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IQ Difference before and after Temporal Lobe Epilepsy Surgery: First report from Indonesia Muhamad Thohar Arifin1 , Fajar H. Niantiarno1 , Nabila Amalina1 , Hardian2 , Muttaqin Z
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10731

Epilepsy is a serious disorder of the brain, affects almost fifty million people in the world. About 40% of the patients finally became refractory to epileptic drugs, especially those with temporal lobe epilepsy (TLE). This refractory condition may cause psychosocial decline, including patient’s intelligence. Surgical therapy has an important role in stopping further damage to brain cells caused by repeated seizures. The elimination of the seizure after surgery will hopefully results in better intelligence score. This study aims to find out the effect ofsurgical therapyin TLE patients after surgery. We were using a Quasi Experimental study with One Group Pre-test and Post-test design. The samples were taken with consecutive sampling method. Subjects were 15 TLE patients who underwent anterior temporal lobectomy and have passed at least one year postoperative period, and also had done an intelligence quotient (IQ) test before surgery. IQ before and after surgery were measured with WAIS and WISC-R method. The statistical tests used were paired t-test. We found the verbal IQ after surgery(98.8±9.88(76-119)) were significantly higher(p=0.01) comparedwithpreoperativeverbalIQ(92.7±9.60(77-113)). On the other hand, performance IQ after surgery (98.2±8.64(82-115)) were higher compared with preoperative performance IQ (96.0±9.39(75-116)) but it was not significant (p=0.5). Total IQ after surgery (97.8 ±7.69(81-107)) also higher compared with preoperative total IQ (93.9±9.28(75-115)) but also not significant (p=0.08). Postoperative verbal IQ improvement was found compared with preoperative verbal IQ.

THE EFFECT OF TURMERIC EXTRACT (Curcuma longa) ON THE IMPROVEMENT OF MUSCLE MASS IN SWISS DIABETES MELITUS MICE SKELETAL MUSCLE INDUCED BY STREPTOZOTOCIN Alfin Ihza Trimahendra; Yora Nindita; Vega Karlowee; Muhamad Thohar Arifin; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Backgrounds. Diabetes mellitus is a degenerative disease that has various complications. One of neglected diabetes mellitus complication is skeletal muscle atrophy. Turmeric and java turmeric extracts were need to be clarified due to those effect as antihyperglycemic agent which might affected muscle atrophy as one of diabetes mellitus complication. Aim. To compared the efficacy of turmeric and java turmeric extract on reducing the progression of skeletal muscle atrophy in streptozotocin-induced diabetes mellitus. Methods. We conducted experimental animal studies with a post test only control group design using 25-30 grams male Swiss mice aged 12 weeks. Diabetes mellitus was induced by streptozotocin (STZ) administration. All 28 samples were randomly divided into 4 groups : control + PBS, control + STZ, STZ + turmeric, and STZ + java turmeric groups. Before treatment, blood glucose and body weight were examined on 3rd day. Blood glucose, body weight, hindlimb muscle weight, and muscle diameter results were examined after treatment (on 21st day). Data was analyzed with statistical software after all procedures were done. Results. STZ + turmeric group showed insignificant decreased in blood sugar levels (p=0.107). Control + STZ group showed significantly reduced hindlimb muscle weight compared to other groups. Hindlimb muscle weight was significantly ameliorated by STZ + turmeric extract (p=0.048). There were no significant improvement on skeletal muscle diameter among groups. Conclusion. The administration of turmeric extract improved hindlimb muscle weight but may not mediated by glucose lowering effect in streptozotocin induced diabetic mice.

PENGARUH PEMBERIAN RANITIDINE TERHADAP HISTOPATOLOGI HIPOKAMPUS TIKUS WISTAR DENGAN INTOKSIKASI METANOL AKUT Fernando Fernando; Mohammad Thohar Arifin; Ika Pawitra Miranti
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar belakang : Metanol merupakan salah satu senyawa yang dapat merusak secara sistemik akibat dari asidosis. Salah satu organ yang terkena dampak adalah hipokampus. Ranitidine diketahui dapat menurunkan kadar asam format dalam darah sehingga dapat mengurangi dampak toksik dari metanol.Tujuan : Mengetahui pengaruh pemberian ranitidine terhadap histopatologi hipokampus tikus Wistar dengan intoksikasi metanol akut.Metode : Penelitian true experimental dengan rancangan parallel post test only control group design ini menggunakan tikus strain Wistar jantan usia 2-3 bulan (n=15) yang secara random dibagi menjadi 3 kelompok (kelompok kontrol negatif (n=5), kelompok kontrol positif (n=5), dan perlakuan (n=5)). Pada 8 jam setelah pemberian perlakuan, otak tikus diambil dan diperiksa persentase nekrosis dari sel hipokampus dengan pengecatan HE . Uji statistik yang digunakan uji Kruskal Wallis dan dilanjutkan uji Mann-Whitney untuk melihat perbedaan antar kelompok perlakuan.Hasil : Pada penelitian ini didapatkan peningkatan jumlah sel nekrosis hipokampus pada kelompok kontrol positif dibandingkan kontrol negatif dan penurunan pada kelompok perlakuan dibandingkan kelompok kontrol positif. Terdapat perbedaan yang bermakna antara kelompok kontrol positif dibandingkan dengan kelompok kontrol negatif (p=0.008), dan perlakuan (p=0.008). Akan tetapi tidak ada perbedaan antara kelompok perlakuan dibandingkan dengan kelompok kontrol negatif (p=0.690).Simpulan : Permberian ranitidine dapat mengurangi derajat nekrosis sel pada sel hipokampus tikus Wistar dengan intoksikasi metanol akut.

PENGARUH PEMBERIAN RANITIDINE TERHADAP SPERMATOGENESIS TIKUS Wistar DENGAN INTOKSIKASI METANOL AKUT DILIHAT SECARA HISTOPATOLOGIS James Otniel; Muhammad Thohar Arifin; Ika Pawitra Miranti
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar belakang: Metanol memiliki efek toksik melalui metabolitnya yaitu asam format yang mengakibatkan gangguan spermatogenesis. Ranitidine mempunyai enzim yang dapat menghambat terbentuknya metabolit asam format sehingga diharapkan akan mengurangi efek toksisitas dari metanol terhadap fungsi spermatogenesis.Tujuan: Untuk mengetahui seberapa besar pengaruh pemberian ranitidine pada tikus Wistar jantan yang terintoksikasi metanol akut terhadap gambaran histopatologi spermatogenesis.Metode: Penelitian ini memakai desain true experimental post test only control group. Tikus Wistar jantan usia 2-3 bulan (n=15) secara random dibagi menjadi 3 kelompok yaitu kelompok kontrol negatif (n=5), kelompok kontrol positif (n=5), dan kelompok perlakuan (n=5). Selama 14 hari, dilakukan pemberian metanol per oral untuk kelompok kontrol positif dan perlakuan, diikuti injeksi ranitidine per intraperitoneal 1 jam setelah pemberian metanol untuk kelompok perlakuan. Kemudian dilakukan terminasi tikus dan testisnya diambil untuk dibuat preparat dengan pengecatan HE. Selanjutnya, pemeriksaan spermatogenesis dilakukan dengan menggunakan skor Johnsen.Hasil: Kelompok kontrol positif secara signifikan (p<0.05) menunjukkan spermatogenesis yang lebih buruk dibandingkan dengan kelompok kontrol negatif. Pemberian ranitidine pada tikus yang terintoksikasi metanol akut secara signifikan (p<0.05) menunjukkan spermatogenesis yang lebih baik dibandingkan dengan kelompok kontrol positif. Tidak terdapat perbedaan spermatogenesis antara kelompok yang diberikan ranitidine dengan kelompok kontrol negatif.Kesimpulan: pemberian ranitidine pada tikus yang terintoksikasi metanol akut dapat mengurangi gangguan spermatogenesis secara histopatologis

Ekspresi Reseptor Estrogen, Reseptor Progesteron Dan Digit Ratio Pada Pasien Meningioma Teguh Iman Prakoso; Mohammad Thohar Arifin; Udadi Sadhana; Dik Puspasari; Meira Dewi Kusuma Astuti
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimbangan hormon estrogen dan progesteron. Digit Ratio (2D : 4D) sangat dipengaruhi oleh paparan hormon androgen prenatal khususnya estrogen dan testosteron. Tujuan Mengetahui hubungan reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio (2D : 4D) pada pasien meningioma. Metode Penelitian observasional analitik dengan desain cross sectional study. Jumlah sampel sebesar 25 pasien meningioma yang dilakukan pemeriksaan ER dan PR. Pengukuran Digit Ratio dilakukan di poliklinik dan bangsal bedah syaraf RSUP Dr. Kariadi Semarang. Uji statistik menggunakan uji spearman. Hasil Digit Ratio kanan, kiri dan selisih kanan-kiri dengan nilai rerata 1,0046; 1,0021 dan 0,0492. Uji spearman, hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan PR didapatkan masin–masing nilai p = 0,5 (r = 0,1), p = 0,8 ( r = 0,1), dan p = 0,3 (r = 0,2). Hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan ER didapatkan masing–masing nilai p = 0,4 (r = 0,2), p = 0,5 ( r = -0,1), dan p = 0,9 (r = 0,1). Secara statistik terdapat hubungan yang sangat lemah antara Digit Ratio kanan, Digit Ratio kiri, selisih Digit Ratio kanan kiri dengan ER dan PR pada pasien meningioma Simpulan Terdapat hubungan yang sangat lemah antara reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio pada pasien meningioma. Kata kunci : Reseptor Estrogen, Reseptor Progesteron, Digit Ratio, Meningioma. Background Meningiomas are primary intracranial benign tumors that are affected by the balance of estrogen and progesterone. Digit Ratio (2D: 4D) is strongly influenced by exposure to prenatal androgen hormones especially estrogen and testosterone. Objective To determine the relationship between estrogen receptor (ER) and progesterone receptor (PR) with Digit Ratio (2D: 4D) in meningioma patients. Method Analytical observational research with cross-sectional study design. The total sample of 25 meningioma patients who underwent ER and PR examinations. Digit Ratio measurements were performed at the clinic and neurosurgical ward of RSUP Dr. Kariadi Semarang. The Spearman test was used for the statistical test. Results Right, left and right-left difference digit ratio with mean value of 1.0046; 1,0021 and 0,0492. After Spearman test, the relationship between right Digit Ratio, left Digit Ratio and Difference between right and left Digit Ratio with PR was p = 0.5 (r = 0.1), p = 0.8 (r = 0.1), and p = 0.3 (r = 0.2). Correlation between right Digit Ratio, left Digit Ratio and Difference between left and right Digit Ratio with ER was p = 0.4 (r = 0.2), p = 0.5 (r = -0.1), and p = 0.9 (r = 0.1). Statistically there is a very weak relationship between right Digit Ratio, left Digit Ratio, difference between right and left Digit Ratio with ER and PR in patients with meningiomas. Conclusions There is a very weak relationship between estrogen receptors (ER) and progesterone receptors (PR) and Digit Ratio in meningioma patient. Keywords: Estrogen Receptor, Progesterone Receptor, Digit Ratio, Meningioma.

Factors Associated With Post-Stroke Self Efficacy Fuji Istiana; Fitria Handayani; Muhamad Thohar Arifin
Media Keperawatan Indonesia Vol 4, No 3 (2021)
Publisher : Universitas Muhammadiyah Semarang

One of the psychological problems experienced by stroke patients is self-efficacy. Stroke patients on average lack confidence in themselves to do exercises or activities that will have an impact on the recovery process of stroke patients. Several factors that vary related to low self-efficacy in stroke patients are one of the causes. The scoping review aims to identify factors related to self-efficacy in a post-stroke patient. The methods use a systematic review through review articles relevant to the topic from CINAHL database, MEDLINE, Academic search ultimate, science direct, and Taylor & Francis with a publication year spanning 2015 to 2020 and with the keyword “self-efficacy” and “stroke” then analyzed using a synthesis matrix. The inclusion criteria in this study were articles in English with longitudinal study design or cross-sectional study and self-efficacy as the dependent variable. The results of a review of four journals that met the inclusion criteria found factors related to self-efficacy in a post-stroke patient including depression, age, vascular history, fear, physical activity, Body Mass Index (BMI) and emotional function. The study concludes that depression, age, vascular history, fear, physical activity, Body Mass Index (BMI) and emotional function are factors related to self-efficacy in post-stroke patients. The factor most strongly associated with post-stroke patients self-efficacy is depression.

Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study Evan Sebastian Gunawan; Muhamad Thohar Arifin; Yuriz Bakhtiar; Yan Wisnu Pradjoko; Muhammad Nur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.588

Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis. Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests. Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue. Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.

Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study Evan Sebastian Gunawan; Muhamad Thohar Arifin; Yuriz Bakhtiar; Yan Wisnu Pradjoko; Muhammad Nur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.588

Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis. Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests. Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue. Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.

The Difference of Intelligence Quotient (IQ) Score Before and After Temporal Lobe Epilepsy (TLE) Surgery: A Quasi-Experimental Study in Indonesia Muhamad Thohar Arifin
Journal of Global Pharma Technology Volume 11 Issue 11 (2019) November 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Epilepsy is a serious disorder of the brain, affects almost fifty million people in the world. About 40% of the patients finally became refractory to epileptic drugs, especially those with temporal lobe epilepsy (TLE). Surgical therapy has an important role in stopping further damage to brain cells caused by repeated seizures. The elimination of the seizure after surgery will hopefully result in better intelligence score. This study aims to find out the effect of surgical therapy in TLE patients on the Intelligence Quotient (IQ) score. Method: A quasi-experimental study with pre-test and post-test group design was conducted among 15 respondents. The respondents were taken with consecutive sampling method that underwent anterior temporal lobectomy and have passed at least one-year postoperative period, and also had done an intelligence quotient (IQ) test before surgery. IQ before and after surgery were measured with WAIS and WISC-R method. The statistical tests used were paired t-test by SPSS version 20 for Windows. Result: Most of the respondents were males (66.7%), average age 24.3±7.17 years-old, and 7.7±4.70 year’s duration of seizures. The verbal IQ score after surgery was 98.8±9.88 significantly higher (p=0.01) compared with preoperative verbal IQ (92.7±9.60) score. On the other hand, the performance IQ score after surgery was higher (98.2±8.64) compared with preoperative performance IQ (96.0±9.39), however not statistically significant (p=0.5). A total IQ score after surgery tends to be higher (97.8 ±7.69) compared with preoperative total IQ (93.9±9.28) but not statistically significant (p=0.08). Conclusion: Our study suggests that postoperative verbal IQ improvement was found to be significantly different compared to the preoperative verbal IQ. However, there was no significant difference in the performance and total IQ score after TLE surgeryKeywords: IQ, Epilepsy, Temporal lobe epilepsy, Surgery.

Hubungan Rotasi Kerja dan Kepuasan Kerja Dengan Komitmen Terhadap Organisasi Giri Susilo Adi; Muhammad Thohar Arifin; Agus Santoso
Jurnal Keperawatan Notokusumo Vol. 3 No. 1 (2015): Jurnal Keperawatan Notokusumo
Publisher : LPPM STIKES NOTOKUSUMO YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (736.278 KB)

Backgroud: Organizational commitment is the core of human resourses management analisys. Hospital policy regarding the human resources management has become more important and it was implemented in increasing nurses commitment to the hospital through the job satisfaction and job rotation. Method: this quantitative reseach employed 137 associate nurses as respondent from 34 units at psychiatric hospital. A modified questionnaire was operated by the researcher with proper validity and reliability test and verified by the experts. The data were analyzed by Chi square test and logistic regression. Result: bivariate analysis found that job rotation and job satisfaction associated with the comitment to organization with p value 0.014 and 0.013 respectively. While multivariate analysis resulted the job rotation with p=0.028 and job satisfaction p=0.029 Conclusion: both job rotation and job satisfaction were significantly associated with the commitment to organization. Job satisfaction was the strongest variable which was correlated to the commitment to the organization.

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