalahi; Sanjaya Abdi L. G
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Mercury is a heavy metal that can have a toxic effect on the body so that it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in river, lake, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine the levels of mercury metal contamination in canned tuna. Sample preparation was carried out using the wet digestion method with a microwave digestion device. The results of the analysis showed that from the six samples of canned tuna fish according to the maximum limit and meet the standard maximum limit of 1.0 mg/kg SNI. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is at 253.7 nm. The results showed that the mercury in tuna brand A was 0.9030±0 mg/kg tuna brand B 0.1029±0 mg/kg, tuna brand C 0.4524±0 mg/kg, tuna brand C D 0.0967±0 mg/kg, tuna brand E 0.9567 ± 0 mg/kg, and tuna brand F 0.8034±0 mg/kg.

Co-Authors Adiansyah Adiansyah Ahmad Gazali Sofwan Ahmad Hafizullah Ritonga Ariyanti Ariska Cut Masyithah Thaib Dicky Yuswardi Wiratma Eka Margaret Sinaga Elly Nurita Sitorus Elly Sitorus Erly Sitompul Erly Sitompul Herdison Simatupang Isra Kristina Sitohang Jon Kenedy Marpaung Julianto Irawan Karnerius Harefa Kesaktian Manurung Khairunnisa Khairunnisa Manahan Situmorang Nurussakinah Nurussakinah Pandapotan Nasution Putri Niat Salma Halawa Realisni Telaumbanua Sanjaya Abdi L. G Sianipar, Artha Yuliana Siti Maimunah Siti Nurbaya Sry Hayati Supartiningsih Supartiningsih Trionaldo Purba Trionaldo Putra Zuhairiah Zuhairiah

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