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All Journal Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Jurnal Material Kedokteran Gigi JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Mandala of Health : A Scientific Journal Medical and Health Journal
Pratiwi Nur Widyaningsih
Jurusan Kedokteran Gigi Fakultas Kedokteran Unversitas Jenderal Soedirman
Humanities Dentistry Education Engineering Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : Mandala of Health : A Scientific Journal

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PENGARUH PEMBERIAN EKSTRAK CABAI RAWIT (Capsicum frustescens L.) TERHADAP GAMBARAN HISTOLOGI ORAL SQUAMOUS CELL CARCINOMA (STUDI IN VIVO) Pratiwi Nur Widyaningsih; Fitri Aniowati; Cantika Nadrotan Naim; Nova Dwi Anggraeni
Mandala Of Health Vol 13 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2021.13.2.8906

Abstract

Oral squamous cell carcinoma (OSCC) is a cancer of the oral cavity that is often associated with a low life expectancy. OSCC is a multifactorial disease, and its symptoms typically manifest as ulceration with exophytic and persistent edges. Cisplatin is a commonly used chemotherapeutic agent for treating OSCC, but it has high toxicity. Cayenne pepper (Capsicum frutescens L.) is a widely consumed plant that contains capsaicin, which can act as an anticancer agent by increasing p53 antibodies in the apoptosis process, thereby preventing cancer cell proliferation and degrading p53 gene mutations. This study aims to determine the effect of administering cayenne pepper extract (Capsicum frutescens L.) on the histological features of oral squamous cell carcinoma (in vivo study). Thirty male Wistar rats, aged 2 months and weighing 150-200 grams, were divided into five groups: negative control group (K-) without treatment, positive control group (K+) given DMBA exposure, treatment group with DMBA exposure and cisplatin induction, treatment group with DMBA exposure and induction of gel nanoparticles containing 1% capsaicin extract, and treatment group with DMBA exposure and induction of gel nanoparticles containing 3% capsaicin extract. The data were analyzed statistically using the One-Way ANOVA test followed by Post hoc LSD. The results showed significant differences (P<0.05) among all groups, except between KP1 and KP2, KP3 and K+, and KP1 and KP-. The administration of 1% capsaisen nanoparticle gel had a similar effect to cisplatin administration in terms of the number of mitoses and atypical cells under OSCC conditions.
Co-Authors Adhela Salsabila H Aldina G Aldina G Amalia Putri Hesantera Annisa Sukma Visanda Aprillya Yuniarni Arina Manasikana Eska Aris Aji Kurniawan Artha Arum P Asyyfa Devy Ayu Intan Nur A Cantika Nadrotan Naim Cantika Nadrotan Naim Dani Intan Prabawati Desi Rachmawati Dian Noviyanti Dicky Satria Ramadhan Basar Diva Sascha P Dwi Cinthya Financia Elisabeth Lorna Dona Erlina Sih Mahanani, Erlina Sih Fani Tuti Handayani Fitranto Arjadi Fitranto Arjadi Fitri Aniowati Fitri Aniowati Ghaida Humaira Susilo Putri Haidy Lailatun Nabila Hanifah Nur Syafa Haryani Devi R Helmi Hirawan Husni Rama Wijayanti Irfan Dwiandhono Irfan Dwiandhono Kunthi Isri Wulandari Licha Permata S Luqman Mahadika Cahyono Minda Anita Mutia Rochmawati Nabilah Annisa R Nadya Elsa Cahyaningrum Nadya Hanan S Nadya Loverina G.P Naila Robbaniyya Fithriyya Nisa Aqila Zulfa Nova Dwi Anggraeni Nova Dwi Anggraeni Nur Faizah Zahirah Nurul Hasanah Tanjung Raihan Zachary Ramadhan Raja Ronaldo Siregar Rakhmawati Rakhmawati Rakhmawati Rakhmawati Ridha Nur A Rinawati Satrio Riski Amalia Hidayah Ryana Budi Purnama Ryana Budi Purnama Ryana Budi Purnama Sabrina Aulia Nurul Hidayah Salma Kaltsum Kayana Salwa Az-Zahra Septina Nur Aini Setyah Sultrasari D Shabrina Nur Zahra S Shahnaz Dwi Permata Putri Tirta Wardana Tirta Wardana Tirta Wardana Tirta Wardhana Yunita K Yunita K