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All Journal Jurnal Kesehatan Masyarakat Indonesia Indonesian Journal of Urology Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Health Notions Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology
Mia Ratwita Andarsini
Departemen Ilmu Kesehatan Anak, Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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HEPATITIS VIRUS INFECTION IN REPEATEDLY TRANSFUSED THALASSEMIA PATIENTS Andarsini, Mia Ratwita
Indonesian Journal of Tropical and Infectious Disease Vol 2, No 1 (2011)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.225 KB)

Abstract

Patients of thalassemia who are conventionally treated by a regular transfusion regimen, are at a risk of developing transfusion transmitted infections, including hepatitis. The present study was conducted to evaluate the prevalence of hepatitis virus infection in repeated transfused thalassemia patients. A total of 83 patients of thalassemia who had received at least 10 transfusions were tested for HBs Ag, anti HBs and anti-HCV using ELISA. Amongst these patients, HBs Ag, anti HBs and anti HBC were detected in 1.2%, 26.5% and 12% patients respectively. the prevalence of HBV and HCV infection were in agreement with the findings in other study.
RISK FACTORS OF MORTALITY IN CHILDREN WITH WILMS’ TUMOR AT SOETOMO HOSPITAL SURABAYA Shanty, Maria Christina; Yuniarchan, Sherly; Andarsini, Mia Ratwita; Ugrasena, I Dewa Gede; Permono, Bambang; Prasetyo, Risky Vitria
Indonesian Journal of Urology Vol 26 No 2 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i2.469

Abstract

Objective: Wilms’ tumor is the most common childhood renal tumor for about 6% of pediatric malignant disease. The 5-year survival rate in United States increased from approximately from 70% (1970-1973) to 92% (1989-1996). This study was aim to analyze the risk factors of mortality in children with Wilms’ tumor. Material & Methods: A cross-sectional study was conducted in children with Wilms’ tumor at Soetomo Hospital during 2006-2011. The data of demographic, clinical profile, complete blood count, blood urea nitrogen, glomerular filtration rate, histological type, disease stage, metastases and relapse were analyzed as risk factors of mortality using logistic regression. Results: There were 37 Wilms’ tumor children and 5 children were excluded because of incomplete data. The mean age was 3.0 (SD 2.6) years, and male-to-female ratio was 2.5 : 1. There were 5/32 children in stage I, 7/32 children in stage II, 8/32 children in stage III, 11/32 children in stage IV, and 1/32 children in stage V. There were 15/32 children underwent operation. Complete remission occurred in 12/32 children and 1/32 children relapsed. There were 20/32 children died, associated with anemia (P=0.033, OR=6.111, 95% CI=1.056-35.352) and advanced stage (P=0.021, OR=8.000, 95% CI=1.575-40.632). The risk of mortality increased 3.284 folds with every increased stage (P=0.007, 95% CI=1.338-7.775). Conclusion: Disease stage is the significant risk factor of mortality in children with Wilms’ tumor.  
Diagnostic Value of Mid Regional Proadrenomedullin as a Sepsis Biomarker in Pediatric Patients with Cancer-Related Chemotherapy Joko Susanto; Muhammad Robiul Fuadi; Mia Ratwita Andarsini
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17569

Abstract

The aim of this study was to analyze the diagnostic value of mid regional proadrenomedullin as a sepsisbiomarker in pediatric patients with cancer-related chemotherapy. This cross-sectional observationalstudy was located in General Hospital Dr. Soetomo Surabaya from September until December 2020.International Pediatric Sepsis Consensus Conference criteria was used to define sepsis term on 2 studygroups. Serum mid regional proadrenomedullin has been drawn from 60 subjects (41 in-ward pediatricpatients) and measured on sandwich enzyme-linked immunosorbent assay from Elabscience® HumanMid Regional Proadrenomedullin. Humareader Single Plus® was used to measure the optical density.ROC analysis was used to find out cut off value, sensitivity, specificity, positive predictive value, negativepredictive value, negative likelihood ratio, positive likelihood ratio, and accuracy, respectively. Statisticsdeclared significant if p<0.05 (95% CI). Between groups, temperature and heart rate were statisticallydifferent (p<0.001; 95% CI). The median difference of mid regional proadrenomedullin between groupswas significant (p<0.05; 95% CI). Cut off value 2,88 nmol/L, sensitivity 60.0%, specificity 56.67%,positive predictive value 58.06%, negative predictive value 58.62%, positive likelihood ratio 1.38,negative likelihood ratio 0.71 and diagnostic accuracy 59.33% was obtained while area under curvewas 0.707, respectively. Sepsis in children with cancer –related chemotherapy has not well diagnosedby serum mid regional proadrenomedullin.
Association between Cortisol and Infection Risk of Children with Acute Lymphoblastic Receiving Induction and Consolidation Chemotherapy in Dr. Soetomo General Hospital Surabaya Tutwuri Handayani; Dewa Gede Ugrasena; Mia Ratwita Andarsini
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17657

Abstract

Background: Mortality due to Infection associated therapy in acute lymphoblastic leukemia (ALL) children remains high, although therapeutic success and survival rate are substantially improving.Methods: This study used a pre and post-test group design for children aged less than 18 years with ALL newly diagnosed and receiving chemotherapy in pediatric patient of Dr. Soetomo hospital Surabaya.Results: The study involved 25 subjects, 10 subjects were male, average age ranged from 3 to 9 years. The high risk-ALL subjects were 15 (60%), hyperleukocytosis 4 (16%) subjects and 7 (28%) subjects with leukopenia. Statistical analysis showed a significant difference in decreasing cortisol levels in week-4 compared to week-0 (p <0.001) and an increased in cortisol levels between week-12 compared to week-10. The incidence of infection during induction phase is higher than the consolidation phase (40vs15). The relationship between the mean cortisol levels and the incidence of infection in general showed a significant difference in the induction phase of week-0 (p=0.029), week-4 (p=0.041), and week-6 (p=0.005).Conclusion: In the induction phase, there is an association between mean cortisol levels and the risk of infection, but there is no such association in the consolidation phase.
The Relationship Between Clinical Manifestation and Histopatological Result in Non- Hodgkin Lymphoma: RSUD Dr. Soetomo Surabaya Glazydia Juwita Rachma; Ugroseno Yudho Bintoro; Mia Ratwita Andarsini; Novira Widajanti
Health Notions Vol 5, No 4 (2021): April
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn50405

Abstract

Non-Hodgkin's lymphoma is a major public health problem with over 14.1 million people are diagnosed with it (2012). In the same year there were 8.2 million deaths due to cancer. The purpose of this study was to determine the relationship between clinical manifestations and the degree of malignancy based on histopathological features in patients with Non-Hodgkin's Lymphoma. This study used a retrospective analytical method with a cross-sectional approach using the patient's medical record at RSUD Dr. Soetomo, Surabaya who was diagnosed with Non-Hodgkin Lymphoma from 1st January 2015 to 31st December 2017. In this study, there were 139 samples include those criteria, with a greater number of male samples (62.6%) compared to women (37.4%). This study showed that 49.3% of patients with non- Hodgkin's lymphoma in RSUD Dr. Soetomo with clinical manifestations without symptoms actually experience malignancy with a high degree, this showed that clinical manifestations without symptoms are not always associated with a low level of malignancy. Then, based on the Chi Square test results obtained p-value of 0.289 (>0.05), so there was no significant relationship between clinical manifestations and the degree of malignancy. Keywords: lymphoma; manifestation; histopatological
Empowering Thalassemia Patients and Family to Increase Public Knowledge on Thalassemia Peter Asa; Danti Nur Indiastuti; Mia Ratwita Andarsini; Jihan Nur Fauziah; Annette d&#039;Arqom
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 4 (2021): December
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.15 KB) | DOI: 10.22146/jpkm.69349

Abstract

Thalassemia, the fifth-most catastrophic disease with 10,555 patients, causes physical, emotional, and economic burden for the patient, their family, and the country. Annually, IDR 500 billion are needed to cover the treatment of thalassemia. This projected number will continue to increase if no action is taken, so education and knowledge dissemination are important for thalassemia prevention. This community development involves thalassemia patients and families as partners and encourages them to share their knowledge and experience about thalassemia with the Indonesian late adolescents, young adult, and middle-aged adult population through an online webinar to increase public knowledge on thalassemia. Education media, such as posters and videos, were developed and disseminated during the activity, followed by live sharing from thalassemia patients, parents, and pediatricians. The respondents’ knowledge of thalassemia was measured using an 11-items questionnaire before and after the online educational activity. The results show that the respondents have a good knowledge of thalassemia, and it increases after attending online education event about the disease (9.74+2.4, 10.22+0.77, p<0.001). Their knowledge was associated with health-related field experience, knowing someone with thalassemia, and their willingness to undergo thalassemia testing (p<0.046, 0.013, and 0.007, respectively). Thus, these findings support the importance of education and dissemination of information regarding Thalassemia. Moreover, strong knowledge might lead to a willingness to undergo thalassemia testing, which might lead to less marriage between carriers and, eventually, a reduction in the incidence of thalassemia major.
ANALYSIS OF DL--TOCOPHEROL AS ANTIOXIDANT ON MALONDIALDEHYDE LEVEL IN PEDIATRIC PATIENTS WITH -THALASSEMIA MAJOR Levana Rismayanti; Yulistiani Yulistiani; Mia Ratwita Andarsini; Mariyatul Qibtiyah
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.274 KB) | DOI: 10.20473/fmi.v53i1.5490

Abstract

Thalassemia is a hereditary form of anemia that affects the synthesis of hemoglobin. The management of therapy in patients with b-thalassemia major which patients should receive continuous blood transfusions and increased iron absorption from the digestive tract causes excess iron in the body. This will lead to an increase of free iron level that triggers Radical Oxygen Species (ROS). Increased level of ROS can initiate lipid peroxidation which used as an indicator of oxidative stress in cells and tissues and produce reactive carbonyl, mainly malondialdehyde (MDA). Thus, MDA measurement is widely used as an indicator of lipid peroxidation. On the other hand, the risk of oxidative damage can be reduced by antioxidant, one of them is Vitamin E that is a fat-soluble vitamin with high potential antioxidant. The objective of this study was to analyze the effect of the dl-a-tocopherol (Vitamin E) administration on decrease of MDA serum level on pediatric patients with b-thalassemia major. This was a longitudinal observational study design for one group without comparison was conducted to examine the use of vitamin E to decreased MDA serum level on children patients with b-thalassemia major. The inclusion criteria were patients who rely on blood transfusions, patients who received only one type of iron chelating agents during the study period, the clinical condition is stable, agrees, and has completed the informed consent. In the course of the study of 21 patients there were variations in patient compliance in taking vitamin E tablet dosage 200 IU once-daily for one month: only 11 out of 21 patients consumed 30 tablets of vitamin E 200 IU (total dose of 6000 IU) in the 1-month study, and only data from those 11 samples will be analysed further. MDA serum level was measured pre- and post-administration of vitamin E and patient’s characteristics of subjects was obtained for additional information. Pre-administration of vitamin E, serum level of MDA was 1239.4 ± 502.55 ng/mL with a range of 216.95 to 2297.3 ng/mL, whereas in the group post administration of vitamin E, MDA serum level was 786.49 ± 704.88 ng/mL with a range of 6.5380 to 1958.6 ng/mL. In conclusion, there was no significant difference in MDA serum level in the group pre- and post- administration of vitamin E (p = 0.15).
HEPATITIS VIRUS INFECTION IN REPEATEDLY TRANSFUSED THALASSEMIA PATIENTS Mia Ratwita Andarsini
Indonesian Journal of Tropical and Infectious Disease Vol. 2 No. 1 (2011)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.225 KB) | DOI: 10.20473/ijtid.v2i1.190

Abstract

Patients of thalassemia who are conventionally treated by a regular transfusion regimen, are at a risk of developing transfusion transmitted infections, including hepatitis. The present study was conducted to evaluate the prevalence of hepatitis virus infection in repeated transfused thalassemia patients. A total of 83 patients of thalassemia who had received at least 10 transfusions were tested for HBs Ag, anti HBs and anti-HCV using ELISA. Amongst these patients, HBs Ag, anti HBs and anti HBC were detected in 1.2%, 26.5% and 12% patients respectively. the prevalence of HBV and HCV infection were in agreement with the findings in other study.
Antibiotic Resistance Control Program in Pediatric Hematology and Oncology Patients at Dr. Soetomo Hospital in 2006–2007 Mia Ratwita Andarsini; I Dewa Gede Ugrasena; Bambang Permono
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.357 KB) | DOI: 10.20473/ijtid.v1i2.2173

Abstract

Antibiotic resistance has been increasing since the first years of the clinical usage. It caused by inappropriate usage and uncontrol of antibiotic drugs. Therfore an Antibiotic Resistance Control Program (ARCP) is needed to overcome the problem. The purpose of this study is to know microorganism pattern and evaluate antibiotic use. Phase 1 (before ARCP), retrospective study by medical record of pediatric hematology-oncology patients with suspision of infection and admitted at dr Soetomo Hospital from June–August 2006 was carried out. Phase 2 (during ARCP), a prospective observational study was done from November 2006 to January 2007. We were evaluated the isolated microorganism, quantity of antibiotic were determined by Defined Daily Doses (DDD)/100 patients-days, quality of antibiotics usage were assessed with Glyssen classification, and the cost calculation of antibiotic therapy. Twenty seven patients were enrolled in phase 1 and 28 patients in phase 2. Coagulase-negative Staphylococci and Acinetobacter Sp as isolated microorganism was reported. Phase 1, the most sensitive antibiotic was Cefoperazone-Sulbactam and the most resistant was Penicillin G. Phase 2, Meropenem was the most sensitive antibiotic and Cotrimoxazole was the most resistant antibiotic. The use of antibiotics were decreased 6 vs 12 and DDD/100 patients-days were 14.52 vs 45.04. There were improving of Glyssen classification. The cost calculation of antibiotics therapy were decreased. ARCP can improve antibiotic use in pediatric hematology-oncology patients.
Hyperglicemia in Childhood Acute Lymphoblastic Leukemia During Induction Chemotherapy Nengcy Erlina Tasik Rerung1, Andi Cahyadi2 , Nur Rochmah3 , Maria Christina Shanty Larasati4, Mia Ra
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13605

Abstract

Background: Hyperglycemia is a recognized side effect of the corticosteroids and asparaginase givenduring induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). The ALL is the malignanttumor with the highest incidence in the childhood. The aim of this study is to investigate the impact ofhyperglycemia during induction chemoteraphy in childhood ALL.Methods: This prospective study was done in Dr. Soetomo hospital from January to April 2018. The subjectwas newly diagnosed as ALL under the age of 18 years, treated with Indonesian childhood ALL 2013protocol (Standard Risk (SR) group and High Risk (HR) group). Hyperglycemia was defined as at leasttwo separate random plasma glucose levels > 200 mg/dL, which was evaluated before and during inductionchemotherapy. Statistical analysis using Paired T-test for parametric and Wilcoxon Test for nonparametric.Results: Thirty-three children were enrolled, 18/33 boys with mean age 5.8 (SD 3.78) years, compromisedas ALL-L1 30/33. They were treated with ALL-HR 19/33 and ALL-SR 14/33. In overall groups, the meanrandom blood glucose level significantly increased from 108 (SD 21.3) mg/dL to 147 (SD 48.1) mg/dL,(mean difference 38.67 mg/dL; 95% CI 18.08 to 59.26 mg/dL, P=0.008). In SR group, there was a significantincreased of mean random blood glucose level from 102 (SD 13.5) mg/dL to 133 (SD 37.3) mg/dL, (meandifference 31.8 mg/dL; 95% CI 8.78 to 54.8 mg/dL; P=0.01). In HR group, the mean random blood glucoselevel increased from 113 (SD 51.9) mg/dL to 165 (SD 25.4) mg/dL, (mean difference 51.9 mg/dL; 95% CI18.6 to 85.2 mg/dL, P=0.004).Conclusion: Blood glucose level is significantly increase during induction chemotherapy in both SR and HR Indonesian childhood ALL 2013 protocol.
Co-Authors Andi Cahyadi Andy Cahyadi Angela Dinaria Kemala Swary Annette d’Arqom, Annette Arifoel Hajat Bambang Permono Danti Nur Indiastuti Danti Nur Indiastuti Dewa Gede Ugrasena Endang Retnowati Glazydia Juwita Rachma I Dewa Gede Ugrasena Jihan Nur Fauziah Joko Susanto Levana Rismayanti Mangihut Rumiris Maria Christina Shanty Larasati Maria Christina Shanty Larasati Mariyatul Qibtiyah Martono Tri Utomo Muhammad Robiul Fuadi Novira Widajanti, Novira Peter Asa Primadita Syahbani Priscilla Putri Harmany Rahmi Rusanti Risky Vitria Prasetyo Shanty, Maria Christina Sherly Yuniarchan, Sherly Siprianus Ugroseno Yudho Bintoro Tutwuri Handayani Ugroseno Yudho Bintoro Yetti Hernaningsih Yulistiani Yulistiani