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All Journal Jurnal Ilmiah Manuntung Journal of Tropical Pharmacy and Chemistry JFIOnline Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Sains dan Kesehatan
Aditya Fridayanti
Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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OPTIMASI SEDIAAN TRANSDERMAL PATCH NATRIUM DIKLOFENAK TIPE MATRIKS Hendradi, Esti; Isnaeni, .; Fridayanti, Aditya; Pujianti, Efrin
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6800.642 KB) | DOI: 10.35617/jfi.v5i3.45

Abstract

The study was designed to investigate the optimation of preparation of transdermal patch sodium diclofenac matrix type. In this study, matrix-type base containing diclofenac sodium were prepared using polymeric combination of EC N-20  and PVP K-30 in different ratios ( 9:1 (Formula I); 8:2 (Formula II); 7:3 (Formula III)) and 6:4 (Formula IV). The moisture content was calculated as a difference between initial and final weight with respect to final weight. The homogeneity of patch surface was determined using Scanning Electron Microscope (SEM) Released test using dissolution tester were carried out in 500 mL of  phosphate buffer salin pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. The concentration of sodium diclofenac released was determined using spectrophotometric method at l 276 nm. Data was analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0.05).  It is concluded that the polymeric combination EC N-20 and PVP K-30 in composition 7:3 (Formula III) was the best formulation. ABSTRAK Telah dilakukan penelitian tentang optimasi sediaan transdermal patch natrium diklofenak tipe matriks. Pada penelitian ini, basis matriks mengandung natrium  diklofenak dibuat dengan kombinasi polimer  etilselulose (EC) N-20  dan polivinilpirolidon (PVP) K-30 dengan berbagai perbandingan yaitu 9:1 (Formula I); 8:2 (Formula II); 7:3 (Formula III)) dan 6:4 (Formula IV). Moisture content (MC) ditentukan dengan cara berat awal dikurangi berat akhir dan dibagi dengan berat akhir. Homogenitas permukaan patch ditentukan dengan menggunakan Scanning Electron Microscope (SEM). Uji pelepasan natrium diklofenak dilakukan dengan alat disolusi dan menggunakan dapar fosfat salin  pH 7,4 ± 0.05 sebanyak 500,0 mL, kecepatan pengadukan 50 rpm dan percobaan dilakukan pada suhu 37 ± 0,5°C. Kadar natrium diklofenak yang terlepas ditentukan dengan metoda spektrofotometer pada panjang gelombang (l) 276 nm. Data yang diperoleh dianalisa secara statistik menggunakan program SPSS dengan derajat kepercayaan 95% (α = 0,05).  Kesimpulan yang didapatkan adalah komposisi polimer EC N-20 dan PVP K-30 dengan perbandingan  7:3 (Formula III) adalah formula yang terbaik.
Co-Authors Agung Rahmadani Arsyik Ibrahim Bravo Prisukarno Defriana Defriana Delvia, Fila Destri Erawaty Diana Ntowe Dwi Nur Afifah Enggar Wijayanti Esti Handayani Esti Hendradi Fila Delvia Fitriyani Fitriyani Ganjar Firmansyah Hadi Kuncoro Hairunisa, Indah Herman Herman Ika Ayu Mentari Isnaeni Laode Rijai Maileh Toding Mardiatul Ulfah Marlyan Bone Mega Silvia MUHAMMAD AMIR MASRUHIM Nazmy Maulidha Ninin Kartika Ulfa Nur Aida Febriana Pindo Hardika P.A.N Pujianti, Efrin Rio Saddam Pratama Rolan Rusli Rosniah Rosniah Santy Dara Krisnawati Shinta Christiani Tri Woro Widyanti Vina Maulidya Welinda Dyah Ayu Yurika Sastyarina Yuspian Nur