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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol 19, No 1 (2012)" : 13 Documents clear
KANKER OVARIUM DISGERMINOMA Hegaria Rahmawati; Darmawaty ER; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.390

Abstract

Ovarian cancer is a female reproductive organ malignancy and the second most common gynaecological type cancers. World Health Organisation classifies ovarian cancer based on their origin: superficial stroma-epithelium tumour, cord-stroma sex tumour, and germ cell tumour originated from germinal cells (yolk sac). Epithelium type of ovarian cancer is common, while the germinal type is rare and can be found in teenagers and young women aged 16-20 years old. A case of suspected dysgerminomas ovarian cancer grade IIIA was reported in a 12 years old girl. The diagnosis was established by tumour markers, USG/CT Scan of abdomen, surgery, and frozen section evaluations. The reviewer expected better survival prognosis after surgery and three cycles of chemotherapy combinations were executed. The evaluations of when serial tumour markers CA-125 were suggested during chemotherapy to detect any recurrences factors possibility of the related cancer.
MYCOBACTERIUM TUBERCULOSIS SISTEM IMUN ALAMIAH TERKAIT PENERIMANYA Jusak Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.395

Abstract

Various attemp to investigate immune response towards tuberculosis has been done in order to eradicate or to make vaccination against tuberculosis (TB) effectively. Recently it is known that innate immunity has an important role in immunity to TB despite adaptive immune response, because it was proved that adaptive immune response alone was not sufficient to eradicate this microorganism thoroughly and completely in patient’s body. After Toll-Like Receptor (TLR) was found in the end of the 20th century, many progresses has been obtained in understanding about the activation of this innate immune response. But it is still needed to understand more deeply in the immune response to M. tuberculosis to lead the development of therapy or vaccination that bring into more precise target. The activation through TLR by parts of Mycobacterium induce cytoplasm protein adaptor MyD88 (Myeloid Differentiation factor 88). MyD88 has the function to activate NF- κB and secrete pro-inflammatory cytokine such as TNF-α, IL-6, IL-12. Involvement of MyD88 is not solely dependent of TLR2 receptor and there are another pathways to induce protective function of immunocompetent cells in TB.
CRYPTOSPORIDIOSIS PARU DI HIV DAN AIDS JS. Hutagalung; R. Heru Prasetyo; Erwin Astha Triyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.386

Abstract

Although the prevalence of intestinal cryptosporidiosis in Indonesian HIV and AIDS patients were high, however the prevalence of pulmonary cryptosporidiosis have not been previously reported. The objective of this study was to know the determination of the pulmonary cryptosporidiosis prevalence in HIV and AIDS patients with pulmonary symptom that was treated in Dr. Soetomo General Hospital Surabaya. The detection of Cryptosporidium in sputum samples used modified versien acid fast stain of Ziehl Neelsen technique. In this study was found that three (3) of the eight (8) sputum samples (37.5%) of ≥55 years old and CD4≤70 HIV and AIDS patients were Cryptosporidium positive. Based on this study the HIV and AIDS patients with pulmonary symptoms should be suspect having the possibility of pulmonary cryptosporidiosis beside suffered tuberculosis.
MEAN PLATELET VOLUME DI STROK Besse Rosmiati; Sulina Y Wibawa; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.392

Abstract

Ischemic stroke is the cause of most cases which occur due to obstruction, this pathogenesis can be caused by the formation of thrombus in the cerebrum blood vessels. Platelet aggregation plays a role in the pathogenesis of thromboembolic cerebrovascular disease. Platelets size, measured as Mean Platelet Volume (MPV) is a marker of platelet function and is associated with the indicator of platelet activity. Several studies have found that there was an increased of MPV in acute ischemic stroke while the correlation with the severity and outcome of stroke was still controversial. The aim of study is to determine the MPV and their association with outcomes in acute ischemic stroke patients. A cohort study during May up to July 2010 was carried out, the researchers measured MPV and analyze their correlation with its outcome using modified Rankin scale score 10 days after the onset in 33 acute ischemic stroke patients. The mean of MPV for the first three days of the onset was 8.9 fl, on the 5th day was increased up to 9.4 but at the 10th day of onset the MPV remains the same value as the 5th day. The MPV of first three days and 5th day have a positive correlation, but insignificant with their outcome, with p values 0.158 and 0.06, respectively. From this study can be concluded that the increased of MPV on the fifth day onset did not have any significant correlation with the outcome of acute ischemic stroke illness.
BAKTERI AEROB DAN UJI KEPEKAAN ANTIMIKROBA Erviani Zuhriah; Nurhayana Sennang; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.385

Abstract

Nosocomial infection is an infection acquired in hospitals, which occur more frequently in poor and developing countries such as Indonesia, one percent of the related cases leads to death. The occurrence of nosocomial infection causes the lengthening of hospitalization and increased risk of disease transmission. According to Permenkes No. 1204/Menkes/SK/X/2004, the Emergency Room is one of the high-risk areas. The objectives of this research were to quantify the number of aerobic bacteria, to know the identification method of the pathogenic bacteria and to determine the antimicrobial sensitivity pattern in the emergency installation. A cross sectional study was performed by collecting air samples at eleven treatment rooms of the Emergency installation in dr. Wahidin Sudirohusodo Hospital Makassar by using Microbiology Air Sampler 100 (MAS 100). The bacterial identification and antimicrobial susceptibility tests (AST) were conducted at the Balai Besar Laboratorium Kesehatan Makassar (July to September 2009). The number of bacterial colonies were 288–6570 CFU/m3. Pathogenic bacteria identified in the study were Stomatococcus mucilaginous, Staphylococcus haemolyticus and Acinetobacter calcoaceticus, which were still sensitive to tetracycline and resistant to ceftazidim and kanamycin.The number of bacterial colonies exceeded the standard number established by the Decree of Indonesian Health Minister
KUNYIT PUTIH DAN BUAH MENGKUDU SEBAGAI HEPATOPROTEKTOR TERKAIT KARBON TETRAKLORIDA Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.389

Abstract

Herbal remedies are prescribed for the treatment of various liver diseases including for Hepatoprotector purpose. The present study was aimed to investigate and to know the hepatoprotective activity of Curcuma zedoaria extract combined with Morinda citrifolia extract against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP, and bilirubin. The results of serum analysis suggest that the use of Curcuma zedoaria extract combined with Morinda citrifolia extract exhibited significant protective effect related to the hepatic damage in CCl4 induced hepatotoxicity model and further evidence of its hepatoprotective activity
SISTEM INFORMASI DALAM PELAYANAN LABORATORIUM Benuriadi Benuriadi; Osman Sianipar; Guardian Yoki Sanjaya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.391

Abstract

The development of information technology has altered the conventional type of hospital laboratoryservices, from mostly paper based into computerized system. In term of quicker and easier, the output of computer-based information is useful for the improving healthcare services management. Laboratory services in the public hospitals mostly used paper-based laboratory data processing, leading to problems of accessibility, usability, clarity and completeness of the information. This study aims to to know how to develop a computer-based laboratory information system for a supporting laboratory management in the hospital toward in depth and systematic assessment among relevant stakeholders. The study was conducted at Praya Public Hospital Central District of Lombok, Nusa Tenggara Barat. Five stages of prototyping method were used for the system development, namely: planning, designing, systems testing, pilot implementation and system evaluation. Data and information obtained to observe in this study were in-depth interviews and questionnaire dissemination. During the planning phase, there were four groups of information should be identified, which should be required by the hospital management, laboratory staff, physicians and other health providers and information for the patient as well. Following the need assessment, a context diagram, Data Flow Diagram (DFD), structure of database, Entity Relationship Diagram (ERD), input and output designs were created. A prototype of computer-based laboratory information system was developed according to these systematic analysis and design. Evaluation on user’s perception demonstrated that the prototype could provide laboratory information easily, understandable, as well as complete and useful for all group of users. In conclusion, developing information system that involved potential users in hospital laboratory unit demonstrated its usefulness and this encouraged that public hospitals should adopt computerized laboratory information systems.
VOLUME PLASMA DAN FAKTOR VIII DALAM KRIOPRESIPITAT Dian Widyaningrum; Purwanto AP; Julia Setyati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.396

Abstract

Blood product such as cryoprecipitate required a quality control. This includes development, implementation and the standard operating procedures use of each step of the process in the production of cryoprecipitated substance to ensure that the produced product contains a minimum of 80 international units (IU) of factor VIII. Cryoprecipitation is prepared from fresh frozen plasma that thawed and centrifuge by immediate spinning the excess plasma which then removed and leaving approximately 40ml which deposit 10 mL cryoprecipitate. One unit of cryoprecipitate contain 70–80 IU/unit factor VIII, ≥100 mg/unit von Willebrand factor, fibrinogen 5–10 mg/dL. The levels of factor VIII and von Willebrand factor (VWF) lowered in individuals with blood group O compared to individuals groups with non-O blood. This research is aimed to investigate whether plasma volume are correlated with the levels of factor VIII in cryoprecipitation. In this study purposive sampling is done in which 25 bags of cryoprecipitate materials (was storage for 11 months) from all types of blood group which were taken from storage, thawed, weighed and the plasma volume measured. Factor VIII was measured by coagulometric method. The researcher used Spearman correlation test to analyze the product, with significance degree p<0.05 and confidence interval 95%. In this study it is found plasma volume which was not related to the factor VIII level in cryoprecipitattion substance (p=0.585). Mean plasma volume of the cryoprecipitated matter was 56 mL, mean factor VIII was 83.3UI. Highest factor VIII level was 160.6 UI of cryoprecipitated blood group AB and lowest factor VIII level was 21.3 UI of cryoprecipitated blood group A.
KEPEKAAN ANTIMIKROBA KULTUR DARAH DI SEPSIS NEONATAL Tajuddin Noor; Nurhayana Sennang; Benny Rusli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.388

Abstract

Sepsis was one of the morbidity and mortality causes in neonatal. The diagnosis and treatment requires the bacterial identification and selection of sensitive antimicrobials. The aim of this study was to know the bacterial pattern and antimicrobial sensitivity of blood culture in the suspected neonatal sepsis patients who were treated at NICU in Dr.Wahidin Sudirohusodo Hospital Makassar. A retrospective study was conducted with secondary data from the culture and antimicrobial susceptibility test between the period of June 2010−July 2011. In this present study was found that from the total 91 blood culture isolates, bacteria Gram-negative group was 85.7% and Grampositive was 14.3% and the isolate encountered in order of frequency were Alkali genes faecalis 50.5%, Klebsiella pneumonia 25.3%, and Staphylococcus epidermidis 9.9%. In the Gram-negatives group, the isolate often encountered were Alkali genes faecalis 59.0%, Klebsiella pneumonia 29.4% and Enterobacter spp 6.4% while in the Gram-positive group were found Staphylococcus epidermidis 69.2% and Staphylococcus saprophytic 23.1%. The more sensitive antimicrobal that belong to Gram-negative group were Meropenem 94.4%, Levofloxacin 92.1%, and Ceftazidime 77.0% while the more resistant were Ampicillin 94.6%, Gentamycin 89.1% and Cefuroxime 82.7%. The more sensitive antimicrobal that belong to Gram-positive group were Vancomycin and Chloramphenicol 91.7% and Novobiosin 76.9% while the more resistant were Gentamycin and Ceftriaxone 100.0% and Amoxicillin 91.7%. Based on this study it can be concluded that Gram-negative aerobe bacteria was more common than the Gram-positive one. Meropenem, Levofloxacin and Ceftazidime antimicrobal were high sensitive to Gram-negative while Vancomycin, Chloramphenicol, and Novobiocin were high sensitive to Gram-positive. The resistance of Ampicillin and Gentamycin were found in both bacterially groups of sepsis suspected neonatal patients in NICU
DISTRIBUSI SEROTIPE DENGUE DI SURABAYA TAHUN 2012 Aryati, Aryati; Wardhani, Puspa; Yohan, Benediktus; Aksono H, Eduardus Bimo; Sasmono, R. Tedjo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.387

Abstract

The characteristics of epidemic dengue often presented as periods of hyperendemicity or as the co-circulation of multiple dengue serotypes. Surabaya is an endemic city for Dengue virus (DENV) transmission. Previous study of DENV distribution in 2008-2009 revealed the predominance of DENV-2. DENV serotypes distribution is known to be dynamic and serotype predominance may change through time. This study aims to determine and follow the circulation of DENV serotype in Surabaya in 2012. We recruited 154 denguesuspected patients attending Dr. Soetomo Hospital during February until August 2012. Dengue cases were confirmed by IgG and IgM serology tests and NS1 antigen detection. Serologically-positive samples were further analyzed using two-steps reverse transcriptasepolymerase chain reaction (RT-PCR) and viruses were isolated by propagation in C6/36 mosquito cell line. Seventy one cases (46.1%) were detected as DENV positive infection. Serotyping revealed that 61 samples have monotypic infection with one of all four of DENV serotypes and 10 samples have mix-infections. Overall serotyping result observed the predominance of DENV-1 (60.56%). Our result revealed the circulation of all four serotypes of DENV and the presence of serotype exchange in Surabaya in 2012. Annual change of predominant serotype and the presence of multiple infections may play an important role in the transmission of dengue infection. This information is valuable to dengue surveillance in the region. Therefore, the laboratory diagnosis of DENV serotype should be routinely performed to follow the dynamic of dengue disease

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