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All Journal Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Jurnal Material Kedokteran Gigi JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Mandala of Health : A Scientific Journal Medical and Health Journal
Pratiwi Nur Widyaningsih
Jurusan Kedokteran Gigi Fakultas Kedokteran Unversitas Jenderal Soedirman
Humanities Dentistry Education Engineering Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : Majalah Kedokteran Gigi Indonesia

 1 
Effectiveness of vitamin D3 supplementation with protein realimentation in osteoblast and osteoclast of the maxilla of breastfed malnourished rat infants Riski Amalia Hidayah; Aris Aji Kurniawan; Pratiwi Nur Widyaningsih; Rakhmawati Rakhmawati
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.78293

Abstract

Child malnutrition can happen because of lack of nutrition during pregnancy. Malnutrition can cause low birth weight in babies. This can cause jaw and alveolar bone abnormalities that can lead to malocclusion, periodontitis, and others. This condition can affect bone cells, such as osteoblast and osteoclast. Vitamin D3 supplementation accompanied by protein realimentation may promote optimum bone growth. This research aims to investigate the effect of protein realimentation and vitamin D3 on osteoblast and osteoclast of malnourished rat pups’ maxilla. In this research, the rat pups were divided into 5 groups: a positive control group (K+), a negative control group (K-), and 3 treatment groups (P1, P2, and P3). The subjects of this research were 10 male and 30 female Wistar rats. A condition of malnutrition was induced in the rat pups and they were given vitamin D3 supplementation with protein realimentation. Rat pups in each group were euthanized on the 22nd day to observe the number of osteoclast and osteoblast in the maxilla. The results showed that the number of osteoblasts between normal and malnourished rats was significantly different (p value < 0.05), but the number of osteoclasts between rats in the control and treatment groups was not significantly different. Administration of vitamin D3 may affect the number of osteoblasts and may not affect the number of osteoclasts on bone. The effective dose of vitamin D3 is 0.36 IU/day.
Co-Authors Adhela Salsabila H Aldina G Aldina G Amalia Putri Hesantera Annisa Sukma Visanda Aprillya Yuniarni Arina Manasikana Eska Aris Aji Kurniawan Artha Arum P Asyyfa Devy Ayu Intan Nur A Cantika Nadrotan Naim Cantika Nadrotan Naim Dani Intan Prabawati Desi Rachmawati Dian Noviyanti Dicky Satria Ramadhan Basar Diva Sascha P Dwi Cinthya Financia Elisabeth Lorna Dona Erlina Sih Mahanani, Erlina Sih Fani Tuti Handayani Fitranto Arjadi Fitranto Arjadi Fitri Aniowati Fitri Aniowati Ghaida Humaira Susilo Putri Haidy Lailatun Nabila Hanifah Nur Syafa Haryani Devi R Helmi Hirawan Husni Rama Wijayanti Irfan Dwiandhono Irfan Dwiandhono Kunthi Isri Wulandari Licha Permata S Luqman Mahadika Cahyono Minda Anita Mutia Rochmawati Nabilah Annisa R Nadya Elsa Cahyaningrum Nadya Hanan S Nadya Loverina G.P Naila Robbaniyya Fithriyya Nisa Aqila Zulfa Nova Dwi Anggraeni Nova Dwi Anggraeni Nur Faizah Zahirah Nurul Hasanah Tanjung Raihan Zachary Ramadhan Raja Ronaldo Siregar Rakhmawati Rakhmawati Rakhmawati Rakhmawati Ridha Nur A Rinawati Satrio Riski Amalia Hidayah Ryana Budi Purnama Ryana Budi Purnama Ryana Budi Purnama Sabrina Aulia Nurul Hidayah Salma Kaltsum Kayana Salwa Az-Zahra Septina Nur Aini Setyah Sultrasari D Shabrina Nur Zahra S Shahnaz Dwi Permata Putri Tirta Wardana Tirta Wardana Tirta Wardana Tirta Wardhana Yunita K Yunita K