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Journal : Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

IDENTIFIKASI DAN ANALISIS KANDUNGAN MAKRONUTRIEN GLUKOMANAN UMBI PORANG (Amorphophallus onchophyllus) Bekti Nugraheni; Anastasia Setyopuspito P; Yustisia Dian Advistasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.528 KB) | DOI: 10.31942/jiffk.v15i2.2570

Abstract

ABSTRACTThe purpose of this study is identification and analysis of the macronutrient glucomannan from porang tuber (Amorphophallus onchopyllus). The stages done in this research are extraction, identification, and macronutrient analysis of glucomannan of the porang tuber. Prior to extraction, the oxalic acid was removed from porang tuber using mixture of 2% lime juice and 5% lime, then the glucomannans was extracted using ultrasonic method. The glucomannan then was identified using Fourier transform infra red spectrometer (FTIR) instrument and macronutrient analyzer such as Soxhlet method for fats and fibers, Kjedahl method for protein, and Antrone method for carbohydrates. The results of identification using FTIR showed the presence of β-pyranose at wave numbers of 900-810 cm -1 . The carbonyl on on acetyl group was found at 1726 cm-1 . The area between 870-800 cm-1 showed the β-glycosidic and β-manosidic compounds. The C-O ether group was shown in the area of 1260-1200 cm -1 , while for C-O alcohol was shown in the area of 1050 cm-1 showed the C-O bond in alcohol. At 2925 cm-1 it showed C-H, while at 3000-3700 cm-1 O-H group. The levels of porang glucomannan macronutrients included fat at 0.50%, protein at 1.05%, fiber at 22.34%, and carbohydrates at 31.33%.Key word: Porang tuber, glucomannan, FTIR, macronutrient analysis.
EFEK HIPOTRIGLISERIDEMIA TEPUNG UMBI KIMPUL (Xanthosoma violaceum Schott.) PADA TIKUS PUTIH JANTAN Yustisia Dian Advistasari; Etty Sulistyowati; Ika Puspitaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.812 KB) | DOI: 10.31942/jiffk.v13i1.1446

Abstract

ABSTRACT Triglycerides (triacylglycerols) is the major lipid compounds in body fat and food deposits. Hypertriglyceridemia is a disorder characterized by an  increase of triglyceridesconcentration  in the blood. Tuber purse known as  Umbi Kimpul(Xanthosomaviolaceum Schott.) is believed as a medicinal plant. This study aims to determine the effect of hipotrigliseridemiaof purse tuber flour and the effective dose. To determine the effect of hipotrigliseridemia of purse tuber flour, 30 white male Wistar rats were used and they were divided into 6 groups. Group I (normal control) was  fed a standard food, group II (negative control) was given suspension CMC Na 0,5%, group III (positive control) was given suspension gemfibrozil 54 mg / kgbody weight of mice, group IV, V and VI were given pursetuber flour wtih graded dose at 270, 540 and 1080 mg / kgbody weight of mice. The Induction of hypertriglyceridemia was  a mixture of standard rat food with 15% lard and 5% egg yolk of duck, as well as fructose 1.8 g / kg body weight of mice. The Induction was conducted for 50 days, unless  the normal control group. Blood triglyceride levels were measured on days 0, 51 and 58. The triglyceride levels were calculated their decline percentagebefore statistically tested using SPSS statistical release16. The results showed a significant difference in the negative control group CMCNa suspension with purse tuber flour suspension. It is concluded that  the purse tuber flour suspension has an effect of hipotrigliseridemia. The effective dose of pursetuber flour as hipotrigliseridemia is 270 mg / kg body weight of mice. Keywords  : flour tuber kimpul, hypotriglyceride, white male rats