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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Indonesian Journal of Cancer Chemoprevention JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Generics: Journal of Research in Pharmacy
Eva Annisaa
Program Studi Farmasi, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Environmental Science Health Professions Medicine & Pharmacology Public Health Social Sciences

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Journal : Indonesian Journal of Cancer Chemoprevention

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Correlation Between Antioxidant and Cytotoxic Activity of Parijoto (Medinilla speciosa Blume) Fractions in 4T1 Cell Line Eva Annisaa'; Widyandani Sasikirana; Nuraini Ekawati; Intan Rahmania Eka Dini
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp21-27

Abstract

Parijoto (Medinilla speciosa Blume) is one of Indonesian plant used for traditional medicine. Previous studies have demonstrated antimicrobial and cytotoxic effects of Parijoto on T47D cells. Therefore, we intended to know the antioxidant and cytotoxic activity of these fractions in 4T1 cell line (a Mus musculus mammary carcinoma). This cancer causes the greatest number of cancer-related deaths This study also investigated the correlation between antioxidant activity and cytotoxicity of Parijoto fractions. Discovering the type of correlation between antioxidant and anticancer activity of botanical extracts could relieve in screening for cytotoxic agent from natural products. The antioxidant and cytotoxic activity investigated using the Diphenylpicrylhydrazyl (DPPH) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay methods. The result showed that ethyl acetate fraction is the higher antioxidant activity (IC50:1.77 μg/mL) and the higher cytotoxicity (IC50:133.57 μg/mL). There was a strong positive correlation (correlation coefficient=0.957) between antioxidant and cytotoxic activity in 4T1 cell line, but the correlation was not significant (p=0.188).Keywords: Parijoto (Medinilla speciosa Blume), antioxidant, cytotoxic, 4T1 cell line.
Co-Authors Abdul Ghofir Abdul Ghofir Antari, Arlita Leniseptaria Astika Widy Utomo, Astika Widy Aulia Sandriani Desy Armalina Dodik Pramono Donna Hermawati Endang Sri Sunarsih Era Ayuk Adistia Faizurrahman Andi Kusuma Fulyani, Faizah Intan Rahmania Eka Dini Intan Rahmania Eka Dini Isnaini Nur Jannah Julia Zahra Ardianti Lusiana Batubara Nabilah Saniyya Wahyudi Nuraini Ekawati Raditiya Firda Maulany Ragil Setia Dianingati Rezha Nur Amalia Rezha Nur Amalia Rezha Nur Amalia Santoso Santoso Sarah Melinda Vivi Nurmalita Widyandani Sasikirana