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All Journal E-Jurnal Medika Udayana JURNAL BIOMEDIK Berkala Ilmu Kesehatan Kulit dan Kelamin Journal of General Procedural Dermatology and Venereology Indonesia ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Neurologico Spinale Medico Chirurgico IJAAM (Indonesian Journal of Anti-Aging Medicine) Journal of Global Pharma Technology

Anak Agung Gde Putra Wiraguna

Department Of Dermatology Faculty Of Medicine, Udayana University

Author-ID : 351025

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 34 Documents Claim Missing Document

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Administration of Ashitaba (Angelica keiskei) Leaf Extracts Cream Prevented The Increase of MMP-1 Expression and The Decrease of Collagen Number in The Male Wistar Rats (Rattus norvegicus) Skin Exposed to UVB Phery Candres; Wimpie Pangkahila; Anak Agung Gede Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 4 No 2 (2020): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v4i2.102

Introduction: Ultraviolet, especially the ultraviolet B (UV-B), is the most dominant cause of skin aging through increasing collagen degradation and activation of matrix metalloproteinase (MMPs). Recently, a lot of research focus on finding natural antioxidants with photoprotective activity. Ashitaba (Angelica keiskei) contains antioxidants and chalcone flavonoids. The purpose of this study was to examine the effect of ashitaba leaf extract, whether it could prevent increasing MMP-1 expression and decreasing collagen amount in rats exposed to UV-B rays. Methods: This study used randomized posttest only control group design. Subjects were 36 albino rats (Rattus norvegicus), male, adult (2.5 - 3 months old), weighing between 180-200 grams. All rats were divided into 18 rats each, namely the control group (the subject was smeared with basic cream and exposed to UVB) and the treatment group (the subject was smeared with ashitaba extract cream and exposed to UVB). The expression of MMP-1 using immunohistochemical staining and the amount of collagen using Sirius red staining. Results: The mean expression of MMP-1 in the control group was 28.14 ± 2.89% and in the treatment group was statistically lower at 9.45 ± 2.67% (p <0.001). The average amount of collagen in the control group was 53.64 ± 2.58% and in the treatment group was statistically higher at 83.57 ± 2.47% (p <0.001). Conclusion: The administration of ashitaba (Angelica keiskei) leaf extracts cream prevented the increase of MMP-1 expression and the decrease of collagen number in the male wistar rats (Rattus norvegicus) skin exposed to ultraviolet B.

Administration of Moringa (Moringa oleifera) Fruit Seed Extract Cream 6% Prevented Collagen Depletion in Ultraviolet B-Induced Guinea Pigs (Cavia Porcelus) Skin Yuziana Yuziana; Wimpie Pangkahila; Anak Agung Gede Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.74

ABSTRACT Background: Skin is often exposed to the environment such as Ultraviolet (UV) radiation which causes skin aging or photoaging. UVB-induced photoaging is characterized by a decrease in the amount of collagen. Natural ingredients that contain antioxidants, such as Moringa fruit seed extract containing bioactive compounds, are expected to prevent a decrease in the amount of collagen that eventually slows skin aging. The purpose of this study was to prove that administration of Moringa (Moringa oleifera) fruit seed extract cream 6% prevents collagen depletion in ultraviolet B-induced guinea pigs (Cavia porcelus) skin. Methods: This study was an experimental study with post-test only control group design. The subjects used in this study were 36 guinea pig (Cavia porcelus), 3 months old, male, and weighing 300-350 gr. The guinea pigs were grouped randomly into 2 groups with 18 guinea pigs/group. The first group (control) was the group treated with basic cream and exposed to UVB rays of 840 mJ/cm2; while the second group (treatment group) was treated with Moringa fruit seed extract cream 6% and exposed to UVB rays of 840 mJ/cm2. After 28 days of treatment, the guinea pigs were euthanized and histopathological examination of collagen was carried out with Sirius red staining. Results: The results showed that the average amount of collagen in the control group was 59.73 ± 2.31%. In the group of Moringa fruit seed extract cream 6%, the collagen amount was 84.07 ± 2.03%. Significance analysis using independent t-test showed a p value of <0.001 which means that there was a difference in the average amount of collagen between groups. Conclusion: In this study, the results indicated that administration of Moringa (Moringa oleifera) fruit seed extract cream 6% prevented collagen depletion in ultraviolet B-induced guinea pigs (Cavia porcelus) skin. Keywords: Moringa fruit seeds, collagen, guinea pigs, ultraviolet B.

Oral Administration of Polypodium leucotomos Powder Inhibited Sunburn Cells Formation in UVB-Induced Male Wistar Rats (Rattus Norvegicus) Priskila Ariana; I Gusti Made Aman; Anak Agung Gede Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.59

Introduction: UVB can cause direct damage to the DNA and eventually cause apoptosis of epidermal keratinocytes, which is called a sunburn cells. Polypodium leucotomos (Heliocare®) is one of the skin photoprotectors that can modulate immune and inflammatory responses that play a role in preventing sunburn. This study aimed to prove that oral administration of Polypodium leucotomos powder inhibits sunburn cells formation in UVB-induced male Wistar rats (Rattus norvegicus). Methods: This study was a true experimental study using post-test only control group design consisted of two groups with 18 rats/group. One group as a control group (P0) that was treated with oral 1ml aquadest (force feeding) for 10 days. The other group was the treatment group (P1) treated with oral Heliocare® dry powder (Polypodium leucotomos) of 80 mg/kg BW diluted in 1 ml aquadest (force feeding) for 10 days. On the day 11, the dorsal skin was shaved and exposed to single dose UVB of 25mJ. Twenty-four hours later, rats were sacrificed and skin samples were collected for histology preparations with Hematoxylin-Eosin staining and sunburn cells were counted as posttest data. Results: The results showed that the average number of sunburn cells in the P0 group was 36.5±7.53 sunburn cells/mm2, while in the P1 group was 8.3±3.59 sunburn cells/mm2 (p <0.05). Those data showed that there was a significant different of average number of sunburn cells among group tested. Conclusion: It can be concluded that oral administration of 80 mg/kg BW Polypodium leucotomos powder inhibited sunburn cells formation in UVB-induced male Wistar rats (Rattus norvegicus).

Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed Guin Chynthia Friama; Anak Agung Gde Putra Wiraguna; Wimpie Pangkahila
Neurologico Spinale Medico Chirurgico Vol 4 No 1 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i1.147

Background: Excessive sun exposure results in increased activity of the tyrosinase enzyme and the amount of melanin in the skin which causes hyperpigmentation, a sign of premature aging. The purpose of this study was to prove that Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin and tyrosinase enzymes as effective as hydroquinone cream 4% in the ultraviolet B-exposed guinea pig (Cavia porcellus) skin. Methods: This study used a randomized post-test only control group design. The subjects were 36 male guinea pigs (Cavia porcellus). Subjects were divided into two groups, the hydroquinone cream 4% group and the Ashitaba leaves extract cream 8% group exposed to UVB light. Skin samples were collected 48 hours after the last exposure to measure the tyrosinase enzyme levels using the ELISA method and the amount of melanin was examined by Masson-Fontana staining. Results: The mean levels of tyrosinase in the hydroquinone cream 4% group was 19.51 ± 5.16 ng/L and the Ashitaba leaves extract cream 8% group was 23.76 ± 3.09 ng/L (p = 0.005). The mean amount of melanin in the hydroquinone cream 4% group was 2.98 ± 2.27% and the Ashitaba leaves extract cream 8% group was 4.77 ± 3.33% (p = 0.069). Conclusion: The administration of Ashitaba (Angelica keiskei) leaves extract cream 8% inhibited the increase of melanin amount as effective as hydroquinone cream 4% and inhibited the increase of tyrosinase enzymes not as effective as hydroquinone cream 4% in the ultraviolet B-exposed guinea pig (Cavia porcellus) skin.

Intradermal injection of umbilical cord mesenchymal stem cell was more effective than platelet rich plasma in increasing amount of collagen and fibroblasts in Wistar rats (Rattus norvegicus) back skin exposed to ultraviolet B rays Anne Carolina Kencanawati; Wimpie Pangkahila; Anak Agung Gde Putra Wiraguna
Neurologico Spinale Medico Chirurgico Vol 4 No 1 (2021)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v4i1.152

Background: Ultraviolet B exposure is one of the causes of extrinsic skin aging. Ultraviolet exposure may lead to skin collagen damage. This study about mesenchymal stem cells from umbilical cord (UCMSC) compared with platelet rich plasma (PRP) with the aim was to prove that the intradermal injection of UCMSC was more effective than PRP in increasing amount of collagen and fibroblasts in Wistar rats' back skin exposed to Ultraviolet B rays. Methods: This study used post-test only control group design. Subjects were 36 Wistar rats aged 2.5 months. A control group consisting of 18 Wistar rats treated with intradermal injection of PRP and the treatment group with UCMSC. Both groups were exposed to UVB with a total radiation dose of 840 mJ/cm2. The parameter of collagen was determined by picro sirius red staining while fibroblasts by Haematoxylin-Eosin staining. Result: The mean amount of collagen in the control group was lower (57,82±6.52%) than the treatment group (65.69±4.51%) with p<0.001. The result showed there were differences in the number of collagen in both groups (p<0.05). The mean number of fibroblasts in the control group was lower (22.63±5.98 cell/field of view) than the treatment group (28.20±8.90 cell/field of view) with p=0.034. The result showed there were differences in mean of fibroblasts in both groups (p<0.05). Conclusion: It can be concluded that the intradermal injection of UCMSC was more effective in increasing the amount of collagen and fibroblasts than intradermal injection of PRP in Wistar rats' back skin exposed to UVB rays.

Centella asiatica extract cream inhibited microphthalmia-associated transcription factor (MITF) expression and prevented melanin amount increase in Guinea pig skin exposed to ultraviolet-B Fatri Idana; Anak Agung Gde Putra Wiraguna; Ni Wayan Winarti
Neurologico Spinale Medico Chirurgico Vol 5 No 1 (2022)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v5i1.177

Background: Centella asiatica has been popularly used in cosmetic products, especially due to its antioxidant benefits in soothing and healing wounds. However, the inhibition of melanogenesis in the content of Centella asiatica has not been widely studied. This study aimed to prove the effectiveness of 10% Centella asiatica cream on male Guinea pig (Cavia porcellus) skin exposed to UVB. Methods: The randomized posttest-only control group study was conducted on 36 Guinea pigs aged 3-months, body weight 300-350 grams with a healthy skin condition. They were randomly divided into two groups; each consists of 18 Guinea pigs. The first group was a control group given base cream 20-minutes before and 4-hours after UVB exposure, 3-times-a-week for two weeks. The second group was the treatment group given 10% Centella asiatica cream and expose to UVB with the same procedure. The histopathological preparations were made using a punch biopsy after intervention was completed. Immunohistochemical staining was performed to measure the expression of microphthalmia-associated-transcription-factor (MITF) and Masson-Fontana to measure the amount of melanin. Data analysis was conducted to compare the results in both groups. Results: The treatment group had a significantly lower mean MITF expression (13.61 ± 5.36 vs. 27.24 ± 6.50%) and melanin amount (5.95 ± 3.81 vs. 16.59 ± 5.77%) (p < 0.001) compared to the control group. Conclusion: The administration of cream consists of Centella asiatica extract 10% effectively inhibits the expression of MITF and prevented the increase of melanin amount in male guinea pigs (Cavia porcellus) exposed to UVB.

Korelasi negatif kuat kadar prolaktin plasma yang rendah terhadap derajat keparahan melasma Angela Sandi Tagaroi Rahasia; Anak Agung Gde Putra Wiraguna; Luh Made Mas Rusyati
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Background: Melasma is a chronic cutaneous hypermelanosis in areas exposed to sunlight. Hormonal factors are known to influence melanogenesis processes such as prolactin as a neuroendocrine modulator in skin epithelial growth and immune system. This study aims to prove the inverse relationship between plasma prolactin levels and the severity of melasma.Methods: A cross-sectional study was carried out on 59 patients in the skin and genital olyclinic at Sanglah Hospital in Denpasar involving 46 subjects of melasma and 13 subjects who were not melasma who met the inclusion and exclusion criteria. Plasma prolactin levels were assessed by the Chemiluminescent microparticle immunoassay (CMIA) method. Data analysis was performed using SPSS ver. 23 software with a P-value <0.05 was considered statistically significant.Results: Plasma prolactin levels in patients with melasma were significantly lower than non-melasma patients (p <0.05). Patients with moderate and severe degrees of melasma had significantly lower plasma prolactin levels compared with mild degree of melasma (p <0.05). Low plasma prolactin levels can increase the likelihood of melasma by 4.79 times (PR 4.79; 95% CI = 0.94-24.27; p <0.05). Low plasma prolactin levels were significantly strong negative correlated with melasma severity (r = -0.820; p <0.05).Conclusion: There is a strong negative correlation of low plasma prolactin levels with the severity of melasma in patients with skin disorders at Sanglah General Hospital

Korelasi jumlah sel CD4 dengan skor nugent pada wanita dengan infeksi human immunodeficiency virus Ni Made Dwi Puspawati; Anak Agung Gde Putra Wiraguna; I Gusti Ayu Agung Dwi Karmila; I Ketut Agus Somia
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Introduction: CD4 cell counts are still used to assess disease progression due to infection with Human Immunodeficiency Virus (HIV). The lower the number of CD4 cells, the more susceptible patients are to various kinds of opportunistic infections. Nugent Score is a rating system to determine the presence of Lactobacillus which is a normal microbiota in the vaginal ecosystem. The purpose of this study was to determine the relationship of CD4 cell counts with Nugent scores in HIV-infected women.Method: This study is an analytic study with a cross-sectional approach in women with HIV infection in Sanglah Hospital Denpasar. Sampling with consecutive sampling technique. For each sample, venous blood was taken to measure CD4 cell counts and gram stains were examined from a vaginal swab to measure Nugent's score.Results: The study found the average age of the study sample was 36.42 years. Most of the samples had a normal Nugent score (0-3) with a CD4 count> 500 or were not immunodeficient (34%). There was a significant difference in the Nugent score based on the number of partners owned (p<0.05). There was no significant difference in Nugent's score based on condom use, vaginal wash and smoking history (p>0.05). The majority of patients who experienced immunodeficiency, mild immunodeficiency, and moderate immunodeficiency had normal Nugent scores (47.1%, 80%, 54.5%, respectively). Only the group with the most severe immunodeficiency had bacterial vaginosis (57.1%).Conclusions: No significant differences were found between CD4 cell counts and Nugent scores. This can be caused because there is no relationship between the two or because of confounding factors that have not been controlled. Further research needs to be done by correcting confounding factors so that subsequent research can improve precision.Â Pendahuluan: Jumlah sel CD4 sampai saat ini masih digunakan untuk menilai perkembangan penyakit akibat infeksi Human Immunodeficiency Virus (HIV). Semakin rendah jumlah sel CD4 semakin rentan penderita terhadap berbagai macam infeksi oportunistik. Skor Nugent adalah sistem penilaian untuk mengetahui keberadaan Lactobacillus yang merupakan mikrobiota normal pada ekosistem vagina. Tujuan penelitian ini untuk mengetahui hubungan jumlah sel CD4 dengan skor Nugent pada wanita terinfeksi HIV.Metode: penelitian ini merupakan penilitian analitik dengan pendekatan cross-sectional pada wanita dengan infeksi HIV di RSUP Sanglah Denpasar. Pengambilan sampel dengan teknik consecutive sampling. Pada setiap sampel dilakukan pengambilan darah vena untuk pengukuran jumlah sel CD4 dan pemeriksaan pengecatan gram dari swab vagina untuk mengukur skor Nugent.Hasil: penelitian didapatkan rerata usia sampel penelitian adalah 36,42 tahun. Sebagian besar sampel memiliki skor Nugent normal (0-3) dengan jumlah CD4 >500 atau tidak imunodefisiensi (34%).Terdapat perbedaan signifikan pada skor Nugent berdasarkan jumlah pasangan yang dimiliki (p<0,05). Tidak ada perbedaan signifikan pada skor Nugent berdasarkan penggunaan kondom, pencuci vagina dan riwayat merokok (p>0,05). Mayoritas pasien yang mengalami imunodefisiensi, imunodefisiensi ringan, dan imunodefisiensi sedang memiliki skor Nugent yang normal (47,1%, 80%, 54,5%, secara berurutan). Hanya kelompok dengan imunodefisiensi berat yang mayoritas memiliki bakterial vaginosis (57,1%).Simpulan: tidak ditemukan perbedaan yang bermakna antara kadar CD4 dengan skor Nugent. Hal ini bisa disebabkan karena memang tidak ada hubungan antara keduanya atau karena faktor perancu yang belum dikontrol. Perlu dilakukan penelitian lanjutan dengan mengkoreksi faktor perancu sehingga penelitian berikutnya dapat meningkatkan presisi.

Gambaran karakteristik pasien kondiloma akuminata dengan infeksi HIV/AIDS di RSUP Sanglah, Denpasar, Indonesia tahun 2011-2015 Ida Bagus Gede Jayadharma; Anak Agung Gde Putra Wiraguna
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Condyloma acuminata, known as genital warts, is a sexually transmitted infection caused by a virus, namely Human Papilloma Virus (HPV). HPV infections are related to other sexually transmitted infections such as the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). This study aims to know the patient characteristics of condyloma acuminata in patients with HIV infection in Sanglah General Hospital, Denpasar, from January 2011 to December 2015.Methods: This research is a retrospective descriptive study with a cross sectional method. This research analyzed 58 patients of condyloma acuminata with HIV infection in Sanglah Public Hospital from January 2011 to December 2015. Research variables were based on age, sex, level of education, marital status, and work level. Data were analyzed using SPSS version 17 for Windows.Results: This study found that the prevalence of condyloma acuminata with HIV infection based on age was 15-24 years old (17.2%), 25-44 years old (81.0%), and 45-64 years old (1.7%). The results based on sex were 91.4% for males and 8.6% for females. The results based on education level were elementary school (8.6%), high school (53.4%), higher education (37.9%). The results based on work level were government employee (3.4%), private employee (77.6%), entrepreneur (10.3%), and do not have a job (8.6%). And the results based on marital status were married (13.8%) and single (86.2%).Conclusion: The highest prevalence of condyloma acuminata with HIV infection based on age was 25-44 years old, males gender, high school level of education, and working in the private sector. Latar Belakang: Kondiloma akuminata atau dikenal sebagai genital wart (kutil kelamin) adalah infeksi menular seksual yang disebabkan oleh virus, yaitu Human papilloma virus (HPV). Infeksi HPV kerap dikaitkan dengan infeksi menular seksual lainnya seperti Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS). Tujuan penelitian ini untuk mengetahui karakteristik pasien kondiloma akuminata pada pasien yang terinfeksi HIV di Rumah Sakit Umum Pusat Sanglah Denpasar dari bulan Januari 2011 sampai dengan bulan Desember 2015.Metode: Penelitian ini merupakan penelitian deskriptif retrospektif, dengan metode cross sectional. Penelitian ini menganalisis 58 pasien dengan kondiloma akuminata dengan HIV di Poliklinik RSUP Sanglah pada periode Januari 2011 sampai dengan Desember 2015. Variable pada penelitian ini yaitu berdasarkan umur, jenis kelamin, tingkat pendidikan, status perkawinan, dan tingkat pekerjaan. Data dianalisis dengan SPSS versi 17 untuk Windows.Penelitian: Hasil dari penelitian ini didapatkan bahwa berdasarkan umur 15-24 tahun (17,2%), 25-44 tahun (81,0%), dan 45-64 tahun (1,7%). Berdasarkan jenis kelamin, yaitu laki-laki (91,4%) dan perempuan (8,6%). Hasil penelitian berdasarkan tingkat pendidikan, kelompok pendidikan dasar (8,6%), pendidikan menengah (53,4%), dan pendidikan tinggi (37,9%). Berdasarkan pekerjaan, yaitu kelompok PNS (3,4%), pegawai swasta (77,6%), wiraswasta (10,3%), dan kelompok tidak bekerja (8,6%). Dan berdasarkan status perkawinan didapatkan hasil yaitu kelompok menikah (13,8%) dan yang belum menikah (86,2%).Kesimpulan: Prevalensi kondiloma akuminata dengan HIV paling banyak berdasarkan kelompok umur yaitu kelompok usia 25-44 tahun, jenis kelamin laki-laki, kelompok pendidikan menengah, dan bekerja di sektor swasta.

Kondiloma akuminata perianal pada seorang laki-laki biseksual disertai infeksi HIV stadium III yang diterapi dengan kombinasi asam trikloroasetat 80% dan seng oral Rahel Lisana Debora Hutagalung; Anak Agung Gde Putra Wiraguna
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Condyloma acuminata in the homosexual population caused by anogenital sexual behavior causes more microabrasion to occur which increases the risk of infection with human papilloma virus (HPV) and HIV. This case report aims to provide an overview of the clinical outcome of condyloma acuminata in homosexual patients with HIV grade III.Case: Male, 26 years old with an itchy and painless lump around the genitals and anal canal since two months ago. The new patient was diagnosed with HIV since two weeks before the visit to the Sanglah Hospital polyclinic. It was found that the patient was a homosexual with a history of multiple partners and had been going on for five years. Physical examination of the perianal region revealed multiple skin-colored tumors, geographic shape, 3x5cm - 3x5.5cm in size, with a verrucous surface, and solid consistency with a positive acetowhite test that concluded as perianal condyloma acuminata. It was decided to give tricolor acetate (TCA) 80% spotted therapy and oral zinc sulfate 100mg/day. Up to 2 TCA session therapy and oral zinc administration in approximately three weeks, the lesion was getting better with efflorescence in the form of multiple papules, color of the mucosa that confluent to form a tumor, geographic shape, size 3x2cm - 3x3cm, smooth surface, solid consistency.Conclusion: The response to treatment with TCA 80% for 2 times and oral zinc for 3 weeks was quite good, the number of lesions was reduced and the size of the lesions was reduced. The prognosis of the patient is dubious because even if the condyloma acuminata lesion has been repaired, the presence of HIV infection can lead to the risk of recurrence and the risk of progression to malignancy. Latar belakang: Kondiloma akuminata pada populasi homoseksual diakibatkan oleh perilaku seksual secara anogenital menyebabkan lebih banyak mikroabrasi yang terjadi yang menyebabkan peningkatan risiko infeksi human papilloma virus (HPV) dan HIV. Laporan kasus ini bertujuan untuk memberikan suatu gambaran luaran klinis dari kondiloma akuminata pada pasien homoseksual dengan HIV derajat III.Kasus: Laki-laki, 26 tahun dengan benjolan risakan gatal dan tidak nyeri pada sekitar kelamin dan lubang anus sejak dua bulan yang lalu. Pasien baru terdiagnosa HIV sejak dua minggu sebelum kunjungan poliklinik RSUP Sanglah. Diketahui pasien merupakan seorang homoseksual dengan riwayat berganti-ganti pasangan dan sudah berlangsung selama lima tahun. Pemeriksaan fisik region perianal menunjukkan tumor sewarna kulit multipel, bentuk geografika, ukuran 3x5cm – 3x5,5cm, dengan permukaan verukosa, dan konsistensi padat dengan hasil tes acetowhite positif yang disimpulkan sebagai suatu kondiloma akuminata perianal. Diputuskan untuk memberikan terapi tutul tricolor acetat 80% dan seng sulfat oral 100mg/hari. Hingga terapi 2 kali tutul dan pemeberian seng oral dalam jangka waktu kurang lebih tiga minggu terjadi perbaikan lesi dengan efloresensi berupa papul multipel sewarna mukosa yang berkonfluen membentuk tumor, bentuk geografika, ukuran 3x2cm – 3x3cm, permukaan licin, konsistensi padat.Simpulan: Respon pengobatan dengan TCA 80% selama 2 kali dan seng oral selama 3 minggu cukup baik, jumlah lesi berkurang dan ukuran lesi mengecil. Prognosis dari pasien adalah dubius karena walaupun telah terjadi perbaikan lesi kondiloma akuminata, adanya infeksi HIV dapat menyebabkan risiko terjadinya rekurensi dan risiko perkembangan ke arah keganasan.

Co-Authors Angela Sandi Tagaroi Rahasia Anne Carolina Kencanawati Astried Haryanto Balqis Wasliati Batan, Putu Nila Wardhani Bunge Dianmentari Chynthia Friama Diana Niti Santoso Dwindi Saptania Erwin Sugito Fatri Idana Fiter, Joni Gde Ngurah Idraguna Pinatih Golda Bernadet Lemewu I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Made Aman I Ketut Agus Somia Ida Bagus Gede Jayadharma Ida Sri Iswari Junivan Lindra Komang Aditya Yudistira Komang Saputra Yadnya Luh Made Mas Rusyati Made Wardhana Maharani, Made Kusuma Dewi Marrietta Sugiarti Sadeli Martina Windari Maya Cesarya Simangunsong Meiny Linda Setiawan Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Ni Wayan Winarti Olivia Julita Pande Agung Mahariski Phery Candres Prima Saraswati Sanjiwani Sudarsa Priskila Ariana Rahel Lisana Debora Hutagalung Somia Sri Subramaniam Stefani Nurhadi Vanessa Vijayamurthy Vijayamurthy, I Dewa Ayu Vanessa Wimpie I Pangkahila Yuziana Yuziana

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