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Wulan Tri Wahyuni
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam; Pusat Studi Biofarmaka Tropika, Lembaga Penelitian Dan Pengabdian Kepada Masyarakat, Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

 1 
Efektivitas Krim Anti Jerawat Kayu Secang (Caesalpinia sappan) Terhadap Propionibacterium acnes pada Kulit Kelinci SITI SA’DIAH; LATIFAH KOSIM DARUSMAN; WULAN TRIWAHYUNI; IRMANIDA BATUBARA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sappan Wood extract (Caesalpinia sappan) is potential as an anti-acne due to its ability as an antioxidant, lipase inhibitor and anti Propionibacterium acnes. The potency is influenced by the quality of simplicia and extracts. To elevate the application, semisolid dosage formulations were made in cream forms using a standardized extract of Sappan Wood. Creams were formulated with the same base composition but different extract concentrations (range of 1-10%). In vivo assay were carried out on rabbit skin induced by intradermal injection of P. acnes. Sappan Wood was collected from Semarang and the resulting extract has met the Materia Medika Indonesia requirement with brazilin level in extract of 224.675 mg / g. In vivo tests showed that all Sappan Wood extract formulations have potency as anti-acne as indicated by curative percentage for 15 days were significantly different from the formula base. Curative effect of all formula were not significantly different with the Mediklin® positive control. Formula with the lowest concentration of the extract was the most effective and efficient with the curative percentage of more than 96% in 15 days.
Co-Authors Abdul Rohman Achmad Fauzi Achmad Fauzi Aditya Widianto Aji Hamim Wigena Aninda Naszwa Kuswanto Antonio Kautsar Apriliani Rahmat Badrunanto Badrunanto Bambang Prajogo Eko Wardoyo Budi Riza Putra Budi Riza Putra Budi Riza Putra Budi Riza Putra Desi Herliani Desi Ramadhanti Diksy, Yuris Era Rahmi Eti Rohaeti Eti Rohaeti Eti Rohaeti Hera Nirwati Herdiyanto Herdiyanto Irma Herawati Suparto Irmanida Batubara Latifah K Darusman Latifah K Darusman Latifah K Darusman Pitria Latifah K. Darusman LATIFAH KOSIM DARUSMAN Latifah Kosim Darusman Latifah Kosim Darusman LATIFAH KOSIM DARUSMAN M. Rafi Makmum Syafi’i Manggar Arum Aristri Moh Arif Rohman Nur Hakim Mohamad Rafi Monica Ina Martha Muhammad Bachri Amran Nur Zamilah Nursifa Mawadah Rany Zalvianita Reni Febriani Ria Apriana Rika Indri Astuti Rizna Azrianiningsari Rudi Heryanto Salmi Afifah Septaningsih, Dewi Anggraini SITI SA’DIAH Sri Purwanti Sri Purwanti Syifa Muflihah Tamida Elinda Ulfiatun Nisa Utami Dyah Syafitri