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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL GIZI INDONESIA Teknologi Indonesia
Galuh Widiyarti
Research Center for Chemistry (RCC-Chem), Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 15314
Agriculture, Biological Sciences & Forestry Computer Science & IT Environmental Science Health Professions

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AKTIVITAS INHIBISI ?-GLUKOSIDASE GRANULAR TEH HIJAU (Camellia sinensis) GRADE Arraca Yabukita HASIL DIAFILTRASI MENGGUNAKAN MEMBRAN NANOFILTRASI Widiyarti, Galuh; Susilowati, Agustine; Aspiyanto, -
Teknologi Indonesia Vol 35, No 1 (2012)
Publisher : LIPI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jti.v35i1.176

Abstract

The activity of ?-glucosidase inhibition test of local granular green tea (Camellia sinensis) grade of Arraca Yabukita has been done. Granular green tea obtained by vacuum drying of the concentrate of the diafiltration process using nanofiltration membrane (DF-NF) at 50C for 0-80 hours. Every 8 hours of drying time, the analysis of water content, total polyphenols, and ?-glucosidase inhibitory activity of granular green tea were conducted. The?-glucosidase inhibitory activity test was performed by by Kim Yong-Mu method and compared to quercetin as standard. The results showed that, the drying process increases the ?-glucosidase inhibitory activity of granular green tea. At the optimum drying time 72 hours, the ?-glucosidase inhibitory activity of granular green tea is about 18 times higher than quercetin.
ANTIOXIDANT ACTIVITY AND TOXICITY OF PUSPA (SCHIMA WALLICHII) LEAVES EXTRACT FROM INDONESIA Widiyarti, Galuh; Supiani, Supiani; Tiara, Yova
Journal of Tropical Life Science Vol 8, No 2 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (406.925 KB) | DOI: 10.11594/jtls.08.02.08

Abstract

Antioxidant and toxicity of Puspa (Schima wallichii) were studied. The plant extracts were prepared for bio-logical screening. Antioxidant activity of extracts was analysed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) as stable free radical, while toxicity of extracts was analysed by Brine Shrimp Lethality Test (BSLT) method. The result showed that ethyl acetate, methanol and butanol extracts were very active as antioxidant, as indicated by IC50 value of 11.44, 17.97 and 12.55 µg/mL for DPPH inhibition, respectively. Whilst n-hexane extract was not active as antioxidant indicated by IC50 value of 257.91 µg/mL, but aquadest extract was less active as antioxi-dant indicated by IC50 value of 171.94 µg/mL. The toxicity test result showed that all extracts were active against Artemia salina Leach with LC50 value of 107.35 ? 902 µg/mL. Furthermore, isolation of individual bio-active compound of ethyl acetate extract that most active as antioxidant was carried out using column chroma-tography followed by preparative Thin Layer Chromatography (TLC). The active isolate was then identified using TLC, Fourier Transform Infra-Red (FTIR) and Liquid Chromatography Mass Spectroscopy (LCMS).. The identification result showed that the major compound contained a putative compound known as theanine with MS 174.26 g/mol. The isolate was very active as antioxidant with IC50 value of 48.04 µg/mL, although it was less active than the extract. The isolate was also toxic with LC50 value of 27.71 µg/mL so that puspa leaf potentially to be developed as a natural antioxidant and anticancer agent for preventing of human diseases.
In vitro lipase enzyme inhibitory activities of green tea and other herbs Megawati, Megawati; Artanti, Nina; Mulyani, Hani; Darmawan, Akhmad; Syahrian, Heri; Lotulung, Puspa Dewi N.; Supriadi, Edi; Widiyarti, Galuh; Dewi, Rizna Triana; Meilawati, Lia; Ernawati, Teni; Dewijanti, Indah Dwiatmi; Minarti, Minarti
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 9, No 1 (2020)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.9.1.48-52

Abstract

Background: Increased lipase activity can increase the amount of monoglycerides and fatty acids absorbed by the body, this is what affects obesity. If pancreatic lipase activity is inhibited, the production of fatty acids will decrease, consequently the level of fat in the blood will also decrease.Objective: To study anti obesity potential of a single herb or a mixture of green tea and other herbs (Syzygium polyanthum. Lv, Artocarpus communis.Lv, Cinnamomum verum..Lv, Manilkara zapota.Lv, Tectona grandis.Lv) by the in vitro inhibition assay of the lipase enzyme activityMethod: A single (8 herbs) or a mixture of three herbs powder (12 formulas) was put into a tea bag with a total weight of 1.5 g to be brewed in 100 mL bottled mineral water at 70⁰-90⁰C for 10 minutes. In vitro lipase enzyme inhibition assay were conducted to measure the ability of these samples as lipase inhibitor. Orlistat used as positive lipase inhibitor. Results: There was a difference results of lipase inhibition activity between the sample of a single and a mixture of herbs. Interestingly, the results shows that formula 3 (mixture of green tea, Manilkara zapota and cinnamon). has 53.942 % inhibition, formula 9 (a mixture of green tea, Syzygium polyanthum and cinnamon) has 67.322 % inhibition and formula 12 (a mixture of green tea, Tectona grandis and cinnamon) has 56.612 % inhibition which close to lipase inhibitory activity by standard Orlistat.Conclusion: The mixture of green tea and two other herbs has a lipase inhibitory activity similar to Orlistat, when compared to the single herb. The highest lipase inhibitory activity is found in formula 9.
Co-Authors Agustine Susilowati Akhmad Darmawan Aspiyanto, - Dewijanti, Indah Dwiatmi Hani Mulyani, Hani Heri Syahrian, Heri Lia Meilawati Lotulung, Puspa Dewi N. Megawati - Minarti Minarti Nina Artanti Rizna Triana Dewi Supiani Supiani, Supiani Supriadi, Edi Teni Ernawati Tiara, Yova