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Nurul Marfu'ah
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INDONESIA
Pharmasipha
Published by Universitas Darussalam Gontor
ISSN : 25810820     EISSN : 25809202     DOI : http://dx.doi.org/10.21111/pharmasipha.v5i1.5706
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Clinical Pharmacy; Biology Pharmacy; Natural Product Pharmacy; Drug, food and cosmetics analysis; Chemistry Pharmacy; and Islamization of Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 151 Documents
 1   2   3   4   5 
FORMULASI SEDIAAN SABUN CAIR EKSTRAK DAUN SIRIH HIJAU (Piper battle folium L.) DAN EKSTRAK BAWANG PUTIH (Allium sativum L.) SEBAGAI ANTIJAMUR Candida albicans Nurul Marfuah, Rohmah Madya Ayu Fitriana, Solikah Ana Estikomah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2632

Abstract

Islam is a religion that likes cleanliness, in case of body hygiene, clothing, and environment. One of the diseases that arise because it does not keep the body clean is white discharge. Piper bettle folium and Alium sativum are some of the natural ingredients that has the potential as an antifungal. This research aims to see the effect of antifungal Candida albicans extract of Piper bettle folium and Alium sativum after formulated as a liquid soap preparation. Liquid soaps are made by hot process methods with 3 formulations of combination of Piper bettle folium and Alium sativum extract with a ratio of 1) 25%: 75% 2) 50%: 50% 3) 75%: 25%. The evaluation of liquid soap include organoleptic examination, pH, high foam, moisture content, homogeneity, and antifungal power test against Candida albicans fungus. The results of the testing of liquid soap quality of green betel leaf extract and garlic have met the standards SNI (Indonesia’s National Standards) set for the manufacture of liquid soap.The results showed that liquid soap extract of green betel leaf and garlic have antifungal activity against Candida albicans. The result of formulation with the highest inhibition zone is formulation 3 and formulation with the lowest inhibition zone is the formulation 1. The test of this liquid soap activity is higher than fluconazole as the positive control and liquid soap of female area spread in the market.
Uji Toksisitas Sub Akut Infusa Daun Afrika(Vernonina amygdalina Del.) terhadap Histopatologi HatiMencit (Mus musculus) Galur Balb/C Wafa Aufia; Surya Amal; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (868.418 KB) | DOI: 10.21111/pharmasipha.v2i1.2130

Abstract

Allah created everything in this world has its benefits, including plants. African Bitter Leaves (Vernonia amygdalina Del.) is an herbal plant that has been experimented as anticancer, antioxidant, antidiabetic and analgesic with the presence of sesquiterpene lactones, saponins, alkaloids, tannins, polyphenol, monoterpene, Quinones, and Saponins. It is employed as an herbal medicine in infuse preparations. This study aims to investigate the safety standard and the effects of African Bitter Leaves infuse (Vernonia amygdalina Del.) againts the liver histopathology in mice strain BALB/c. This study is an experimental research using Completely Randomized Design (CRD). The practices are grouped into 4 different with 3 times repeatedly. The practices given, among others, control (Aquades 0.25 ml), P1 (doses of 10% b/v), P2 (doses of 20% b/v) and P3 (doses of 30% b/v). The observed object is the liver histopathology in mice strain BALB/c at the centrilobular area, midlobular and periportal, then analysis by one-way ANOVA followed by Tukey's Post hoc test. The results of this study stated that the doses of 10% b/v destroyed 24% cell degeneration and 9% cell necrosis, at a dose of 20% b/v destroyed 53% cell degeneration and 21% cell necrosis, and at doses of 30% b/v destroyed 55% cell degeneration and 40% cell necrosis. Based on ANOVA results it can be concluded that the African Bitter Leaves infuse influence liver histopathology in mice strains BALB/c. Destroyed of liver histology include degenerate cells at doses 10% b/v, 20% b/v, 30% b/v, and necrosis cell at doses 20% b/v and 30% b/v.
VARIASI JENIS HUMEKTAN PADA FORMULASI SEDIAAN MASKER Gel Peel Off EKSTRAK KULIT BUAH PISANG KEPOK (Musa paradisiaca pericarpium) Fitria Susilowati, Frida Ardina Pratiwi, Surya Amal,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2633

Abstract

Peel-off gel mask is one type of facial mask that has advantages in its use that is easily removed or released like an elastic membrane. This study aims to determine the kepok banana peelcan be formulated into a peel-off gel mask and the effect of adding properly humectant so that the product of peel-off gel mask is effective, stable, and safe in its use. The gel mask formulation is made with Polyvinyl Alcohol (PVA) base on 13% concentration. Evaluations of gel mask preparation include observation of changes in color, odor, texture, pH, dry time, dispersion and viscosity for 28 days at 40ºC storage temperature. The result data of peel-off gel mask preparation is analyzed by SPSS 16.0, with one way ANOVA. The results showed that humectant variation significantly affected organoleptic and drying time (p < 0.05) and humectant variation significantly did not affect pH, homogeneity, viscosity and dispersion (p > 0,05). The best formula of the facial mask extract from the Musa paradisiaca pericarpium peel extract in the form of peel off gel based on the organoleptic test and the dry time is the formula three, which is honey as humectant.
PROFIL KASUS TUBERKULOSIS RESISTEN OBAT DI RSUP Dr. SOERADJI TIRTONEGORO KLATEN PERIODE TAHUN 2012-2017 Surya Amal, Alifia Rimadhani Yuwono, Lija Oktya Artanti,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2629

Abstract

DR TB (Drug Resistance Tuberculosis) is the resistance of Micobacterium tuberculosis to anti-tuberculosis drugs. These study aims are to observe and identify the case profile of drug-resistant tuberculosis, which includes patient characteristics and resistance patterns of Micobacterium tuberculosis against ATD at dr. Soeradji Tirtonegoro Klaten. The type of research is descriptive-retrospective based on secondary data from laboratory data and medical records in the period 2012-2017. Sampling was done by total sampling technique. Obtained a total population of TB patients resistant was 15 patients with 10 patients who met the inclusion criteria expressed in the study sample. Characteristics of patients with drug-resistant tuberculosis, mostly found were female (60%) with an age range of 60-70 years (40%). Mostly origins of Klaten (central region) (90%). The educational status was high school graduated  (50%), not working (60%), comorbidities were bronchiectasis (15.4%), the nutritional status was underweight (60%), and suffering the pulmonary TB (70%). The result of this study showed the resistance patterns were primary resistance (50%) and secondary resistance (50%). Resistant to 1 ATD (60%), 2 ATD (30%), 3 ATD (10%). The highest resistance was monoresistant streptomycin (20%), ethambutol (20%), rifampicin (10%), Isoniazid(10%). Polyresistant found was the combination of ethambutol and streptomycin (30%). MDR TB incidence (10%) was the combination of rifampicin + ethambutol + streptomycin. The highest sensitivity was toward Isoniazid (22.5%). The highest resistance was toward ethambutol (15%) and streptomycin (15%).
FORMULASI TABLET EFFERVESCENT DAUN KERSEN (Muntingia calabura L.) DENGAN VARIASI KONSENTRASI EFFERVESCENT MIX Fitria Susilowati, Anggun Mahirotun Nur Sholikhah, Surya Amal,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2634

Abstract

Muntingia calabura L. is one of the type genus Muntingia which grows ever green and always has a lot of benefits but has not been used optimally. This study aims to utilize Muntingia calabura leaves take one form of pharmaceutical preparations namely effervescent tablet. Effervescent tablets are made using dry granulation of the metanol : water extract Muntingia calabura leaves. This study used variations of the concentration of effervescent mix to know the best concentration of the effervescent mix. Method to make it in relative humidity condition (RH) and appropriate temperature. Three of the formula that has made qualified evaluation of granules (time flow, angle of repose, and compresibility) and evaluation of  effervescent tablets (weight variation, hardness test, time dissolved, assay test water, and pH level test). The results of analysis, showed that the three all formulas meet the requirement of test characteristics of granule and effervescent tablet.  Based on the results of the research can be conclude that the  formula with a concentration of 60% (formulation 2) effervescent mix is the best formula. This is due to the formula for concentration of 60% effervescent mix is the concentration that is ideal concentration for effervescent tablets.
PENGARUH PUASA TERHADAP JUMLAH DAN MORFOLOGI SPERMATOZOA MENCIT (Mus musculus) Surya Amal, Nurul Marfuah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2630

Abstract

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this  study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.
UJI EFEKTIVITAS AIR PERASAN JERUK NIPIS (Citrus aurantifolia) DAN MADU RANDU DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Propionibacterium acnes Surya Amal, Nursalinda Kusumawati Solikah Ana Estikomah
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2631

Abstract

Acne is one of the diseases that occurs in the skin due to inflammation caused by bacteria. Propionibacterium acnes is a main bacterium causes acne that forms part of the normal flora of the skin and only live in normal-alkaline pH. Lime juice and honey are the most commonly used by the community to overcome the problem of acne to avoid the side effects of acne medications in the form of antibiotics. Lime juice and honey have a low pH value so that it can be used as an antibacterial by inhibiting bacterial growth, even killing bacterial cells that are not acid resistant. The purpose of this study was to determine the effectiveness of lime juice and Randu honey in inhibiting the growth of Propionibacterium acnes bacteria. The study was conducted using the disk diffusion method with 4 variations of concentration; 25% v/v, 50% v/v, 75% v/v and 100% v/v in 4 repetitions incubated for 24 hours at 37 °C. The results of this study are in the form of clear zones around the disc paper which are considered as an inhibitory zones. The formation of inhibitory zones shows the potential of lime juice and honey randu (Randu honey) against the Propionibacterium acnes bacteria as antibacterial. Lime juice and Randu honey each with a concentration of 25% v/v, 50% v/v, 75% v/v and 100% v/v has the potential as an antibacterial against Propionibacterium acnes bacteria. It is concluded that the optimal concentration of lime juice and Randu honey in inhibiting the growth of Propionibacterium acnes were at a concentration of 100% v/v with a inhibition zone of 9.11 mm for lime juice and 28.10 mm for honey randu (Randu honey).
UJI EFEKTIVITAS AIR PERASAN JERUK NIPIS (Citrus aurantifolia) DAN MADU RANDU DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Propionibacterium acnes Surya Amal, Nursalinda Kusumawati, Solikah Ana Estikomah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (20.332 KB) | DOI: 10.21111/pharmasipha.v2i2.2775

Abstract

Acne is one of the diseases that occurs in the skin due to inflammation caused by bacteria. Propionibacterium acnes is a main bacterium causes acne that forms part of the normal flora of the skin and only live in normal-alkaline pH. Lime juice and honey are the most commonly used by the community to overcome the problem of acne to avoid the side effects of acne medications in the form of antibiotics. Lime juice and honey have a low pH value so that it can be used as an antibacterial by inhibiting bacterial growth, even killing bacterial cells that are not acid resistant. The purpose of this study was to determine the effectiveness of lime juice and Randu honey in inhibiting the growth of Propionibacterium acnes bacteria. The study was conducted using the disk diffusion method with 4 variations of concentration; 25% v/v, 50% v/v, 75% v/v and 100% v/v in 4 repetitions incubated for 24 hours at 37 °C. The results of this study are in the form of clear zones around the disc paper which are considered as an inhibitory zones. The formation of inhibitory zones shows the potential of lime juice and honey randu (Randu honey) against the Propionibacterium acnes bacteria as antibacterial. Lime juice and Randu honey each with a concentration of 25% v/v, 50% v/v, 75% v/v and 100% v/v has the potential as an antibacterial against Propionibacterium acnes bacteria. It is concluded that the optimal concentration of lime juice and Randu honey in inhibiting the growth of Propionibacterium acnes were at a concentration of 100% v/v with a inhibition zone of 9.11 mm for lime juice and 28.10 mm for honey randu (Randu honey).
Variasi Jenis Humektan pada Formulasi Sediaan Masker Gel Peel Off Ekstrak Kulit Buah Pisang Kepok (Musa paradisiaca pericarpium) Frida Ardina Pratiwi; Surya Amal; Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.241 KB) | DOI: 10.21111/pharmasipha.v2i2.2778

Abstract

Peel-off gel mask is one type of facial mask that has advantages in its use that is easily removed or released like an elastic membrane. This study aims to determine the kepok banana peelcan be formulated into a peel-off gel mask and the effect of adding properly humectant so that the product of peel-off gel mask is effective, stable, and safe in its use. The gel mask formulation is made with Polyvinyl Alcohol (PVA) base on 13% concentration. Evaluations of gel mask preparation include observation of changes in color, odor, texture, pH, dry time, dispersion and viscosity for 28 days at 40ºC storage temperature. The result data of peel-off gel mask preparation is analyzed by SPSS 16.0, with one way ANOVA. The results showed that humectant variation significantly affected organoleptic and drying time (p < 0.05) and humectant variation significantly did not affect pH, homogeneity, viscosity and dispersion (p > 0,05). The best formula of the facial mask extract from the Musa paradisiaca pericarpium peel extract in the form of peel off gel based on the organoleptic test and the dry time is the formula three, which is honey as humectant.
FORMULASI SEDIAAN SABUN CAIR EKSTRAK DAUN SIRIH HIJAU (Piper battle folium L.) DAN EKSTRAK BAWANG PUTIH (Allium sativum L.) SEBAGAI ANTIJAMUR Candida albicans Nurul Marfu'ah, Rohmah Madya Ayu Fitriana, Solikah Ana Estikomah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (20.332 KB) | DOI: 10.21111/pharmasipha.v2i2.2777

Abstract

Islam is a religion that likes cleanliness, in case of body hygiene, clothing, and environment. One of the diseases that arise because it does not keep the body clean is white discharge. Piper bettle folium and Alium sativum are some of the natural ingredients that has the potential as an antifungal. This research aims to see the effect of antifungal Candida albicans extract of Piper bettle folium and Alium sativum after formulated as a liquid soap preparation. Liquid soaps are made by hot process methods with 3 formulations of combination of Piper bettle folium and Alium sativum extract with a ratio of 1) 25%: 75% 2) 50%: 50% 3) 75%: 25%. The evaluation of liquid soap include organoleptic examination, pH, high foam, moisture content, homogeneity, and antifungal power test against Candida albicans fungus. The results of the testing of liquid soap quality of green betel leaf extract and garlic have met the standards SNI (Indonesia’s National Standards) set for the manufacture of liquid soap.The results showed that liquid soap extract of green betel leaf and garlic have antifungal activity against Candida albicans. The result of formulation with the highest inhibition zone is formulation 3 and formulation with the lowest inhibition zone is the formulation 1. The test of this liquid soap activity is higher than fluconazole as the positive control and liquid soap of female area spread in the market.

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