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UJI AKTIVITAS ANTIINFLAMASI EKSTRAK DAUN TEMBELEKAN (Lanatana camara Linn.) SECARA IN VITRO MENGGUNAKAN METODE STABILITASI MEMBRAN SEL DARAH MERAH Damiti, Sukmawati A; Ysrafil, Ysrafil; Abidin, Zaenal; Rahmawati, Rahmawati; Kamba, Vyani; Hartati, Hartati; Ishak, Pratiwi; Yusuf, Ghaitsa Zahira Sopha
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): Februari, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.202

Pengobatan berbagai penyakit saat ini perlahan kembali menerapkan konsep back to nature yakni menggunakan produk herbal untuk menyembuhkan penyakit tidak terkecuali inflamasi. Tembelekan adalah tanaman yang telah lama digunakan seara empiris untuk mengobati penyakit radang. Namun, bukti kemanfaatannya secara ilmiah untuk mengobati inflamasi masih kurang. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi ekstrak metanol daun tembelekan dengan menggunakan metode stabilisasi membran sel arah merah. Kontrol positif yang digunakan adalah natrium diklofenak pada konsentrasi 400 ppm, 600Â Â ppm, 800 ppm dan 1200 ppm sedangkan pada larutan ekstrak digunakan konsentrasi 250 ppm, 500 ppm, 1000 ppm dan 2000 ppm. Pengukuran aktivitas antiinflamasi dihitung berdasarkan persen stabilitasnya. Semakin tinggi nilai % stabiitas, maka dianggap semakin baik efek inflamasinya. Hasil pengujian menunjukan bahwa pada ekstrak dengan konsentrasi 2000 ppmÂ mempunyai daya stabilitas tertinggi yakni sebesar 62,171%. Dari hasil dapat dilihat bahwa semakin tinggi konsentrasi ekstrak, maka daya inflamasinya juga semakin baik.Kata Kunci : antiinflamasi, daun tembelekan, ekstrak metanol, stabilisasi membran sel darah merah

Uji Aktivitas Antiinflamasi Ekstrak Metanol Daun Tembelekan (Lanatana camara Linn.) Secara In Vitro Menggunakan Metode Stabilitasi Membran Sel Darah Merah Sukmawati A Damiti; Ysrafil Ysrafil; Zaenal Abidin; Rahmawati Rahmawati; Vyani Kamba; Hartati Hartati; Pratiwi Ishak; Ghaitsa Zahira Sopha Yusuf
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 1 (2021): Februari, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i1.202

Pengobatan berbagai penyakit saat ini perlahan kembali menerapkan konsep back to nature yakni menggunakan produk herbal untuk menyembuhkan penyakit tidak terkecuali inflamasi. Tembelekan adalah tanaman yang telah lama digunakan seara empiris untuk mengobati penyakit radang. Namun, bukti kemanfaatannya secara ilmiah untuk mengobati inflamasi masih kurang. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi ekstrak metanol daun tembelekan dengan menggunakan metode stabilisasi membran sel arah merah. Kontrol positif yang digunakan adalah natrium diklofenak pada konsentrasi 400 ppm, 600 ppm, 800 ppm dan 1200 ppm sedangkan pada larutan ekstrak digunakan konsentrasi 250 ppm, 500 ppm, 1000 ppm dan 2000 ppm. Pengukuran aktivitas antiinflamasi dihitung berdasarkan persen stabilitasnya. Semakin tinggi nilai % stabiitas, maka dianggap semakin baik efek inflamasinya. Hasil pengujian menunjukan bahwa pada ekstrak dengan konsentrasi 2000 ppm mempunyai daya stabilitas tertinggi yakni sebesar 62,171%. Dari hasil dapat dilihat bahwa semakin tinggi konsentrasi ekstrak, maka daya inflamasinya juga semakin baik.Treatment of various diseases is now slowly re-applying draft “back to nature” namely using herbal products for curing disease is no exception inflammation. The smack is plants that have long been used empirically to treat inflammatory disease. However, scientific evidence of its usefulness for treat inflammation is still lacking. This research aims to determine the anti-inflammatory activity of tembelekan leaf methanol extract using the red blood cell membrane stabilization method. Control The positive test used was diclofenac sodium at a concentration of 400 ppm, 600 ppm, 800 ppm and 1200 ppm while in the extract solution used concentrations of 250 ppm, 500 ppm, 1000 ppm and 2000 ppm. Measurement of anti-inflammatory activity was calculated based on percent stability. The higher the stability percentage value, the more good inflammatory effect. The test results show that the extract with a concentration of 2000 ppm has the highest stability, namely by 62.171%. From the results it can be seen that the higher the concentration of extract, then the inflammatory power is also getting better.

Analisis Pengelolaan Obat di Instalasi Farmasi Dinas Kesehatan Kabupaten/Kota Se-Provinsi Gorontalo Periode Tahun 2018 dan 2019 Fadli Husain; Vyani Kamba; Zulfiayu Zulfiayu; Arlan K Imran
Journal of Experimental and Clinical Pharmacy (JECP) Vol 2, No 1 (2022): Februari 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v2i1.352

Instalasi farmasi sering menghadapi permasalahan pada tahap seleksi, perencanaan dan pengadaan. Pengelolaan obat yang buruk menyebabkan tingkat ketersediaan obat menjadi berkurang, terjadi kekosongan obat, banyaknya obat yang menumpuk karena tidak sesuainya perencanaan obat, serta banyaknya obat yang kadaluwarsa/rusak akibat sistem distribusi yang kurang baik sehingga dapat berdampak kepada inefisiensi penggunaan anggaran/biaya obat di tingkat Kabupaten/Kota. Penelitian ini menggunakan rancangan deskriptif dengan pengambilan data secara retrospektif dan concurent. Penelitian ini dilaksanakan di Instalasi Farmasi Kab. Kota se-Provinsi Gorontalo. Alat ukur penelitian ini adalah daftar pertanyaan berdasarkan indikator standar yang telah ditetapkan sesuai pedoman yang digunakan untuk monitoring dan evaluasi pengelolaan obat kabupaten/kota, serta melakukan wawancara langsung kepada penanggung jawab Instalasi Farmasi setempat. Hasil penelitian didapatkan bahwa; alokasi dana pengadaan obat tahun 2018 > 2 Miliar rupiah dan tahun 2019 1,7 Miliar - 4,3 Miliar rupiah. Terdapat 50% Kabupaten/kota yang sudah memiliki Tim Perencanaan Obat Terpadu (TPOT) di lingkungan Dinas Kesehatan. Biaya obat perkapita bila menggunakan standar WHO 1 US$ perkapita maka 80% Kabupaten/Kota sudah sesuai bahkan melampaui, hanya 1 kabupaten yang dibawah standar WHO. Terdapat 83% Kabupaten/kota yang kesesuaian item obat dengan DOEN diatas 80% dan seluruh Kabupaten Kota mempunyai kesesuaian FORNAS lebih dari 80%.Pharmaceutical installations often face problems at the selection, planning, and procurement stages. Poor drug management causes decreasing the level of drug availability, drug vacancies, overstock of drugsdue to inappropriate drug planning, and expired/damaged drugs due to a poor distribution system can have an impact on inefficiency in the use of drug budgets/costs at the Regency/City. This study used a descriptive design with retrospective and concurrent. This research was conducted at the Pharmacy Installation at the Regency/City in Gorontalo Province. The measuring instrument for this research is a list of questions based on standard indicators that have been set according to the guidelines used for monitoring and evaluating regency/citydrug management and conducting direct interviews with the PIC of the local Pharmacy Installation. The results of the study found that; the allocation of funds for drug procurement in 2018 was more than 2 billion rupiah and in 2019 was 1.7 billion - 4.3 billion rupiah. There are 50% of regencies/cities already have an Integrated Drug Planning Team (TPOT) within the Health Office. Drug costs per capita when using the WHO standard of US$ 1 per capita, 80% of districts/cities comply and even exceed, only 1 district is below the WHO standard. There are 83% of regencies/cities whose conformity of drug items with DOEN is above 80% and all regencies/cities have FORNAS conformity of more than 80%.

Tingkat Pengetahuan, Sikap dan Rasionalitas Swamedikasi pada Masa Pandemi di Kota Gorontalo Vyani Kamba; Prisca Safriani Wicita; Insyira Fadliana Basri; Pratiwi Y Ishak
Jurnal Surya Medika (JSM) Vol 8 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3248

Changes in people's lifestyles tend to pay less attention to health, and the development of diseases in the community is also unavoidable, especially during the current Covid-19 pandemic. The development of this disease encourages people to look for alternative treatments that are cost-effective and therapeutically effective. In this regard, self-medication or self-medication is an alternative that is taken by the community. Community efforts to treat themselves are known as self-medication or self-medication. This study aims to determine the knowledge, attitudes, and rationality of self-medication in the community in Gorontalo City with a descriptive cross-sectional design method. The sample in this study were people who did self-medication and met the inclusion criteria, namely aged 18-60 years and willing to be respondents as many as 80. The level of knowledge related to self-medication of the people of Gorontalo City is 43.8% in the good category, self-medication attitude in a good category is 55%, and rationality is 65%. There is a significant relationship between respondents' knowledge level and self-medication attitude, with a p-value of 0.001.

Peran Apoteker dalam Meningkatkan Kepatuhan Berobat pada Pasien Diabetes Melitus Vyani Kamba
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 1, No 1 (2021): April 2021
Publisher : Poltekkes Kemenkes Gorontalo

Apoteker mempunyai peran besar dalam meningkatkan kualitas hidup pasien seiring dengan pergeseran orientasi pelayanan kefarmasian dari pengelolaan obat sebagai komoditi menjadi pelayanan yang komprehensif. Apoteker harus mampu meningkatkan pengetahuan, keterampilan dan perilaku agar dapat melaksanakan interaksi langsung dengan pasien dalam pemberian informasi obat maupun konseling bagi pasien yang membutuhkan, diantaranya pada pasien Diabetes Melitus. Diabetes melitus merupakan penyakit degeneratif yang prevalensinya terus meningkat. Penyakit ini berdampak besar pada kualitas sumber daya manusia, sosial dan tingginya biaya kesehatan, oleh sebab itu pasien diabetes harus diperhatikan agar tidak semakin parah dan tidak mengalami komplikasi. Metode yang digunakan adalah mengumpulkan berbagai tulisan pada jurnal nasional maupun Internasional dengan menggunakan mesin pencari Googgle Scholar terkait kepatuhan pasien DM dalam menjalani pengobatan dan peran apoteker dalam pelayanan kefarmasian. Teks lengkap diambil kemudian dianalisa menjadi suatu tulisan yang mudah dipahami. Keterlibatan apoteker sebagai tenaga kesehatan di bidang kefarmasian dalam pengobatan pasien baik melalui pemberian konseling, pemberian informasi obat telah dilaporkan dalam beberapa publikasi dapat meningkatkan kepatuhan pasien. Apoteker sebagai tenaga kesehatan mempunyai peran besar dalam meningkatkan kualitas hidup pasien DM dengan terlibat aktif memberi intervensi pada terapi pasien DM yang dapat meningkatkan kepatuhan pasien menjalani pengobatannya.

Tingkat Pengetahuan, Sikap dan Rasionalitas Swamedikasi pada Masa Pandemi di Kota Gorontalo: Patient Knowledge, Attitude and Rationality of Self-Medicatio During Pandemic in Gorontalo City Vyani Kamba; Prisca Safriani Wicita; Insyira Fadliana Basri; Pratiwi Y Ishak
Jurnal Surya Medika (JSM) Vol. 8 No. 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3248

Changes in people's lifestyles tend to pay less attention to health, and the development of diseases in the community is also unavoidable, especially during the current Covid-19 pandemic. The development of this disease encourages people to look for alternative treatments that are cost-effective and therapeutically effective. In this regard, self-medication or self-medication is an alternative that is taken by the community. Community efforts to treat themselves are known as self-medication or self-medication. This study aims to determine the knowledge, attitudes, and rationality of self-medication in the community in Gorontalo City with a descriptive cross-sectional design method. The sample in this study were people who did self-medication and met the inclusion criteria, namely aged 18-60 years and willing to be respondents as many as 80. The level of knowledge related to self-medication of the people of Gorontalo City is 43.8% in the good category, self-medication attitude in a good category is 55%, and rationality is 65%. There is a significant relationship between respondents' knowledge level and self-medication attitude, with a p-value of 0.001.

Analysis of prescribing error incidence in out-patient prescription at community health center of Tilamuta Boalemo Regency Sukmawati Damiti; Syamsul Thalib; Vyani Kamba; Ysrafil Ysrafil; Hartati Hartati
Science Midwifery Vol 10 No 5 (2022): December: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i5.1060

Prescribing error can also be referred to as the error in medicine prescription that could endanger the patients. The absence of the right preparation dose can be potentially lead to misread by the transriber, as different medicines might have various preparation doses. The aimed of this study to identify the prescribing errors cases in patients in Tilamuta Community Health Center. The analysis on the prescription was conducted to identify the administrative and pharmaceutical completeness of the prescription. The data involved retrospective and prospective towards 300 prescriptions of out patients in Tilamuta Community Health Center by random sampling Method. The inclusion criteria employed out patient prescription for patients age 1-15 years old and 60 years old and above. The results showed that the highest percentage of prescribing error cases was in administrative error at 98,3% (295 prescription), while in the pharmaceutical error, the percentage arrived at 52,3% (157 prescription). This study was concluded that the highest prescribing error cases in Tilamuta community Health Center were the administrative error in the form of the absence of Occupational License at 96,7% or 293 prescriptions, while the pharmaceutical error at 37,3% or 112 prescriptions involved too low dosage.

Community Empowerment in Handling Non-Communicable Diseases Through Self-Medication and Use of Toga in Alale Village, Central Suwawa District, Bone Bolango Regency Hartati Hartati; Vyani Kamba; Insyira Fadliana Basri
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2023): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v6i1.2951

Self-medication is an effort in treatment that is carried out independently. Based on data from the Central Statistics Agency (BPS) for 2019 regarding health indicators for the Indonesian population, it is known that the data obtained on self-medication by Indonesian people from 2017 to 2019 for self-medication has increased from 71.46%. In Gorontalo Province, self-medication has been carried out by 76.60% of the population. Preliminary studies that have been carried out, many people in Alale Village, Suwawa Tengah District, buy drugs at the weekly market with the intention of self-medication, but there is still a lack of knowledge of proper self-medication and the use of natural plant materials as an alternative treatment. This community service aims to apply the results of research related to self-medication carried out by the community in increasing immunity during the current COVID-19 pandemic. The application is manifested in the form of CBIA (Community Based Interactive Method) in the form of counseling in the form of lectures, discussions, consultations, educational games as well as training assistance for cadres/community groups related to procedures for making traditional ingredients using plants in the surrounding environment. This is to increase knowledge and understand procedures for self-medication using conventional medicines and traditional medicines in the form of Family Medicinal Plants (TOGA) in dealing with non-communicable diseases, especially at the location of the community service implementation. Community service activities in Alale Village, Central Suwawa District, Bone Bolango Regency were carried out in 2 (two) stages, where stage I included a pretest prior to socialization, providing material and outreach about self-medication, providing drug information services, providing training on how to make simple traditional concoctions. Phase II includes monitoring of self-medication actions, mentoring and monitoring of making samples of Family Medicinal Plants (TOGA), and evaluation through posttest. The evaluation results obtained from the survey on community service activities show that the community's understanding has increased from 55.5% to 90%. This shows that community service activities have succeeded in increasing the understanding of the people of Alale Village.

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