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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Majalah Kulit, Karet, dan Plastik WMJ (Warmadewa Medical Journal) JPPS (Jurnal Penelitian Pendidikan Sains) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Soetjipto Soetjipto
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Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Engineering Health Professions Medicine & Pharmacology Physics Public Health Other

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The Influence of MMP-3 towards MMP-9 among Emphysematous Patients from Gingival Crevicular Fluid and Sputum Mulkan Azhary; Muhammad Amin; Soetjipto Soetjipto; Mulyadi Mulyadi; Sunnati Sunnati
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 5, No 2 (2015): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.872 KB)

Abstract

The elevated activity of matrix metalloproteinase (MMP)-9 has been responsible for degradation of extracellular matrix (ECM) within lung parenchyma leading to emphysema among patientssuffering from chronic obstructive pulmonary disease (COPD). Prolonged exposure of smokinghad triggered activation of both MMP-9 and MMP-3. Active MMP-3 might degrade numerous kinds of ECM and act as MMP-9 inducer as well. The study aimed to correlate active MMP-3 towards elevated MMP-9 activity from both gingival crevicular fluid (GCF) and sputum to assess breakage of extracellular matrix (ECM) among emphysematous patients. Fifteen emphysematous respondents suffering from COPD were recruited to undergo thoroughly physical assessment, spirometry, and radiological examination. Then, both GCF and sputum were collected for measurement of MMP-3 and MMP-9 activity. Results showed that MMP-3 activities were correlated positively and significant with elevated MMP-9 activities from both GCF and sputum i.e. r = 0.899 (p0.05) and r = 0.770 (p0.05) respectively. Smoking exposure released many radicals and oxidants generating elevation of MMP-3 activity which then influenced repeatedly influx of neutrophils and activation of MMP-9. The role of active MMP-3 also involved in either acute inflammatory or broad ECM breakage. Moreover, active MMP-9 might lead mainly the degradation of ECM within lung parenchyma. Because of similar effect and impact concerning ECM degradation, both active MMP-3 and MMP-9 might concurrently cause larger breakage of ECM leading to lung emphysema among COPD patients. This study showed that both GCF and sputum would be assigned to evaluate active MMP-3 and MMP-9 for assessing ECM degradation among emphysematous patients.
Distribution of Hepatitis B Virus Genotypes Among Patients at Internal Medicine Unit, Dr. Soetomo General Hospital, Surabaya Citrawati Dyah Kencono Wungu; Mochamad Amin; Ulfa Kholili; Gwenny Ichsan Prabowo; Poernomo Boedi Setiawan; Soetjipto Soetjipto; Retno Handajani
WMJ (Warmadewa Medical Journal) Vol 4 No 1 (2019): May 2019
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.4.1.1032.6-13

Abstract

Background: Hepatitis B virus (HBV) infection is a major health problem worldwide, especially in developing countries. The study of HBV genotypes is important to find out the diversity of HBV genotypes related to the severity of the disease, response to therapy, and clinical symptoms. Objective: This study was aimed to detect HBV genotypes in patients at Hepatology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Methods: This study was conducted on new patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya in one month. Nested PCR was performed by targetting HBV surface genes. Samples with positive HBV DNA were sequenced and analysed further. Results: In this study, a total of 27 samples were obtained. The prevalence of HBV infection shown by positive HBsAg in patients with symptoms of liver disease was 55.55% (15/27 patients). Based on the results of electrophoresis from PCR products, positive HBV DNA was obtained in these 15 patients (100%). After sequencing samples with positive HBV DNA, genotype B of Indonesian strain was found to be predominant genotype (100%). Subgenotype analysis showed that 7/15 samples had B3 subgenotype (46.67%). Conclusion: In patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya, the prevalence of HBV infection was high (55.55%) and genotype B was predominant. In Surabaya, HBV genotype infection still remained like the previous pattern, although in Indonesia there have been many inter-island and ethnic migration. Further similar studies are needed to obtain the diversity of other HBV genotypes.
Penelitian konversi kulit domba, kambing krom basah menjadi kulit jaket, glase ditinjau dari parameter prosesnya sebagai produk perdagangan Soetjipto Soetjipto
Majalah Kulit, Karet, dan Plastik Vol 7, No 12-13 (1992): Majalah Barang Kulit, Karet, dan Plastik
Publisher : Center for Leather, Rubber, and Plastic Ministry of Industry, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1758.363 KB) | DOI: 10.20543/mkkp.v7i12-13.474

Abstract

The object of this research is to determine mutual converted value between unfinished leather to finished leather as commercial commodity. The raw materials are wet chrome tanned goatskins which are converted into jacket leather and chrome tanned goatskins into glace leather. Weight, wide, thickness is measured during this process, and the last is carried out in accordance with Indonesia Industrial Standard, for each step of the process. The sample taken in accordance with ISO. 2588 1973 is n = 0,5 √N, where N is the number of cattle slaughtered. The sheeps taken were 148 sheets (197 sheets available) and the goats taken were 130 sheets (195 sheets available). The conclusion of this research are the conversion value of some sheepskins and goatskins from chrome tanned, sheepskins into glace  and goatskins into jacket. INTISARI Penelitian ini bertujuan untuk menentukan nilai konversi hubungan timbal balik antara tahap sebelum dan sesudah pengolahan kulit sesuai produk perdagangan. Dimulai dari kulit krom basah, menjadi kulit jaket untuk domba dan menjadi kulit glase untuk kulit kambing. Dilakukan pengukuran terhadap  berat, luas dan tebal. Cara pengambilan sampel menurut ISO. 2588-1975. Jumlah sampel adalah n = 0,5 √N, dimana N = jumlah ternak yang dipotong, sehingga sampel untuk domba = 130 lembar diperoleh 195 lembar, untuk kulit kambing 148 lembar diperoleh 197 lembar. Dari pengolahan data dapat disimpulkan, beberapa harga konversi kulit domba dan kulit kambing dimulai dari kulit krom basah sampai kulit jaket dan kulit glase. 
PENGEMBANGAN PERANGKAT PEMBELAJARAN IPA BERBASIS PENDEKATAN SAINTIFIK UNTUK MENUNTASKAN HASIL BELAJAR SISWA POKOK BAHASAN SISTEM GERAK MANUSIA DI SMP Netty M Arumisore; Sifak Indana; Soetjipto Soetjipto
JPPS (Jurnal Penelitian Pendidikan Sains) Vol. 7 No. 1 (2017)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jpps.v7n1.p1386-1396

Abstract

The objective of this research is produce science learning tools that eligible for  the completeness of learning outcome students  at subject human motion system  on the junior high school. The development of this learning tools is based on 3-D model  by using test based on One Group Pretest-Posttest Design. The test is conducted on eighth grade student of SMP Negeri Rasiei Teluk Wondama district-Papua Barat. The research consisted of two stages which is: 1) Developing the learning tools consisted of lesson plan, students book, and students worksheet, learning achievement test validated by experts. 2) the lesson learning tools which has been  validated by expert is a tested. The instrumental used including observational sheet of students activity, and students response questionnaire. He result of the research shows that: 1) the learning tools is valid; 2) the lesson plan accoplishment is categorized as good; 3) the students activities indicate tha they learn to actively build their own knowledge through a scientific approach; 4) the students responded positively to the learning process; 5) the students learning outcomes of attitude, knowledge, and skill aspects is accomplished. Based on the following results can be concluded that the science learning tools based scientific approach on human motion system is a valid, practical, and effective. Thus the science learning tools can be used on the learning process and proofed to be effective for the completeness of students learning outcome
PENGEMBANGAN PERANGKAT PEMBELAJARAN MODEL GUIDED INQUIRY UNTUK MENURUNKAN MISKONSEPSI SISWA PADA MATERI OPTIK Sufiyah Sufiyah; Wasis Wasis; Soetjipto Soetjipto
JPPS (Jurnal Penelitian Pendidikan Sains) Vol. 7 No. 1 (2017)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jpps.v7n1.p1441-1446

Abstract

Penelitian ini bertujuan mendeskripsikan kelayakan perangkat pembelajaran model guided inquiry untuk menurunkan miskonsepsi siswa MAN Bangkalan pada materi optik menggunakan model pengembangan Borg and Gall. Perangkat pembelajaran berupa Silabus, RPP, Buku Ajar Siswa, LKS, dan Lembar Penilaian Hasil pengembangan perangkat divalidasi oleh 5 orang validator. Uji coba perangkat menggunakan one grup pretes posttest design pada kelas XI MIPA 3 dan kelas XI MIPA 4 MAN Bangkalan. Teknik analisis data yang digunakan adalah deskriptif teknik inferensial Kruskal Wallis dan Wilcoxons Sign Rank Test. Hasil penelitian berupa: (1) Validitas perangkat yang dikembangkan dinyatakan sangat valid berdasarkan skor yang diperoleh dari validator, (2) Kepraktisan perangkat yang dikembangkan ditinjau dari aspek keterlaksanaan perangkat dan aspek aktivitas siswa yang berkategori baik berdasarkan skor yang diperoleh dari pengamat, dan (3) Efektivitas perangkat yang dikembangkan ditinjau dari dampak penurunan beban miskonsepsi siswa kelas XI MIPA 3 awalnya 57% menjadi 3% dan siswa kelas XI MIPA 4 awalnya 53% menjadi 3%.
PHYLOGENY MAGNITUDE OF Mycobacterium tuberculosis BASED ON GENOMIC ANALYSIS Budi Yanti; Mulyadi Mulyadi; Soetjipto Soetjipto; Ni Made Mertaniasih; Muhammad Amin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art12

Abstract

Mycobacterium tuberculosis (MTB) is mostly found in humans, and it can cause more than two million deaths each year with increasing morbidity. Although lineages of MTB show identical nucleotide relationships, they have different characteristics such as evolution, transmission, drug resistance, host interaction, latency, and vaccine effectiveness. It is necessary to have better understanding of MTB relationships based on similarities in genome sizes and phylogenetic analysis. This paper observes the relationships of MTB based on nucleotide through phylogenetic frameworks. The MTB species consist of six lineages, and each lineage has various size of genomes . This difference contributes to virulence of MTB affecting levels of severity, morbidity, and mortality of diseases. Genetic diversity of MTB can contribute to global threats in the world such as outbreak of tuberculosis, Multi Drug Resistant (MDR) and Extensively Drug Resistant (XDR) tuberculosis.
Co-Authors Budi Yanti Citrawati Dyah Kencono Wungu Mochamad Amin Muhammad Amin Mulkan Azhary Mulyadi Mulyadi Netty M Arumisore Ni Made Mertaniasih Poernomo Boedi Setiawan Prabowo, Gwenny Ichsan Retno Handajani Sifak Indana Sufiyah Sufiyah Sunnati Sunnati Ulfa Kholili Wasis Wasis