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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Pharmasipha Journal of Tropical Pharmacy and Chemistry Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) ad-Dawaa : Journal of Pharmaceutical Sciences Mattawang: Jurnal Pengabdian Masyarakat Journal of Fundamental and Applied Pharmaceutical Science Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Acta Holistica Pharmaciana
Niluh Puspita Dewi
Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : ad-Dawaa : Journal of Pharmaceutical Sciences

 1 
Histopathological Study of Streptozotocin Induced Liver Regeneration of Wistar Mice after Administration of Pumpkin Leaf Ethanol Extract Niluh Puspita Dewi; Windi Olivia Kawanga; Debora Rislianti Lakiu
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v4i2.25115

Abstract

This study aims to prove that the ethanol extract of pumpkin leaf can improve the liver histological structure of Wistar rats streptozotocin and find out the effective dose in regenerating the liver cells of Wistar rats. Wistar rats were divided into six groups so that each group has five replications. The control group was not given the extract, and the treatment group was administered the extract with three doses of 125 mg/kg BW, 150 mg/kg BW, and 175 mg/kg BW which were carried out for three weeks. Rats were then sacrificed and the liver organs were taken for the histopathology preparations with Hematoxylin-Eosin staining (HE). The results showed fatty degeneration and necrosis of the livers. The results of the Mann-Withney test analysis showed that there was a significant difference in liver histopathology scoring from each treatment group. Ethanol extract  of pumpkin leaves at a dose of 150 mg/kg BW gave an effect on the  regeneration of liver cells of Wistar rats with a damage score of 1.4 and had no effective dose
Effectiveness Of Cassia alata L Leaf Extract Decrease Blood Glucose Level On Streptozotocin-Induced Male White Rats Niluh Puspita Dewi; Febry Grasela Aula; Indah Kurnia Utami; Ayu Wulandari; Rezky Yanuarty; Wayan Wirawan
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38400

Abstract

Introduction: Diabetes mellitus (DM) is a condition in which the body either fails to produce enough insulin at the right time or fails to use it properly. Aims: The goal of this study is to show how Cassia alata L. leaf extract affects blood glucose levels in streptozotocin-induced diabetic rats. Methods: Cassia alata L. leaves therapy is an alternative treatment for DM. In this investigation, laboratory techniques were employed. Streptozotocin was administered intraperitoneally to mice at a dose of 40 mg/kg body weight initially. Except that they produce normal controls. Six groups of 30 rats each received treatment with Cassia alata L. leaf extract at doses of 500 mg/kg body weight, 600 mg/kg body weight, and 700 mg/kg body weight in addition to the usual control group. Trial outcome data were first examined using one-way ANOVA to confirm differences between treatments and then put through the DUNCAN trial. Result: As a result, it was discovered that secondary metabolites of alkaloids, flavonoids, saponins, and tannins were present in the ethanol extract of Cassia alata L. leaves. A dose of 700 mg/kg body weight is an effective blood sugar-lowering dose, with an average reduction of 121 mg/dl. Conclusion: Ethanol extract from Cassia alata L. leaves has this effect.
Co-Authors Aris Widiastuti Ayu Wulandari David Pakaya Debora Rislianti Lakiu Dermiati tatto DIAN RAHMAWATI Elasari Dwi Pratiwi Febry Grasela Aula Feiverin Tibe Fikhta Agnesya Tarusu Franciska Diana Pratiwi Gabriella Bamba Ratih Lintin Gunawan Pamudji Indah Kurnia Utami Indah Kurnia Utami Joni Tandi, Joni Magfirah - - Megawati R. Surat Meilinda Handayani Pasaribu Muthmainah Tuldjanah Patala, Recky Puput Octaviani Solehah Putri Pratiwi Ramla Allia Resky Chandra Wirawan Rezky Yanuarty Sri Mulyani Sabang surisna surisna Syafika Alaydrus Wayan Wirawan Wayan Wirawan Windi Olivia Kawanga Yuli Fitriana