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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ilmiah Medicamento Journal of Pharmaceutical and Health Research Jurnal Sains dan Kesehatan Bandung Conference Series: Pharmacy Borneo Journal of Pharmacy
Vinda Maharani Patricia
Farmasi, Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Penelusuran Pustaka Kandungan Senyawa dari Ekstrak Kulit Pisang Raja (Musa paradisiaca var raja) dan Kulit Pisang Cavendish (Musa cavendishii) dalam Beberapa Aktivitas Farmakologi Muhammad Fadhil Safari; Vinda Maharani Patricia; Livia Syafnir
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.617 KB) | DOI: 10.29313/bcsp.v2i2.4714

Abstract

Abstract. Plantain (Musa paradisiaca var raja) and cavendish banana (Musa cavendishii) is a plant that has long been used by the public as a medicinal plant. The parts of the banana plant are known to have pharmacological activity, while the banana peel is only considered waste that is thrown away after the fruit is taken. The research method used is a Systematic Literature Review with literature searches related to the pharmacological activity of the extracts of raja banana peel and cavendish banana peel. The data obtained is then displayed in tabular form and explained in paragraph form. The results showed that the extracts of plantain peel and cavendish banana peel had pharmacological activities such as antibacterial, antihyperglycemic and antioxidant. which is thought to come from the content of a class of compounds in plantain peels and cavendish banana peels such as alkaloids, phenols, flavonoids, tannins and saponins. Abstrak. Pisang raja (Musa paradisiaca var raja) dan pisang cavendish (Musa cavendishii) merupakan tanaman yang sejak dahulu sudah digunakan oleh masyarakat sebagai tanaman obat. bagian-bagian dari tanaman pisang sudah diketahui memiliki aktivitas farmakologis, sedangkan kulit pisang hanya dianggap limbah yang dibuang setelah diambil buahnya. Tujuan dari penelusuran pustaka ini adalah untuk mengetahui aktifitas farmakologi dari kandungan golongan senyawa ekstrak kulit pisang raja (Musa paradisiaca var. Raja) dan kulit pisang cavendish (Musa cavendishii). Metode penelitian yang digunakan adalah Systematic Literature Review dengan penelusuran pustaka terkait aktivitas farmakologi dari ekstrak kulit pisang raja dan kulit pisang cavendish. Data yang diperoleh kemudian ditampilkan dalam bentuk tabel dan dijelaskan dalam bentuk paragrafh. Hasil yang didapat menunjukan bahwa ekstrak kulit pisang raja dan kulit pisang cavendish memiliki aktivitas farmakologis seperti antibakteri, antihiperglikemia dan antioksidan yang diduga berasal dari kandungan golongan senyawa pada kulit pisang raja dan kulit pisang cavendish seperti alkaloid, fenol, flavonoid, tannin dan saponin.
Penelusuran Pustaka Tanaman yang Berpotensi sebagai Antibakteri untuk Penyakit Infeksi Saluran Kemihluran Kemih Kenny Utami Prameswari; Indra Topik Maulana; Vinda Maharani Patricia
Bandung Conference Series: Pharmacy Vol. 3 No. 1 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i1.6347

Abstract

Abstract. Urinary Tract Infection is a disease that has a fairly high prevalence in Indonesia. The common treatment for this disease is using antibiotics. However, uncontrolled and irrational use causes resistance to these antibiotics. Thus, medicinal plants that have the potential to inhibit UTI-causing bacteria can be used as an alternative to reduce the occurrence of resistance to these antibiotics. MIC value (Minimum Inhibitory Concentration) is a parameter of plants that have potential. The results of the literature search show that there are several plants that have the potential to be antibacterial for UTIs, namely Garlic (Allium sativum), Fennel (Foeniculum vulgare mill), Seribu Leaf (Achillea mille folium) Horse Chestnut (Aesculus hippocastanum L.), Parsley ( Petroselinum crispum), Rosemary (Rosmarinus officinalis), Rosella (Hibiscus sabdariffa), Syrian Rue (Peganum harmala L.), Horsetail Ferns (Equisetum ramosissimum Desf. Stem), Galunggang (Sida acuta), Phyllanthus amarus, Phyllanthus muellerianus, and Cumin White (Cuminum cyminum). Abstrak. Penyakit Infeksi Saluran Kemih merupakan penyakit yang memiliki prevalensi yang cukup tinggi di Indonesia. Pengobatan umum yang dilakukan untuk menangani penyakit tersebut adalah menggunakan antibiotik. Namun, penggunaan yang tidak terkontrol dan tidak rasional menyebabkan resistensi terhadap antibiotik. Sehingga, tanaman-tanaman obat yang berpotensi untuk menghambat bakteri penyebab ISK dapat dijadikan alternatif untuk mengurangi terjadinya resistensi. Nilai KHM (Konsentrasi Hambat Minimum) merupakan parameter dari tanaman yang memiliki potensi. Hasil dari penelusuran pustaka menunjukkan bahwa terdapat beberapa tanaman yang berpotensi sebagai antibakteri untuk penyakit ISK yaitu Bawang Putih (Allium sativum), Berangan Kuda (Aesculus hippocastanum L. ), Rosemari (Rosmarinus officinalis), Galunggang (Sida acuta), Phyllanthus amarus, Phyllanthus muellerianus, dan Jintan Putih (Cuminum cyminum).
Penetapan Kadar Fenol Total Dan Aktivitas Antioksidan Dari Ekstrak Etanol Kulit Kentang (Solanum Tuberosum L.) Vinda Maharani Patricia; Tasya Luthfiyyah; Livia Syafnir
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2886

Abstract

Indonesia is one of the countries with a diversity of plants, one of which is the potato plant (Solanum tuberosum L.). Some compounds found in potato peels have pharmacological activities, one of which is antioxidants. This study aimed to determine the total phenol content and the antioxidant activity produced by potato peel ethanol extract. The methods for total phenolic content used the Folin-Ciocalteu method and the DPPH(2,2-diphenyl-1-picrylhydrazyl) method for antioxidant activity. The result obtained from this study was that the total phenol content in ethaol extract of potato peel was 152.9 mg GAE / g extract and antioxidant activity showed with IC50 value was 30,339 ppm, which means that potato peel ethanol extract has a very strong antioxidant activity.
Kandungan Fitokimia dan Aktivitas Antioksidan Tanaman Waru (Hibiscus tiliaceus L.) Farendina Suarantika; Vinda Maharani Patricia
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3093

Abstract

The mangrove plant (Hibiscus tiliaceus L.) is widely cultivated in tropical regions such as Indonesia because almost all parts of plant are believed to provide many benefits. Som of the benefits of the mangrove plant include laxative, treating earache, antibacterial, and antioxidant. The aim of the research is to analyze the content of phytochemical compounds contained in the mangrove plant and its antioxidant activity. This research uses a journal review method based on data collection carried out by inclusion and exclusion obtained from the google scholar, science direct, taylor and francis, garuda, and sage publication data search engine, including textbooks and scientific articles published above year of 2013. The result of the research is the phytochemical compounds found in mangrove plant are anthocyanin compounds, amides, coumarins, phenols, organic acids and flavonoid compounds that identified in the leaves, stems, and bark in mangrove plants uses several of solvents, there are methanol water, chloroform, and ethanol. The part of the plant that has antioxidant activity is the leaves which has strong antioxidant activity (IC50 = 86,5 µg/mL).
Optimasi Proses Ekstraksi Daun Sirih Hijau (Piper betle L.) yang Memiliki Aktivitas Antioksidan Berdasarkan Penggunaan secara Empiris Farendina Suarantika; Vinda Maharani Patricia; Hanifa Rahma
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.5253

Abstract

Green betel (Piper betle L.) exhibits various pharmacological activities, including antiallergic, analgesic, antibacterial, antiproliferative, and antioxidant, and contains various chemical compounds such as chavibetol, chavibetol acetate, carvacrol, caryophyllene, allyl pyrocatechol diacetate, campene, chavibetol methyl ether. This research was conducted to optimize green betel leaf processing techniques which were applied empirically by the community, through testing the antioxidant activity using the Ferric Reducing Antioxidant Power (FRAP) method. Processing techniques that are optimized are infusion, fresh brewed, and soaked boiled. The antioxidant activity of fresh brewed green betel leaf extract has an antioxidant capacity of 18.126 mg Trolox/g extract. For green betel leaf extract boiled and soaked, it is 21.848 mg Trolox/g extract, while for infusion green betel leaf extract is 22.809 mg Trolox/gram extract. The highest antioxidant activity was given by green betel leaf infusion extract, 22.809 mg Trolox/gram extract.
Penentuan Nilai Persentase Eritema dan Pigmentasi Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale L.) secara Invitro Satyawati; Livia Syafnir; Vinda Maharani Patricia
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8510

Abstract

Abstract. Sunlight plays an important role in survival, especially humans, but prolonged exposure to sunlight can harm the skin due to ultraviolet radiation. The use of sunscreen is one way to protect the skin from the harmful effects of UV rays. The ethanol extract of cashew leaves contains flavonoid compounds which have potential as sunscreens because they have chromophore groups that are able to absorb UV rays thereby reducing the intensity on the skin. This study aims to determine the percentage transmission of erythema and the percentage transmission of pigmentation of the ethanol extract of cashew leaves in vitro using the spectrophotometric method. On the purchase of % Te and % Tp concentrations of 200 ppm, 400 ppm, 600 ppm, 800 ppm and 1000 ppm, the UV A and UV B sunblock categories showed the best values ​​of % Te 0.004 % and % Tp 0.0177 %. Based on these results indicate that the higher the concentration, the better the protection power of the percentage of erythema transmission and the percentage of pigmentation transmission.. Keywords: Sunscreen, Cashew leaves, %Te, % Tp Abstrak. Sinar matahari sangat berperan penting dalam keberlangsungan hidup terutama manusia, tetapi paparan sinar matahari yang terlalu lama dapat membahayakan kulit karena radiasi sinar ultraviolet. Penggunaan tabir surya merupakan salah satu cara untuk melindungi kulit dari pengaruh buruk sinar UV. Ekstrak etanol daun jambu mete mengandung senyawa flavonoid yang memiliki potensi sebagai tabir surya karena memiliki gugus kromofor yang mampu menyerap sinar UV sehingga mengurangi intensitas pada kulit. Penelitian ini bertujuan untuk mengetahui nilai persen transmisi eritema dan persen transmisi pigmentasi ekstrak etanol daun jambu mete secara in vitro dengan menggunakan metode spektrofotometri. Pada penentuan nilai % Te dan % Tp dari konsentrasi 200 ppm, 400 ppm, 600 ppm, 800 ppm dan 1000 ppm menunjukkan kategori sunblock UV A dan UV B dengan nilai terbaik % Te 0,004 % dan % Tp 0,0177 %. Berdasarkan hasil tersebut menunjukkan bahwa semakin tinggi konsentrasi maka daya proteksi dari persen transmisi eritema dan persen transmisi pigmentasi semakin baik. Kata Kunci : Tabir surya, Daun jambu mete, %Te, % Tp
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN KELOR (Moringa oleifera L.) TERHADAP BAKTERI Staphylococcus epidermidis Deva Nissyarah Effendi; Kiki Mulkiya Yuliawati; Vinda Maharani Patricia
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract. Moringa plants (Moringa oleifera L.) have many benefits, one of which is found in the leaves. Moringa leaves (Moringa oleifera L.) contain secondary metabolite compounds in the form of flavonoids, alkaloids, saponins and tannins. In addition, Moringa leaves (Moringa oleifera L.) are thought to inhibit bacteria. This study aims to determine the antibacterial activity of Moringa leaves ethanol extract of Moringa leaves (Moringa oleifera L.). The extract was made by maceration using 96% ethanol as solvent. Antibacterial testing in this study used the wells diffusion method with concentrations of 2%, 4%, 6%, 8% and 10% b/v. The results showed that the inhibition zone of moringa leaf ethanol extract was 4% on Staphylococcus epidermidis bacteria by 8.2 mm . So It can be concluded that ethanolic extract of Moringa leaves had the potential to inhibit Staphylococcus epidermidis. Abstrak. Tanaman kelor (Moringa oleifera L.) memiliki banyak manfaat, salah satunya terdapat pada bagian daunnya. Daun kelor (Moringa oleifera L.) mengandung senyawa metabolit sekunder berupa flavonoid, alkaloid, saponin dan tanin. Selain itu, daun kelor (Moringa oleifera L.) diduga dapat menghambat bakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun kelor (Moringa oleifera L.). Ekstrak dibuat dengan metode maserasi menggunakan pelarut etanol 96%. Pengujian antibakteri pada penelitian ini menggunakan metode difusi sumuran dengan konsentrasi 2%, 4%, 6%, 8%, dan 10% b/v. Hasil penelitian menunjukkan bahwa zona hambat ekstrak etanol daun kelor konsentrasi 4% terhadap bakteri Staphylococcus epidermidis sebesar 8,2 mm. Sehingga dapat disimpulkan bahwa ekstrak etanol daun kelor memiliki potensi untuk menghambat Staphylococcus epidermidis
STUDI LITERATUR AKTIVITAS DARI EKSTRAK UMBI BIT MERAH (Beta vulgaris L.) SEBAGAI PENANGANAN TERHADAP BEBERAPA PENYAKIT TIDAK MENULAR Nadia Rahayu Nadia; Vinda Maharani Patricia; Yani Lukmayani
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.9022

Abstract

Abstract. Non-communicable diseases are a health problem in Indonesia that significantly increased. Red beetroot extract (Beta vulgaris L.) has benefits in several non-communicable diseases. The purpose of this literature study is to collect information and analyze the results of research on red beet tuber extract from pharmacological activity, content and mechanism of action of active compounds that can be used as a treatment for several non-communicable diseases. The method of this Systematic Literature Review (SLR) where the literature search for research articles comes from National and International Journals and then analyzed based on inclusion and exclusion provisions. The results of the literature study showed that red beet root extract has activity in several non-communicable diseases such as cancer based on a decrease in the percentage (%) of cell viability, alzheimer's disease based on a decrease and inhibition of acetylcholinesterase (AChE) activity, acute renal failure disease based on a decrease in urea and creatinine levels, and gout disease based on the percentage (%) inhibition of xanthine oxidase (XO) activity. The content and mechanism of action of active compounds that play a role in red beetroot extract are flavonoid compounds with a mechanism of action that can induce apoptosis, modulate AChE activity, and prevent XO activity. In addition, a typical compound contained in red beet tubers is betanin, which can inhibit cell growth by preventing cancer cell proliferation. Betasianin compounds can activate the extrinsic apoptotic pathway. Betalain compounds can prevent lipid peroxidation, protect the kidney from nephrotoxic effects, and can inhibit XO activity. Abstrak. Penyakit tidak menular menjadi masalah kesehatan di Indonesia yang terus mengalami peningkatan. Ekstrak umbi bit merah (Beta vulgaris L.) memiliki manfaat pada beberapa penyakit tidak menular. Tujuan dari studi literatur ini untuk mengumpulkan informasi dan menganalisis hasil penelitian mengenai ekstrak umbi bit merah dari aktivitas farmakologi, kandungan dan mekanisme kerja senyawa aktif yang dapat digunakan sebagai penanganan terhadap beberapa penyakit tidak menular. Metode yang digunakan yaitu Systematic Literature Review (SLR) dimana pencarian literatur artikel penelitian berasal dari Jurnal Nasional dan Internasional kemudian dianalisis berdasarkan ketentuan inklusi dan ekslusi. Hasil dari studi literatur menunjukkan bahwa ekstrak umbi bit merah memiliki aktivitas di beberapa penyakit tidak menular seperti penyakit kanker berdasarkan penurunan persentase (%) viabilitas sel, penyakit alzheimer berdasarkan penurunan dan penghambatan aktivitas asetilkolinesterase (AChE), penyakit gagal ginjal akut berdasarkan penurunan kadar urea dan kreatinin, serta penyakit gout berdasarkan persentase (%) penghambatan aktivitas xanthine oxidase (XO). Kandungan dan mekanisme kerja senyawa aktif yang berperan pada ekstrak umbi bit merah adalah golongan senyawa flavonoid dengan mekanisme kerja dapat menginduksi apoptosis, memodulasi aktivitas AChE, dan mencegah aktivitas XO. Selain itu, senyawa khas yang terkandung di dalam umbi bit merah adalah betanin dapat menghambat pertumbuhan sel dengan mencegah proliferasi sel kanker. Senyawa betasianin dapat mengaktifkan jalur apoptosis ekstrinsik. Senyawa betalain dapat mencegah peroksidasi lipid, melindungi ginjal dari efek nefrotoksik, dan dapat menghambat aktivitas XO.
Antioxidant Properties of Pyrus communis and Pyrus pyrifolia Peel Extracts Vinda Maharani Patricia; Fauzia Ningrum Syaputri; Titian Daru Asmara Tugon; Athina Mardhatillah
Borneo Journal of Pharmacy Vol. 3 No. 2 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i2.1337

Abstract

With the rise of global health awareness by embracing a healthy lifestyle and natural product consumption, the search for natural antioxidant sources has invited more research performed especially in fruits as a whole product or in its components, especially the ones that are usually discarded/not the mainly consumed component. Pyrus communis and Pyrus pyrifolia are two of the most popular species of pear fruits consumed in the world, and while there exist several studies about the antioxidant potential of its flesh, specific studies about the antioxidant properties of their peels are still lacking. To achieve an understanding of antioxidant properties of peel extract of P. communis and P. pyrifolia, several tests have been performed in controlled laboratory conditions to gauge phenolic and flavonoid contents through three different extraction measurements. This research has shown that peel extracts of both P. communis and P. pyrifolia contain natural antioxidants that are beneficial for health, with P. communis extracted with methanol having a higher concentration of antioxidant contents compared to P. pyrifolia.
Co-Authors Adinda Fitri Salsabila Athina Mardhatillah Deva Nissyarah Effendi Dwiratnasari Farendina Suarantika Farendina Suarantika Fauzia Ningrum Saputri Fauzia Ningrum Syaputri Hanifa Rahma Indra Topik Maulana Jihan Hana Fauziah Kenny Utami Prameswari Kiki Mulkiya Yuliawati Livia Syafnir Muhammad Fadhil Safari Nadia Rahayu Nadia Nanda Aulia Rahma Rodhiatul Jurdillah Saputri, Fauzia Ningrum Satyawati Tasya Luthfiyyah Tasya Luthfiyyah Titian Daru Asmara Tugon Yani Lukmayani Yuliani Ika Pratiwi