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All Journal Majalah Kedokteran Gigi Indonesia Padjadjaran Journal of Dentistry JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Farmasi Higea
Dian Handayani
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effectiveness of Aspergillus sp. extract in denture adhesive on surface roughness of acrylic resin on Candida albicans biofilm formation Okmes Fadriyanti; Ismet Danial Nasution; Widowati Siswomihardjo; Dian Handayani
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.64485

Abstract

The denture adhesive increases retention on the denture base and affects oral microorganisms. Adding antifungals to denture adhesives can inhibit the Candida albicans biofilms formation and prevent denture stomatitis. The combination of denture adhesives and herbal medicines is an alternative to antifungals, which have few side effects because it is a plant. Moreover, one of them is the endophytic Aspergillus sp. extract containing chemical compounds that can inhibit the Candida albicans biofilms formation. This study aims to analyze the effectiveness of the endophytic Aspergillus sp. extract in denture adhesive materials for Candida albicans biofilm formation on acrylic resin surfaces. The research method is to extract the Aspergillus sp. extract antibiofilm test. Denture adhesive formulation was adjusted to the standard, and added Aspergillus sp. with concentrations of 3.125%, 6.25%, 12%, and 25%. The research sample used hot polymerized acrylic resin. The control group used X denture adhesive and added nystatin, each group suspended by Candida albicans for 24, 48, and 72 hours. Examination of biofilm formation activity on the surface of acrylic resin used SEM. The analysis used Two Way Anova. Aspergillus sp. extract in denture adhesive effectively prevents Candida albicans biofilm formation within 24 hour incubation time. In conclusion, extract of the endophytic Aspergillus sp. in denture adhesive can inhibit the formation of Candida albicans biofilm on the surface roughness of acrylic resin.
UJI IMUNOMODULATOR BEBERAPA SUBFRAKSI EKSTRAK ETIL ASETAT MENIRAN (Phyllanthus niruri [L]) PADA MENCIT PUTIH JANTAN DENGAN METODA CARBON CLEARANCE Yufri Aldi; Nisya Ogiana; Dian Handayani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 1, Nomor 1, Juni 2014
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (579.16 KB) | DOI: 10.33854/JBDjbd.55

Abstract

Meniran has scientific name Phyllanthus niruri L..It uses to increase imun system of human body. Nonspecific of Imun system is first defendent to protect human body from microorganism, because it gives direct respon to antigen then it will destroy bacteria with phagocytosis process. Meniran extract is known can obstruct xanthin oksidase invitro, protect hepatocyte cell of liver from carbon tetrachloride and cytotoxity that induction with galaktosamin.To determined imunomodulator activity of some ethyl acetat extract subfraction of meniran (Phyllanthus niruri [L.]). Some ethyl acetat extract subfraction of meniran (Phyllanthus niruri [L.]) administered orally with single dose 100 mg/kg BB for eight group of subfraction and Tween 80 1% as control for 6 days. After 6 days subfractions have been conducted in white male mice with carbon clearance method. A value of Index Phagocytosis (IF) < 1 has imunosupressant activity and IF > 1 has imunostimulant activity. The increasing of phagositosis index with carbon clearance method showed the effect from each group of subfraction with control was unsignificant (P>0,05). The incerasing of leucocyte cell component especially for limfosit cell, eusinofil, and segmen neutrofil was significant for each group of subfraction (P0,05). The increasing of spleen limfosit cell showed optimal effect in subfraction number three (P
Co-Authors Akmal Djamaan Anzharni Fajrina Corry Handayani Deddi Prima Putra Elza Masriza Indah Pratiwi Friardi Ismed Harrizul Rivai Ismet Danial Nasution Krisyanella Krisyanella Lendra Yunance Mega Yulia Meliyana Meliyana Mieke Hemiawati Satari Nicole J. de. Voogd Nisya Ogiana Okmes Fadriyanti Rafky Putra Rendowaty, Agnes Syafruddin Ilyas Utmi Arma Widowati Siswomihardjo Wiza Leila Puspita Sari Yahdian Rasyadi Yohanes Allen Yufri Aldi