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HUBUNGAN PEMBELAJARAN KESEHATAN REPRODUKSI REMAJA DENGAN PENGETAHUAN TENTANG NAPZA SISWA SMU DI SURAKARTA Soetrisno, Soetrisno; Trimulya, Didon Muhammad; Riyanto, Slamet
JURNAL KESEHATAN REPRODUKSI Vol 1, No 3 (2014)
Publisher : IPAKESPRO

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Abstract

HUBUNGAN PEMBELAJARAN KESEHATAN REPRODUKSI REMAJA DENGAN PENGETAHUAN TENTANG NAPZA SISWA SMU DI SURAKARTASoetrisno1, Didon Muhammad Trimulya2 , Slamet Riyanto3ABSTRACTBackground: Narcotics, psychotropic and other addictive substances misuse (drugs abuse) could effect various society segments, mostly young people age 15-24 years. The young generation is a strategic target for drug distribution including illegal trade in Surakarta. Necessary precautions should be taken as it could lead to addiction, could affect on survival, especially the young generation, including senior high school students. Policy to introduce adolescent reproductive health (ARH) education in particular with drugs abuse topic has been enacted in Surakarta since 2012, but had not covered the entire high school.Objective: Observing the correlation between adolescent reproductive health education with knowledge of NAPZA on high school students in Surakarta.Method: This study used an observational analytic with cross sectional design. A total of 120 students were taken by purposive random sampling. Total of 120 students were involved from second grade they consisted 60 students who had been given adolescent reproductive health education for one year (since first grade) and 60 students who had not. Students were given a questionnaire about NAPZA that has been tested for validity and reliability. Data analysis was then performed using chi-square.Results and Discussion: There is a significant correlation between adolescent reproductive health education with knowledge about types, characteristic of high risk youth, sign of addiction, category of drug users, as well as the dangers of drug prevention among high school students in Surakarta (p<0.05).Conclusion: There is a significant correlation between adolescent reproductive health education with knowledge of NAPZA on high school students in Surakarta.Keywords: Knowledge of NAPZA, Adolescent Reproductive Health Education, Youth of Surakarta. ABSTRAKLatar Belakang: Penyalahgunaan Narkotika, Psikotropika, dan Zat adiktif lain (NAPZA) dapat dilakukan oleh berbagai lapisan masyarakat, terbanyak generasi muda 15–24 tahun. Generasi muda adalah sasaran strategis perdagangan gelap NAPZA termasuk di Surakarta. Diperlukan kewaspadaan terhadap bahaya serta pengaruh NAPZA yang dapat menimbulkan ketagihan, dengan dampak terhadap kelangsungan hidup dengan pembinaan, khususnya generasi muda termasuk siswa Sekolah Menengah Umum (SMU). Kebijakan pembelajaran kesehatan reproduksi remaja (KRR) khususnya topik NAPZA telah diberlakukan di Surakarta sejak ajaran baru 2012 sampai sekarang, namun belum mencakup keseluruhan SMU.Tujuan: Mengamati hubungan pembelajaran KRR dengan pengetahuan NAPZA siswa SMU di Surakarta.Metode: Penelitian observasional analitik rancangan cross sectional. 120 subyek penelitian (siswa) diambil secara purposive random sampling. Sebanyak 60 subyek penelitian diambil dari siswa SMU kelas 2 yang sudah mendapatkan pembelajaran KRR selama satu tahun (sejak kelas 1) dan sebanyak 60 subyek penelitian siswa SMU yang belum mendapatkan pembelajaran. Subyek penelitian, baik yang sudah dan belum mendapatkan pembelajaran KRR diberikan kuesioner tentang NAPZA yang sudah diuji validitas dan reliabilitas. Kemudian dilakukan uji chi square.Hasil dan Pembahasan: Terdapat hubungan bermakna pembelajaran KRR dengan pengetahuan tentang jenis, ciri remaja beresiko pengguna, tanda kecanduan, golongan gangguan pengguna, bahaya serta penanggulangan NAPZA siswa SMU di Surakarta (p<0.05).Kesimpulan: Terdapat hubungan bermakna pembelajaran Kesehatan Reproduksi Remaja (KRR) dengan pengetahuan tentang NAPZA siswa SMU di Surakarta.Kata Kunci: Pengetahuan NAPZA, KRR, siswa SMU 1,2 Bagian Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Negeri Sebelas Maret Surakarta telp:0271-665145/08166725643 Dinas Kesehatan Kota Surakarta
FAKTOR ANGIOGENIK SOLUBLE FMS-LIKE TYROSINE KINASE-1 DAN VASCULAR ENDOTHELIAL GROWTH FACTOR PADA IBU HAMIL 8 – 20 MINGGU DENGAN RISIKO PREEKLAMPSIA Sulistyowati, Sri; Soetrisno, Soetrisno; Respati, Supriyadi Hari; Wiyono, Bambang Eko
JURNAL KESEHATAN REPRODUKSI Vol 2, No 1 (2015)
Publisher : IPAKESPRO

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Abstract

Sri Sulistyowati1, Soetrisno2, Supriyadi Hari Respati3, Bambang Eko Wiyono4 ABSTRACTBackground: Preeclampsia is still the main cause for maternal and neonatal mortality or morbidity. Anti-angiogenic Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) and proangiogenic Endhothelial Vascular Growth Factor (VEGF) factors can be used as an early detection of preeclampsia due to itsrole in the pathogenesis of preeclampsia, so it can be used as one effort to reduce maternal or perinatal morbidity and mortality.Objective: To analyze sFlt-1 and VEGF levels in the serum of normal pregnancy and pregnancy with preeclampsia risk in 8 – 20 weeks gestation.Method: Observational analytic with cross sectional method performed at the Obstetrics and Gynecology, Dr. Moewardi Hospital/ Medical Faculty Sebelas Maret University Surakarta and Prodia laboratory since November – December 2013. Number of samples studied was 30 samples, comprising 15 samples of normal pregnancy and pregnancy with preeclampsia risk with 8 – 20 weeks of gestational age. The sFlt-1 and VEGF serum levels was assessed using ELISA and analyzed using t-test.Result & Discussion: Serum level of sFlt-1 in normal pregnancy is (1252,17±564,65 ng/ml), and in pregnancy with preeclampsia risk is (1741,90±640,97 ng/ml) with p=0,023 serum level of VEGF in normal pregnancy was 96,88±144,29 ng/ml and in pregnancy with preeclampsia risk was 14,24±8,73 ng/ ml with p=0,044.Conclusion: sFlt-1 level is higher and VEGF level is lower in pregnant women with preeclampsia risk than normal pregnancy on 8 – 20 weeks gestational age.Keywords: Pregnancy, Preeclampsia Risk, sFlt-1, VEGF.ABSTRAKLatar belakang: Preeklampsia saat ini masih merupakan masalah pada ibu hamil yang berhubungan dengan mortalitas dan morbiditas maternal dan perinatal. Faktor anti-angiogenik Soluble FMS-Like Tyrosine Kinase-1 (sFLt-1) dan proangiogenik Vascular Endhothelial Growth Factor (VEGF) diduga dapat digunakan sebagai deteksi dini karena perannya dalam patogenesis preeklampsia, sehingga dapat digunakan sebagai upaya untuk mengurangi angka morbiditas dan mortalitas maternal dan perinatal. Tujuan: Untuk menganalisis kadar sFlt-1 dan VEGF pada serum ibu hamil normal dan ibu hamil dengan risiko preeklampsia pada usia kehamilan 8 – 20 minggu.Metode: Penelitian observasional analitik dengan metode Cross Sectional yang dilakukan di bagian Obstetri dan Ginekologi, RSUD Dr. Moewardi/ FK UNS, Surakarta dan Laboratorium Prodia mulai Nopember – Desember 2013. Jumlah sampel terdiri 30 yang terbagi menjadi 15 sampel ibu hamil normal dan dan 15 sampel ibu hamil dengan risiko preeklampsia usia gestasi 8 – 20 minggu. Masing-masing dianalisis kadar sFlt-1 dan VEGF pada serumnya dengan metode ELISA dan dianalisis menggunakan uji t.Hasil & Pembahaasan: Kadar serum sFlt-1 pada kehamilan normal (1252,17±564,65 ng/ml), kehamilan dengan risiko preeklampsia (1741,90±640,97 ng/ml) dengan nilai p=0,023 dan kadar VEGF pada kehamilan normal (96,88±144,29 ng/ml), kehamilan dengan risiko preeklampsia (14,24±8,73 ng/ ml) dengan nilai p=0,044.Kesimpulan: Kadar sFlt-1 lebih tinggi dan kadar VEGF lebih rendah pada kehamilan dengan risiko preeklampsia dibanding kehamilan normal pada usia hamil 8 – 20 minggu.Kata kunci: Kehamilan, Risiko Preeklampsia, sFlt-1, VEGF.1,2,3,4Sri Sulistyowati, Bagian Obgin FK UNS/ RSUD Dr. Moewardi, Jl. Kol. Sutarto 132 Surakarta. Telp. 08122968215, Email: elis_spog@yahoo.co.id
A comparative study of Cycloprovera and Depoprovera contraceptive methods. The menstrual patterns and continuation rates Soetrisno, Soetrisno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 04 (1993)
Publisher : Universitas Gadjah Mada

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Abstract

The change of menstrual patterns caused by progestogen only contraception may influence the womens psychologic condition and sometimes requires discontinuation of its usage. Cycloprovera, a monthly injectable contraceptive method, containing progestogen + estradiol cypionate is considered to overcome the problems. The study was aimed at comparing the menstrual pattern changes and continuation rates between Cycloprovera and Depoprovera acceptors.The study is a part of a multicentered study comparing menstrual pattern changes between Cycloprovera and HRP 102 acceptors conducted in 5 countries including 7 research centers in Indonesia. For each Cycloprovera acceptors recruited in Yogyakarta, one Depoprovera acceptor was selected as control. Menstrual patterns and continuation rates of both groups were followed up in 3, 6. 9 and 12 months after having first injection. From July 1, to December 31, 1990. 31 acceptor for each group were recruited from several family planning clinics in Yogyakarta. The comparability of the two groups was not statistically significant except for blood pressure level. However, it was not clinically significant. The normal menstrual patterns was significantly higher in Cycloprovera group compared to Depoprovera group (p<0.05). No amenorrhoea and drop-out among Cycloprovera acceptors, while among Depoprovera group were 19.4%, 35.5%, 38.7% and 9.7%, 19.3%, 29.0% after 3, 6 and 9 to 12 months respectively. The changes of menstrual patterns after 3 and 6 months were significantly higher among Depoprovera groups compared to Cycloprovera (p<0.05), however, after 9 to 12 months were not statistically different (p<0.05).It is concluded that the menstrual patterns and continuation rates of Cycloprovera acceptors are better compared to Depoprovera acceptors, and no drop-out among Cycloprovera acceptors.Key Words: Cycloprovera - Depoprovera - menstrual patterns - user continuation rate - family planning clinic
Recombinant vascular endothelial growth factor 121 decreases vascular cell adhesion molecule-1 in murine pre-eclampsia model placenta Sulistyowati, Sri; Sondakh, John Arianto; Yuliantara, Eric Edwin; Respati, Supriyadi Hari; Soetrisno, Soetrisno
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.192-198

Abstract

BackgroundPreeclampsia is one of the major contributors to maternal and fetal morbidity and mortality. Imbalance of soluble Fms-like tyrosine kinase (sFlt-1) as anti-angiogenic factor and vascular endothelial growth factor (VEGF) as pro-angiogenic factor plays a role in the pathogenesis of preeclampsia. Endothelial dysfunction in preeclampsia causes vascular cell adhesion molecule-1 (VCAM-1) to be expressed on its surface. This study aims to evaluate the effect of recombinant VEGF-121 on VCAM-1 expression in the placenta of a murine preeclampsia model. Methods An experimental analytical study conducted from February until March 2016 in the Biomedical Laboratory, Faculty of Veterinary Medicine, Airlangga University. The study sample consisted of 30 pregnant mice, divided into three groups, i.e. 10 normal pregnant mice, 10 mice with preeclampsia model and 10 mice with preeclampsia model and recombinant VEGF-121 therapy. All animals were subjected to immunohistochemical examination of VCAM-1 expression in their placentas. The results were assessed semiquantitatively according to a modified Remmele method. Data analysis was done using one-way ANOVA and Tukey’s multiple comparisons method. ResultsMean VCAM-1 expression in normal (0.97 ± 0.54%) murine placentas, compared with placentas (2.94 ± 0.96%) of murine preeclampsia models (p=0.000), while mean VCAM-1 expression in placentas of murine preeclampsia models with VEGF intervention was 2.14 ± 0.68% (p=0.030).Conclusion Recombinant VEGF-121 can reduce VCAM-1 expression in placentas of murine preeclampsia models. The present study has shown the potential benefits of VEGF therapy, justifying serious consideration of this therapeutic approach for use in women with preeclampsia.
The Level of Heat Shock Protein 70 is Lower in Postterm Pregnancy Soetrisno, Soetrisno
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To analyze whether there are differences between the levels of HSP70 of Postterm pregnancy and aterm pregnancy in Dr. Moewardi Hospital, Surakarta, Central Java. Method: This was a cross-sectional study. The independent variable was the level of Heat Shock Protein 70 (HSP70), and the dependent variable was the incidence of postterm pregnancy. The data was then analyzed by t test. Result: The subjects were 45 women, who were divided into 2 groups of women with postterm pregnancies (15 women) and aterm pregnancies (30 women). The mean levels of HSP70 in the serum of women with postterm pregnancy is lower (0.40 ng/ml) compared to the level of the normal pregnant group (3.94 ng/ml) and this difference was statistically significant (p
L-arginine improves uterine spiral arterial wall thickness in mouse models of preeclampsia Soetrisno, Soetrisno; Sulistyowati, Sri; Wibowo, Anwar Sandi
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.131-137

Abstract

BackgroundPreeclampsia is a major cause of maternal and fetal morbidity and mortality. The imbalance of anti-angiogenic and angiogenic factors plays a role in endothelial dysfunction in preeclampsia. L-arginine is expected to improve the process of spiral artery remodeling. This study aims to examine the use of L-arginine to repair endothelial damage by measuring the thickness of uterine spiral arteries in mouse (Mus musculus) models of preeclampsia.MethodsThe researchers carried out an experimental study using 30 sixteen-day old pregnant Swiss mice (in good health, weighing 20-25 grams), which were randomly divided into 3 groups (each consisting of 10 mice). The groups were as follows: 1) normal pregnancy K(-); 2) preeclampsia model K(+); and 3) preeclampsia model receiving L-arginine (P). The authors performed histopathological examination of the mouse placenta, which had been dissected, embedded in paraffin wax and subsequently stained with hematoxylin and eosin (HE). The results were analyzed in SPSS v. 21 for Windows using Anova with Tukey.ResultsThe mean thickness of spiral arteries in group K(-) was 53.95 + 26.96 mm, in K(+) 96.50 + 16.66 mm, and in P 62.79 + 8.04 mm. Statistically, there were significant differences between groups K(-) and K(+) (p=0.001) and between K(+) and P (p=0.000), but non-significant differences between K(-) and P (p=1.000).ConclusionsThe treatment with L-arginine proved to be effective in repairing endothelial damage by reducing intimal hyperplasia and atherosis and, in turn, the thickness of uterine spiral arteries in mouse models of preeclampsia.
Faktor Risiko Transmisi Virus HIV pada Ibu Hamil di Papua Rabrageri, Alberthzon Kris Silo; Siswosudarmo, Risanto; Soetrisno, Soetrisno
JURNAL KESEHATAN REPRODUKSI Vol 4, No 1 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.555 KB) | DOI: 10.22146/jkr.35433

Abstract

Background: Human Immunodeficiency Virus (HIV) has been transmitted all over the world and attack people including pregnant women and their fetus. HIV-AIDS has become the main cause of maternal death. The transmission is started from Africa to Indonesia, specifically to Papua Island. In Papua, HIV is a serious threat for pregnant women’s life because of its fast transmission, even faster from other regions in Indonesia. Until present, there has no research about HIV transmission on pregnant women in Papua Island.Objective: To conduct analysis on risk factors related to HIV transmission on pregnant women in Papua Island.Method: Cross sectional continued with retrospective cohort. Data was taken from medical record of all patients delivering in eight state-owned hospitals in Papua and West Papua provinces started from 1 January 2013 to 31 December 2013. Inclusion criteria were all pregnant women who delivered vaginally or by caesarean sections with HIV and non HIV diagnosis and had complete medical record data. Data being taken included mother’s age when delivered the baby, mother’s education, parents’ social economic status, mother’s ethnicity, parents’ domicile, prematurity and infant’s birth weight. The two research groups were HIV (+) and HIV (-) groups. Data were statistically analyzed using Pearson Chi Square for univarian and logistic regression for multivarian.Result and Discussion: In Papua island, prevalence of pregnant women with HIV was 15.3%, and mostly occurred in reproductive age ( 85.1%). The main transmission source was heterosexual (100%). Univarian analysis found that mothers’s age <20 years old when delivered the baby increase 1.12 times compared to > 20 years old but it’s statistically insignificant (p=0.53). Mothers education < 9 years increases the risk of HIV 1.4 times compared to mother’s education > 9 years (p=0.01). The husband’s low socioeconomic status increase the risk of 5.51 times compared with husband’s high socioeconomic status (p<0.01). The wife’s low socioeconomic status increase the risk of 1.22 times, in which statistically insignificant (p=0.14). Native Papuanese pregnant women has significantly 3.05 times higher risk for HIV transmission compared to non Papuanese (p<0.01). Pregnant women’s domicile in villages increase the transmission significantly 2.21 times compared to cities’ domiciles (p<0.00). Premature delivery increased HIV transmission by 1.7 times (p<0.01). Low infant body weight increased the transmission by 1.64 times significantly (p<0.01). Multivarian analysis showed that husband’s low socioeconomic status, Papuanese ethnicity and domicile in villages are the most dominant factors influencing HIV transmission on pregnant women in Papua Island.Conclusion: Varied risk factors on HIV transmission resulted in the occurrence of HIV (+) cases in Papua Island, while the most dominant factors are husband with low socioeconomic status, Papua ethnicity and domicile in villages.Keywords: HIV, risk factors, birthing mothers, Papua Island.
Pengaruh Konseling Antenatal terhadap Penerimaan AKDR pascasalin sebuah uji klinis non randomisasi Faris, Abdul; Soetrisno, Soetrisno; Siswosudarmo, Risanto; Malinta, Umar
JURNAL KESEHATAN REPRODUKSI Vol 5, No 2 (2018)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.014 KB) | DOI: 10.22146/jkr.38547

Abstract

Background: During postpartum period women have a high motivation to start using contraception and postpartum IUD is an ideal method to offer. The rate of IUD use is still low, 14.06% of all postpartum contraceptive use. This might be attributed to lack of information and counseling from health providers.Objective: To compare the number of postpartum IUD used among groups of clients who were counseled during ANC and re-counseled during latent phase (exposed group), and group counseled during latent phase only (control group).Method: This study was a prospective quasi-experimental or randomised clinical trial. The first group was those counseled during ANC  and latent phase, and the second was those counseled at latent phase only. Chi square and relative risk were used for statistical test two proportions.Result and Discussion: A total of 342 subjects who met  inclusion and exclusion criteria were recruited. They consisted of the 210 subjects (61,4%) for the first group and 132 subjects (38,6%) for the second.The rate of IUD used in the first group was 82 of 210 (39%) and 30 of 132 (22.7%) in the second, RR 1,72  (95% CI 1.20 – 2.46), p 0,002. The rate of IUD used was also significantly influenced by a history of IUD acceptor RR 2,90 with 95% CI 2.23 – 3.77), a history of contraceptive used (RR 1,79 with95% CI 1,18 – 2,71) and a history of contraceptive counselling (RR 1,50 with 95% CI 1,03 – 2,19).Conclusion: Clients who were counseled twice (during ANC and repeated at latent phase) had higher rate of postpartum IUD used significantly than those who were counseled at latent phase only. Other factors that significantly affected the rate of postpartum IUD used were history of IUD acceptor, history of contraceptive used.Keywords: Postpartum IUD; counseling; rate of postpartum IUD use; antenatal care
The Role of HLAC and NK Cells in Fetal Growth Restriction Sulistyawati, Sri; Trimulya, Didon M; Respati, Supriyadi H; Soetrisno, Soetrisno
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.898 KB) | DOI: 10.32771/inajog.v5i3.539

Abstract

Objective: To determine the role of HLA-C and NK cell expressions in fetal growth restriction (FGR). Methods: A cross sectional study design was used. This study was conducted at the Obstetrics and Gynecology Department of Dr. Moewardi General Hospital, Surakarta, its affiliated hospitals, and at the Pathological Anatomy Laboratory of the Faculty of Medicine, University of Sebelas Maret Surakarta. A total of 40 samples were included in this study. The samples consisted of 20 normal pregnancies and 20 pregnancies with FGR. HLA-C expression in the trophoblast and NK cells in decidua of the subjects who met the inclusion and exclusion criteria were examined using immunohistochemical method and statistical analysis with T test. Results: The mean expression of HLA-C in the trophoblast in the pregnant group with FGR was 9.021.30, normal pregnancy was 7.96 ± 0.97, p=0.01 (p&lt;0.05). The mean expression of NK cells in decidua of pregnancy with FGR was 10.59 ± 2.11, normal pregnancy was 0.91 ± 8.18, with p=0.00 (p&lt;0.05). Conclusion: The expressions of HLA-C in trophoblast and NK cells in decidua of pregnancy with FGR were higher compared with those of normal pregnancy. [Indones J Obstet Gynecol 2017; 5-3: 142-148] Keywords: fetal growth restriction, HLA-C, NK cells
The Level of Heat Shock Protein 70 is Lower in Postterm Pregnancy Soetrisno, Soetrisno
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.219 KB) | DOI: 10.32771/inajog.v2i1.376

Abstract

Objective: To analyze whether there are differences between the levels of HSP70 of Postterm pregnancy and aterm pregnancy in Dr. Moewardi Hospital, Surakarta, Central Java. Method: This was a cross-sectional study. The independent variable was the level of Heat Shock Protein 70 (HSP70), and the dependent variable was the incidence of postterm pregnancy. The data was then analyzed by t test. Result: The subjects were 45 women, who were divided into 2 groups of women with postterm pregnancies (15 women) and aterm pregnancies (30 women). The mean levels of HSP70 in the serum of women with postterm pregnancy is lower (0.40 ng/ml) compared to the level of the normal pregnant group (3.94 ng/ml) and this difference was statistically significant (p&lt;0.001). Conclusion: The mean level of HSP70 in postterm pregnancy is lower than in normal full-term pregnancy.&nbsp; Keywords: Heat Shock Protein 70, Maternal Stress, postterm pregnancy