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Journal of Medicine and Health

jmh
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Published by Universitas Kristen Maranatha

ISSN : 24425227 EISSN : - DOI : -

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.

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Articles 10 Documents

Search results for , issue "Vol. 1 No. 4 (2016)" : 10 Documents clear

The Effect of Ethanol Extract from Mangosteen Pericarps towards Parasitemia in Plasmodium berghei-Inoculated Mice Debora R. Marito; Susy Tjahjani; Khie Khiong
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Mangosteen pericarps contains fenolic antioxidant, such as xanthone that acts as free radical scavenging substances and preventing heme polymerization. In this research we evaluated the effect of ethanolic extract of mangosteen pericarps on the parasitemia in Plasmodium berghei-inoculated mice and compared its antimalarial activity with artemisinin monotherapy in reducing the parasitemia in Plasmodium berghei-inoculated mice. Deutschland Denken Yoken (DDY) Â mice were randomly divided into 5 groups and inoculated by Plasmodium berghei and given 0.1 mL aquadest (KN), 0.1 mg of artemisinin (KP), 2.5 mg (E1), 0.5 mg (E2) and 0,1 mg (E3) of ethanolic extract from mangosteen pericarps in 0.1 mL aquadest in 3 days. The parasitemia was observed on one day before the treatment, namely on the first day and on the day after the last treatment. We found a highly significant decrease highly significant decrease of the parasitemia in each treatment group compared to the Negative Control group (p < 0.01), and the decrease of parasitemia level in E1 group is similar to the artemisinin monotherapy group (p < 0.05).Â Â Keywords: ethanol extract of mangosteen pericarps, artemisinin, Plasmodium berghei, malaria

The Probiotic Effect towards Aspirin-induced Gastric Ulcer Healing Process as Measured by Mucous Thickness, Reepithelization, Gastric Glands Formation, and Angiogenesis in Animal Model Teresa Lucretia; Achadiyani Achadiyani; Sadeli Masria
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Gastric Ulcer is a common side effect of Non-Steroid Anti Inflammatory Drugs (NSAIDs) use such as Aspirin. Probiotic has many benefits especially for the alimentary system, but the effect on gastric ulcer have yet to be explored. In this research we aimed to find the probiotic effect on histological structure changes during aspirin induced gastric ulcer healing process in animal model. This was simple random sampling animal experimental laboratory, that divided Wistar Rats into two main groups. Both groups were induced with Aspirin (300mg/Kg BW) per oral, once daily for three consecutive days,and subsequently the test group were given probiotic suspension (cfu >108/gr) per oral, once daily, for 14 days. Each subgroups were sacrified serially at day 0, 3, 7, 14. The gaster were collected and processed for histology examination. Better histological structures were shown in the test group at day 14. MANOVA result showed probiotic's effect in enhancing histological structure changes during gastric ulcer healing process. Better histological structure changes were observed in mucus thickness; reepitelization, gastric glands formation, and angiogenesis process of the test group. As a conclusion, probiotic enhanced mucus thickness, reepitelization, glands remodelling, and angiogenesis in Aspirin induced gastric ulcer healing process in animal model.Â Key words: probiotic, gastric ulcer, histological structure, aspirin, healing process

The Preventive Effect of Fig Leavesâ€™s (Ficus carica L.) towards Colon Histopathological Feature and IL-6 Serum Level on Ulcerative Colitis Induced Mice Hartini Tiono
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Ulcerative colitis is a chronic inflammatory disease mainly affects sigmoid colon and rectum. The inflammation process will activate NF-ÎºB and leads to proinflamatory cytokine release such as Interleukin-6 (IL-6). Fig leaves contain a high level of flavonoid which can prevent NF-ÎºB activation, and further inhibits IL-6 secretion. This research aims to see the preventive effect of methanolic extract of fig leaves towards colon histopathological feature and IL-6 serum level on ulcerative colitis induced mice. Balb/C male mice were randomly assigned into 5 groups (n=5). The treatment groups were dextran suphate sodium (DSS) control group (group I), methanolic extract of Fig leaves dose 28 mg/ day control group (group II), and methanolic extract of Fig leaves dose 7 mg/ day (group III), 14 mg/ day (group IV), and 28 mg/ day (group V) for 14 days, which at the 8th till 14th day were given DSS to induce colitis. The results showed that both of colon mucosal damage and IL-6 serum level of group I were significantly different from other groups (p=0,029). InÂ conclusion, the methanolic extract of Fig leaves can improve colon mucous damage and decrease IL-6 serum level on ulcerative colitis-induced mice.Â Keywords: ulcerative colitis, fig leaves, colon mucousal damage, interleukin-6

The Effect of Chicken (Gallus gallus domesticus) Eggshellâ€™s Powder towards Wound Healing of Incision Wound on Male Swiss-Webster Mice Rahman A. Nugraha; Harijadi Pramono; Roro Wahyudianingsih
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Domestic chicken eggshells contain calcium and protein that could be useful in wound healing process. This research was conducted to determine whether domestic chicken eggshells can accelerate wound healing. Twenty one male Swiss-Webster miceÂ with 2 cm incision were divided into 3 groups. Negative control group were given Carboxymethyl cellulose 1% (CMC), positive control group were given feracrylum 1% (FER), and the eggshells group given domestic chicken eggshells powder (KT). Treatment and data mesurement was measured every day untilÂ the 7th day. On the 7thÂ day the average length of the wound were analyzed and the skin tissue is taken for microscopic examination. Data analyzed using one-way ANOVA followed by Post Hoc Least Significant Difference (LSD) with p=0,05. On macroscopic examination, there wereÂ highly significant differences between KT compared to CMC and highly significant differences between KT compared to FER. the average length of wound on the 7th day on KT 0,63 cm shorter than CMC 1,07 (p=0,000) and FER 0,81 cm (p=0,003). On microscopic examination, the degree of reepithelization on KT groups are severe, moderate for collagen density, fibroblasts density, subepithelial neutrophil density, degree of edema, and mild for angiogenesis. We conclude domestic chicken eggshells powder can accelerate wound healing.Â Key words: domestic chicken eggshells, incision wound, wound healing

Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Hidayat, Meilinah; Prahastuti, Sijani; Chikita, Vibiola; Safitri, Dewi; Rahmawati, Siti F.; Soemardji, Andreanus A.
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.Â This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretationâ€™s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJBÂ have a good effect on kidney function, didÂ not lead to changes in organ weight and at low doses did not cause disturbance ofÂ renal histopathology.Â Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidneyâ€™sÂ weight, kidneyâ€™s histopathology

Difficulty in Diagnosing Secondary Peripheral Chondrosarcoma: Radiology versus Anatomical Pathology Undang Ruhimat; Arie Hendarin
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Chondrosarcoma is a malignant tumor derived from bone cartilage. This tumor can be either primary or secondary. Secondary chondrosarcoma has some differences compared to the primary type i.e. the incidence is rarer, the younger age group, and many are low grade. The authors report a case of a 26-year-old man came to Hasan Sadikin Hospital with a chief complaint of a lump in the right thigh with mild pain since 5 months before consulation that is increasingly enlarging. After undergoing physical and radiological examinations, the patient was diagnosed with suspect chondrosarcoma in right thigh. Histopathologic examinations were performed 2 times, one of which used ultrasound guidance, giving a diagnosis of chondroma in right thigh. However the lesion was finally treated as chondrosarcoma. We suspected that the patient was more likely to suffer from secondary peripheral chondrosarcoma originating from malignant transformation of multiple osteochondromas. As widely known, it is almost impossible to differentiate between the low grade chondrosarcoma and chondroma with full certainty and this poses a classical problem in diagnostic medicine. Case described here was an example of the difficulty in distinguishing between these two diseases.Â Key words: secondary chondrosarcoma, peripheral chondrosarcoma, chondrosarcoma arising Â in osteochondroma

Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period Achmad R. Permadi; Hana Ratnawati; Teresa L. Wargasetia
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver.Â Key words: liver cancer, patients' characteristics, prevalenceÂ

Peer Reviewers of JMH Volume 1 Number 4 August 2016 Editorial Team
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

We would like to thank our peer reviewers for the precious contributions in providing clinical, scientific, and methodological expertise for JMH Volume 1 Number 4. We appreciate every thoughtful review of submitted manuscripts and for making important contributions to improve the scientific quality of articles published inÂ JMH. We listed the names in alphabetical order.Â Dr.Achadiyani,dr.,M.KesProf. Andreanus A. Soemardji, DEAdr.Andri Rezano,M.Kes,PhDdr. Cindra Paskaria,MKMdr.Cherry Azaria, M.KesDr. dr Diana Krisanti Jasaputra, M.KesDr. Irda Fidriannydr.Jonathan,Sp.Raddr. Limdawati,Sp.PDdr. Lusiana Darsono, M.Kes.Dr. dr. Oeij Anindita Adhika, M.Kes., PA(K)Prof.Dr. Ridad Agoes,MPHdr.Sunny Wangko,M.Si,PA(K)dr. Sylvia Soeng, M.Kes., PA(K)Dr. Wahyu Widowati, M.Si.Prof. dr. Wahyuni Lukita Atmadja, PhDÂ Â

The Effect of Jati Belanda Leaves (Guazuma ulmifolia Lamk.) Ethanol Extract on Microscopic Features of Atherosclerotic Animal Modelâ€™s Aorta Ryan J. Permana; Cherry Azaria; Rosnaeni Rosnaeni
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

â€œJati Belandaâ€ leaves (Guazuma ulmifolia Lamk.) possesses antidyslipidemia effect and in this study we assessed the effect of "Jati Belandaâ€ leaves ethanol extract in delaying the progression of atherosclerosis in aorta of the rats.Thirty atherosclerosis animal models were divided into six groups, which are three variant dose of â€œJati Belandaâ€ leaves (EEDJB 1-2-3), standard control (SC), negative control (NC) and Comparative control/ CC (simvastatin). The parameters measured were the wall thickness and lumen diameter (both in mm), and the amount of foam cells. The result for Kruskal Wallis test showed highly significant differences (p=0.00) of wall thickness Dose2 (0.056 mm) and Dose3 (0.056 mm) compared to NC (0.075 mm) and non-significant compared to CC (0.055 mm). ANOVA result for lumen diameter, p=0.773.Â ANOVA result for foam cells amount, p=0.000, Duncan test showed significantly different between EEDJB and NC group.It is concluded that â€œJati Belandaâ€ leaves ethanol extract reduced aortic wall thickness and the amount of foam cells, but did not increase lumen diameter on the athersclerotic aorta, and had an equal therapeutic effect compared to simvastatin in delaying the progression of atherosclerosis.Â Keywords: atherosclerosis, Jati Belanda, wall thickness, lumen diameter, foam cell

Height Estimation Based on Foot Length and Breadth in Children, Teenager, and Adult in Bandung City, Indonesia Sani Tanzilah; Noorman Herryadi; Andri A. Rusman
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Stature estimation is important for forensic identification, particularly in dismembered body. The equation used to estimate the height of a population is not necessarily applicable to other populations (population spesific). This study was conducted to generate the linear regression equation for stature estimation based on foot length and foot breadth on the population in the city of Bandung.Â This cross-sectional study is conducted to 908 people, consisting of three age groups (children, adolescents, adults), in the city of Bandung. Sampling was done by multistage sampling. The stature was measured using a stadiometer SECA 213, right foot length (RFL), right foot breadth ( RFB), left foot length (LFL), and left foot breadth (LFB) were measured using sliding calipers. Data were analyzed with SPSS version 21.0 for Windows. There is correlation between height with the RFL, RFB, LFL, and LFB. In contrast to the group of teenagers and adults, there is no boys-girls difference between height, RFL, RFB, LFL, and LFB. 21 regression equation for stature estimation based on the foot size. Stature estimation can be done using the linear regression equation based on the foot length and foot breadth, according to population, gender, and age of the subject being examined.Â Key words: height estimation, foot length, foot breadth

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