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All Journal Jurnal Biologi Tropis JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Sastraningsih Setiawati
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HIPERTENSI, DIABETES MELLITUS, DAN OBESITAS SEBAGAI FAKTOR KOMORBIDITAS UTAMA TERHADAP MORTALITAS PASIEN COVID-19: SEBUAH STUDI LITERATUR Luh Ade Dita Rahayu; Jannatul Cahya Admiyanti; Yumna Iftinan Khalda; Fatikha Rudia Ahda; Nur Feby Febiana Agistany; Sastraningsih Setiawati; Nabila Indah Shofiyanti; Cut Warnaini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.342

Abstract

Background: COVID-19 patients with comorbid diseases have a higher mortality rate than patients without congenital diseases. The most common comorbids found in COVID-19 patients are diabetes mellitus, hypertension, and obesity. The prevalence of COVID-19 patients with diabetes mellitus reached 41.7%, hypertension reached 56.6%, and obesity reached 41.7%. Methods: The method used in this paper is literature review from various references and focused on the correlation of comorbid with the risk of death in COVID-19 patients. The references are being retrieved from NCBI and Google Scholar. Overall, 21 sources were used which were obtained from various data bases including PubMed, ScienceDirect, Researchgate, and WHO. Discussion: There is an increase in ACE-2 expression which causes a high susceptibility to SARS-CoV-2 infection on COVID-19 patient with hypertension. Impaired T-cell function and increased levels of interleukin-6 (IL-6) also play an important role in increasing the severity on COVID-19 patient with diabetes. Obesity can cause abnormalities in the secretion of cytokines, adipokines, and inferferon which will disrupt the immune system in the human body. Conclusion: The complex pathophysiological mechanisms of hypertension, diabetes mellitus, and obesity as comorbid in COVID-19 patients increase the severity and mortality risk.
Clinical Manifestations, Diagnosis, Management and Prevention of Cervical Cancer Sastraningsih Setiawati; Yunita Hapsari
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5594

Abstract

The second most prevalent cancer in women and one that may be mainly prevented or treated if discovered at an early stage, cervical cancer is a serious health concern worldwide, particularly in Indonesia. This literature review aims to provide related information about clinical manifestations, diagnosis, management and prevention of cervical cancer. We searched online databases and used review articles, research, guidelines from professional organizations, such as POGI from Indonesia and FIGO from London. The disease's clinical manifestations often appear in advanced stages and can include abnormal vaginal bleeding, pelvic pain, and pain during intercourse. Diagnosis typically involves a multi-step process beginning with physical examination, Pap smear tests, HPV testing, and possibly leading to colposcopy and biopsy procedures for confirmatory analysis. Management strategies for cervical cancer range from conservative watch-and-wait approaches in early-stage disease to more aggressive interventions such as surgery, radiation, and chemotherapy in more advanced cases. Prevention strategies have centered on HPV vaccination and regular screening tests, both of which remain underutilized in regions like Indonesia. Despite the availability of effective preventative and therapeutic measures, the high incidence and mortality rates emphasize the critical need for enhanced public health efforts to increase screening and vaccination rates, improve access to treatment, and promote education on cervical cancer. Cervical cancer usually does not appear until the cancer has reached an advanced stage trough increased awareness, education, and access to screening and treatment services, the burden of cervical cancer can be reduced.
Co-Authors Cut Warnaini Fatikha Rudia Ahda Jannatul Cahya Admiyanti Luh Ade Dita Rahayu Nabila Indah Shofiyanti Nur Feby Febiana Agistany Yumna Iftinan Khalda Yunita Hapsari