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Ratnaningsih Dewi Astuti
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Journal : JPP Jurnal Kesehatan Poltekkes Palembang

 1 
PENGARUH SUHU PENYIMPANAN KOMBINASI AMOKSISILIN DAN ASAM KLAVULANAT DALAM SEDIAAN DRY SIRUP TERHADAP DAYA HAMBAT BAKTERI (Staphylococcus aureus) Muhamad Taswin .; Ratnaningsih Dewi Astuti; Bherta Tiara Handayani
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 16 No 1 (2021): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : POLITEKNIK KESEHATAN KEMENKES PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v16i1.690

Abstract

Sediaan dry sirup kombinasi amoksisilin dan asam klavulanat merupakan obat pilihan pertama untuk pengobatan penyakit infeksi seperti pneumonia. Sediaan dry sirup kombinasi amoksisilin dan asam klavulanat merupakan sediaan antibiotik yang perlu disuspensikan terlebih dahulu sebelum digunakan. Suhu penyimpanan dan stabiltas zat aktif didalam sediaan sangatlah penting karena dengan adanya penambahan air didalam sediaan suspensi kombinasi amoksisilin dan asam klavulanat akan mempengaruhi degradasi kimiawi, fisik dan mikrobiologi. Penelitian ini bertujuan untuk mengukur adanya pengaruh suhu penyimpanan kombinasi amoksisilin dan asam klavulanat dalam sediaan dry sirup yang telah disuspensikan terhadap daya hambat bakteri Staphylococcus aureus. Jenis penelitian ini adalah penelitian eksperimental karena adanya perlakuan terhadap sediaan antibiotik kombinasi amoksisilin dan asam klavulanat yang dipengaruhi oleh suhu penyimpanan terhadap aktivitas antibakteri. Berdasarkan hasil pengukuran diameter daya hambat pada antibiotik suspensi kombinasi amoksisilin dan asam klavulanat pada penyimpanan hari ke-7 semua sampel suspensi dry sirup mengalami penurunan. Penurunan diameter zona hambat tertinggi terjadi pada sampel suspensi dry sirup generik yang disimpan pada suhu kamar. Dari hasil penelitian dapat disimpulkan bahwa adanya pengaruh suhu penyimpanan kombinasi amoksisilin dan asam klavulanat dalam sediaan dry sirup terhadap daya hambat bakteri Staphylococcus aureus dengan adanya penurunan daya hambat di akhir penyimpanan
PENGARUH PEMBERIAN EKSTRAK ISOFLAVON TEMPE TERHADAP TINGKAT STRESS OKSIDATIF PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus novergicus) SETELAH DIINDUKSI DENGAN DOSIS TOKSIK PARASETAMOL Muhamad Taswin; Ratnaningsih Dewi Astuti; Dewi Marlina; Ocktariyana Ocktariyana; Ade Agustianingsih
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 17 No 2 (2022): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : POLITEKNIK KESEHATAN KEMENKES PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v17i2.1513

Abstract

ABSTRACT Background: As a producing country and at the same time the largest consumer of tempeh in the world, Indonesia has become the largest soybean market in Asia. As much as 50% of soybean consumption in Indonesia is done in the form of tempeh. Tempe is a potential food ingredient as a hepatoprotector. The content of isoflavones in tempeh has been shown to protect rat liver function under stress conditions. Isoflavones contained in tempeh have activity as antioxidants, which can prevent oxidation reactions from occurring by working as reducing agents and protecting cell membranes from oxidation, as well as counteracting free radicals by stopping chain reactions and protecting cells from DNA activation so as to reduce cell damage. This situation has prompted the authors to investigate the effect of the isoflavone extract of tempeh on the histochemistry and histopathology of the livers of male white Wistar rats (Rattus novergicus) after being induced by toxic doses of Paracetamol. Methods: This study was an experimental study using the Randomized Posttest Only Control Group Design to determine the level of oxidative stress after administration of tempeh isoflavone extract to male white rats (Rattus novergicus) induced with a toxic dose of paracetamol. 5 groups, namely group 1 was given tempe extract 160 mg/kgBB, group 2 was given tempe extract 320 mg/kgBB, group 3 was given tempe extract 640 mg/kgBB, group 5 was given distilled water and group 6 was given 1% NaCMC solution. Each rat was treated for 14 days. On day 12, 13 and 14 rats were given paracetamol at a dose of 900 mg/kg BW in 1% NaCMC. And on the 15th day, rat blood serum was examined for levels of SGOT, SGPT and MDA. Results: It was found that tempeh at a dose of 640 mg/kgBW could significantly reduce SGOT, SGPT and MDA levels (p<0.05) compared to other doses as well as distilled water and 1% NaCMC. Conclusion: So it can be concluded that tempeh can be an alternative source of antioxidants that can protect liver cells from the effects of substances that can damage the liver. Keywords: Tempe, SGOT, SGPT, MDA
Co-Authors Ade Agustianingsih Bherta Tiara Handayani Dewi Marlina Heni Sumastri Indah Puji Septeria Marta Pastari Muhamad Taswin Muhamad Taswin . Ocktariyana, Ocktariyana