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All Journal Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Jurnal Material Kedokteran Gigi JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Mandala of Health : A Scientific Journal Medical and Health Journal
Pratiwi Nur Widyaningsih
Jurusan Kedokteran Gigi Fakultas Kedokteran Unversitas Jenderal Soedirman
Humanities Dentistry Education Engineering Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : Dental Journal (Majalah Kedokteran Gigi)

 1 
Effect of various inductions of sleep deprivation stress on proinflammatory cytokine levels in gingival crevicular fluids of white male Wistar strain rats (Rattus novergicus) Pratiwi Nur Widyaningsih; Fitranto Arjadi; Erlina Sih Mahanani
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 1 (2020): March 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i1.p24-29

Abstract

Background: Stress that is induced by sleep deprivation can modulate the damage of periodontal tissue by elevating the levels of proinflammatory cytokines (i.e. IL-1β and TNF-α). The effects of sleep deprivation can be resolved with sleep recovery. Gingival crevicular fluid (GCF) is fluid in sulcular gingiva which acts as an oral biomarker for evaluating periodontal abnormalities. Purpose: The aim of this study was to determine the effect of various induction methods of sleep deprivation stress on cytokine levels in GCF of white male Wistar strain rats (Rattus novergicus). Methods: The study method was true experimental with a posttest-only control group design. Thirty male Wistar rats were randomly divided into five groups: paradoxical sleep deprivation (PSD), total sleep deprivation (TSD), partial sleep deprivation with sleep recovery for five days (PSD+SR), total sleep deprivation with sleep recovery for five days (TSD+SR) and a healthy control group. Data were analysed via one-way ANOVA to determine differences between groups. Result: The results showed the highest level of IL-1β and TNF-α was found in the PSD group. One-way ANOVA analysis showed significant differences (p<0,05) of IL-1β level between PSD and control groups, PSD and PSD+SR groups and PSD and TSD+SR groups; in contrast, the analysis of TNF-α levels showed significant differences (p<0,05) between PSD group to control group, PSD to PSD+SR group and TSD to TSD+SR group. Conclusions: There is an effect of various induction methods of sleep deprivation stress on proinflammatory cytokines (IL-1β and TNF-α).
Effectiveness of capsaicin nanoparticle gel of Capsicum frutescens L. on oral squamous cell carcinoma in Rattus norvegicus Fitri Aniowati; Cantika Nadrotan Naim; Nova Dwi Anggraeni; Pratiwi Nur Widyaningsih
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 4 (2021): December 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i4.p210-215

Abstract

Background: Oral squamous cell carcinoma (OSCC) is an oral cancer with a low life expectancy, less than five years after diagnosis. The drug therapy often used for OSCC patients is cisplatin, but it is considered to cause tumour persistence, drug resistance, and high toxicity. Therefore, it is important to test the development of alternative drugs from natural ingredients. One potential ingredient is green chilli pepper (Capsicum frutescens L.). It contains capsaicin that functions as an anticancer agent by suppressing BCa tumorigenesis so that proliferation is inhibited, as well as increasing and preventing p53 antibody mutations that play a role in cancer cell apoptosis. Purpose: This study aimed to compare effectiveness using capsaicin nanoparticle gel from green chilli pepper extract levels of 1% and 3.3% to reduce OSCC nodules. Methods: This study used 20 Rattus norvegicus that were randomly divided into five groups; C- (rat without treatment), C+ (rat induced to 7,12-Dimethylbenz(a)anthracene (DMBA)), E1 (DMBA exposed and given cisplatin, E2 (rat induced to DMBA and capsaicin extract nanoparticle gel with a concentration of 1%), and E3 (rat induced to DMBA and capsaicin extract nanoparticle gel with a concentration of 3.3%). The data were analysed statistically with the one-way ANOVA and least significance difference (LSD) test. Results: The comparison of mean nodule volume between C+ (5.834 ± 2.77 mm3) with E1 (1.75 ± 0.37 mm3), E2 (1.747 ± 0.36 mm3), and E3 (1.812 ± 0.11 mm3) had a significant difference (p = 0.00, p ≤ 0.05). Conclusion: Capsaicin nanoparticle gel with green chilli pepper extract at levels of 1% (E2) reduces OSCC nodules by more than gel with green chilli pepper extract at 3.3% (E3) concentration.
Co-Authors Adhela Salsabila H Aldina G Aldina G Amalia Putri Hesantera Annisa Sukma Visanda Aprillya Yuniarni Arina Manasikana Eska Aris Aji Kurniawan Artha Arum P Asyyfa Devy Ayu Intan Nur A Cantika Nadrotan Naim Cantika Nadrotan Naim Dani Intan Prabawati Desi Rachmawati Dian Noviyanti Dicky Satria Ramadhan Basar Diva Sascha P Dwi Cinthya Financia Elisabeth Lorna Dona Erlina Sih Mahanani, Erlina Sih Fani Tuti Handayani Fitranto Arjadi Fitranto Arjadi Fitri Aniowati Fitri Aniowati Ghaida Humaira Susilo Putri Haidy Lailatun Nabila Hanifah Nur Syafa Haryani Devi R Helmi Hirawan Husni Rama Wijayanti Irfan Dwiandhono Irfan Dwiandhono Kunthi Isri Wulandari Licha Permata S Luqman Mahadika Cahyono Minda Anita Mutia Rochmawati Nabilah Annisa R Nadya Elsa Cahyaningrum Nadya Hanan S Nadya Loverina G.P Naila Robbaniyya Fithriyya Nisa Aqila Zulfa Nova Dwi Anggraeni Nova Dwi Anggraeni Nur Faizah Zahirah Nurul Hasanah Tanjung Raihan Zachary Ramadhan Raja Ronaldo Siregar Rakhmawati Rakhmawati Rakhmawati Rakhmawati Ridha Nur A Rinawati Satrio Riski Amalia Hidayah Ryana Budi Purnama Ryana Budi Purnama Ryana Budi Purnama Sabrina Aulia Nurul Hidayah Salma Kaltsum Kayana Salwa Az-Zahra Septina Nur Aini Setyah Sultrasari D Shabrina Nur Zahra S Shahnaz Dwi Permata Putri Tirta Wardana Tirta Wardana Tirta Wardana Tirta Wardhana Yunita K Yunita K