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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Biotechnology Indonesian Journal of Cancer The Indonesian Biomedical Journal Medical Laboratory Technology Journal Jurnal Gizi Klinik Indonesia Majalah Kedokteran Neurosains Jurnal Pandu Husada
Teguh Aryandono
Division Of Surgical Oncology, Department Of Surgery, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Clinicopathological Characteristic and Prognostic Significance of Indonesian Triple Negative Breast Cancer Irianiwati Widodo; Ery Kus Dwianingsih; Teguh Aryandono; Soeripto Soeripto
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.831

Abstract

BACKGROUND: Triple negative breast cancer (TNBC) is a breast cancer subtype with negative expressions of estrogen receptors (ER), progesterone receptors (PR) and Her-2 protein receptors. This subtype exhibits aggressive behavior and poor prognosis since it is unresponsive to hormonal and Her-2 targeted therapy. The identification of clinicopathological characteristics and their prognostic values will provide guidance in developing effective treatment. This study was performed to analyze the clinicopathological characteristics and prognostic significance in Indonesian TNBC.METHODS: Forty paraffin-embedded tissues of TNBC, stage I to IIIA, dating from 2008 to 2010 in Dr. Sardjito Hospital, were enrolled. Survival follow-up was done from January 2008 to June 2013. The samples were immunostained with ER, PR and Her-2 monoclonal antibodies to determine the TNBC subtypes. The clinicopathological characteristics were statistically analyzed. The survival was analyzed using the Kaplan Meier method. The Cox proportional hazards model was used for multivariate analysis.RESULTS: Mean age of TNBC patients was 51.42±11.72 years old, whereas the mean of tumor size was 5.4±2.92 cm. Lymph node metastasis was found in 70% of cases. Number of locally advanced samples (IIIA) was 37.5%, while moderate to high grade samples were 95%. Number of still alive patients at the end of the study was 55%. Number of patients that still alive up to the end of the study was 45.50%. Lymph node was an independent prognostic factor for survival of TNBC patients as positive status of lymph node increases the death risk to 6 times higher (p=0.02, RR=6.6). However, after being adjusted with age and stage, lymph node status was suggested as a modifier effect for the survival of TNBCs patients (RR=0.19).CONCLUSION: Indonesian TNBC patients were mostly found already with large tumor size, lymph node metastasis, high pathological grade and relatively young age. Lymph node status serves as a modifier effect for the survival of Indonesian TNBC.KEYWORDS: NBC, clinicopathological characteristics, prognostic significance 
Hipoalbuminemia praoperasi pasien kanker kolorektal terhadap risiko komplikasi pascaoperasi dan lama rawat inap Yohanes Benny; Teguh Aryandono; Susetyowati Susetyowati
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18365

Abstract

Background: Malnutrition is most commonly found in gastrointestinal cancer that affects the result of an operation. Albumin serum is an effective and simple way of assessing risk which is associated with malnutrition intensity so that it is generally used as the prognostic index for the development of the incidence of colorectal cancer postoperative complications.Objective: To identify the effect of preoperative hypoalbumin to the incidence of postoperative complications and length of stay of colorectal cancer in patients.Method: The study used the quantitative approach with a nonconcurrent cohort (retrospective analysis) design. The population was patients diagnosed having colorectal cancer who would undergo an operation at Kasih Ibu, Dr. Oen, and Panti Waluyo Hospital of Surakarta. Data analysis used Chi-Square test and logistic regression.Results: Hypoalbumin, either based on admission or pre-operation, was significant risk factor for the incidence of post operative complications in colorectal cancer patients as well as age and American Society of Anesthesiologist Physical Status Classification (ASA) status. The result of multivariate analysis showed age of 20-59 years (OR=2), hypoalbumin based on admission (2.1 times) and preoperation (1.9 times) were risk factors for the incidence of postoperative complication (infection). ASA status III-IV had risk 2.8 times for the incidence of postoperative sepsis complications and 3.7 times for mortality than ASA status I-II. Status of hypoalbumin did not influence total length of stay or postoperative length of stay but age influenced postoperative length of stay.Conclusion: Hypoalbumin influenced the incidence of postoperative complications in colorectal cancer patients, particularly infection complication; whereas factors of age and ASA status were external factors strongly influenced. Hypoalbumin did not influence length of stay. Age was an external factor that strongly influenced postoperative length of stay.
Kadar mRNA Hypoxia Inducible Factor Alpha Plasma Darah Pasien Kanker Ovarium Tipe Mucinous Dan Serous Siti Nur Chasanah; Teguh Aryandono; Sofia Mubarika Haryana
JURNAL PANDU HUSADA Vol 1, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v1i2.4613

Abstract

Proses karsinogenesis pada kanker ovarium melibatkan regulasi tingkat molekular, salah satunyaadalahmRNA. Beberapa penelitian sebelumnya menyebutkan bahwa disregulasi mRNA HIF1A terjadi pada berbagai kanker.Penelitian melaporkan adanyapeningkatanekspresimRNA HIF1Apada kanker ovarium.Kanker sering berada dalam kondisi hipoksia, mRNA HIF1A merupakan regulator gen pada kondisi hipoksia. HIF1Aterlibat dalamberbagaihallmarkkanker.Berdasarkan hal tersebut, penelitian inidilakukanuntuk mengetahui apakah terdapat perbedaan ekspresimRNA HIF1Apada plasma penderita kanker ovarium tipe mucinous dan serous.Sampel plasma diambil dari pasien kanker ovarium di RSUP Dr. Sardjito,tipe mucinoussebanyak 9 sampel dantipe seroussebanyak 9 sampel. Total RNAdiisolasi dari sampel plasma darah pasien kanker ovarium dengan menggunakanmiRCURY RNA isolationKit-Biofluid. Kuantifikasi mRNA HIF1A dilakukan One-step qRT-PCR dengan kit KAPATMSYBR. Hasil qRT-PCR dianalisis dengan menggunakanBiorad CFX ManagerTMSoftware.Hasilanalisismenunjukkan bahwa terdapat perbedaanekspresi mRNA HIF1Apada tipe serous dibandingkan dengan tipe mucinous (p value =0,018). Ekspresi mRNA HIF1Apada tipe serous meningkat5,62 kali lipat dibandingkan dengan tipe mucinous. Penelitian ini telah berhasil membuktikan bahwa mRNA HIF1A lebih tinggi pada kanker ovarium tipe serous.
Co-Authors . Irianianiwati . Supomo . Supomo Addin Trirahmanto Ahmad Ghozali Ahmad Hamim Sadewa Akbar Satria Fitriawan Anwar, Sumadi Lukman Aprilia Indra Kartika Aprilia Indra Kartika Arif Faisal Bambang Karsono Benny, Yohanes Cita Herawati DENNI JOKO PURWANTO, DENNI JOKO Dewajani Purnomosari Dewi Sahfitri Tanjung Dewi Sahfitri Tanjung Didik Setyo Heiyanto Dinna Rakhmina Dwi Nur Indah Sari Dwianingsih, Ery Kus Hardyanto Soebono Haryono, Samuel J. Heru Pradjatmo Ibnu Purwanto Indwiani Astuti Indwiani Astuti Irianiwati Widodo Ishandono Dachlan Iwan Dwiprahasto Iwan Dwiprahasto Karsono, Ramadhan Lenny Sari, Lenny Lina Choridah Mae Sri Hartati Wahyuningsih Marsetyawan Soesatyo Marsetyawan Soesatyo Meutia Srikandi Fitria Oktriani R Paulus Sudiharto Paulus Sudiharto Risky Oktriani Sa’adah N Siti Nur Chasanah Siti Nur Chasanah Soeripto Soeripto Sofia Mubarika Sofia Mubarika Sofia Mubarika H Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Susetyowati Susetyowati Susetyowati Susetyowati, Susetyowati Tirta wardana Torizal GF Wardana T Yohanes Benny Yohanes Widodo Wirohadidjojo Ysrafil . Yulia Pratiwi