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All Journal PROSIDING SEMINAR NASIONAL Jurnal Penelitian Saintek Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedika Jurnal Kesehatan Pharmacon Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Nutraceuticals and Herbal Medicine I-Com : Indonesian Community Journal Jurnal Farmasi Sains dan Praktis Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium
Andi Suhendi
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Muhtadi, .; Suhendi, Andi; Wahyuningtyas, Nurcahyanti; Sutrisna, EM.
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
PENETAPAN KADAR LOGAM Pb DAN Cd DALAM SEDIMEN DAN TANAMAN KANGKUNG (Ipomoea aquatica) DI SEKITAR SUNGAI BENGAWAN SOLO DI KAWASAN INDUSTRI-KARANGANYAR Suhendi, Andi
Pharmacon Vol 11, No 2 (2010)
Publisher : Pharmacon

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Abstract

Air sungai Bengawan Solo digunakan untuk berbagai keperluan, khususnya pertanian dan perikanan. Keberadaan industri-industri di sekitar aliran sungai diduga telah mencemari kandungan airnya. Penggunaan air tercemar ini untuk kebutuhan pertanian dan perikanan dapat menimbulkan masalah kesehatan karena bisa terjadi bioakumulasi. Penelitian ini bertujuan untuk mengevaluasi kandungan cemaran logam Pb dan Cd pada tanaman kangkung dan tanah yang diairi sungai Bengawan Solo. Sampel tanah dan tanaman kangkung diambil secara acak dari satu lahan yang menggunakan pengairan sungai Bengawan Solo. Destruksi sampel dilakukan prosedur Standar Nasional Indonesia. Analisis logam Pb dan Cd larutan sampel dilakukan dengan menggunakan Spektrofotometri Serapan Atom (SSA). Kadar logam terukur dibandingkan dengan batas aman kandungan logam dalam pangan menurut Standar Nasional Indonesia dan dihitung nilai bioaccumulation factor (BAF). Hasil analisis menunjukkan konsentrasi Pb dan Cd dalam sedimen dan tanaman kangkung berturut-turut adalah 6,94±0,60 ppm; 0,23±0,04 ppm; dan 1,19±0,18 ppm; 0,32±0,01 ppm. Berdasarkan nilai ambang batas keamanan untuk Pb 0,5 ppm dan Cd maka disimpulkan tanaman kangkung tidak aman untuk dikonsumsi. Nilai bioaccumulation factor Cd>Pb, maka disimpulkan bahwa kemampuan tanaman kangkung menyerap logam Cd lebih besar dari pada Pb.  Kata kunci : Tanah, Tanaman kangkung (Ipomoea aquatica), kadar Pb, kadar Cd, Bioaccumulation Factor (BAF).
ISOLASI DAN IDENTIFIKASI FLAVONOID DARI DAUN DEWANDARU (Eugenia uniflora L.) Suhendi, Andi
Pharmacon Vol 12, No 2 (2011)
Publisher : Pharmacon

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Abstract

Dewandaru (Eugenia uniflora L.) secara tradisional digunakan sebagai penurun panas dan sakit perut. Penelitian membuktikan aktivitas biologis dewandaru sebagai antibakteri, antidiabetes, dan antioksidan. Senyawa yang diduga bertanggungjawab adalah flavonoid. Penelitian ini dilakukan untuk mengetahui jenis senyawa flavonoid yang terdapat dalam daun dewandaru (Eugenia uniflora L.). Ekstraksi dilakukan dua tahap yaitu tahap penghilangan lemak dengan metode sokletasi menggunakan pelarut kloroform dan tahap kedua maserasi dengan etanol 70%. Ekstrak difraksinasi dengan etil asetat dan air, kemudian fraksinya diperiksa dengan KLT menggunakan fase gerak asam asetat 15% dan BAW. Fraksi etil asetat diisolasi dengan KLT preparatif. Bercak pita yang memiliki harga Rf dan warna yang sama dengan deteksi awal diambil dan disari. Kemudian dianalisis menggunakan spektrofotometer UV-Vis, pereaksi diagnostic NaOH, NaOAc, H3BO3, AlCl3, HCl, KLT dua dimensi, hidrolisis isolat fraksi etil asetat. Berdasarkan pergeseran panjang gelombang spektra UV-Vis dengan dan tanpa pereaksi   diagnostik serta uji KLT didapatkan struktur parsial yang diduga kuat 5,7,3’,4’-tetra hidroksi flavonol atau kuersetin. Kata Kunci : dewandaru (Eugenia uniflora L.), flavonoid, KLT, spektrofotometer UV-Vis.kombinasi ekstrak; tikus jantan dan betina galur SD. 
Hypoglycemic Effect of Zingiber Zerumbet Ethanolic Extracts and Channa Striata Powder in Alloxan-Induced Diabetic Rats Muhtadi, M.; Annissa, Yanis Nur; Suhendi, Andi; Sutrisna, EM.
Journal of Nutraceuticals and Herbal Medicine Volume 1, No. 1, Februari 2018
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.149 KB) | DOI: 10.23917/jnhm.v1i1.5736

Abstract

The ethanolic extracts of the Zingiber zerumbet rhizome contains flavonoid and zerumbon compounds, the fish meat powder from Channa striata has an albumin content. The active compounds was contained in both materials had activity that can lower blood sugar levels in diabetic rats. This study aims to determine the hypoglycemic effect of each ingredients and the combination of Z. zerumbet rhizome extract and C. striata powder in alloxan-induced diabetic rats. This research uses pre and post test method with the control group design. The treatment was consisted of 5 groups, the first group was given aquades (as negative control), the second group was given glibenclamide with dose 5 mg/kgBW (as positive control), the third group was given 300 kg/kgBW of Z. zerumbet rhizome extract, the fourth group was given of C. striata fish powder 300 mg/kgBW, and the last group was given a combination materials with dosesrespectively, 300 mg/kgBW. The ingredient was given for 12 days and blood was taken on days 3, 6, and 12. The results shows the percentage of decrease in blood sugar of combination materials of 70.4% is greater than the single content of Z. zerumbet and C. striata, with the value of successive activity of 62.9% and 34.4%, respectively. The antidiabetic activity of combinations of materials had produced not different significant (p> 0.05) compared with single of C. striata powder as well as the Z. zerumbet rhizome extract.
Reduksi Kadar Besi Dalam Air Sumur di Lingkungan Universitas Muhammadiyah Surakarta dengan Filter Pawarti, Hesti; Citradewi, Lia Intan; Fadhilla, Aulia Tassya; Suhendi, Andi
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.6527

Abstract

Iron was silvery white, clay, and can be formed.  it was usually obtained as hematite in nature. Iron was a chemical element that could be found in almost all places on the face of the earth, in all parts of the geological layer, and all bodies of water. In surface water, Fe was rarely found more than 1 mg / L, but in the water, Fe content could be much higher. When it accumulated in the body, iron could cause health problems, such as skin irritation, respiratory problems, and cause cancer in a long time. This study aims to determine the reduction of iron content in well water at the Universitas Muhammadiyah Surakarta (UMS) using the Spectrophotometry method with phenanthroline reagents. The samples were taken as many as five points in three different regions, namely Tanuragan (near the river), Menco and Nilasari (dense settlements), and Gonilan (near the rice fields) showed positive results containing iron with the highest levels in the sample without filtering at 9,478 ppm. These levels decreased after filtration using four filters, namely filters made of carbon, cotton, foam, carbon three layers in each sample. The iron content reduction was best to use cotton filters with 100% reduction in percent.
PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i2.266

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 ?g / mL. The fruit contains ? avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Muhtadi, .; Suhendi, Andi; Wahyuningtyas, Nurcahyanti; Sutrisna, EM.
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i1.283

Abstract

Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
ISOLASI DAN IDENTIFIKASI FLAVONOID DARI DAUN DEWANDARU (Eugenia uniflora L.) Suhendi, Andi
Pharmacon: Jurnal Farmasi Indonesia Vol 12, No 2 (2011)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v12i2.36

Abstract

Dewandaru (Eugenia uniflora L.) secara tradisional digunakan sebagai penurun panas dan sakit perut. Penelitian membuktikan aktivitas biologis dewandaru sebagai antibakteri, antidiabetes, dan antioksidan. Senyawa yang diduga bertanggungjawab adalah flavonoid. Penelitian ini dilakukan untuk mengetahui jenis senyawa flavonoid yang terdapat dalam daun dewandaru (Eugenia uniflora L.). Ekstraksi dilakukan dua tahap yaitu tahap penghilangan lemak dengan metode sokletasi menggunakan pelarut kloroform dan tahap kedua maserasi dengan etanol 70%. Ekstrak difraksinasi dengan etil asetat dan air, kemudian fraksinya diperiksa dengan KLT menggunakan fase gerak asam asetat 15% dan BAW. Fraksi etil asetat diisolasi dengan KLT preparatif. Bercak pita yang memiliki harga Rf dan warna yang sama dengan deteksi awal diambil dan disari. Kemudian dianalisis menggunakan spektrofotometer UV-Vis, pereaksi diagnostic NaOH, NaOAc, H3BO3, AlCl3, HCl, KLT dua dimensi, hidrolisis isolat fraksi etil asetat. Berdasarkan pergeseran panjang gelombang spektra UV-Vis dengan dan tanpa pereaksi   diagnostik serta uji KLT didapatkan struktur parsial yang diduga kuat 5,7,3?,4?-tetra hidroksi flavonol atau kuersetin. Kata Kunci : dewandaru (Eugenia uniflora L.), flavonoid, KLT, spektrofotometer UV-Vis.kombinasi ekstrak; tikus jantan dan betina galur SD. 
PENETAPAN KADAR LOGAM Pb DAN Cd DALAM SEDIMEN DAN TANAMAN KANGKUNG (Ipomoea aquatica) DI SEKITAR SUNGAI BENGAWAN SOLO DI KAWASAN INDUSTRI-KARANGANYAR Suhendi, Andi
Pharmacon: Jurnal Farmasi Indonesia Vol 11, No 2 (2010)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v11i2.52

Abstract

Air sungai Bengawan Solo digunakan untuk berbagai keperluan, khususnya pertanian dan perikanan. Keberadaan industri-industri di sekitar aliran sungai diduga telah mencemari kandungan airnya. Penggunaan air tercemar ini untuk kebutuhan pertanian dan perikanan dapat menimbulkan masalah kesehatan karena bisa terjadi bioakumulasi. Penelitian ini bertujuan untuk mengevaluasi kandungan cemaran logam Pb dan Cd pada tanaman kangkung dan tanah yang diairi sungai Bengawan Solo. Sampel tanah dan tanaman kangkung diambil secara acak dari satu lahan yang menggunakan pengairan sungai Bengawan Solo. Destruksi sampel dilakukan prosedur Standar Nasional Indonesia. Analisis logam Pb dan Cd larutan sampel dilakukan dengan menggunakan Spektrofotometri Serapan Atom (SSA). Kadar logam terukur dibandingkan dengan batas aman kandungan logam dalam pangan menurut Standar Nasional Indonesia dan dihitung nilai bioaccumulation factor (BAF). Hasil analisis menunjukkan konsentrasi Pb dan Cd dalam sedimen dan tanaman kangkung berturut-turut adalah 6,94±0,60 ppm; 0,23±0,04 ppm; dan 1,19±0,18 ppm; 0,32±0,01 ppm. Berdasarkan nilai ambang batas keamanan untuk Pb 0,5 ppm dan Cd maka disimpulkan tanaman kangkung tidak aman untuk dikonsumsi. Nilai bioaccumulation factor Cd>Pb, maka disimpulkan bahwa kemampuan tanaman kangkung menyerap logam Cd lebih besar dari pada Pb.  Kata kunci : Tanah, Tanaman kangkung (Ipomoea aquatica), kadar Pb, kadar Cd, Bioaccumulation Factor (BAF).
Co-Authors 'Aina Fahrina Anwar . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Agus Triyono Agus Ulinuha Ainur Tri Hapsari Alida Rahmalia Damayanti Alvita Marshanda Purnama Puteri Amalinda Ayu Faroska Annissa, Yanis Nur Ardalia Rinanda Oktaviani Arifah Sri Wahyuni Atikah Hapsari Aulia Tassya Fadhilla Broto Santoso Burhanudin Ichsan Citradewi, Lia Intan Dedi Hanwar Dewi, Listiana Masyita Dhinar Asti Dwi Sarbini Eka Prasnaparamita W Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Erlya Ayusari Ramly Erna Herawati Fadhilla, Aulia Tassya Fahriza Mei Trihatmoko Farah Salsabila Faridita khoirun Nisa' Faroska, Amalinda Ayu Fidhia Nur Rifaini Frida Rosenova Gunawan Setyadi Haliza Arzeti Nurseptiria Hamimatusalma Alkautsar Haryoto - Haryoto Haryoto Haya Nabilah Utama Hesti Pawarti Hidayah Karuniawati Husna Amalia Halwa Ida Maesaroh Ika Trisharyanti Jessica Rosalinda Kasful Asra Sakika Kharisma Aulia Husna Khusnul Khotimah Laila Dzafira Lia Intan Citradewi Lina Ayu Kusumastuti M Muhtad Mariska Sri Harlianti Marsilia Rosa Sinensis HI Muhammad Da'i Muhtadi - Muhtadi Muhtadi Nida’ Nur Jannah Novea Kumalla Nur Muhammad Arrizky Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurul Tri Anggraini Pawarti, Hesti Pawarti, Hesti Peni Indaryudha Peni Indaryudha, Peni Puspa, Fajrina Eka Raafika Studiviani Rahardian Surya Basusena Ria Hidayati Rizki Ainun Fitriani Rizky Ainun Fitriani Rosa Sayentina Amin S Selviana Sayyidah Nurul Muslihah Siti Aisyah Subhan R Abidi Tanti Azizah Sujono Tia Mella Citra Tista Ayu Fortuna Vitania Marsya Vivi Resty Handayani Yanis Nur Annissa