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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) JURNAL GIZI INDONESIA Prosiding Seminar Nasional MIPA Natural B Majalah Obat Tradisional Jurnal Media Sains Acta Chimica Asiana Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Jurnal aplikasi IPTEK

I Made Wisnu Adhi Putra

University Of Dhyana Pura

Author-ID : 524363

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Uji Aktivitas Antioksidan Ekstrak Daun Akasia (Acacia Auriculiformis) Yunita Sari, Ni Kadek; Adhi Putra, I Made Wisnu
Jurnal Media Sains Vol 2, No 1 (2018): JURNAL MEDIA SAINS
Publisher : LPPM Universitas Dhyana Pura

ABSTRAKRadikal bebas merupakan suatu senyawa asing yang masuk ke dalam tubuh dan merusak sistem imunitas tubuh. Jika jumlahnya berlebih, radikal bebas akan memicu efek patologis seperti arterosklerosis, kanker, diabetes dan penyakit degeneratif lainnya. Untuk meredam aktivitas radikal bebas diperlukan antioksidan. Antioksidan merupakan senyawa yang mampu menetralisir atau menstabilkan radikal bebas dengan cara melengkapi kekurangan elektron pada radikal bebas tersebut. Tanaman yang termasuk ke dalam suku fabaceae merupakan tumbuhan yang sebagian besar spesiesnya mengandung senyawa antioksidan. Aktivitas antioksidan pada tanaman Acacia auriculiformis selama ini belum pernah dilaporkan. Penelitian terhadap tanaman Acacia auriculiformis perlu dilakukan, mengingat pemanfaatannya masih sebatas memenuhi kebutuhan serat terutama untuk bahan baku industri pulp dan kertas serta sebagai tanaman pelindung. Tujuan penelitian ini untuk mengetahui aktivitas antioksidan dan untuk mengetahui nilai IC50 (inhibitory concentration) dan nilai AAI (Antioxidant Activity Index) dari ekstrak daun muda dan tua Acacia auriculiformis. Sampel kering daun diekstraksi secara maserasi menggunakan pelarut etanol. Ekstrak tersebut selanjutnya diuji aktivitas antiradikal bebas berdasarkan kemampuan pengikatan radikal bebas DPPH (2,2-difenil-1-pikrilhidrazil). Hasil penelitian menunjukkan ekstrak daun muda dan tua Acacia auriculiformis memiliki aktivitas sebagai antioksidan, nilai IC50 dan AAI ekstrak daun muda dan daun tua Acacia auriculiformis berturut-turut adalah 464,2361 ppm (AAI=0,0861), 433,6332 ppm (AAI=0,0922) sedangkan vitamin C sebagai pembanding memiliki nilai IC50 159,6216 ppm (AAI=0,2505).Kata kunci: Antioksidan, radikal bebas, akasia, IC50, AAIABSTRACTFree radicals are foreign compounds that enter the body and damage the body's immune system. If the amount is excessive, free radicals will trigger the effects of pathologists such as arterosklerosis, cancer, diabetes and other degenerative diseases. To reduce free radical activity required antioxidants. Antioxidants are compounds capable of neutralizing or stabilizing free radicals by supplementing electron deficiencies in these free radicals. The plant of fabaceae is a plant that most of the species contain antioxidant compounds. The antioxidant activity of Acacia auriculiformis plants has not been reported. Research on Acacia auriculiformis plant needs to be done, considering the utilization is still limited to meet the needs of fiber, especially for the raw materials of the pulp and paper industry and as a protective plant. The purpose of this research is to know the antioxidant activity and to know the value of IC50 (inhibitory concentration) and the value of AAI (Antioxidant Activity Index) from young and old leaf extract of Acacia auriculiformis. Dry samples of leaves are extracted by maceration using ethanol solvent. The extract was then tested for free antiradical activity based on DPPH free radical binding ability (2,2-diphenyl-1-picrylhydrazyl). The results showed that Acacia auriculiformis leaf extract had activity as antioxidant, IC50 and AAI value of young leaf extract and old leaves of Acacia auriculiformis were 464,2361 ppm (AAI = 0,0861), 433,6332 ppm (AAI = 0,0922) while vitamin C as comparison have value of IC50 159,6216 ppm (AAI = 0,2505).Keywords: Antioxidant, free radicals, Acacia, IC50, AAI

Pengaruh pH dan Konsentrasi Terhadap Enkapsulasi Metformin HCl pada Monmorillonit Teraktivasi Asam Sitrat Sitanggang, Katrin Walensky; Suarya, Putu; Simpen, I Nengah; Adhi Putra, I Made Wisnu
Jurnal Media Sains Vol 1, No 2 (2017): JURNAL MEDIA SAINS
Publisher : LPPM Universitas Dhyana Pura

ABSTRAKMonmorillonit telah banyak digunakan sebagai pembawa beberapa jenis obat. Dalam penelitian ini, metformin HCl dienkapsulasi pada monmorillonit alam pada pH yang berbedabeda(3 ? 10) dan konsentrasi larutan metformin HCl yang bervariasi (50 ? 500 mg/L). Sebelumenkapsulasi, monmorillonit alam diaktivasi terlebih dahulu menggunakan asam sitrat 1 N. Spektrofotometer FTIR, diffraktometer sinar-X, and N?Sorption Analyzer digunakan untukmengkarakterisasi material hasil aktivasi. Hasil penelitian menunjukkan jumlah metformin HClyang terenkapsulasi secara maksimum terjadi pada pH 7.? Uji pengaruh konsentrasi larutan awalmenunjukkan bahwa semakin tinggi konsentrasi larutan, semakin banyak metformin HCl yangterenkapsulasi pada monmorillonit teraktivasi. Jumlah maksimum metformin HCl yangterenkapsulasi teramati pada konsentrasi larutan 500 mg/L. Luas permukaan dan volume porimonmorillonit alam ditemukan menurun setelah aktivasi menggunakan asam sitrat. Analisis 2menggunakan FTIR menunjukkan pergeseran puncak-puncak serapan monmorillonit setelahaktivasi dengan asam sitrat. Pergeseran puncak difraksi tidak teramati pada pola difraksi sinar-Xyang mengindikasikan kristalinitas monmorillonit tetap terjaga meskipun setelah diaktivasidengan asam sitrat.Kata kunci: monmorillonit, metformin HCl, pH, konsentrasi awal, enkapsulasi, sistem penghantar obat?ABSTRACTMontmorillonite has been widely used as a carrier of several drugs.? In this research, metformin HCl was encapsulated on natural monmorillonite on various pH (3 ? 10) andconcentration of metformin HCl (50-500 mg/l). Natural montmorillonite was activated by citricacid 1 N prior to encapsulation process. FTIR Spectrophotometer, X-ray diffractometer, and NSorption Analyzer were used to characterize the materials. The results showed that the highestamount of metformin HCl encapsulated on natural monmorillonite was occurred at pH of 7. Theeffect of initial concentration showed that the higher the concentration of metformin HCl, the greater the amount of drugs encapsulated on activated monmorillonite. The maximum amount of drug encapsulated was occurred at initial concentration of 500 mg/L. The surface area andpore volume of natural monmorillonite were found to be decrease after activation using citricacid. Analysis using FTIR confirmed the dislocation of absorption peaks after activation withcitric acid. However, the dislocation of diffraction peaks are not observed in XRD pattern,indicated the there were no changes in the crystallinity of monmorillonit after activation. Key words: monmorillonite, metformin HCl, pH, initial concentration, encapsulation, drug delivery system.

Aktivitas Antioksidan dan Penghambatan Enzim α-amilase Ekstrak Air Kombinasi Daun Papasan (Coccinia grandis [L.]) dan Daun Sembung (Blumea balsamifera [L.] DC) Atikawati, Atikawati; Kusumawati, I Gusti Ayu Wita; Putra, I Made Wisnu Adhi; Yogeswara, Ida Bagus Agung
Jurnal Media Sains Vol 3, No 2 (2019): JURNAL MEDIA SAINS
Publisher : LPPM Universitas Dhyana Pura

ABSTRAKPenelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan penghambatan ?-amilase pada kombinasi ekstrak air daun papasan dan daun sembung. Ekstrak dibuat dengan cara menyeduh serbuk daun papasan dan daun sembung dengan berbagai rasio (1:3, 1:1, dan 3:1). Penyeduhan dilakukan menggunakan 100 ml air mendidih (100?C) selama 5 menit. Hasil penelitian menunjukkan bahwa aktivitas antioksidan dalam menangkal radikal bebas DPPH tertinggi terdapat pada sampel kombinasi 1:3 yang dinyatakan dengan IC50 sebesar 1,58?0,06 mg/ml danaktivitas penghambatan ?-amilase tertinggi juga terdapat pada sampel kombinasi rasio 1:3 dengan nilai IC50 sebesar 1,29?0,02 mg/ml. Secara umum, semua kombinasi berpotensi sebagai minuman fungsional antidiabetes.Kata kunci: Daun papasan, daun sembung, aktivitas antioksidan, aktivitas penghambatan ?-amilase, ekstrak air.ABSTRACTThis study aims to determine the antioxidant and inhibition of ?-amylase activities of the combination of Coccinia grandis [L.] and Blumea balsamifera [L.] DC water extracs. The extracts wass made by decoctingthe leaves powder in various ratios (1: 3, 1: 1, and 3: 1). Decoction process was done using 100 ml of infuced water (100?C) for 5 minutes. The results showed that thethe highest antioxidant activity in counteracting free radicals DPPH was found in combination of 1:3 expressed by IC50 of 1.58?0.06 mg/ml and the highest ?-amylase inhibitory activity was also found in combination of 1:3sample with IC50 values of 1.29?0.02 mg/ml. In general, all combinations have potential to be antidiabetic functional drinks.Keywords: Coccinia grandis [L.], Blumea balsamifera [L.] DC, antioxidant and inhibition of ?-amylase, water extract.

Pembuatan dan Karakterisasi Katalis CaO/Zeolit Alam Putra, I Made Wisnu Adhi
Jurnal Media Sains Vol 1, No 1 (2017): JURNAL MEDIA SAINS
Publisher : LPPM Universitas Dhyana Pura

ABSTRAKCaO telah banyak digunakan sebagai katalis heterogen dalam reaksi transesterifikasi. Dalam penelitian ini, katalis CaO/zeolit alam telah berhasil disintesis menggunakan metode impregnasi basah. Campuran zeolit alam dan CaO diaduk di dalam refluks selama 90 oC selama 3 jam. Variasi rasio massa CaO/zeolit alam yaitu 5%, 10%, dan 15% yang selanjutnya diberi label CaO/NZ5%, CaO/NZ10%, and CaO/NZ15%, secara berturut-turut. Analisis menggunakan FTIR menunjukkan bahwa gugus-gugus fungsi zeolit alam tidak mengalami perubahan ketika pengembanan CaO dilakukan. Hasil ini didukung oleh hasil pengukuran menggunakan XRD yang menunjukkan kemunculan puncak-puncak difraksi dari mineral-mineral zeolit alam. Luas permukaan katalis yang diukur manggunakan N2 sorption analyzer menunjukkan bahwa semakin banyak jumlah CaO yang diembankan pada zeolit alam, semakin kecil luas permukaan katalis dari 15,201 m2/g sampai 12,928 m2/g. hasil tersebut mengindikasikan bahwa CaO menyusutkan ukuran pori zeolit, sehingga luas permukaan zeolit menurun. Analisis menggunakan metode titrasi asam basa menunjukkan bahwa kebasaan katalis meningkat seiring dengan meningkatnya jumlah CaO yang diembankan pada zeolit alam.Kata kunci : Katalis, CaO, zeolit alam, impregnasi basah.ABSTRACTCaO has been well known as a great heterogenous catalyst in the transesterification reaction to produce biodiesel. In the present study, synthesis of CaO/natural zeolite catalyst has been succesfully conducted using wet impregnation method. Impregnation was done by stirring the mixture of natural zeolite and CaO in reflux apparatus at 90 oC for 3 hours. The amount of CaO impregnated into natural zeolite were 5%wt, 10%wt, and 15%wt. These catalysts were then labeled as CaO/NZ5%, CaO/NZ10%, and CaO/NZ15%, respectively. Analysis using FTIR showed no change in functional groups when CaO was impregnated into the pores of the zeolite. This result was supported by the result of the XRD pattern which shows the appearance of natural zeolite diffraction peaks. Surface area measurement using N2 sorption analyzer showed the greater the amount of CaO impregnated into zeolite, the smaller the surface area of the catalyst from 15.201 m2/g to 12.928 m2/g. This result indicates that the CaO shrinked the pore size of zeolite, thus, the surface area of natural zeolite decreased. Acid-base titration result showed that the basicity of catalyst increased as the amount of CaO impregnated into natural zeolite increased.Keywords: Catalyst, CaO, natural zeolite, wet impregnation

Analisis Kadar Total Flavonoid dan Fenolik dari ekstrak air kombinsi daun papasan (Coccinia grandis L) dan buah belimbing wuluh (Averrhoa blimbi L) Ate, Olyn Tien; Putra, I Made Wisnu Adhi; Kusumawati, I Gusti Ayu Wita; Nursini, Ni Wayan
Jurnal Media Sains Vol 3, No 2 (2019): JURNAL MEDIA SAINS
Publisher : LPPM Universitas Dhyana Pura

ABSTRAKPenelitian ini bertujuan untuk membuat ekstrak air dari kombinasi daun papasan dan buah belimbing wuluh. Selanjutnya total flavonoid dan total fenolik ekstrak diuji. Ekstrak dibuat dengan merebus kombinasi serbuk daun papasan dan buah belimbing wuluh pada berbagai rasio massa (1:0, 1:3, 1:1, 3:1, dan 0:1) dan jumlah sampel serbuk 1-5 g. Proses ekstraksi dilakukan dalam 100 ml air mendidih selama 5 menit. Hasil penelitian menunjukkan bahwa kandungan flavonoid total tertinggi dan kadar fenolik total 135,1?0,18 mg QE/g bahan kering dan 48,5?3,09 mg GAE/g bahan kering, ditemukan dalam sampel dengan rasio kombinasi 1:3 (1 g). Secara umum, semua kombinasi daun papasan dan buah belimbing wuluh memiliki jumlah flavonoid dan fenolik yang besar dan memiliki potensi besar sebagai minuman kesehatan antidiabetik.Kata kunci: Papasan, belimbing wuluh, total flavonoid, total fenolikABSTRACTCoccinia grandis L and Averrhoa blimbi L have been known to have a great activity to treat type 2 diabetes mellitus. This study was aimed to make water extracts from the combination of Coccinia grandis L and Averrhoa bilimbi L. The total flavonoid and total phenolic content of the extracts was then tested. The extracts were made by brewing the combination of powdered Coccinia grandis L leaves and Averrhoa bilimbi L fruits at various mass ratios (1:0, 1:3, 1:1, 3:1, and 0:1) and amount of powdered samples (1-5 g). The process was done in 100 ml of boiling water for 5 minutes. The results showed that the highest total flavonoid content and total phenolic content of 135.1?0.18 mg QE/g d.m. and 48.5?3.09 mg GAE/g d.m., respectively, were found in the sample with combination ratio of 1:3 (1 g). This results revealed that, generally, all combinations of Coccinia grandis L leaves and Averrhoa bilimbi L fruits have a great amount of flavonoid and phenolic and have a great potential as antidiabetic health beverages.Keywords: Coccinia Grandis L, Averrhoa Bilimbi L, total flavonoid, total phenolic

Co-Authors Adiari, Ni Wayan Lisa Ana Malia Ate, Olyn Tien Atikawati, Atikawati I Gede Mustika I Gede Widhiantara I Gusti Ayu Wita Kusumawati I Nengah Simpen I. A. R. Astiti Asih Ida Bagus Agung Yogeswara Indriana Kartini Indriana Kartini Ketut Ayu Sukesi Krismawintari, N.P.D. Made Agung Raharja NI KADEK YUNITA SARI Ni Luh Utari Sumadewi Ni Putu Eny Sulistyadewi Ni Wayan Nursini Putu Suarya Sitanggang, Katrin Walensky Yateman Arryanto Yateman Arryanto

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