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Indonesian Journal of Pharmacology and Therapy

JPT
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Published by Universitas Gadjah Mada

ISSN : - EISSN : 2745455X DOI : https://doi.org/10.22146/ijpther.4468

Core Subject : Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Neuroscience

Indonesian Journal of Pharmacology and Therapy (IJPTher ) is a scientific journal which managed by Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada. IJPTher is an open-access, and double-blind peer-reviewed journal published twice Issues a year. IJPTher aims to communicate high-quality articles in the fields of pharmacology. IJPTher publishes original articles, review articles, case reports and book reviews in the fields of pharmacology including basic pharmacology, clinical pharmacology, pharmacotherapy, pharmacoepidemiology, pharmacogenetics, pharmacogenomics, pharmacoeconomic, toxicology and toxicogenomics.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 58 Documents

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Molecular docking study of Indonesian phytochemicals as inhibitor of 6-HB formation by binding to HR1 subunit of SARSCOV-2 S2 protein Jeffry Julianus; Phebe Hendra; Maywan Hariono; Nico Frederick; Satrio Ardyantoro; Mustofa; Jumina
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Coronavirus disease 2019 (COVID-19) is still as global pandemic. No officially drugs to treat COVID-19 are available until now. Increasing number of patients and deaths trigger new antiCOVID-19 discovery efforts. In this study, we have conducted in silico screening employing molecular docking for Indonesian phytochemicals. Docking process was performed by employing AutoDock4 software on crystal structure 6VSB. Based on molecular docking results, several compounds had potential as antiCOVID-19 drugs, such as β-carotene, veramiline, ecliptalbine, betulinic acid, and lupeol. β-carotene was the most potential compound to treat COVID-19.

Clinical trial and therapeutical progress of COVID-19 treated with remdesivir: A review Anna Maria Manullang; Monia Agni Wiyatami; Muhammad Azril Hardiman Mahulauw
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that first reported in Wuhan City, China. Most confirmed cases of COVID-19 develop mild, moderate, severe to critical symptoms. One of the therapies given and of concern is remdesivir. Remdesivir is an antiviral with a broad spectrum that has activity against various types of viruses including Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV. The aim of this review was to evaluate the clinical trial and the therapeutical progress of remdesivir in the treatment of COVID-19 patients. Databases used for this review were Google Scholar, JAMA, PubMed and Science Direct library. The inclusion criteria were covering any literature using remdesivir in clinical studies and COVID-19 therapy published from December 2019 to October 2020. Overall no pattern of laboratory abnormalities and clinically significant changes in vital signs or ECG shifts was observed in patients receiving remdesivir. The decision to use remdesivir in COVID-19 treatment should consider its potential benefits and risks.

Current pharmacological treatments for COVID-19: A narrative review Sudi Indra Jaya; Yacobus Christian Prasetyo
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

The coronavirus disease 2019 (COVID-19) pandemic has lasted more than one year. The number of daily cases and the number of deaths is still changing dynamically. As of this writing, specific drugs for COVID-19 are not yet available. This review aims to describe the key clinical evidence in pharmacological treatments for COVID-19. The article search process was carried out on the PubMed database with a combination of keywords ((“COVID-19”) OR (“SARS-CoV-2”)) AND ((“treatment”) OR (“therapy”)). In this article, there were six drugs reviewed that is corticosteroids, remdesivir, lopinavir-ritonavir, hydroxychloroquine, ivermectin, and interleukin-6 (IL-6) receptor blockers. Hydroxychloroquine, lopinavir-ritonavir, remdesivir, and ivermectin were not recommended for COVID-19 treatments regardless of disease severity and duration of symptoms. Therefore, they were excluded from the list of drugs for the treatment of COVID-19 by World Health Organization (WHO) stated strong recommendations in favor of two drugs, namely systemic corticosteroids and IL-6 receptor blockers namely tocilizumab or sarilumab. Both of them are recommended for the treatment of patients with severe and critical covid-19 so they are included in the list of COVID-19 therapeutic drugs by WHO.

The effects of probiotics in strengthening immunity against the COVID-19 infection . Yuliana
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

A severe form of COVID-19 infection causes increasing in inflammatory cytokines, namely cytokine storm. Therefore, immunity of patients with COVID-19 should be strengthened in order against this infection. This paper aimed to evaluate the possible effects of probiotics in strengthening immunity patients with COVID-19. It is a narrative literature review papers based on PubMed, Science Direct, and Google Scholar databases. The keywords were COVID-19 pandemic, immunity, probiotics. Inclusion criteria were review and research paper. Exclusion criteria were not peer-reviewed journals and unavailable full text. Probiotics are beneficial live microbes, and they are well known for their immune and nutritional properties. The potential roles of probiotics to increase the immune system against the COVID-19 infection need to be studied in further clinical research. Most of the research related to the roles of lactic acid bacteria (LAB) are found in fermented food as probiotics. Many LAB are found in Indonesian fermented foods. Lactic acid bacteria roles are essential in the production of fermented foods. They also give some health benefits such as improving antioxidant activity, increasing antimicrobial agents production, and as probiotics.

Cytotoxic activity of hantap (Sterculia oblongata Mast) leaves extract against breast cancer cells line (MCF7/HER2): the effect on the expression of HER2 mRNA and the apoptosis Sitti Ayu Suhartina Yahya; Mustofa; Woro Rukmi Pratiwi; Adika Suwarman
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Hantap leaves (Sterculia oblongata Mast) has been used traditionally to treat breast cancer in Palu, Central Sulawesi. However, its use is just based on empirical evidences rather than scientific evidences. The study aimed to investigate the cytotoxic activity of hantap leaves extracts against breast cancer cells line. The effect of this extract on the HER2 expression and the apoptosis was also evaluated. The hantap (S. oblongata Mast) leaves extracts were prepared by consecutive maceration method using n-hexane, methanol and water, respectively. The cytotoxic activity against MCF7/HER2 breast cancer cells line was evaluated using the MTT assay with doxorubicin as a positive control. The HER2 mRNA expression was examined using RT-PCR and the apoptosis after 24 h incubation was examined using a fluorescence microscope after AO-PI (acridine orange-propidium iodide) staining. Among three extracts tested, the methanolic extract exhibited the most cytotoxic against MCF7/HER2 cells with an IC50 of 91.25 μg/mL. Therefore, the methanolic extract was subjected to further study. The methanolic extract at concentration of 1/2IC50; 1IC50 and 2IC50 μM induced 6.8; 26.3 and 25.3% apoptosis of the MFC7/HER2 cell lines, respectively. The methanolic extract at concentration of 1/2IC50; 1IC50 and 2IC50 μM inhibited HER2 mRNA expression to be 0.6; 0.25 and 0.33 compared to control cells. In conclusion, the methanolic extract of hantap leaves (S. oblongata Mast) has cytotoxic activity against MCF7/HER2 breast cancer cell lines by induce cells apoptosis and inhibit HER2 mRNA expression. Further study, will be conducted to isolate active constituents as anticancer.

Efficacy and safety of antidiabetics agents in gestational diabetes mellitus (GDM): a literature review Rommy; Aldia Dwi Karinaningrum; Berliana Luthfiananda; Laduna Aniq; Lydia Sherly Evelina; Rifani Fauzi
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

One of the most common metabolic diseases during pregnancy period is gestational diabetes mellitus (GDM). It is associated with several perinatal complications, especially in those who have risk factors such as obesity, polycystic ovary syndrome, and a family history of type 2 diabetes mellitus (DM). Some research has shown that physical exercise and medical nutrition treatment can give beneficial effects to control glycemic and body weight for GDM affected women. Furthermore, pharmacological agents such as insulin and a specific oral antidiabetic can be prescribed safely during pregnancy to decrease maternal glucose blood. Therapy of GDM is needed to control blood for the wellness of the patient during and after the pregnancy. The main treatment therapy for GDM is lifestyle modification, which includes medical nutritional therapy and daily physical exercise. In the special case of disorder glucose level, drug therapy will be given to the patient. Insulin is the chosen drug because it is safe and does not cross the placenta. It is the gold standard pharmacological agent for GDM treatment. However, it still has some disadvantages such as the difficulties of how to use it, how many doses must be given, and the price that tends to be expensive. Consequently, the alternative drug may have to substitute it. Insulin can be substituted by metformin and glyburide (glibenclamide) in the form of oral antidiabetic. They are equal in terms of efficacy and safety compare to insulin as a treatment for GDM. Besides, they are also cheaper, and easy to use.

Effectiveness of nifedipine compared with other antihypertension on hypertension during pregnancy Juwita Permata Sari; Aisyah Nur Sapriati; Cyndi Yulanda Putri; Satya Prima Kustanto; Umu Kholifah
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Hypertension is the most common complication of pregnancy. It is a major cause of maternal, fetal, and neonatal morbidity and mortality. In this article, the effectiveness of nifedipine compared with other antihypertensives in pregnant women with hypertension was reviewed. The randomized control trial (RCT) of nifedipine and other antihypertension in pregnancy without complications published from 2016 to 2021 in Google Scholar, Cochrane and PubMed were gathered. It was reported that antihypertensives administration to pregnant women with hypertension was very meaningful both for the mother herself and for the fetus or baby. Furthermore, nifedipine has better effectiveness in lowering blood pressure compared to other antihypertensives such as IV labetalol, oral labetalol, IV hydralazine, methyldopa in the treatment of preeclampsia, severe preeclampsia, severe pre-eclampsia/eclampsia, chronic hypertension, hypertension emergency, and severe hypertension.

Conventional synthetic disease-modifying antirheumatic drugs (csDMARD) in rheumatoid arthritis during pregnancy and lactation: a review Yulianasari Pulungan; Andy Kurniawan Saputra; Desy Purnamasari; Nunuk Wijayanti; Laras Ratna Sari
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Rheumatoid arthritis (RA) is an autoimmune and prominent inflammatory disorder that can affect wide of variety body systems, mainly joints. In Indonesia, the prevalence of RA is about 7.3% and mostly are women. The majority of women with RA are at childbearing and can be worsening throughout pregnancy and lactation. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are the most common used medicine in RA for pregnancy and lactation. This scoping review was conducted using publications obtained from PubMed, Embase, The Cochrane Library, POPLINE, and Google Scholar concerning the safety of csDMARD in rheumatoid arthritis during pregnancy and lactation from 2011 to 2021. Among csDMARDs reviewed, sulfasalazine, hydroxychloroquine, chloroquine, and cyclosporine are relatively safe for pregnant and lactating women. However, they should be used in caution by considering the risk and benefit as well as under clinical supervision.

Liposome as carrier therapy for Alzheimer’s disease Andi Sri Dewi Anggraeni; Emilia Vivi Arsita; Adika Suwarman; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Alzheimer's disease (AD) is the most common type of dementia. Approximately 50 million people suffer from Alzheimer's and it is expected to increase more than 100 million by 2050. According to the Diagnostic and Statistical Manual of Mental Disorders V (DSM-V), the diagnosis of AD has an onset of memory impairment and cognitive decline. Effective treatment of AD is a major challenge in the field of pharmacy and science due to the restriction from blood brain barrier (BBB). This causes poor access to pills or oral administration. Liposome as a part of nanoparticle showed to be a potential AD treatment because of its biocompatibility, flexibility, and capability to carry various therapeutic molecules across the BBB and into brain cells. Several types of liposomes provide varied therapy effect. Some factors which determine liposomes effectiveness are its structure, mechanism of action; formed; and delivery, and its preparation method. This article reviewed liposomes characteristics which has potency as carrier therapy for AD.

Pharmacogenomic of asthma in children Nova Satriyani; Hartati Mahmuda; Septiayu D. Hartienah
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Asthma is an inflammatory airway disease characterized by bronchial hyper-responsiveness, reversible airflow limitation, and respiratory symptoms. Asthma affects 300 million people in developed countries. More than 10% of asthma complaints in children occur at school age. Asthma therapy in children using pharmacological agents is still the main choice until now. However, the response of pediatric patients to asthma treatment varies. In addition to age, organ function, and drug interactions, genetic factors are often associated with drug response variability. This variability can occur due to single nucleotide polymorphisms (SNP) in protein-coding genes that play a role in bioavailability and drug response. Understanding of pharmacogenomics as the basis of individualized medicine aims to avoid adverse drug reactions and maximize drug effectiveness. The existence of genetic variation allows the drug response between individuals to be different. Pharmacogenomics provides important information in individual-based medicine so that it can predict the existence of a population that can respond well to certain drugs and a population that has a higher risk of adverse drug reactions. Implementation of individual treatment can optimize treatment in patients because the dose of treatment and therapeutic options have been adjusted based on individual genetic characteristics.

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Contact Name Nurhadiyahya

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Editorial Address Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta 55281

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Contact Name
Nurhadiyahya

Contact Email
nurhadiyahya@ugm.ac.id

Phone
+6289672800034

Journal Mail Official
ijpther@ugm.ac.id

Editorial Address
Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta 55281

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA