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All Journal VALENSI Bulletin of Chemical Reaction Engineering & Catalysis Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Eksakta : Berkala Ilmiah Bidang MIPA PROFESSIONAL HEALTH JOURNAL Jurnal Akademika Kimia Jurnal Pengabdian Pada Masyarakat Bulletin of Chemical Reaction Engineering & Catalysis
Mohammad Rofik Usman
Bachelor In Pharmacy Program, Faculty Of Health Science, Universitas Dr. Soebandi, Jember, Jawa Timur
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Journal : Eksakta : Berkala Ilmiah Bidang MIPA

 1 
Development and Validation of RP-HPLC Analysis Method for Determination of Total Alkaloid Content of Soursop (Annona muricata L.) Leaf Extract Lindawati Setyaningrum; Dyah Purwaningtyas; Ayik Rosita Puspaningtyas; Dyan Wigati; Mohammad Rofik Usman; Maasyitoh Sari Latifah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 23 No. 03 (2022): Eksakta: Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1166.627 KB) | DOI: 10.24036/eksakta/vol23-iss03/325

Abstract

Soursop leaves contain alkaloids that have pharmacological effects. This study aims determine the total alkaloid content of soursop leaf ethanol extract using a validated HPLC method. Extraction was carried out by soxhletation followed by liquid-liquid extraction using chloroform. Optimizing HPLC conditions on the mobile phase, flow rate, concentration, and wavelength, further testing the validation of the analytical method. Optimizing HPLC conditions obtained optimal results at concentration of 500 ppm with a flow rate of 1.0 mL/min using acetonitrile: methanol: water (80:5:15) at wavelength of 272 nm. These results have met the validation requirements of analytical methods including System Suitability Test (UKS), selectivity, linearity with y = 2.01914x –219,97226, correlation coefficient value (r) = 0.9995, and Vx0 value 0.11201%. The limit of detection and quantization were 8,78525 ppm and 29,28418 ppm, respectively. The RSD percentage of the precision test is 1.0453%, and the accuracy test is obtained from the recovery of 98-102%. The result of determining the total alkaloid content  sample was 0.0862 ± 0.004 % (%w/w) of the entire alkaloid content (TALC) triple replication. This research concludes that the analytical method using the HPLC system for determining the total alkaloid content of the ethanolic extract of soursop leaves is validate
Antioxidant Activity of Red Dragon Fruit Teabag (Hylocereus polyrhizus) Peels with the Addition of Ginger (Zingiber officinale var. amarum) and Cinnamon (Cinnamomum zeylanicum, BI) Wima Anggitasari; Lindawati Setyaningrum; Muhammad Rofik Usman; Dyan Wigati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 02 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol24-iss02/377

Abstract

Free radicals have very unstable and reactive molecules. Excessive free radicals can trigger oxidative stress and cause various diseases. The peel of red dragon fruit contains chemical compounds that shows potential as an antioxidants. This study aims to optimize the benefits of red dragon fruit peels as tea bags because its convenient and simple to use. Design of this study was a randomized block design (RBD) which consisted of two factors, the drying temperature of the red dragon fruit skin (T) and the teabag formulation (F). Ginger and cinnamon are added as flavoring ingredients to the formula. The result showed that the drying temperature of the peel red dragon fruit affects the antioxidant activity of the teabag, where T1 has the highest antioxidant activity. The formulation of teabags also affects the antioxidant activity of the teabag, where F1 has the highest antioxidant activity. T1F1 had the highest antioxidant activity, and the interaction between the two (T and F) had a significant effect on antioxidant activity (p < 0.05).
Co-Authors Ade Nisa’ Kartika Azzahra Aditya F. Ardinsyah Alfian Nur Firdaus Alfian Nur Firdaus Aliyah Purwanti Atiek Rostika Noviyanti Ayik Rosita Puspaningtyas Ayu Wanda Marita Ayu Wanda Marita Azmi Prasasti Azmi Prasasti Diana Rakhmawaty Eddy Diana Rakhmawaty Eddy Dwiki Yudistira Dyah Purwaningtyas Dyan Wigati Eka Fitri Yanti Eka Fitri Yanti Erma Pujiawati Eviyanti Nazareth Fathor Rosi Frida Oktavia Putri Hermanto Haikal Alhamdi Sirojul Alam Ikfira Agustina Putri Ima F. Lestari Ima Fitria Lestari Lindawati Setyaningrum lindawati setyaningrum Lutfiah Nurul Hakiki Maasyitoh Sari Latifah Mega T. Wulandari Muhamad D. Permana Reno Kurnia Ramadhan Reza Zarkasih Adytia Ridho Anil Shohibul Falah Rifka Nabila Rosita Dina Dwi Ayunliana Sovia Islamiah Sovia Islamiah Stephanie D. Artemisia Syamsiyatul Fajriyah Syamsiyatul Fajriyah Yuana Dwi Agustin