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All Journal Jurnal Ilmu Pertanian Indonesia VALENSI JURNAL KIMIA SAINS DAN APLIKASI Microbiology Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Chemistry Indonesian Journal of Chemical Research JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Analit: Analytical and Environmental Chemistry

Wulan Tri Wahyuni

Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam; Pusat Studi Biofarmaka Tropika, Lembaga Penelitian Dan Pengabdian Kepada Masyarakat, Institut Pertanian Bogor

Author-ID : 411386

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Optimization and Validation of High Performance Liquid Chromatographic Fingerprint of Phyllanthus niruri Wulan Tri Wahyuni; Latifah K. Darusman; Aji Hamim Wigena
Indonesian Journal of Chemistry Vol 14, No 2 (2014)
Publisher : Universitas Gadjah Mada

Split-plot mixture-mixture design has been applied for optimization of Phyllanthus niruri chromatographic fingerprint. The design was applied for unreplicated and simultaneous optimization of extraction mixture and chromatographic mobile phase mixture. The whole-plot was extraction solvent contained various combinations of methanol, ethyl acetate and dichloromethane in a simplex centroid with axial design. The sub-plot was reversed phase chromatographic mobile phase in simplex centroid design contained varying proportions of methanol, acetonitrile and acetonitrile:water (55:45 v/v). Each extract was eluted with seven mobile phases of high performance liquid chromatography and detected at 210, 225 and 254 nm. The optimum condition was determined based on the number of peaks. The correlation between extraction solvent, chromatographic mobile phase and number of peak were evaluated with Ordinary Least Square method. The root mean square error of calibration and root mean square error of prediction obtained at 210, 225 and 254 nm were 1.8634 and 4.0076; 2.2220 and 5.2839; 1.5436 and 2.2606, respectively. The optimum condition was obtained when the ethyl acetate extract was eluted with acetonitrile:water (55:45 v/v) and detected at 254 nm. Precision of retention time at optimum condition was excellent, with the relative standard deviation in a range of 0.0698% and 0.3006%.

FIRST-ORDER ULTRAVIOLET DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF RESERPINE IN ANTIHYPERTENSION TABLET Latifah K Darusman; Mohamad Rafi; Wulan Tri Wahyuni; Rizna Azrianiningsari
Indonesian Journal of Chemistry Vol 12, No 3 (2012)
Publisher : Universitas Gadjah Mada

A new ultraviolet derivative spectrophotometry (UVDS) method has been developed for determination of reserpine in antihypertension tablets. A first-order UVDS based on the measurement of the distance between peaks to baseline (DZ) at the wavelength of 312 nm was used. Evaluation of analytical performance showed that accuracy as percentage recovery was 99.18-101.13%, precision expressed as relative standard deviation (RSD) was 1.91% and linear correlation was also obtained 0.9998 in the range of 10-50 µg/mL. Estimation of limit of detection and limit of quantitation was 0.8868 µg/mL and 2.6874 µg/mL, respectively. As a reference method, HPLC methods from United States Pharmacopiea (USP) were used. Commercially tablets available were analyzed by the two methods. The content of reserpine in tablets was found 0.2260±0.0033 mg by UVDS and 0.2301±0.0051 mg by the USP methods. The result obtained from the two methods was compared statistically using F-test and t-test and showed no significant differences between the variance and mean values of the two methods at 95% confidence level. This method was faster, easier, low cost and gave result as well as the reference method published by USP.

Data Fusion of UV-Vis and FTIR Spectra Combined with Principal Component Analysis for Distinguishing of Andrographis paniculata Extracts Based on Cultivation Ages and Solvent Extraction Antonio Kautsar; Wulan Tri Wahyuni; Utami Dyah Syafitri; Syifa Muflihah; Nursifa Mawadah; Eti Rohaeti; Zulhan Arif; Bambang Prajogo; Muhammad Bachri Amran; Abdul Rohman; Mohamad Rafi
Indonesian Journal of Chemistry Vol 21, No 3 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.60321

Andrographis paniculata is one of the medicinal plants used for the treatment of antidiabetic. Cultivation ages and solvent extraction affected metabolites' composition and concentration that directly cause the plant's efficacies. This research aimed to distinguish A. paniculata based on cultivation ages and solvent extraction using data fusion of UV-Vis and FTIR spectra combined with principal component analysis (PCA). A. paniculata with 2, 3, and 4 months post-planting were extracted by water, 50% ethanol, 70% ethanol, and ethanol. In each extract, we measured UV-Vis and FTIR spectra. Then, we used the data fusion from both spectra. We used UV-Vis and FTIR absorbance from 200–400 nm and 1800–400 cm–1, respectively. Each extract gives a similar pattern of UV-Vis and FTIR spectra, only differ in their intensities. PCA score plot in two and three-dimensional showed A. paniculata extracts could be distinguished based on cultivation ages and solvent extraction with a total variance of 86 and 92%, respectively. Furthermore, this study confirms the data fusion of UV-Vis and FTIR spectra could distinguished A. paniculata extracts combined with chemometrics based on cultivation ages and solvent extraction.

Co-Authors Abdul Rohman Achmad Fauzi Achmad Fauzi Aditya Widianto Aji Hamim Wigena Aninda Naszwa Kuswanto Antonio Kautsar Apriliani Rahmat Badrunanto Badrunanto Bambang Prajogo Eko Wardoyo Budi Riza Putra Budi Riza Putra Budi Riza Putra Budi Riza Putra Desi Herliani Desi Ramadhanti Diksy, Yuris Era Rahmi Eti Rohaeti Eti Rohaeti Eti Rohaeti Hera Nirwati Herdiyanto Herdiyanto Irma Herawati Suparto Irmanida Batubara Latifah K Darusman Latifah K Darusman Latifah K Darusman Pitria Latifah K. Darusman Latifah Kosim Darusman LATIFAH KOSIM DARUSMAN LATIFAH KOSIM DARUSMAN Latifah Kosim Darusman M. Rafi Makmum Syafi’i Manggar Arum Aristri Moh Arif Rohman Nur Hakim Mohamad Rafi Monica Ina Martha Muhammad Bachri Amran Nur Zamilah Nursifa Mawadah Rany Zalvianita Reni Febriani Ria Apriana Rika Indri Astuti Rizna Azrianiningsari Rudi Heryanto Salmi Afifah Septaningsih, Dewi Anggraini SITI SA’DIAH Sri Purwanti Sri Purwanti Syifa Muflihah Tamida Elinda Ulfiatun Nisa Utami Dyah Syafitri

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Journal : Indonesian Journal of Chemistry