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All Journal Journal of Agromedicine and Medical Sciences Jurnal Pengabdian UntukMu NegeRI Jurnal Biologi Tropis Jurnal Biotek Jurnal Dunia Farmasi Journal of Pharmaceutical and Sciences.
Muhammad Amin Nasution
Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara Al Washliyah, Medan, 20147, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Penyuluhan Penyakit Diabetes Melitus Dan Pemeriksaan Kesehatan Di Dusun I Desa Kolam Kecamatan Percut Sei Tuan Muhammad Amin Nasution; Nia Novranda Pertiwi; Hindri Syahputri
Jurnal Pengabdian UntukMu NegeRI Vol 6 No 2 (2022): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v6i2.4017

Abstract

Kesehatan merupakan faktor penting dalam kehidupan seseorang agar dapat beraktivitas setiap harinya. Kesibukan serta sarana transportasi yang memadai untuk menunjang aktivitas sehari-hari menyebabkan sebagian orang kurang melakukan gerakan fisik dan berolahraga, sehingga mengakibatkan proses metabolisme tubuh menjadi terganggu, hal tersebut merupakan sebagian dari faktor yang mendukung terjadinya penyakit diabetes melitus. Diabetes Melitus (DM) merupakan penyakit gangguan metabolik menahun dan juga menjadi masalah kesehatan di masyarakat paling utama karena komplikasinya bersifat jangka pendek dan jangka panjang. Oleh karena itu perlu diadakannya penyuluhan dan edukasi kepada masyarakat terkhusus di dusun I desa kolam terkait dengan penyakit diabetes melitus dengan tujuan memberikan tambahan pengetahuan mengenai diabetes melitus baik cara pencegahannya dan penanganannya bagi yang telah terkena diabetes melitus. Metode yang digunakan dalam kegiatan ini dengan memberikan penyuluhan berupa ceramah interaktif dalam bentuk presentase kepada masyarakat. Selain itu, pada acara ini juga dilakukan pemeriksaan Kadar Gula Darah (KGD) gratis bagi masyarakat. Dari hasil kegiatan pengabdian yang dilakukan sebanyak 24 orang peserta diperoleh 7 orang memiliki kadar gula darah diatas normal > 200 mg/dl dan sebanyak 17 orang kadar gula darahnya normal < 200 mg/dl. Kata Kunci: Kesehatan, Diebetes Melitus, Penyuluhan, KGD
Anti-Inflammatory Activity of Stem Barks Ethanol Extracts of Asam Kandis On Male White Rats Hanafis Sastra Winata; Muhammad Andry; Muhammad Amin Nasution; Firman Rezaldi; Ade Shindy F Br Sembiring
Journal of Agromedicine and Medical Sciences Vol 9 No 1 (2023)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v9i1.37478

Abstract

Inflammation is a complex series of changes in tissue due to tissue injury caused by bacteria, trauma, chemicals, heat, and pain. Gamboge (Garcinia xanthochymus) is a fruit-bearing tree native to Southeast Asia. Plants of the genus garcinia are rich in secondary metabolites such as flavonoids, steroids, and triterpenes which have potential pharmacological activity. This study aimed to determine the anti-inflammatory activity based on the reduction in edema volume of Gamboge (Garcinia xanthochymus) stem bark. The inquiry was experimental. Through maceration, an ethanol extract of the gamboge stem was created. The animals were divided into five groups, each containing five white male rats. The test given was a suspension of gamboge ethanol extract at doses of 200, 400, and 600 mg/kgBW, a negative control of 1% Na CMC suspension, and a positive control of 2.25 mg/kgBW sodium diclofenac. Observations were made for 6 hours, and then data were analyzed using a two-way analysis of variance (ANOVA) test. The results showed that gamboge ethanolic extract was proven to have an anti-inflammatory effect in white male rats induced by carrageenan starting at doses of 200, 400, and 600 mg/kgBW, marked by a significant difference to the negative control (p<0.05). The 600mg/kgBW dose group showed no significantly different results from the positive control group (p>.05). These results concluded that the dose group 600mg/kgBW was the best dose of gamboge stem ethanol extract had an anti-inflammatory activity based on reducing the volume of leg edema of white male rats. Keywords: Asam Kandis Stem Bark; Anti-Inflammation; Male White Rats
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sisik Naga terhadap Bakteri Staphylococcus aureus dan Salmonella typhi Muhammad Amin Nasution; Muhammad Andry; Hindri Syahputri; Nia Novranda Pertiwi; Melia Sari
Jurnal Dunia Farmasi Vol 7, No 2 (2023): Edisi April
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v7i2.5693

Abstract

Latar Belakang: Paku sisik naga (Pyrrosia piloselloides) termasuk dalam family Polypodiaceae merupakan tanaman epifit yang hidup dan menempel di bebatuan atau pepohonan dan mengandung metabolit sekunder seperti alkaloid, flavonoid, saponin. Tujuan: Untuk mengetahui metabolit sekunder yang terdapat pada sampel serta menguji aktivitas antibakteri dan konsentrasi yang paling baik ekstrak etanol sisik naga (Pyrrosia piloselloides) dalam menghambat pertumbuhan bakteri Staphylococcus aureus dan Salmonella typhi. Metode: Penelitian ini eksperimental dengan ekstraksi metode maserasi dengan pelarut etanol 96%. Sampel penelitian ini adalah daun tropofil sisik naga (Pyrrosia piloselloides) diambil secara purposive sampling yang diekstrak kemudian diencerkan dengan konsentrasi 10%, 20% dan 30%. Uji daya hambat menggunakan metode difusi cakram. Data yang diperoleh dari hasil penelitian di laboratorium diolah dengan statistik yaitu uji Analysis of Varians (ANOVA). Hasil:  Berdasarkan uji anova diketahui nilai sig sebesar 0,000 (0,005) terdapatl perbedaan signifikan antara konsentrasi 10%, 20%, 30%, kontrol (+) dan kontrol (-) dengan kata lain penambahan konsentrasi mempengaruhi zona hambat mikroba. Kesimpulan: Pada penelitian ini dapat disimpulkan bahwa uji aktivitas antimikroba dan konsentrasi pada ekstrak etanol sisik naga (Pyrrosia piloselloides) mempunyai aktivitas antimikroba terhadap bakteri Staphylococcus aureus dan Salmonella typhi.
Growth Inhibition Test of Gram and Negative Bacteria in Pharmaceutical Biotechnology Products in the Form of Hand Sanitizer Formulations Based Fermented Telang Flower Kombucha Hari Hariadi; Muhammad Andry; Muhammad Amin Nasution; Ade Sumiardi; Firman Rezaldi; Suseno Amien; Yusep Ikrawan
Jurnal Biologi Tropis Vol. 23 No. 3 (2023): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i3.5219

Abstract

Telang flower kombucha is proven to have various pharmacological activities, so that it can be developed as medicines, cosmetics, and its waste can be applied in agriculture as an ingredient in organic liquid fertilizer to support plant development and growth. This research aims to make hand sanitizer gel formulations and preparations with active butterfly pea flowers. Disk diffusion is used to stop gram-positive and gram-negative bacteria from growing. Post hoc analysis and one-way ANOVA were used to analyze the data. The one-way ANOVA analysis yielded results with a significance level of P<0.05, allowing the post hoc test to continue. When tested at a sugar concentration of 40%, the butterfly pea flower kombucha hand sanitizer significantly outperformed the control when it came to inhibiting the growth of the test bacteria. The best way to stop the test bacteria from growing is to use a concentration of 40%.
UJI AKTIVITAS KRIM ANTI JERAWAT EKSTRAK ETANOL DAUN SEROJA (Nelumbo nucifera G.) TERHADAP BAKTERI Propionibacterium acnes DAN Staphylococcus aureus Khairani Fitri; Tetty Noverita Khairani; Muhammad Andry; Nidia Rizka; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.024 KB) | DOI: 10.36490/journal-jps.com.v6i1.6

Abstract

Background; Lotus leaves (Nelumbo nucifera G.) is one of the plants that are potentially in the field of treatment, like antibacterial antiacne. Lotus leaves contain alkaloids, saponins, tannins, flavonoids and steroids are compounds of secondary metabolites in plants that are effective as an antibacterial. Objective; The study aimed to determine the antibacterial activity of lotus leaves ethanol extract against bacteria of Propionibacterium acnes and Staphylococcus aureus. Method; The ethanol extract of lotus leaves was made by maceration method using 96% ethanol as a solvent. The in-vitro antibacterial activity test used the well method with a concentration of 10%, 20% and 30%. Results; The results of the study with concentration of 10%, 20% and 30% have the inhibition zone on the bacteria Propionibacterium acnes where the concentration of 10% of 8.7mm, a concentration of 20% of 12.4mm and a concentration of 30% by 14.5mm. And the zone of inhibition on Staphylococcus aureus bacteria has a 10% concentration of 8.1mm, the concentration of 20% of 11.1mm and a concentration of 30% of 14.1mm. Concentration is the cream of the ethanol extract of the leaves of lotus at a concentration of 30%. Conclusion; The conclusion of this study showed that the ethanol extract of lotus leaves could be formulated in a cream dosage form and has antibacterial activity against Propionibacterium acnes and Staphylococcus aureus bacteria. It is suggested to the next researchers to do fractionation to get better dosage results.
Penetapan kadar flavonoid total ekstrak etanol buah asam kandis (Garcinia xanthochymus) dengan metode spektrofotometri Uv-Vis dan LCMS Hanafis Sastra Winata; Hendri Faisal; Muhammad Andry; Nurul Aulia; Muhammad Amin Nasution; Ika Julianti Tambunan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.159

Abstract

Background: Kandis acid fruit (Garcinia xanthocymus Hook. f ex T. Anderson) is a plant of the Clusiase family with many species. Kandis acid fruit has various biological and pharmacological activities such as cytotoxic, anti-inflammatory, antimicrobial, antifungal and antioxidant. Purpose: To determine the content and total flavonoid content of tamarind kandis using quercetin as a reference standard. Method: This study used the TLC (Thin Layer Chromatography) method in qualitative analysis with the parameter Rf, then used the spectrophotometric method in the quantitative analysis with the parameter total flavonoid content (Value of mg QE/g sample) and the LCMS method (Liquid Chromatography Mass Spectrometry) with the parameter retention time (Rt). Result: Shows that tamarind kandis has an Rf value of 0.86 which states that tamarind kandis is positive for flavonoids with a reference standard of quercetin, total flavonoid content of 34.8364 mg QE/g sample with a standard deviation of 0.4355 and a percentage of 0.6967% and has five types of flavonoid compounds namely methyl dihydro quercetin, 1,5-Dihydroxy-3-methoxy xanthone, Afzelechin, Myricetin-3-O-ß-D-galactopiranoside, and Myricetin 7-glucoside. Methyl dihydro quercetin is the largest flavonoid with a composition of 49.57% with a retention time of 0.485 minutes. Conclusion: The identified total flavonoids have different types and levels
Skrining Fitokimia Dan Analisis Kadar Kafein Pada Kopi Bubuk Jenis Arabika Di Kota Takengon Menggunakan Spektrofotometri Ultraviolet Muhammad Andry; Fahma Shufyani; Muhammad Amin Nasution; M. Fariz Fadillah; Ika Julianti Tambunan; Firman Rezaldi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.176

Abstract

Background: Coffee is a type of plant that contains caffeine and can be made into a delicious drink. Currently, coffee is the world's most popular drink after water and tea. The stuay aimed was to determine the caffeine content in Arabica ground coffee circulating in the Takengon market according to Indonesian national standards (SNI 01-7152-2006). This research was experimental by taking samples purposively. The research method used was phytochemical screening, qualitative analysis, and ultraviolet spectrophotometry at a wavelength of 273nm. The specified validation parameters were precision, linearity, LOD and LOQ. The results of the phytochemical screening of sample A in the Meyer test treatment obtained negative results but the others were positive. And in sample B, all tests were positive. In the three qualitative analyses tests on samples A and B, the results were positive. The average yield of quantitative analysis in sample A was 11.632 mg once and the daily concentration was 34.897mg. while in sample B the level was 6.663 mg once and drank 19.989mg per day. Validation test results obtained linearity r2 = 0.998, LOD and LOQ namely 0.882µg/ml and 2.94µg/ml, RSD value of 1.11%. Based on the conclusion, sample A and sample B met the requirements according to SNI 2006 (50mg once and 150mg daily) and also met the requirements according to the Pharmacopoeia Edition III, namely a maximum dose of 500 mg once and 1.5g daily.
Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat Asyrun Alkhairi Lubis; Muhammad Yunus; Jefri Naldi; Muhammad Andry; Pricella Ginting; Fira Safitri; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.209

Abstract

Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).
Formulasi sediaan pasta gigi ekstrak etanol buah takokak (Solanum torvum Sw.) dan tulang ikan tuna sirip kuning (Thunnus albacares) terhadap bakteri Streptococcus viridans dan bakteri Escherichia coli Hendri Faisal; Hanafis Sastra; Muhammad Andry; Melia Sari; Adek Chan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.218

Abstract

Takokak (Solanum torvum Sw.) is a traditional plant used as vegetables, fruits, ornamental plants and medicinal purposes. Takokak fruit contains secondary metabolites of alkaloids, flavonoids, saponins, tannins and steroids. Tuna fish bones are one of the biggest wastes from the tuna processing industry. Tuna fish bones contain minerals that are quite high compared to other parts of the body because the main elements of fish bones are calcium, phosphorus and carbonate. This study aims to make toothpaste preparations of ethanol extract of large chili fruit and yellowfin tuna bones and to determine the inhibition zone against Streptococcus viridans and Escherichia coli bacteria. This type of research is done experimentally. This type of research includes the manufacture of toothpaste preparations with concentrations of F1 (10%), F2 (15%), F3 (20%). Preparation evaluation included organoleptic test, homogeneity test, spreadability test, foam formation test, pH test, viscosity test, extrudability test and activity test for Streptococcus viridans and Escherichia coli bacteria. The results of the research were carried out to evaluate the physical preparations of toothpaste with ethanol extract of large chili fruit and yellow fin tuna bones, each toothpaste formulation met the organoleptic requirements, homogeneity, spreadability, foam formation, pH, viscosity and extrudability. Toothpaste preparations of ethanol extract of takokak fruit and yellow tuna bones have antibacterial effectiveness on Streptococcus viridans F1 (9.85 ± 0.32), F2 (11.85 ± 0.45), F3 (13.05 ± 0.34) and Escherichia coli F1 (3.15 ± 0.73), F2 (3.75±0.40), F3 (4.5±0.25). One way Anova data analysis showed a sig value of 0.00 <0.05 meaning that each concentration was significantly different, so that the results of the bacterial inhibition zone affected each concentration of toothpaste preparations.The conclusion of this study is that the ethanol extract of large chili fruit and yellow fin tuna bones can be formulated as a toothpaste preparation and effectively inhibits the growth of Streptococcus viridans and Escherichia coli bacteria in the weak, medium and strong categories.
Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus) Lilik Septiana; Rida Evalina Tarigan; Muhammad Andry; Vannissa Andriani Irawan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.220

Abstract

Background; Senggani leaves have secondary metabolites that can inhibit the release of aldosterone so that more water is removed from the body and blood pressure will drop. Objectives; The purpose of this study was to determine the effectiveness of the ethanol extract of senggani leaves (Melastoma malabathricum L.) on reducing blood pressure of male white mice (Mus musculus). Method; this research is experimental which includes sampling, sample processing, extract making, simplicia characteristics, preparation of test materials, treatment of test animals and data analysis. The samples used were senggani leaves (Melastoma malabathircum L.). The test animals used were 15 male white mice then divided into 5 groups. Measurement of blood pressure using a blood pressure analyzer with the tail cuff method. The measurement data were then analyzed using a paired t-test with a significance limit of 0.05. Result; showed that the ethanol extract of senggani leaves had antihypertensive effectiveness with the lowest systolic blood pressure measurement results after treatment at EEDS 150 mg/kgBW which was 86.66 mmHg and diastolic blood pressure obtained the lowest after treatment at EEDS 150 mg/KgBW, which was 59 mmHg. . The results of the statistical paired t-test showed that there was an effect of giving the test material EEDS 50 mg/kgBW, EEDS 100 mg/kgBW, EEDS 150 mg/kgBW test for 14 days with p-value <0.05. On diastolic blood pressure, the effect of treatment with the test material on blood pressure was significant at EEDS 150 mg/kgBW with p-value = 0.001. Conclusion; this study was that the administration of the ethanol extract of the leaves of senggani (Melastoma malabathricum L.) could reduce the blood pressure of experimental male mice (Mus musculus). The ethanol extract of senggani leaves (Melastoma malabathricum L.) was effective in lowering blood pressure at a dose of 150 mg.
Co-Authors Ade Shindy F Br Sembiring Ade Sumiardi Adek Chan Anny Sartika Daulay Aris Ma'ruf Asyrun Alkhairi Lubis Dwiyarina Margarisa Fahma Shufyani Fira Safitri Firman Rezaldi Firman Rezaldi Firman Rezaldi Firman Rezaldi Firman Rezaldi Hafizhatul Abadi Hanafis Sastra Winata Hari Hariadi Haris Munandar Nasution Haris Munandar Nasution Hendra Jaya Hendri Faisal Hendri Faisal Hendri Faisal Hendri Faisal Hindri Syahputri Ika Julianti Tambunan Ika Yeni Siahaan Indra Ginting Indra Ginting Isti Dwi Pruschia Jefri Naldi Khairani Fitri Leni Halimatusyadiah Lilik Septiana M. Fariz Fadillah M. Fariz Fadillah M. Pandapotan Nasution Mayang Sari Melia Sari Melia Sari Muhammad Andry Muhammad Yunus Mutia Muhardiyanti Nazirah Nazirah Nia Novranda Pertiwi Nidia Rizka Nurul Aulia Pricella Ginting Rafita Yuniarti Rahma Yanti Rida Evalina Tarigan Ridwanto Ruth Mayana Rumanti Selfia Lestary Singgar Ni Rudang Siska Dwi Anggraeni Suseno Amien Syifa Naziyah Tetty Noverita Khairani Tri Damaiyanti Vannissa Andriani Irawan Winata, Hanafis Sastra Yayuk Putri Rahayu Yulia Nanda Putri Yusep Ikrawan Zikra Maqfirah