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All Journal Biosfer: Jurnal Tadris Biologi KOVALEN: Jurnal Riset Kimia Jurnal Kimia Mulawarman Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas (JFSK) Jurnal Kreativitas PKM BERNAS: Jurnal Pengabdian Kepada Masyarakat Bakti Cendana: Jurnal Pengabdian Masyarakat Jurnal Sains dan Edukasi Sains Jurnal Biosense Aptekmas : Jurnal Pengabdian Kepada Masyarakat Journal of The Indonesian Society of Integrated Chemistry
Maximus M Taek
Universitas Katolik Widya Mandira
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Journal : Jurnal Biosense

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KAJIAN SENYAWA HEXOSE DAN MALIC ACID SEBAGAI INHIBITOR PAPAIN LIKE PROTEASE (PLPro) CORONA VIRUS Yohanes Bare; Frederiksen Novenrius Sini Timba; Sukarman Hadi Jaya Putra; M A Yohanita Nirmalasari; Dewi Ratih Tirto Sari; Maximus M Taek
JURNAL BIOSENSE Vol 5 No 01 (2022): Edisi Juni 2022
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.965 KB) | DOI: 10.36526/biosense.v5i01.1997

Abstract

Papain-like protease is a SARSCOV-2 protease that functions for ubiquitination in host cells. Caffeine compounds have been widely reported to have antioxidant, anti-inflammatory, antidiabetic, and antiobesity activities. However, hexose and malic acid compounds in coffee rind as potential inhibitors of the papain-like protease SARSCOV2 have not been reported. This study investigated the potential of malic acid and hexose compounds as PLPro inhibitor agents in inhibiting SARSCOV2 ubiquitination. In silico studies were used to identify the potential of the two compounds by interacting hexose and malic acid compounds with papain-like protease (PLPro) proteins with the Molegro virtual Docker 5 program. Next, the ligand-protein complex visualization was done with discovery studio version 5.0. hexose and malic acid compounds showed interactions with papain-like protease proteins on several active site residues. The interactions showed inhibition of ubiquitination and stimulation of interferon in host cells. The two compound complexes – PLPro protein showed hydrophobic interactions, hydrogen bonds, and van der Waals forces, which contributed to the formation of bond energy and strong bonds between compounds and proteins. In this study, it was concluded that hexose and malic acid compounds have the potential to act as inhibitors of papain-like protease (PLPro) protein.
Co-Authors Adilson de Castro Ruas Adri Gabriel Sooai Adrianus Ketmoen Alfry Aristo Jansen Sinlae Aloisius Masan Kopon Aloysius Djalo Ambrosius Faofeto Angela Nona Angeliana Desimaris Nita Anggelinus Nadut Anselmus Boy Baunsele Bare, Yohanes Burhan Ma'arif Christiani Dewi Q. M. Bulin Destiya Argo Pamuji Fihuda Erly Grizca Boelan Faisal Akhmal Muslikh Gerardus Diri Tukan Hildegardis Missa Husnul Khotimah Juvencio de Castro Ruas Lodowik Landi Pote Lusia Ina Dai M A Yohanita Nirmalasari Mangestuti Agil Maria Aloisia Uron Leba Maria Augustin Lopes Amaral Maria O. Krisdayanti Maria Vitriani Barek Sabon Noemia A. Ruas Paskalis Andrianus Nani Paulus Adrianus K. L. Ratumakin Priscilla M. A Hornay Sardina Ndukang Sari, Dewi Ratih Tirto Sisilia Daeng Bakka Mau Timba, Frederiksen Novenrius Sini Viany Cecilia Pah Yustina Dwisofiani Lawung