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All Journal Biomedical Journal of Indonesia Health and Medical Journal Jurnal Ners Nusantara Hasana Journal Jurnal Pengabdian Masyarakat Bangsa AMMA : Jurnal Pengabdian Masyarakat
Roland Helmizar
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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EFEKTIVITAS DOSIS MODIFIKASI SORAFENIB TERHADAP KESINTASAN PASIEN KARSINOMA SEL HATI STADIUM LANJUT: SUATU LAPORAN KASUS BERBASIS BUKTI Roland Helmizar
Nusantara Hasana Journal Vol. 2 No. 9 (2023): Nusantara Hasana Journal, February 2023
Publisher : Yayasan Nusantara Hasana Berdikari

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Abstract

Background: Sorafenib is a multi-tyrosine kinase inhibitor that has been shown to improve survival in patients with advanced stage hepatocellular carcinoma (HCC). Based on the search to date, there are quite number of studies evaluating the effectiveness and safety of sorafenib dose modification on the survival of patients with advanced HCC; however, the previous studies have showed varying results. Method: A comprehensive literature search was conducted using three electronic databases: PubMed, Cochrane and EBSCohost. Meta-analyses, randomized controlled trials (RCTs), and cohort studies were selected based on inclusion and exclusion criteria. The quality of selected studies was evaluated using critical appraisal tools developed by the Center for Evidence-Based Medicine. Results: Three cohort studies were included in this report. In general, of the three studies that have been reviewed, show that reducing the dose of sorafenib from 800 mg/day to 400 mg/day does not affect the mean or median survival of patients with advanced HCC. Conclusion: Administration of sorafenib with initial dose of 400 mg/day or decreasing the dose from 800 mg/day to 400 mg/day has good tolerance, with not significantly difference on overall survival. But more evidence is required before they can be widely recommended in clinical practice for this indication.
VARICOSE ULCERS OF THE LOWER LEGS Dessy Abdullah; Khomeini Khomeini; Adetetivani Adetetivani; Nadia Purnama Dewi; Roland Helmizar
Jurnal Ners Vol. 7 No. 1 (2023): APRIL 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v7i1.12793

Abstract

Disorders that are often found in the lower extremities are vascular disorders. Varicose veins are very common, especially in women due to venous insufficiency due to poor blood circulation such as reflux and obstructive and can be inherited. The chronic phase of varicose veins can manifest as venous ulcers which is the development of wound below the knee. The lesions appear irregular in shape with clear boundaries, these ulcers can be prevented as early as possible by treating the trigger factor first before referring to the chronic direction. Physical examination is a medical process that must be undertaken when diagnosing a disease. The results are recorded in the medical record which is used to make a diagnosis and plan further treatment. Physical examination will be carried out systematically, starting from head to toe which is carried out in four ways, namely inspection, palpation, auscultation, and percussion. Varicose ulcers are a manifestation of chronic venous insufficiency. Patients with varicose ulcers have a history of varicose veins which, if treated, prevent the occurrence of varicose ulcers.
Pelayanan Kesehatan Bagi Masyarakat Dalam Rangka Kegiatan Pengabdian Kepada Masyarakat Rifkind Malik; Irma Primawati; Roland Helmizar; Annisa Lidra Maribeth; Yahdian Rasyadi; Relin Yesika
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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The economy and education are important aspects of the community but the other most important is health because health can affect economy and social productivity. Health can be imbalanced due to a poor lifestyle, diet, and lack of physical activity which will trigger various non-communicable diseases. The aim of this service community is to provide understanding on disease, good diet and daily physical activity. The method used is leaflets, posters, and short lectures. The result of this service is that many respondents are elderly. With this service we hope that in the future the elderly can begin to increase their physical activity, consume healthy food and routine health checks to increase the quality of life.
The Role of Probiotics as An Adjuvant Therapy for Sepsis Against Multidrug-Resistant Bacteria Ruhsyahadati Ajisman; Rinita Amelia; Rahma Triyana; Roland Helmizar; Sri Nani Jelmila; Nana Liana; Dian Puspita; Letvi Mona
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.170

Abstract

The role of probiotics on sepsis, particularly when induced by multidrug-resistant (MDR) bacteria, is mediated through complex biochemical pathways. Probiotics demonstrate a capacity to effectively combat infections and reduce mortality rates in sepsis cases. A significant contributor to this efficacy is attributed to the short-chain fatty acids (SCFAs) produced by these probiotics. SCFAs play a critical role in modulating the immune system, primarily by influencing the production of inflammatory cytokines, fortifying the integrity of intestinal epithelium, preventing cellular apoptosis, and maintaining the balance of gut microbiota. Moreover, probiotics are instrumental in counteracting the detrimental impacts of excessive antibiotic use, which is a major contributing factor to the emergence of MDR bacterial strains. The integration of probiotics with conventional therapeutic approaches offers a viable and potentially effective strategy in the management of sepsis caused by MDR bacteria, suggesting a promising direction for future clinical interventions.
Perbandingan Efektivitas Infusa Bunga Lawang (Illicium Verum) dan Infusa Daun Kunyit Terhadap Mortalitas Larva Aedes aegypti Instar III Rahma Triyana; Prima Adelin; Ruhsyahadati Ruhsyahadati; Roland Helmizar
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1490

Abstract

Pendahuluan: Nyamuk Aedes sp merupakan vektor penyebab penyakit Demam Berdarah (DBD) yang menginfeksi jutaan orang setiap tahunnya. Salah satu penanganan DBD yaitu membasmi vektor dengan cara pemberian insektisida alami pada larva nyamuk. Bunga Lawang (Illicium verum) dan daun kunyit berpotensi sebagai larvasida alami. Tujuan: Membandingkan efektivitas larvasida infusa bunga lawang dan daun kunyit terhadap mortalitas larva Aedes aegypti. Metode: Penelitian eksperimental menggunakan rancangan Post Test Only Control Group Design, populasi terjangkau penelitian ini adalah larva Aedes aegypti instar III dengan kebutuhan total sampel 560 larva, analisa data menggunakan uji one way anova. Hasil penelitian: Infusa bunga lawang efektif membunuh larva Aedes aegypti instar III pada konsentrasi 2% selama 24 jam dengan kematian sebanyak 8,75%,  konsentrasi 32% sebanyak 100% dalam waktu 24 jam sedangkan kematian larva pada konsentrasi infusa daun kunyit sebesar 30% dalam 24 jam sebanyak 2,5%,   pada konsentrasi 100% selama 24 jam kematian larva hanya mencapai 17,5%. Kesimpulan: Infusa bunga lawang lebih efektif sebagai larvasida dibandingkan infusa daun kunyit.
Skrining Status Gizi dan Edukasi Nutrisi untuk Kesehatan Reproduksi Remaja di Pesantren Putri Al-Fallah Kota Padang Sri Nani Jelmila; Ruhsyahadati Ajisman; Dita Hasni; Nana Liana; Roland Helmizar; Rahma Triyana
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 10 (2023): Desember
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i10.518

Abstract

Pemenuhan nutrisi di masa remaja sangat penting untuk mendukung pertumbuhan dan perkembangan yang akan berpengaruh terhadap kehidupan di masa yang akan datang. Kegiatan skrining status gizi dan edukasi nutrisi yang dilakukan di Pesantren Putri Al-Fallah, Kota Padang, Sumatera Barat, bertujuan untuk meningkatkan kesadaran remaja tentang pentingnya gizi seimbang, khususnya bagi kesehatan reproduksi. Metode yang digunakan meliputi skrining status gizi berdasarkan BMI dan LILA pada 50 santriwati Pondok Pesantren Al-Fallah, disertai edukasi nutrisi seimbang dan diskusi interaktif. Hasil skrining menunjukkan 56% santriwati memiliki status gizi normal, 22% kurus, 18% kelebihan berat badan, dan 4% obesitas. Rerata LILA 25,74 cm berada pada kisaran normal. Edukasi nutrisi memberikan pemahaman tentang hubungan antara status gizi dan kesehatan reproduksi. Kesimpulan kegiatan ini adalah status gizi berpengaruh terhadap kesehatan reproduksi, penting memenuhi nutrisi seimbang di pesantren.
PROFIL RESPIRATORY DISTRESS PADA BAYI BARU LAHIR DI NICU RSIA SITI HAWA PADANG TAHUN 2021 Febiane Eldrian; Nana Liana; Yudhi Aditia Permana; Lismawati; Roland Helmizar
Nusantara Hasana Journal Vol. 3 No. 12 (2024): Nusantara Hasana Journal, May 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i12.1121

Abstract

Respiratory distress (RD) poses a significant issue that can lead to fatal consequences such as respiratory failure, brain damage, and an increase in morbidity and mortality among newborns. The diagnosis of RD is based on the identification of one or more signs of increased respiratory activity, including tachypnea, nasal flaring, retractions in the intercostal area, and grunting. Objective: The purpose of this research is to provide an overview of the occurrence of RD among neonatus who were hospitalized in the Neonatal Intensive Care Unit (NICU) at RSIA Siti Hawa Padang in the year 2021. Methods: This study is an analytic descriptive research. The accessible population in this study consists of newborns who were treated at the NICU of RSIA Siti Hawa Padang during the year 2021. Results: From the study findings, it was observed that 94 newborns (approximately 5.2%) experienced RD. Among them, males were more predominant, accounting for 54 infants (57%). The majority of infants had a gestational age categorized as full-term, totaling 56 infants (59.6%). Furthermore, the birth weight for the majority of newborns was within the normal range, with 65 infants (69.1%) falling into this category. Conclusion: In conclusion, the majority of newborns at NICU RSIA Siti Hawa Padang in 2021 did not experience RD. Among those affected by RD, males were predominant, and most had a gestational age categorized as full-term, indicating a low risk of prematurity. The average birth weight also tended to be within the normal range for newborns born and cared for in NICU RSIA Siti Hawa Padang in 2021.
THE PROFILE OF COLORECTAL ADENOCARCINOMA AT DR. M. DJAMIL GENERAL HOSPITAL PADANG, INDONESIA Nana Liana; Roland Helmizar; Ruhsyahadati Ruhsyahadati; Sri Nani Jelmila; Rahma Triyana; Lismawati Lismawati
Nusantara Hasana Journal Vol. 4 No. 1 (2024): Nusantara Hasana Journal, Juny 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i1.1132

Abstract

Colorectal carcinoma is the third most common malignancy in the world. This malignancy originates from the epithelium of the colon and/or rectum, showing glandular or mucinous differentiation, where tumor cells have penetrated the muscularis mucosae layer. The study aims to report on epidemiological, clinical, and pathological characteristics of colorectal adenocarcinoma. Methods: We performed a retrospective descriptive study of 140 cases of colorectal adenocarcinoma in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia conducted from January 2022 to December 2022. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, site, and differentiation grade of the tumor. Results: Our study included 140 patients 80 males (57,1%) and 60 females (42.9%), with a median age range of 51-60 years. The tumors were found in the rectum 82 (58.6%), distal colon 37(26.4%), and proximal colon 21(15.0%). The differentiation grade was majority low grade 117 (83.6%). Conclusion: In conclusion, our result showed that colorectal adenocarcinoma is highest in the male population with an age range of 61-70 years. The most common site of adenocarcinoma is rectum. A low grade is the most differentiated grade. Keywords: colorectal adenocarcinoma, anatomical location, differentiation grade, profile
Co-Authors Adelin, Prima Adetetivani Adetetivani Annisa Lidra Maribeth Dessy Abdullah Dian Puspita Dita Hasni Febiane Eldrian Irma Primawati Khomeini Khomeini Letvi Mona Lismawati Lismawati Lismawati Malik, Rifkind Nadia Purnama Dewi Nana Liana Nana Liana Nana Liana Rahma Triyana Rahma Triyana Rahma Triyana Relin Yesika Rinita Amelia Ruhsyahadati Ajisman Ruhsyahadati Ajisman Ruhsyahadati Ruhsyahadati Sri Nani Jelmila Sri Nani Jelmila Sri Nani Jelmila Yahdian Rasyadi Yudhi Aditia Permana