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All Journal Farmaka KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Pharmacology and Clinical Pharmacy Research JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Jurnal Abdi Masyarakat Indonesia Jurnal Sains dan Kesehatan JIFI (Jurnal Ilmiah Farmasi Imelda)
Patala, Recky
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

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Anticancer Activity of Rosella Flowers (Hibiscus Sabdariffa l.) In HepG2 cells Viani Anggi; Recky Patala; Arfiah Arfiah; Niluh Puspita Dewi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6350

Abstract

The natural ingredients of rosella flowers have the potential as natural anti-cancer and chemopreventive agents, contain secondary metabolite compounds with cancer therapeutic mechanisms with inhibiting and killing cancer cells and their development through inhibition of apoptosis (cell death program) and in vitro inhibited cell flow. The study aims to identification of secondary metabolite compounds and also determine the cytotoxic activity of ethanol extract from the rosemary plant against HepG2 cancer cells. This study used by identification of secondary metabolite compounds of ethanol extract from the rosemary plant (Hibiscus sabdariffa L.) and the cytotoxicity test used with MTT assay on HepG2 liver cancer cells with a test concentration series of 12,5; 25; 50; 100; 200; 250; 500 and 1000 µg/ml. : The results showed the secondary metabolite compounds of rosella flowers have flavonoids, alkaloids, saponins and tannins and data of 50% cell growth inhibition activity, which was showed that rosella flower had IC50 values 629,919 μg/mL. The ethanol extract of rosella flowers have activity on HepG2 cells growth inhibition had considered moderately active anticancer activity
Co-Authors Akhmad Khumaidi Arfiah Arfiah Fahruddin Fahruddin Irnawati Irnawati Joni Tandi, Joni Kiki Rizki Handayani Mariyani Megawati Megawati Meilinda Handayani Pasaribu Niluh Puspita Dewi Niluh Puspita Dewi Nurkhaliza Awilia Nurlina Ibrahim Nurul Ulzmi Rezky Yanuarty Sri Hudayah Sri Mulyani Viani Anggi Yunlis Silintowe Kenta