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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Borneo Journal of Pharmacy
Hilkatul Ilmi
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Anti-inflammatory Activity of Water Extract of Luvunga sarmentosa (BI.) Kurz Stem in the Animal Models Sabar Deyulita; Hilkatul Ilmi; Hanifah Khairun Nisa; Lidya Tumewu; Aty Widyawaruyanti; Achmad Fuad Hafid
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2968

Abstract

The study was aimed to determine the anti-inflammatory activity of water extract of the Luvunga sarmentosa stem in an animal model. Twenty-five Wistar rats were divided into five groups (n=5). Group 1 was administered 0.9% normal saline (negative control), group 2 was administered 150 mg/kg diclofenac sodium (positive control), and groups 3 to 5 were administered 50, 300, and 550 mg/kg BW of L. sarmentosa extract, respectively. Carrageenan was injected subcutaneously into each rat's subplantar region of the left hind paw. The paw volume was measured using a plethysmometer. The results showed that the water extract of L. sarmentosa stem (doses of 50, 300, and 550 mg/kg BW) significantly reduced the paw edema volume from the 4th to 5th hour compared to the negative control. The percent inhibition of edema at the 5th hour is 47.45; 46.95; 50.39%. The first phase of the edema (1st and 2nd hour) was not affected by the extract. Meanwhile, diclofenac sodium decreased paw edema volume from the 1st to 5th hour with a percent inhibition of 95.90% at the 5th hour. The histopathology result is relevant to the percentage inhibition of edema. Treatment with L. sarmentosa extract showed slight improvement, destruction of epidermal tissue, hyperkeratotic skin, and subepidermal edema. Meanwhile, positive control showed no inflammatory signs with normal keratin, subepidermal, and subcutaneous layers. The water extract of L. sarmentosa stem has anti-inflammatory activity. This extract effectively reduces the paw edema volume in the late phase with decreased neutrophil infiltration.
Free Radical Scavenging and Analgesic Activities of 70% Ethanol Extract of Luvunga sarmentosa (BI.) Kurz from Central Kalimantan Utami Islamiati; Hanifah Khairun Nisa; Hilkatul Ilmi; Lidya Tumewu; Myrna Adianti; Tutik Sri Wahyuni; Aty Widyawaruyanti; Achmad Fuad Hafid
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2983

Abstract

Luvunga sarmentosa, commonly known as saluang belum, is widely used in Kalimantan to relieve pains, rheumatism, boost the immune system, and fever. The research on the free radical scavenging and analgesic effect of the L. sarmentosa stem extract has not been reported. This study aimed to evaluate the free radical scavenging and analgesic activity of the ethanol extract of L. sarmentosa. The L. sarmentosa stem was extracted using 70% ethanol and tested for free radical scavenging using the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and analgesic activity, acetic acid-induced writhing test, and hot plate test in an animal model. The results showed that the 70% ethanol extract of the L. sarmentosa had an anti-free radical scavenging and analgesic activity. The extract has weak free radical scavenging with an IC50 value of 293.45 µg/mL. Analgesic activity using the writhing test indicated that the extract significantly reduced the writhes count after oral administration in a dose-dependent manner compared to the negative control. Extract at a dose of 550 mg/kg BW can reduce the writhing test by 67.60% compared to others. In contrast, the diclofenac sodium reduced the number of writhes by 74.74%. While in a hot plate, the extract at a dose of 550 mg/kg BW produced a maximum possible analgesia (MPA) of 17.64%, lower than the MPA of diclofenac sodium (51.01%). Analgesic activity of the extract has higher inhibition on the writhing test than on the hot plate. The extract could be responsible for the peripheral mechanism by inhibiting the prostaglandin biosynthesis.
Pelatihan pembuatan pangan fungsional dari jambu merah, mengkudu dan daun kelor untuk meningkatkan kesehatan lansia di desa Pandansari. Poncokusumo, kabupaten Malang Devanus Lahardo; Hilkatul Ilmi; Suryanto Suryanto; Firmansyah Ardian Ramadhani; Agus Pratiwi; Yusuf Alif Pratama; Wiwied Ekasari; Maria Lucia Ardhani Dwi Lestari; Andang Miatmoko; Rosita Handayani; Retno Sari; Aty Widyawaruyanti
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 1 (2024): March
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i1.21979

Abstract

AbstrakDesa Pandansari mempunyai potensi hasil pertanian melimpah terutama mengkudu, kelor, jahe, sereh dan jambu biji. Permasalahan yang terjadi adalah hasil panen yang tidak terserap di pasaran yang akan menjadi limbah karena belum dimanfaatkan dengan baik. Pengolahan hasil pertanian menjadi pangan fungsional menjadi peluang karena dapat meningkatkan nilai tambah dan nilai manfaat dari produk tersebut untuk kesehatan terutama bagi penduduk usia lanjut. Tim dosen Fakultas Farmasi UNAIR dengan keahlian dan kompetensi keilmuan yang dimiliki memanfaatkan aneka hasil sumber daya alam itu menjadi produk yang bernilai tinggi. Kegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk memberikan pegetahuan dan ketrampilan tentang manfaat hasil pertanian dan bagaiamana mengolahnya menjadi pangan fungsioanal. Tim PkM bekerjasama dengan PKK, Kader Kesehatan dan badan relawan kebakaran dan kebencanaan (BALAKARCANA). Kegiatan dilakukan Minggu, 6 Agustus 2023 di balai desa Pandansari dengan peserta 32 orang. Materi yang disampaikan adalah cara memanfaatkan sumber daya alam , cara memanfaatkan buah atau tanaman herbal yang sudah dipanen dan cara mengemas produk. Untuk praktek yang diberikan adalah beberapa produk hasil inovasi yaitu pembuatan stik daun kelor, simplisia kering mengkudu, jus jambu biji dan sirup jahe plus. Dari hasil pre dan post test, didapatkan bahwa skor rata-rata meningkat dari 63,5 menjadi 77,9. Hal tersebut menunjukkan terjadi penambahan pengetahuan saat dilakukan kegiatan pengabdian kepada masyarakat. Saat pelaksanaan peserta terlihat antusias dalam mengikuti praktik, mereka berharap pelatihan seperti ini sering dilakukan supaya semakin banyak warga yang mengetahui bahwa tanaman yang dapat dimanfaatkan terutama untuk pendukung kesehatan lansia. Kata Kunci : lansia; obat tradisional; olahan pangan; pelatihan AbstractPandansari Village has the potential for abundant agricultural products, especially noni, moringa, ginger, lemongrass and guava. The problem that occurs is that the harvest is not absorbed in the market which will become waste because it has not been utilized properly. Processing agricultural products into functional food is an opportunity because it can increase the added value and beneficial value of these products for health, especially for the elderly population. UNAIR Faculty of Pharmacy lecturer team with their expertise and scientific competence utilizes various natural resources into high-value products. This community service activity aims to provide knowledge and skills about the benefits of agricultural products and how to process them into functional food. The PkM team collaborated with PKK, Health Cadres and the fire and disaster volunteer body (BALAKARCANA). The activity was held on Sunday, August 6, 2023 at Pandansari village hall with 32 participants. The material presented was how to utilize natural resources, how to utilize harvested fruit or herbal plants and how to package products. For the practice given are some innovative products, namely the making of moringa leaf sticks, dried noni dried simplisia, guava juice and ginger plus syrup. From the pre and post test results, it was found that the average score increased from 63.5 to 77.9. This shows that there is an increase in knowledge when community service activities are carried out. During the implementation, the participants seemed enthusiastic in participating in the practice, they hoped that training like this was often carried out so that more and more residents knew that plants could be utilized, especially for supporting the health of the elderly..Keywords: elderly; traditional medicine; food processing; training
Co-Authors Achmad Fuad Hafid Agus Pratiwi Andang Miatmoko Aty Widyawaruyanti Devanus Lahardo Firmansyah Ardian Ramadhani Hanifah Khairun Nisa Lidya Tumewu Maria Lucia Ardhani Dwi Lestari Myrna Adianti Retno Sari Rosita Handayani Sabar Deyulita Suryanto, Suryanto Tutik Sri Wahyuni Utami Islamiati Wiwied Ekasari Yusuf Alif Pratama