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JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 80 Documents
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EKSTRAK ETIL ASETAT DAUN JAMBU BIJI MERAH (PSIDIUM GUAJAVA L.) SEBAGAI ANTIOKSIDAN SECARA IN VITRO Jihan Farah
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1503.237 KB) | DOI: 10.37090/jfl.v8i2.143

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak daun jambu biji (Psidium gujava L.). Ekstrak daun jambu biji (Psidium gujava L.) diekstraksi secara maserasi dengan pelarut etil asetat. Uji aktivitas antioksidan diuji dengan metode DPPH (2,2-Diphenyl-1-Picrylhidrazil) dengan kuersetin sebagai kontrol positif. Antioksidan ditentukan dengan menguji terhadap radikal bebas DPPH dengan mengukur absorbansi DPPH pada panjang gelombang 516 nm. Hasil aktivitas antioksidan menunjukkan bahwa nilai IC50 pada etil asetat adalah 37,39 ppm (sangat kuat). dan kuersetin sebesar 0,562 ppm (sangat kuat). Berdasarkan hasil analisis antioksidan diperoleh bahwa ekstrak etil asetat daun jambu biji memiliki aktivitas antioksidan sangat kuat. Kata kunci: Jambu biji, antioksidan, DPPH, kuersetin.
PENGARUH FRAKSI AIR BIJI KABAU (Archidendron buballinum (Jack.) I.C.Nielsen) TERHADAP KADAR GULA DARAH MENCIT JANTAN YANG DIINDUKSI ALOKSAN Triyandi Ramadhan
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.148

Abstract

Biji kabau (Archidendron buballinum (Jack.) I.C.Nielsen) secara empiris dimanfaatkan oleh masyarakat dibeberapa daerah di Indonesia sebagai obat tradisional seperti obat sakit perut dan penurun demam. Penelitian ini bertujuan untuk mengamati aktivitas fraksi air biji kabau (Archidendron buballinum (Jack.) I.C.Nielsen) terhadap kadar gula darah mencit jantan yang diinduksi aloksan. Biji kabau diekstraksi dengan cara maserasi menggunakan pelarut etanol 70 % dan difraksinasi menggunakan pelarut kloform dan n-heksan. Uji antidiabetes dilakukan terhadap mencit jantan yang diinduksi aloksan secara intraperitonial dengan dosis 3,36 mg/20 g BB selama 7 hari. Sebanyak 20 ekor mencit dikelompokkan menjadi 5 kelompok. Kelompok I sebagai kontrol negatif diberi aquadest dan kelompok II sebagai kontrol positif diberi Glibenklamid dosis 0,013 mg/20 g BB, Kelompok III, IV dan V sebagai kelompok perlakuan diberi fraksi dengan dosis 1,71 mg/20 g BB, 3,43 mg/20 g BB dan 6,86 mg/20 g BB, kelima kelompok diberi perlakuan secara oral sebanyak 1 kali sehari selama 4 hari. Penurunan kadar gula darah diukur dan diamati pada hari ke-8 dan-11, kemudian pada hari ke-12 dianalisis dengan metode Kruskal-Wallis Test. Hasil karakteristik simplisia terhadap kadar air 0,24 %, kadar abu 3,33 % dan kadar abu tidak larut asam 2,3 %. Uji fitokimia fraksi air biji kabau menunjukkan adanya senyawa saponin, alkaloid dan tanin. Hasil analisis menunjukkan kelompok I, II dan III berbeda nyata terhadap kontrol negatif dan berefek sama terhadap kontrol positif dalam menurunkan kadar gula darah mencit jantan diabetes yang diinduksi aloksan. Dari ketiga dosis tersebut dosis 6,86 mg/20 g BB menunjukkan penurunan yang paling baik, namun dosis 1,71 mg/20 g BB tidak berbeda nyata secara statistik terhadap glibenklamid, sedangkan dosis 3,43 mg/20 g BB dan dosis 6,86 mg/20 g BB berbeda nyata secara statistik terhadap glibenklamid. Berdasarkan hasil pengujian dapat disimpulkan bahwa fraksi air biji kabau berpengaruh terhadap penurunan kadar gula darah mencit jantan diabetes yang diinduksi aloksan. Kata kunci: Archidendron buballinum, Diabetes, Fraksi, Kabau
DECREASE IN FREE FATTY ACID CONTENT AND COLOR AT USED COOKING OIL WITH ACTIVATED CARBON OF REEDS (Imperata cylindrica L. Raeusch) Samsuar Samsuar
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.144

Abstract

Cooking oil is one of the foods that are needed by the community in daily life. The use of cooking oil continuously at high temperatures, produces cooking oil that is no longer feasible to use. Therefore, it’s necessary to purify used cooking oil so that it can be reused for non-foood purposes such as making soap or biodiesel fuel. This purification process is utilie the activated carbon of reeds (Imperata cylindrica L. Raeusch) as an adsorbent to reduce the levels of free fatty acids and colors in used cooking oil. Free fatty acid content test using acid base titration method and color change using Uv-Vis spectrofotometry method. This study aims to determine the optimum concentration of reeds activated carbon as an adsorbent in reducing the levels of free fatty acids and colors in used cooking oil, which consists of the concentration of reeds activated carbon which is a consentration of 2,5; 5; 7,5; 10; dan 12,5%. The results of variance analysis showed the optimum concentration of reeds activated carbon to reduce the levels of free fatty acids and colors absorbance in used cooking oil at a concentration of 7,5%. The percentage of decreasing levels of free fatty acids gorengan and pecel lele are 78.57% and 78.85%. Decrease in absorbance of gorengan color from 1,792% to 0,384% and the pecel lele color absorbance from 2,521 to 0,515. Keywords : Activated Carbon,Color, Free Fatty Acid, Reeds, and Used Cooking Oil.
THE RELATION BETWEEN KNOWLEDGE AND ATTITUDE TOWARD BEHAVIOR OF ANTIBIOTIC USAGE ON SOCIETY IN TALANG JAWA HEALTH CENTER OF SOUTH LAMPUNG AUGUST PERIOD 2019 Lilik Koernia Wahidah
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.149

Abstract

In developing countries, many antibiotics are used without a doctor's prescription, causing someone to use antibiotics incorrectly. Lack of knowledge about antibiotics is a major factor that triggers an increase in the rate of bacterial resistance to antibiotics. Knowledge and attitude become one of the social cognitive factors that influence antibiotic use behavior.This study aims to determine the relationship of knowladge and attitudes toward of antibiotic usage behavior in community of Talang jawa public health centre. The research is an observasional analytic research using cross sectional study design. sampling using non-probability sampling methode with type purposive sampling and instruments in the form of questionnaires. The data analysis was based univariate and bivariate analysis eqipped with chi square. The study was conducted on 100 community respondents in the Talang Jawa Health Center. The results showed respondents with good knowledge (25%), enough (27%) and less (48%). Respondents with positive attitudes (64%) and negative attitudes (35%). Respondents with positive behavior (43%) and negative behavior (57%). Chi square test result showed that there was a significant relationship between knowladge and antibiotic use behavior (p= 0,000) and there was a significant relationship between attitude and antibiotic use behavior (p= 0,000). This study has a meaningful relationship between and attitudes with antibiotic use behavior in Talang Jawa Health Center. Keywords: Antibiotics,Knowledge, Attitudes, Behavior
Ethanol Fraction of Corn Silk (Zea mays L.) to Decrease Uric Acid Levels in Male White Mice Laila Susanti
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.145

Abstract

Corn silk (Zea mayz L.) were empirically used by the community in some regions as traditional remedies for hypertension,kidney stones,diabetes mellitus, urinary tractinfections and gout. This study aimed to determine the effect of corn silk ethanol fraction on decrease uric acid levels in male white mice.corn silk were extracted by macerate used 70% ethanol for 4 days.Urin acid test was performed on male mice induced by beef liver for 7 days.25 mice were grouped into 5 groups, groups dose I, II and III weregiven a fraction at a dose of 27.5 mg / bwBB, 55 mg / bwBB and 110 mg / bwBB, control given Na.CMC 0.5% and as positive controls were given allopurinol dose of 13 mg / bwBB. The five groups were treated orally 1 time a day for 7 days. Decreased uric acid levels were measured and observed on days 7 using an acid (easy touch). The results of ANOVA statistical analysis showed that negative controls gave a significant difference with positive controls, dose I, II and III because the sig value was
FRAKSI AIR EKSTRAK DAUN WUNGU (Graptopphyllumpictum L.) SEBAGAI ANTIINFLAMASI TERHADAP TIKUS PUTIH JANTAN Ramadhan Triyandi; Akhmad Rokiban; Catur Setia Pratiwi MS
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.325

Abstract

Abstract This study aims to determine the anti-inflammatory effect of the water extract of Daun wungu (Graptophyllum pictum L.) extract which was observed from the decrease in the volume of edema of rat’s feet which was induced by 1 % carrageenan as much as 0,1 ml, was carried out in 25 male white rats divided into 5 groups. Negative controlwas given distilled water given 5 % Na CMC, diclofenac sodium as a positive control with a dose of 0,9 mg/200 g BB and water fraction of wungu leaf extract with a dose 1 (1,125 mg/kg bb), dose 2 (2,25 mg/kg bb) dan dose 3 (4,5 mg/kg bb). The measurement of edema volume is carried out every hour for six hours after induced carrageenan. From the results of testing the water fraction of wungu leaf extract, % inhibition showed that the dose group 3 (4,5 mg/kg bb) had anti-inflammatory activity that was comparable to the positive control group. Of all dosage variatons in this study the effective dose which has the highest percentage of edema is the dose 3 (4,5 mg/kg bb). Based on the results of statistical analysis, the percentage of edema inhibition data on the water fraction of wungu lear extract from all dose variations showed significant differences with negative controls. Keyword : Graptophyllum pictum L Anti-Inflamasi
UJI TOKSISITAS EKSTRAK ETANOL DAUN JAMBU BIJI AUSTRALIA (Psidium guajava L) DENGAN METODE BSLT (Brine Shrimp Lethality Test) Nofita Nofita; Ade Maria Ulfa; Miera Delima
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.326

Abstract

ABSTRACTGuava is one of the plants that can traditionally be used for the treatment of diseases. Many kinds of guava, one of which is the Australian guava has the characteristics of roots, stems, leaves, dark red fruit. This study aims to determine the toxicity of the ethanol extract of Australian guava leaves (Psidium guajava L) using the BSLT (Brine Shrimp Lethality Test) method and determine the chemical content of Australian guava leaves (Psidium guajava L). The extract was made by the ultrasonic method using 96% ethanol solvent. Toxicity tests were carried out using 48-hour-old Artemia salina Leach shrimp larvae. The toxic effect of the extract was identified by the percentage of shrimp larvae mortality using probit analysis (LC50). From the research results, phytochemical content includes tannins, flavonoids, alkaloids, terpenoids and saponins, and flavonoid compounds have the highest content compared to the others. Research shows that the ethanol extract of Australian guava leaves is of a moderate category (LC50 441,977 ppm).Keywords :Australia guava leaves, BSLT, Artemia salina L, Ultrasonic
UJI AKTIVITAS ANTIBAKTERI SPRAY BAU KAKI EKSTRAK KULIT JERUK NIPIS (Citrus aurantifolia) DENGAN VARIASI Gelling agent TERHADAP BAKTERI Bacillus subtilis Ade Maria Ulfa; Nofita Nofita; Bangun Saras Sandi
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.327

Abstract

ABSTRACT Sweat is produced by the apocrine glands, if infected by bacteria that play a role in the decay process will certainly produce foot odor. Some of the bacteria that cause, including Staphylococcus epidermis, Corynebacterium acne and there is one bacterium that causes pungent foot odor that is Bacillus subtilis. Bacillus subtilis enzyme leucine dehydrogenase produced the highest, resulting in isovaleric acid foot odor. Lime peel (Citrus aurantifolia) has the potential to be developed for the antibacterial active ingredient of foot odor contained in tannins, alkaloids and flavonoids. Spray can be effective for inhibition of feet due to water fleas or bacterial infections. The purpose of this research is to test the inhibitory zone of the preparation of foot odor spray ethanol extract of lime peel (Citrus aurantifolia) with variations of gelling agent. Bacterial inhibition zone testing on extracts of lime peel spray preparations using the disc method. This test was carried out on spray with extract concentration of 0% extract base carbopol, 0% extract base HPMC, 0.2% extract base carbopol, 0.2% extract base HPMC, 0.4% extract base carbopol, 0.4% extract base HPMC and positive control with an average inhibition zone of 9,13 mm, 9,12 mm, 11,86 mm, 11,29 mm, 13,17 mm, 12,30 mm, 8,13 mm against the bacterium Bacillus subtilis. Antibacterial test results were analyzed using ONE WAY ANOVA, the results of statistical analysis on the preparation of lime peel extract showed a significant inhibition zone difference of 0.000 (P = <0.05) between all concentrations. Lime peel extract spray is effective in inhibiting the bacterium Bacillus subtilis. Key words: Sweat of foot odor, Lime skin (Citrus aurantifolia), Spray, bacteri Bacillus subtilis
RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT INAP DI RS DAERAH Dr. A. DADI TJOKRODIPO BANDAR LAMPUNG Mashuri Yusuf; Subur Widodo; Diah Pitaloka
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.329

Abstract

Abstract Hypertension is one of non contagious diseases marked by the increase of systolic blood pressure > 140 mmHg and diastolic blood pressure > 90 mmHg. Hypertension becomes the main risk factor of other cardiovascular diseases. The number of hypertension occurance with or without companion increases every year. The purpose of this research is to know the rationality of anti - hypertension medicine usage on hypertension inpatients at RSUD of Dr. A. Dadi Tjokrodipo Bandar Lampung year of 2019 based on precise patient, precise indication, precise medicine, and precise dosage using reference standard of Guidelines JNCVIII. This research was a descriptive research with data collection of medical record retrospectively. The technique of sample selection used purposive sampling technique. The research results obtained from 82 samples based on the patients’ characteristics of genders such as 50 female patients (60,98%) and 42 male patients (39,02%). The patients’ characteristics based on age obtain mostly the patients are at age of 46-55 years old in the amount of 39 patients (47,6%). The patients’ characteristics based on the pattern of medicine usage obtain the most anti-hypertension used is amlodipin CCB class in the amount of 54 patients (45%). Rationality evaluation of anti-hypertension medicine usage obtains precise patient in the amount of 81 patients (99,8%), precise indication in the amount of 82 patients (100%), precise medicine in the amount of 61 patients (74,4%), and precise dosage in the amount of 82 patients (100%). The conclusion of this research is the usage of hypertension on the hypertension inpatients at Public Hospital of Dr. A. Dadi Tjokrodipo Bandar Lampung is already rational. Keywords: Anti-hypertension, Hypertension, Rationality of Medicine Usage
EVALUATION OF THE USE OF ANTIMALARIA MEDICINES IN HANURA HEALTH CENTRE PESAWARAN DISTRICT PERIOD JANUARY-DECEMBER IN 2018 Akhmad Rokiban; Ramadhan Triyandi; Karnila Sari
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.330

Abstract

Abstract Malaria is a public health problem in Indonesia, especially those living in isolated areas. This is published in Presidential Regulation No. 5/2010 concerning the National Medium Term Development Plan for malaria endemic areas, which are divided into high, medium and low endemic areas. High endemic if the API is greater than 50 out of 1,000 population in the provinces of Maluku, Papua, North Sumatra and East Nusa Tenggara. Moderate endemic if the API is 1 to less than 50 dari 1,000 population in the provinces of Aceh, Bangka Belitung, Jambi and West Nusa Tenggara. Low endemic if the API is 0-1 per 1,000 population in Kalimantan, Sulawesi, and parts of Java. This study aims to determine the evaluation of the use of antimalarial drugs with the characteristics of age, sex, and type of malaria plasmodium at the Hanura Public Health Centre based on the criteria of the right indication, the right drug, the right dose, the right interval of drug administration (4T). This research is a descriptive research with purposive sampling method. Collection of prescription data and medical records in January-December 2018. The results showed that in cases of Malaria based on age, the most common cases occurred in the age range of 56-65 years, amounting to 99.6%, based on sex experienced in men by 77.41%, based on body weight the most occurred at 41-59 kg at 45.16%, based on the type of plasmodium experienced plasmodium vivax mostly at 84.95%. Based on these data, it was concluded that the evaluation of the use of antimalarial drugs based on 4T criteria was 100% accurate indication, 100% correct drug, 72.04% correct dose, 98.92% correct interval of drug administration. Keywords: Malaria vivax, treatment, Puskesmas, 4T

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