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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Indonesian Journal of Cancer Chemoprevention JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Generics: Journal of Research in Pharmacy

Eva Annisaa

Program Studi Farmasi, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275

Author-ID : 5284840

Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Environmental Science Health Professions Medicine & Pharmacology Public Health Social Sciences

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LONGAN PEEL EXTRACT (DIMOCARPUS LONGAN L.) AS AN ANTIOXIDANT AGAINST OXIDATIVE STRESS IN WISTAR RATS INDUCED BY TOXIC DOSES OF PARACETAMOL Aulia Sandriani; Faizah Fulyani; Donna Hermawati; Santoso Santoso; Eva Annisaa
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Oxidative stress is an imbalance between free radicals and antioxidants, characterized by increase in malodialdehyde (MDA) levels. Stress oxidative caused by paracetamol overdose consumption and can be a serious problem for the structure and liver cell function. Oxidative stress prevented and controlled by antioxidant. Longan peel has phenolic and flavonoid which can potentially be sources of natural antioxidants. This study aimed to prove the longan peel extract had an antioxidant effect that could affect the oxidative stress in rats induced by toxic doses of paracetamol. Method: : Experimental research with control group design. Group P1, P2, and P3 were treatment group induced by paracetamol with a toxic dose of 2000 mg/kgBW and given extracts of longan peel (Dimocarpus longan L.) with multilevel doses, that were 25 mg/kgBW, 50 mg/kgBW, and 75 mg/kgBW wistar rat. Then, blood samples from each group were collected and measured plasma MDA levels and the animals were terminated, then their livers were taken for measurement of liver SOD enzyme activity. Result: One Way ANNOVA test showed a significant difference in plasma MDA (p=0,000) in the whole group of wistar rats. Significant differences were also shown on the examination of plasma MDA levels in the K1-K2, K2-P1, K2-P2, and K2-P3 groups (p<0,05). Conclusion: Longan peel extract had the effect of reducing plasma MDA levels of wistar rats induced by toxic doses of paracetamol compared to the control group.Keywords: Paracetamol, longan peel extract, MDA.

ANTIOXIDANT EFFECT OF LONGAN PERICARP EXTRACT IN PARACETAMOL-INDUCED IN RATS Nabilah Saniyya Wahyudi; Lusiana Batubara; Endang Sri Sunarsih; Eva Annisaa'
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29324

Background: Oxidative stress is a condition which were free radicals harm biological molecules, like lipid, protein, and DNA. Consume paracetamol can increase oxidative stress, which can cause increased level of AST and ALT serum. Longan pericarp (Dimocarpus longan L.) is one of natural ingredients that contain phenolic and flavonoids as an antioxidant to prevent oxidative stress. This study aims to prove the effect of longan pericarp (Dimocarpus longan L.) on AST and ALT serum levels of Wistar rats induced paracetamol. Methods: Experimental research with post-test only control group design. Thirty males wistar aged 2-3 months weighing 140-250 grams randomly divided into 5 groups. Group K1 was normal control group. Group K2 was induced by paracetamol 2000 mg/kgBW. Group P1, P2, P3 were induced by paracetamol 2000 mg/kgBW administered by longan shell extract (Dimocarpus longan L.) in multilevel dose 5 mg/200 gBW, 10 mg/200 gBW, and 15 mg/200 gBW. Blood samples in each group were collected to measure AST and ALT serum levels of wistar rats. Results: There were signifficant differences groups of AST serum. There were signifficant difference groups of K1-K2 (p=0,000), K2-P2 (p=0,041), and K2-P3 (p=0,010). There were signifficant differences groups of ALT serum. There were signifficant differences groups of K1-K2 (p=0,001), K2-P2 (p=0,032), and K2-P3 (p=0,006). Conclusions: The longan pericarp extract can lower the AST and ALT serum levels of Wistar rats induced by paracetamol.

HUBUNGAN KEPATUHAN MINUM OBAT ANTIHIPERTENSI TERHADAP KUALITAS HIDUP PADA PASIEN HIPERTENSI Vivi Nurmalita; Eva Annisaa; Dodik Pramono; Endang Sri Sunarsih
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 4 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Hipertensi merupakan penyakit kardiovaskular paling lazim yang tergolong dalam penyakit degeneratif, dan disebut sebagai penyakit “Silent Killer”. Salah satu faktor risiko yang dapat menyebabkan peningkatan angka kejadian morbiditas dan mortalitas penderita hipertensi adalah ketidakpatuhan pasien dalam meminum obat antihipertensi. Pengobatan antihipertensi harus dilakukan secara rutin agar kualitas hidup pasien menjadi lebih baik. Tujuan : Penelitian ini bertujuan untuk mengetahui hubungan kepatuhan minum obat antihipertensi terhadap kualitas hidup pada pasien hipertensi. Metode : Penelitian ini menggunakan jenis penelitian non-eksperimental yang bersifat observasional dengan pendekatan penelitian dilakukan secara cross sectional. Responden penelitian adalah semua pasien hipertensi yang datang memeriksakan diri maupun berobat di Puskesmas Halmahera, Puskesmas Kedungmundu, dan Puskesmas Pandanaran Kota Semarang pada bulan Mei-Juni tahun 2018 yang memenuhi kriteria inklusi serta tidak memiliki kriteria eksklusi. Data yang digunakan dalam penelitian merupakan data primer berupa kuesioner MMAS-8 dan WHOQOL-BREF, serta data sekunder berupa rekam medis pasien hipertensi. Uji statistik yang dilakukan adalah uji Chi-square. Hasil : Tingkat kepatuhan minum obat antihipertensi dalam kategori kepatuhan tinggi sebesar 64,4%, kategori kepatuhan sedang sebesar 28,9%, dan kategori kepatuhan rendah sebesar 6,7%. Tingkat kualitas hidup pasien hipertensi dalam kategori kualitas hidup baik sebesar 93,3%, dan kategori kualitas hidup kurang sebesar 6,7%. Hasil uji statistik antara kepatuhan minum obat antihipertensi terhadap kualitas hidup pasien hipertensi adalah p<0,001. Kesimpulan : Terdapat hubungan yang signifikan antara kepatuhan minum obat antihipertensi terhadap kualitas hidup pasien hipertensi.Kata Kunci : Kepatuhan Minum Obat, Kualitas Hidup, Hipertensi.

CORRELATION BETWEEN KNOWLEDGE AND BEHAVIOR OF USING VITAMIN C SUPPLEMENTS AMONG HEALTH AND NON-HEALTH STUDENTS IN CENTRAL JAVA DURING THE COVID-19 PANDEMIC Isnaini Nur Jannah; Eva Annisaa'; Intan Rahmania Eka Dini
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37549

Background: During the COVID-19 pandemic, 57.1% of students used vitamin C. Everyone's behavior/actions in using vitamin C are different. This is influenced by several factors, one of which is knowledge. Objective: Knowing the differences in the level of knowledge and the different levels of behavior in using vitamin C supplements and the correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java. Methods: Cross sectional analytic research using a questionnaire with purposive sampling technique. Data were analyzed using Chi-Square difference test and Rank Spearman correlation test. Results: The level of knowledge of health students related to vitamin C was in the good category (75%) and non-health students was in the sufficient category (42%). The behavior level of health students related to the use of vitamin C was in the good category (83.3%) and non-health students was in the poor category (58%). Chi-Square test showed that there were differences in the level of knowledge and behavior in using vitamin C between health students and non-health students with a p value = 0.000. There was a correlation between knowledge and the behavior of using vitamin C with a p value = 0.000. The Spearman correlation coefficient (r) obtained was 0.612. Conclusion: There were differences in the level of knowledge and different levels of behavior between health students and non-health students. There was a correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java.

PENGARUH PEMBERIAN MINYAK JELANTAH TERHADAP PROFIL FARMAKOKINETIK PARASETAMOL PADA TIKUS WISTAR Faizurrahman Andi Kusuma; Endang Sri Sunarsih; Eva Annisaa
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Penggunaan minyak goreng yang telah dipanaskan berulangkali banyak dilakukan di masyarakat untuk menekan pengeluaran biaya dalam memasak. Minyak goreng yang dipanaskan dan digunakan berulang akan membentuk suatu radikal bebas yang dapat menjenuhkan antioksidan endogen, yaitu gluthation. Parasetamol mempunyai efek analgesik dan antipiretik yang banyak digunakan masyarakat. Dalam metabolisme parasetamol, gluthation mempunyai peran yang penting.Tujuan : Mengetahui pengaruh minyak jelantah terhadap profil farmakokinetik parasetamol dalam darah tikus wistarMetode : True experimental dengan post test only control group design. Setelah diadaptasi dengan diet standar selama 7 hari, 14 ekor tikus wistar jantan dibagi menjadi 2 kelompok. Kelompok K sebagai kelompok kontrol, dan kelompok P sebagai kelompok perlakuan. Kelompok K diberi diet standar dan kelompok P diberi diet minyak jelantah ad libitum selama 56 hari. Pada hari ke-57 semua tikus diberi parasetamol oral 12,5 mg/200gramBB. Pengambilan cuplikan darah dilakukan dari vena retroorbita pada menit ke-3, 5, 10, 20, 30, 40, 60, 90, 120, 180, 240, 300, dan 360. Kadar parasetamol dalam plasma diukur dengan spektrofotometer UV pada panjang gelombang 242 nm.Hasil : Uji statistik dengan uji t tidak berpasangan menunjukkan perbedaan bermakna pada parameter Cl, Kel, t1/2e, Cmaks, AUC (p<0,05) dan menunjukkan perbedaan tidak bermakna pada parameter Ka,Vd, tmaks (p>0,05).Simpulan : Minyak jelantah dapat mempengaruhi profil farmakokinetik parasetamol dengan meningkatkan parameter t1/2e, Cmaks, AUC dan menurunkan parameter Cl, dan Kel.

Co-Authors Abdul Ghofir Abdul Ghofir Antari, Arlita Leniseptaria Astika Widy Utomo, Astika Widy Aulia Sandriani Desy Armalina Dodik Pramono Donna Hermawati Endang Sri Sunarsih Era Ayuk Adistia Faizurrahman Andi Kusuma Fulyani, Faizah Intan Rahmania Eka Dini Intan Rahmania Eka Dini Isnaini Nur Jannah Julia Zahra Ardianti Lusiana Batubara Nabilah Saniyya Wahyudi Nuraini Ekawati Raditiya Firda Maulany Ragil Setia Dianingati Rezha Nur Amalia Rezha Nur Amalia Rezha Nur Amalia Santoso Santoso Sarah Melinda Vivi Nurmalita Widyandani Sasikirana

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