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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

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Articles 7 Documents

Search results for , issue "Vol 16 No 1 (2019): Jurnal Farmasi Indonesia" : 7 Documents clear

Pengaruh Pemberian Minyak Hati Ikan Hiu Botol (Centrophorus atromarginatus) Terhadap Kolesterol Total Darah Tikus Hiperkolesterolemia Siti Fatimah; Muhammad Radifar; Tiara Madanti
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Research has been conducted to determine the effect of bottle shark liver oil (Centrophorus atromarginatus) on total cholesterol levels of the blood of hypercholesterolemic rats fed high fat feed. This research was carried out experimentally using 25 male rats, aged 2-3 months with a weight of 150-200 g, which were divided into 5 treatment groups randomly, ie group K1 (normal control) were given standard feed, group K2 (positive control) given high fat feed for 7 days, while group P1, P2, and P3 were given bottle shark liver oil in a sonde with a dose of 54 mg / 200 mg / day, 108 mg / 200 mg / day, 216 mg / 200 g BW / day. Each treatment consisted of 5 rats which were examined 3 times the total cholesterol level by the CHOD-PAP method. Data obtained from examinations were analyzed using one-way ANOVA p <0.005 followed by post hoct test. The results of the P1, P2, and P3 groups were significantly different from K1 (p = 0,000). Groups P1, P2, and P3 were significantly different from K2 (p = 0,000). Bottle shark liver oil with a dose of 54mg / 200g BB / day, 108mg / 200g BB / day, 216mg / 200g BB / day each can reduce cholesterol levels by 23% or 43.67 mg / dl, 30% or 55, 72 mg / dl, and 38% or 70.94 mg /

Formulasi Dan Uji Aktifitas Nanoemulsi Minyak Atsiri Daun Kemangi (Ocimum basilicum L.) Terhadap Salmonella typhi Monica Kristiani; Septiana Laksmi Ramayani; Klara Yunita; Meilina Saputri
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Essential oil of basil (Ocimum basilicum L.) leaves with a concentration of 2.5% can be estimated to have a diameter of inhibition zone with an average value of 8.67 ± 0.58 mm. Essential oils have volatile characteristics, and are easily oxidized so that they can affect their activities as antibacterial. To increase stability, essential oils of basil leaves need to be packaged in a special delivery system. Nanoemulsion is made by spontaneous emulsification method. Nanoemulsion was further tested for physical characteristics including droplet size, polydispersity index, zeta potential and nanoemulsion morphology using a Transmission Electron Microscope (TEM). The preparation was then tested for its activity against Salmonella thypi. The method used is the Kirby-Bauer disk diffusion method. From the test of physical characteristics obtained the average particle size of 10.6 nm, polydispersity index 0.03 and zeta potential -36.4. The results of the observation using TEM form the particles produced are spherical. Antibacterial test results were shown by the formation of inhibition zones of basil leaf essential oil (9.3 mm), positive control (6.6 mm), negative control (7.5 mm), nanoemulsion of basil leaf essential oil (8.3 mm), Virgin Coconut Oil (7 mm). Based on the results of statistical analysis it was found that there were no significant differences in treatment between groups.

Uji Stabilitas Spironolakton Terhadap Perubahan pH dengan Menggunakan Kromatografi Cair Kinerja Tinggi (KCKT) Nelly Suryani; Yardi Supandi; Ririn Astri Sabdowati
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Spironolactone is an aldosterone diuretic antagonist for hypertension. In practice spironolactone is sometimes combined with other drugs, and in unconscious patients the drug must use a feeding tube and be susceptible to instability. The object of this study was to see the effect of pH changes on spironolactone tablets which were crushed and suspended in water. The method of measuring spironolactone levels using High Performance Liquid Chromatography based on methods in the United State Pharmacopeia. Spironolactone suspension was made at pH 3, 5, 7, and 9 with sampling time in minutes 0, 15, 30, 45, and 60. The results showed that the level of spironolactone at pH 3 was ≤ 0%, pH 5 was 74% - 100%, at pH 7 it was in the range of 27% - 61%, and at pH 9 was 38% - 54%. This explains that percent of spironolactone at pH 3.7, and 9 at all sampling times did not match the minimum therapeutic level in the monograph. Only at pH 5 does the level of spironolactone still match the levels specified in the monograph. In this study it can be concluded that changes in pH can significantly reduce spironolactone levels in suspension.

Formulasi dan Uji Stabilitas Mekanik Hand and Body Lotion Sari Buah Tomat (Licopersicon esculentum Mill.) sebagai Antioksidan Anasthasia Pujiastuti; Monica Kristiani
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Antioxidants are contained in various types of fruits and vegetables. One of them is tomato (Lycopersicumesculentum Mill). Tomato has lycopene, flavonoids and vitamin C as antioxidants. Tomato can be made into fruit juice using the pressing method. Tomato extracts can be made in pharmaceuticals in the form of hand and body lotion (H&B lotion). The aim of this study is to recognize the physical characteristics and stability of mechanical H&B fruit extracts and to know the antioxidant activity.The free variable in this study is the concentration of fruit juice as active as 20%, 35%, and 50%. The binding variable from this study is the physical characteristics of the tomato juice extract, which is bioleptic, pH, viscosity, emulsion type, mechanical stability lotion and activity of antioxidant. The data obtained from the research results are compared with those in the literature whose relevance to statistical analysis between 95% trusts.The results of the research for physical characteristic show that concentrated fruit extract were not affected by the physical equipment of H&B lotion. The results for stability of mechanical H&Blotion fruit extracts test show that all the formulations had the phase separation. The test also shows that H&Blotion of Tomato had an activity of oxidation with IC50 value in formula I 5.697 μg/mL, formula II 6,530 μg/mL, and formula III 5,106 μg/mL.

Deteksi Molekuler Ekson 3 Gen Beta Globin pada Pasien Beta Talasemia Mayor di RSUD DR. Soeroto Ngawi menggunakan Metode Polymerase Chain Reaction- Single Strand Conformation Polimorfism Choirul Huda; Ana Indrayati; Elfahmi Elfahmi
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Talasemia is a genetic disease that causes globin chain synthesis disorder, a major component of the hemoglobin molecule. With the synthesis of unbalanced globin chains will decrease the production of red blood cells. This study aims to determine the presence of mutations in exon 2 gene beta globin thalassemia patients using PCR method, where 5 samples in DNA isolation and continued PCR amplification, the amplification result of electrophoresis region 2 beta globin gene Region II is the result of amplification of primary 4 and primer primer reverse 5 with a target of 350 bp, on PCR there is amplification or doubling of the desired DNA sequence based on the primary selection for the reaction, the PCR product of each of these regions which is subsequently performed by SSCP. PCR-SSCP could analysis the mutation in exon 3 beta globin genes. In the PCR-SSCP result, there was no mutation in region 4 exon 3 in five samples but probably there was mutation in another regions.

Optimasi Ekstraksi Fenolik Daun Legetan Warak (Adenostemma Lavenia (L.) Kuntze) Berbantu Gelombang Mikro Muhamad Najibufahmi; Muhammad Walid; Dewi Azizah
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Legetan warak (Adenostemma lavenia (L.) Kuntze) is a wild plant which has phenolic compounds and widely used as a natural antibacterial ingredient. The purpose of this study is to obtain the optimum condition of solvent concentration, microwave power and extraction time that appropriate with characteristic of phenolic compounds of leaf of Legetan warak. This experimental laboratory study developed a microwave asissted extraction method. The solvent concentrations which were tested are ethanol 50%, 60%, 70%, 80% and 90% in various extraction times, 1 minute, 3 minute, 5 minute and 9 minute. Meanwhile, the microwave powers which were used are 100 watt, 150 watt, 200 watt, 300 watt and 400 watt. The results showed that the optimum condition of microwave asissted extraction process of leaf of the Legetan warak used ethanol 80% as the solvent with the microwave power 200 watt and the extraction time 5 minute.

GAMBARAN PHARMACOVIGILANCE DAN HUBUNGAN FAKTOR YANG MEMPENGARUHI REAKSI OBAT YANG TIDAK DIINGINKAN (ROTD) PADA PASIEN PERESEPAN OBAT TUBERCULOSIS DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG Abdur Rosyid; Farroh bintang sabiti; Destiara Firstie Roshani
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Tuberculosis (TB) is still a growing global problem every year. TB disease is one of the 10 diseases that cause death worldwide (WHO, 2017). The design of this study is a qualitative observation with a prospective cross sectional design approach. The research was conducted at Sultan Agung Islamic Hospital, Semarang, from February to the desired sample size. From the subjects of tuberculosis patients with 92 patients. The number of patients experiencing ROTD with a dubious category was 56 patients (60.9%), in patients who experienced ROTD events with a possible category of 32 patients (34.8%), and in patients with ROTD with a category of probable 4 patients (4.3%). There is a significant relationship between age and ROTD incidence of a significance value of 0,000 and a significant relationship between sexes with ROTD incidence with a significance value of 0,000. Keyword : Therapy Tuberculosis, Adverse Drug Reactions

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