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All Journal EKSAKTA: Journal of Sciences and Data Analysis KOVALEN: Jurnal Riset Kimia Jurnal Pendidikan Kimia (JPKim) Jurnal Kartika Kimia Jurnal Ilmiah Teknik Kimia
Micha Mahardika
Jurusan Kimia, Sekolah Tinggi Analis Kimia Cilegon
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Materials Science & Nanotechnology

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Journal : KOVALEN: Jurnal Riset Kimia

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Sintesis dan Karakterisasi Cangkang Kapsul Non Gelatin dari Rumput Laut (Eucheumma cottonii) dan Kaktus Koboi (Cereus peruvianus) untuk Sistem Penghantaran Obat: Synthesis and Characterization of Non Gelatinized Capsule Shells from Seaweed (Eucheumma cottonii) and Koboi Cactus (Cereus peruvianus) for Drug Delivery Systems Micha Mahardika; Ninik Triayu Susparini; Dany Dewaldo; Boima Situmeang; Fauzan Amin
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 1 (2023): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i1.16098

Abstract

Research on drug delivery systems continues to develop, including making the latest formulations on capsule shells as a medium for drug delivery. The effort that has been done was developing non-gelatine drug delivery materials made from the combination of seaweed and cactus. The main component in making gel on seaweed and cactus is the polysaccharide pectin. This study aims to make and determine the characterization of capsule shells from a combination of seaweed and cactus. Capsule shells are made from a combination of pectin extracts from seaweed and cactus with 5 different ratios of 0:4 (A), 1:3 (B), 2:2 (C), 3:1 (D), and 4:0 (E). The characterization involved weight uniformity test, disintegration time test, water swelling test, and dissolution test. Pectin from green seaweed and koboi cactus weighed 235 g and 75 g. The capsule shell weights based on Farmakope Indonesia sixth edition were 307.2, 311.6, 309.7, 304.6, and 308.7 mg. The capsule shell disintegration times, based on Farmakope Indonesia sixth edition, 2020, were 15,16, 14, 21, and 12 minutes, and the best result of the water swelling test was C capsule (2:2) of 666.7%. The results of the capsule shell dissolution test showed that the reduction of the capsule shells did not exceed 10% for 30 minutes according to the Farmakope Indonesia sixth edition. The capsule shells made from a combination of seaweed and cactus can be used as material in drug delivery systems. Non-gelatinized capsule shell which is expected to have anti-inflammatory activity.
Determination of Boron Concentration at Sausage Samples with Distillation of Ester Borane Method using Fluorescence Spectrophotometry Isna Lailatusholihah -; Aisyiah Restutiningsih Putri Utami; Micha Mahardika
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 3 (2023): December Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i3.16673

Abstract

The study of borax contamination in food samples was successfully analyzed. This study used sausage samples using the Fluorescence Spectrophotometry method. Sausage samples were from Daerah Istimewa Yogyakarta (DIY). This study used 4 sausage samples. The samples were given labels A, B, C, and D. The steps of the research were optimation of distillation time, optimation of catalyst, optimation of solvent, and then followed by analyzing the borax concentration on sausage samples. Based on this study, the optimum distillation time was 24 hours. On the other hand, the best catalysts and solvents were sulphuric acid and ethanol. The A and B samples contained borax contamination and the concentration was under 5 ppm. The C and D samples contained borax contamination and the concentration was above 5 ppm. The conclusions were that A and B samples were not given borax addition and C and D samples were given borax addition.
Co-Authors Agus Malik Ibrahim Aisyiah Restutiningsih Putri Utami Arda Ganda Risdiyono Boima Ramses Situmeang Boima Situmeang Boima Situmeang Dany Dewaldo Dianastya Yuniarti Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Ibrahim, Agus Malik Ika Agustia Umami Isna Lailatusholihah - Nada Morisca Ninik Triayu Susparini Siti Fatimah Umar Fauzi Uvi Dwiyana