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All Journal Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks
Intan, Shinta Ayu
Anatomic Pathology Department, Faculty Of Medicine, Universitas Andalas, Padang.
Computer Science & IT Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Hubungan Ekspresi Survivin dengan Subtipe Molekuler Karsinoma Mammae Invasif Shinta Ayu Intan; Yenita Yenita; Tofrizal Tofrizal; RZ Nizar
Jurnal Kesehatan Andalas Vol 8, No 3 (2019): Online September 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i3.1036

Abstract

Karsinoma mammae merupakan salah satu penyebab utama kematian pada perempuan di seluruh dunia. Karsinoma ini memiliki prognosis, respon pengobatan serta perilaku klinis yang berbeda yang disebabkan oleh karakteristik molekuler yang berbeda. Berbagai faktor prognostik telah menjadi dasar dalam pemberian terapi adjuvan (dan kelangsungan hidup). Salah satu molekul yang memiliki peran sebagai faktor prognostik adalah survivin. Tujuan penelitian adalah menentukan hubungan ekspresi survivin dengan subtipe molekuler karsinoma mammae invasif. Penelitian ini menggunakan metode analitik potong lintang. Sampel adalah 40 kasus dari sediaan blok parafin karsinoma mammae invasif yang didiagnosis histopatologi di Sentra Diagnostik Patologi Anatomik Fakultas Kedokteran Universitas Andalas Sumatera Barat periode Januari 2014-Desember 2017 serta reevaluasi subtipe molekuler yang telah diperiksa di Laboratorium Patologi Anatomik Fakultas Kedokteran Universitas Padjadjaran Bandung berdasarkan pemeriksaan imunohistokimia ER, PR, Her-2 dan Ki-67. Ekspresi survivin dinilai secara imunohistokimia ditandai dengan warna coklat pada inti dan sitoplasma sel tumor. Hasil penelitian dianalisis dengan uji Chi-square. Ekspresi survivin positif ditemukan pada 27 kasus dengan 9 sampel (33,3%) subtipe luminal, 8 sampel (29,6%) subtipe Her-2, dan 10 sampel (37%) subtipe Triple-negative. Karsinoma mammae invasif paling banyak ditemukan pada kelompok usia 50-59 tahun serta subtipe molekuler terbanyak adalah subtipe Triple-negative. Kesimpulan penelitian ini tidak terdapat hubungan bermakna antara ekspresi survivin dengan subtipe molekuler karsinoma mammae invasif (p=0,770).
Upaya Optimalisasi Pertumbuhan Anak Stunting melalui Peningkatan Pengetahuan Ibu tentang Kesehatan Keluarga Ulya Uti Fasrini; Desmawati Desmawati; Masrul Masrul; Nur Indrawaty Lipoeto; Delmi Sulastri; Fathiyyatul Khaira; Rahmani Welan; Shinta Ayu Intan; Rinaldiansyah Rinaldiansyah; Muhammad Rayyan Rifqi; Annisaul Husna; Rahmi Nurjannah
Warta Pengabdian Andalas Vol 28 No 3 (2021)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.28.3.232-238.2021

Abstract

The nutritional problem such as stunting will impact human resource quality. Various factors, including family economic problems, contributed to it, such as in Lambung Bukit Village, Pauh District in Padang City. Apart from financial issues, the mother's lack of illiteracy on child health and nurture also contributes to nutritional problems in this area. Health services that involve physical examinations, child development, nutritional problems and the mother's understanding of family health need to be carried out. Nutrition education was given together with maternal education about parenting and maternal health by the community service team from the Nutrition Science Section and Anatomical Pathology Section, Faculty of Medicine, Andalas University. Thirty mothers accompanied by their toddlers attended the activity. The service team provided five steps that participants must pass, including registration activities, anthropometric examinations, nutritional history, problem assessments, and nutritional consultations. It was hoped that both individual and group approaches would provide significant leverage for changing maternal behaviour. The mother benefited of the education provided. They requested that the team carry out this activity regularly at least once every three months, both to assess the growth and development of children and provide the knowledge about family health they need.
Kromomikosis yang menyerupai karsinoma sel skuamosa: suatu kasus jarang Shinta Ayu Intan; Salmiah Agus; Anandia Putriyuni
Majalah Kedokteran Andalas Vol 41, No 3 (2018): Published in September 2018
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v41.i3.p112-119.2018

Abstract

Kromomikosis merupakan infeksi jamur kronik yang disebabkan oleh jamur berpigmen (dematiaceous) yang masuk ke dermis dari lingkungan sekitar. Kromomikosis mengenai laki-laki dewasa dengan rentang usia antara 40-50 tahun. Predileksi paling sering yaitu di ekstremitas bawah terutama kaki. Tanah, sayur-sayuran dan bahan organik lainnya merupakan habitat normal dari jamur ini. Tujuan: Melaporkan satu kasus kromomikosis jarang. Kasus: Dilaporkan kasus pada seorang laki-laki usia 53 tahun dengan bercak berwarna keabu-abuan tanpa rasa gatal dan nyeri yang semakin bertambah besar sejak ±1 tahun yang lalu pada pergelangan kaki kiri.  Simpulan: Kromomikosis sering salah didiagnosis sebagai karsinoma sel skuamosa, konfirmasi histopatologi penting untuk menegakkan diagnosis karena pemeriksaan secara histopatologi menunjukkan gambaran khas yaitu adanya copper pennies sehingga dapat menyingkirkan diagnosis bandingnya. 
Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia Nita Afriani Azmal; Shinta Ayu Intan; Tofrizal Tofrizal
Jurnal Kesehatan Andalas Vol 11, No 1 (2022): Online March 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1982

Abstract

 Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was  5 cases (13.5%).   Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma.Keywords:  SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signaling
Co-Authors Anandia Putriyuni Annisaul Husna Delmi Sulastri Desmawati Desmawati Fathiyyatul Khaira Masrul Muhammad Rayyan Rifqi Nita Afriani Azmal Nur Indrawaty Lipoeto Rahmani Welan Rahmi Nurjannah Rinaldiansyah Rinaldiansyah RZ Nizar Salmiah Agus Tofrizal Tofrizal Tofrizal Ulya Uti Fasrini Yenita Yenita