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All Journal JURNAL PHARMASCIENCE INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Surya Medika Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Biomedika Cendekia Journal of Pharmacy Avicenna : Journal of Health Research SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Jurnal Farmasi Indonesian Journal of Pharmaceutical Education Bengawan :Jurnal Pengabdian Masyarakat Jurnal Kesehatan Farmasi
Mamik Ponco Rahayu
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : JURNAL PHARMASCIENCE

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Aktivitas Imunomodulator Fraksi n-Heksan dari Herba Sambiloto (Andrographis paniculata, (Burm.F) Nees ) Terhadap Mencit yang Diinduksi Vaksin Hepatitis B dengan Parameter Ig G Rahayu, Mamik Ponco
JURNAL PHARMASCIENCE Vol 2, No 1 (2015): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

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Abstract

Herba sambiloto (Andrographis paniculata Burm. Nees) mengandung banyak komponen senyawa kimia yang telah banyak di teliti dengan aktivitas sebagai hepatoprotektor dan salah satu kandungan zat aktifnya yaitu andrographolid. Penelitian ini bertujuan untuk mengetahui aktivitas dari A. paniculata yang mempunyai aktivitas sebagai imunomodulator dan hepatoprotektor terhadap mencit Balb/c yang telah diinduksi vaksin hepatitis B. Ekstraksi herba sambiloto menggunakan alat Soxhlet dengan pelarut yang berseri. Vaksin hepatitis B digunakan sebagai penginduksi mencit Balb/c. Sebagai tolok ukur imunostimulator adalah peningkatan jumlah antibodi IgG dengan ELISA tidak langsung. Hasil penelitian menunjukkan bahwa ekstrak n-heksan (2,7 mg/20 g BB mencit) menunjukkan peningkatan IgG tertinggi. Tiga fraksi teraktif dengan peningkatan jumlah IgG tertinggi sampai terendah yaitu F2 (0,569 mg/20 g BB mencit), F1(0,126 mg/20 g BB mencit), F4(0,094 mg/20 g BB mencit). Kata Kunci : Herba sambiloto (Andrographis paniculata Burm. Nees), Imunomodulator, Hepatoprotektor, Vaksin Hepatitis B Abstract Andrographis herbs (Andrographis paniculata Burm. Nees) has many active compounds , which shown hepatoprotector activity and one of its component is andrograpolide. Therefore, the aim of this study were to search the active compounds from A. paniculata as imunomodulator from the BALB/c mice was induced by hepatitis B vaccine. Andrographis herbs was extracted using Soxhlet by series of solvents. The isolation process was guided with in vivo imunommodulatory assay induced by hepatitis B vaccine in Balb/c mice. The imunostimulant activity was assesed through the increasing of IgG antibody. Hexane extract (2.7 mg /20 g mice) was increasing the titer of IgG higher than others. The fractions activity on increasing IgG titer from highest to lowest were F2 (0.569 mg/20 g mice), F1(0.126 mg/20 g mice), F4(0.094 mg/20 g mice). Keywords : Andrographis herbs (Andrographis paniculata Burm. Nees), Immunomodulator, Hepatoprotektor, hepatitis B vaccine
Co-Authors Aditya Prasetyo AROFATUL HIDAYAH Asaddah Dwi Mulyani Bunga Yuniasakti Desi Ratna Dyah Susilowati Eka Umayasari Endang Sri Rejeki Endang Sri Rejeki Endang Sri Rejeki Endang Sri Rejeki ESTU SYA’BANA Fransiska Leviana Ghani Nurfiana Fadma Sari Ghani Nurfiana Fadma Sari Ghani Nurfiana Fadma Sari Gunawan Pamudji Gunawan Pamudji Widodo Gunawan Pamudji Widodo Gunawan Pamudji Widodo Gunawan Pamudji Widodo Hilda Khairunnisa Ika Purwidyaningrum Ilham Kuncahyo, Ilham Ismi Rahmawati Kartinah Wiryosoendjoyo Kiki Puspitasary Lucia VIta Inandha Dewi Natasya Sava Agasta Nuraini Harmastuti Nuraini Harmastuti Nuraini Harmastuti Nuraini Harmastuti Purnamasari, Nur Aini Dewi Reslely Harjanti Rika Arfiana Safitri Rini Prastiwi Rosa Juwita Hesturini Siti Aisiyah Supriyadi Supriyadi Supriyadi Supriyadi Taufik Turahman Taufik Turahman Taufik Turahman Turahman, Taufik Wahyu Listiantoro Wayndy Chrisantoso Wulandari, Destik