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All Journal Jurnal Kesehatan Masyarakat Indonesia Indonesian Journal of Urology Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Health Notions Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology
Mia Ratwita Andarsini
Departemen Ilmu Kesehatan Anak, Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Characteristic of Hemophilia A Patients in Initial Diagnosis in Dr. Soetomo General Hospital Surabaya Angela Dinaria Kemala Swary; Mia Ratwita Andarsini; Arifoel Hajat
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.927 KB) | DOI: 10.20473/bhsj.v2i1.12888

Abstract

Introduction: This research is conducted to describe the characteristic of Hemophilia A patients.Methods: Cross-sectional study conducted in 55 patients with Hemophilia A. The variables were age, bleeding episode, factor VIII level, and bleeding site. The data presented descriptively.Results: The largest group was 2-10 years old (52,73%). The most common bleeding episode occured in the patients was moderate level (60,0%). The most common patient’s factor VIII level was moderate level (52,7%). The patient’s bleeding most likely took place in muscle or known as hematoma (41,8%). While the less likely bleeding were intracranial and nose bleeding.Conclusion: 2-10 years old patient are the largest group because of hemophilia A mostly diagnosed in childhood, where children are actively moved so that the spontaneous bleeding or abnormal bleeding can be seen easily. Parents needs to be aware if there were abnormal or spontaneous bleeding which takes place in muscle or known as hematoma with moderate episode of bleeding which meant that the occurrence of spontaneous bleeding is periodically happened or in prolonged bleeding accompanied by minor trauma or invasive action.
ACQUIRED β−THALASSEMIA IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) Maria Christina Shanty Larasati; Mangihut Rumiris; Mia Ratwita Andarsini; I Dewa Gede Ugrasena; Bambang Permono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.444

Abstract

Thalassemias are heterogeneous group of genetic disorders. β-thalassemia is existed due to impaired production of beta globins chains, which leads to a relative excess of alpha globin chains. The abnormalities of haemoglobin synthesis are usually inherited but may also arise as a secondary manifestation of another disease, most commonly haematological neoplasia. This article presenting two cases of acquired β-thalassemia in children with ALL focusing on the diagnosis and the possible relationship between the two haematological diseases. The first case is a four (4) year old boy with ALL-L1 type at maintenance phase of chemotherapy, he suffered from anaemia with Hb 8.0 g/dL, WBC 22,600/mm3 and platelets count of 200,000/mm3, peripheral blood smear revealed anisocytosis, polychromes, hypochromia, basophilic stippling, and normoblastocytes. The result of Hb electrophoresis of Hb A of 54.9%, Hb F of 29.4%, Hb E of 13.4% and Hb A2 of 2.3%. The patient was diagnosed as ALL-L1 type and β-thalassemia. The second case, is a 13 year old girl with remission ALL-L1 type after chemotherapy, she suffered from anaemia with Hb 6.7 g/dL, WBC 12,400/mm3, platelet count was 200,000/mm3, and peripheral blood smear obtained anisocytosis, hypochromia, normoblastocytes, myelocytes and basophilic stippling. The result of Hb electrophoresis are: Hb F 0.41%, Hb A1c 0.78%, Hb A2 2.95% with the conclusion of a β-thalassemia trait, this patient was diagnosed with ALL-L1 type remission + β-thalassemia trait. The case reviewers assume that acquired β-thalassemia which happened in those patients were the altered expression of globin chain which mechanism for this syndrome might be the acquisition of a mutation that affects RNA or proteins involved in β-globin gene regulation and resulting the reduction of the (α/β)-globin biosynthetic ratios, or/and associated with chemotherapy-inducement.
CORRELATION OF BLAST PERCENTAGE TO CD34 OF BONE MARROW IN ALL PEDIATRIC PATIENTS Rahmi Rusanti; Yetti Hernaningsih; Endang Retnowati; Mia Ratwita Andarsini; Andy Cahyadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1156

Abstract

Leukemia Limfoblastik Akut (LLA) adalah penyakit keganasan sel progenitor limfoid yang berasal dari sumsum tulang. Tanda khasdari diagnosis leukemia akut adalah sel blas. Pemeriksaan mikroskopis dilakukan untuk menentukan persentase sel blas pada diagnosisleukemia akut. Immunophenotyping merupakan metode diagnostik yang dapat membantu menegakkan diagnosis pada keganasanhematologi. CD34 merupakan antigen yang sering digunakan untuk identifikasi sel induk hemopoeisis atau blas. Penelitian ini bertujuanuntuk mengetahui kenasaban antara persentase blas dengan ekspresi CD34 di sumsum tulang di pasien leukemia limfoblastik akut anaksebelum dan sesudah pengobatan kemoterapi fase induksi.
Analisis Faktor yang Mempengaruhi Kejadian Leukemia Limfoblastik Akut (LLA) pada Anak di RSUD Dr. Soetomo Primadita Syahbani; Mia Ratwita Andarsini; Martono Tri Utomo; Siprianus Ugroseno Yudho Bintoro
Jurnal Kesehatan Masyarakat Indonesia Volume 17. No. 2. Tahun 2022
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jkmi.17.2.2022.38-47

Abstract

Background: Childhood acute lymphoblastic leukemia (ALL) cases were in the first place in several Indonesia’s hospitals. The survival rate in Indonesia was low compared to other countries. Objective: To analyze the influencing factors of ALL among parental age, BW, cigarettes, hydrocarbons, and insecticides. Method: A matched case-control study involved children with malignancies at Dr. Soetomo General Hospital Surabaya on April 2019-June 2021. The cases were children with ALL and children with malignancies other than ALL as the control. The study included 55 people in each case and control group. Data were obtained from medical records and questionnaires. Result: Influencing factors of childhood ALL are paternal age <25 years old (OR=3; 95% CI=0,96–9,3), two types of hydrocarbon products (OR=0,23, 95% CI=0,065–0,8) and none (OR=3,33, 95% CI=1,33–8,30) maternal exposure of hydrocarbons, preconception exposure (OR=0,3; 95% CI=0,12–0,74), and none (OR=3,5; 95% CI=1,41–8,67) maternal period exposure to hydrocarbons. BW, cigarette exposure, and insecticides exposure are not the influencing factors. Using the multivariate analysis, no factors was found to be the most influential. Conclusion: Influencing factors of childhood ALL were paternal age <25 years, two types and none maternal exposure to hydrocarbons, preconception and none maternal period of hydrocarbon exposures
Co-Authors Andi Cahyadi Andy Cahyadi Angela Dinaria Kemala Swary Annette d’Arqom, Annette Arifoel Hajat Bambang Permono Danti Nur Indiastuti Danti Nur Indiastuti Dewa Gede Ugrasena Endang Retnowati Glazydia Juwita Rachma I Dewa Gede Ugrasena Jihan Nur Fauziah Joko Susanto Levana Rismayanti Mangihut Rumiris Maria Christina Shanty Larasati Maria Christina Shanty Larasati Mariyatul Qibtiyah Martono Tri Utomo Muhammad Robiul Fuadi Novira Widajanti, Novira Peter Asa Primadita Syahbani Priscilla Putri Harmany Rahmi Rusanti Risky Vitria Prasetyo Shanty, Maria Christina Sherly Yuniarchan, Sherly Siprianus Ugroseno Yudho Bintoro Tutwuri Handayani Ugroseno Yudho Bintoro Yetti Hernaningsih Yulistiani Yulistiani