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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 111 Documents
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EFEK AFRODISIAKA EKSTRAK KULIT BATANG SANREGO (Lunasia amara Blanco) TERHADAP MENCIT JANTAN (Mus musculus) Hamsidar Hasan; Juliyanty Akuba; Beatrice Nathania Wilkinson
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11375

Abstract

Sanrego (Lunasia amara Blanco) merupakan salah satu jenis tanaman yang digunakan sebagai afrodisiaka oleh masyarakat Sulawesi Selatan. Penelitian ini bertujuan untuk mengetahui efek afrodisiaka dari ekstrak n-heksan, kloroform, etil asetat dan metanol kulit batang Sanrego (Lunasia amara Blanco) serta mengetahui dosis yang diperlukan untuk memberikan efek afrodisiaka pada mencit jantan. Metode ekstraksi yang digunakan adalah maserasi bertingkat menggunakan pelarut dengan kepolaran meningkat yaitu n-heksan, kloroform, etil asetat dan metanol. Dilakukan pengamatan pada mencit serta menghitung jumlah Introduksi (Pendekatan), Climbing(Penunggangan) dan Coitus(Senggama) selama 5 hari. Data dianalisis menggunakan SPSS One way Anova. Hasil penelitian skrining fitokimia menunjukkan adanya senyawa steroid yang terkandung dalam ekstrak N-Heksan, kloroform, etil asetat dan metanol, terdapat senyawa flavonoid dalam ekstrak kloroform, etil asetat, metanol. Terdapat senyawa tanin dalam ekstrak etil asetat dan metanol dan terdapat senyawa alkaloid dalam ekstrak metanol. Ekstrak yang memberikan efek afrodisiaka yaitu ekstrak metanol dan dosis yang diperlukan untuk memberikan efek afrodisiaka pada mencit yaitu 35mg/kgBB dan 70 mg/kgBB. Hasil analisis data One way Anova (p kurang dari 0,01) dengan tingkat kepercayaan 99%
POLA PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI Teti Sutriyati Tutoli; Nur Rasdiana; faradilasandi tahala
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11083

Abstract

Hypertension is an increase in systolic blood pressure of at least 140 mmHg or a diastolic pressure of at least 90 mmHg. This study aimed to determine the use of drugs in outpatient hypertension patients at the PuskesmasTilamuta. The design employed in this study wa a non-analytic descriptive analysis method by calculating the percentage of the amount of 3T, namely the right indication, the right drug, and the right dose in a non-experimental manner with a cross sectional design (cross-sectional) and retrospective data collection. Data were collected through mecical records of outpatient hypertension patiens in the area from January 2020 to Desember 2020. Then, the research subjects who met the inclusion criteria were 92 patients. The results showed that the calcium channel bloker (Amlodipine) class antihypertensives were mostly used at 53%. Based on the results of the study, it was found that some patients were not given anthypertensive drugs with inappropriate  drug percentage (23%), incorrect indications (23%), inapporiate dosage (23%). Therefore, it is concluded that some patients do not comply with the accuracy of the indication, drugs, and the accuracy of dosage, so it is necessary to monitor the administration of antihypertensive drugs.
Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah Umi Latifiana; Deny Budi Legowo; erna fitriany; Andri Priyoherianto; Muhammad Novianto Ainul Huri
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.10638

Abstract

Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.
UJI TOKSISITAS EKSTRAK DAUN KENCUR (Kaempferia galanga L) DENGAN METODE BRINE SHRIMP LETHALY TEST (BSLT) sy pakaya, mahdalena; hasan, hamsidar; umar, linsih
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022 (in press)
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11283

Abstract

One of the plants that has potential as medicine is kencur(Kaemoferia galanga L). Many studies have asserted that the rhizome of kencur is useful for bacterial infections, cough medicine, dysentery, cold, and stomachache. Therefore, the research aimed to identify the toxic effect of kencur leaf extract on artemia salina larvae applying the BSLT (Brine shrimp lethaly test) method. It employed three concentration treatments using 10 artemia salina larvae that died after 48 hours. Futher, it was calculated by LC50with probit analysis. The result of probit analysis revealed that the value of LC50from n-hexane extract was 96,13µg/mL, ethyl acetate extract was 98,22 µg/mL and methanol extract of kencur leaf was 156,06 µg/mL. The LC50 value of the extract was in the active category, with the value of LC50was lower than 1000 ppm.
Formulasi, Karakterisasi, Dan Evaluasi Drops Liquid Self Nano-Emulsifying Drug Delivery System (SNEDDS) Astaxanthin Robert Tungadi; Nur Ain Thomas; Wanda Gita Van Gobel
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11400

Abstract

SNEDDS are isotropic mixtures of oil, surfactant, and cosurfactant that produce spontaneous nanoemulsions once they make contact with gastric juices in order to increase the solubility of active pharmaceutical ingredients. One of the active pharmaceutical ingredients with low solubility is Astaxanthin. This research aims at formulating, characterizing, and evaluating SNEDDS containing Astaxanthin in the form of droplets. This research is a laboratory experiment. SNEDDS containing Astaxanthin droplets are made in 3 formulas using the ratio of surfactants and co-surfactants which are characterized to produce F1, F2, and F3 transmittance values of 91%, 90%, and 95%, respectively. Furthermore, the F1 particle size value of 183.75 nm obtains a PDI value of 0.272, the F2 particle sizevalue of 195.25 nm obtains a PDI value of 0.341, and the F3 particle size value of 105.75 nm obtains a PDI value of 0.392. This signifies that the absorption efficiency of F1, F2, and F3 are 94.62%, 94.35%, and 95.57%, respectively. The evaluation reveals the insignificant changes in the emulsion viscosities of SNEDDS containing Astaxanthin liquid drop after having received a stability test for 28 days using Paired T. Test data analysis (p0.05). The research findings show that the F3 of 72% surfactant and 18% co-surfactant concentrations are the best formula in producing SNEDDS. It concludes thar the higher the surfactant concentration produced, the greater the ability to, oil droplets resulting in obtaining small partidles and high absorption efficiency.
PROFIL TERAPI OBAT PADA PASIEN ISPA DI PUSKESMAS KOTA TENGAH TAHUN 2019 Sutriyati Tuloli, Teti; Rasdiana, Nur; Bakululu, Lesmiyati
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022 (in press)
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.10980

Abstract

Acute respiratory infections (ARI) is an infectioan that commonly occurs in human of any age however, children and infants are the most vulnerable and most exposed to ARI. The study aims to identify the utilization of drug therapy in patients with ARI, specifically those infants and children patients at Puskesmas Kota Tengah in 2019. it employs a descriptive research design where the obtained data are secondary data that are collected retrospectively besides, the data used in this study are medical prescription documents, including the patient’s name, age, type of drug used, and drug use patternThe finding discloses that drug therapy administered to 116 infants and children patients who suffer from ARI at Puskesmas Kota Tengah in 2019 reveals that the most widely used therapy is the expectorant group(Gliceryl Guaicolate) as many as 61 (62,2%), Antihistamine group (Chlorpheniramine maleate) with a frequency of 75 times (64,1%), Vitamin B Complex with a frequency of 69 times (55,2%), Antibiotik group (Amoxicillin) with a frequency 47 times (41%), Analgesic and Antipyretic group (Paracetamol) is the most widely prescribed with a prescription frequency of 65 times (55,7%). In addition, the parameter of right drug obtains frequency of 22 times with 94 times with the percentage of (81,0%) and incorrect drug obtains a frequncy of 22 times with a percentage of (19,0%), the parameter of right dose for 83 times with a percentage of (71,6%), and incorrect dose for 33 times with a percentage of (28,4%). At the same time, the right drug use pattern parameter involves the right dose, and the right drug obtains a frequency of  94 times with a percentage 0f 8 (81,0%) while the incorrect drug use pattern obtains a frequency 0f 22 times with a percentage 0f (19,0%)
FORMULASI SEDIAAN SAMPO ANTIKETOMBE EKSTRAK ETANOL SELEDRI (Apium graveous L.) DAN UJI AKTIVITASNYA TERHADAP JAMUR Malassezia furfur Ain Thomas, Nur; Adam Mustapa, Mohamad; Abto, Nazarudin
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022 (in press)
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.10772

Abstract

Ketombe merupakan salah satu masalah kulit kepala yang disebabkan oleh jamur Malassezia furfur. Tanaman seledri (Apium graveolus L.) merupakan salah satu tanaman yang diketahui memiliki aktivitas sebagai antijamur. Tujuan dari penelitian ini adalah untuk memformulasikan ekstrak etanol seledri (Apium graveolus L.) menjadi sampo dan uji aktivitas antijamur terhadap jamur penyebab ketombe yaitu Malassezia furfur. Penelitian diawali dengan proses ekstraksi seledri dengan metode maserasi, kemudian dilakukan optimasi basis sampo dengan variasi konsentrasi cocamidopropyl betain 4%, 6%, 8% dan 10% sebagai surfaktan sekunder dan peningkat viskositas. Basis optimum yang terpilih yaitu basis dengan cocamidopropyl betain 10% kemudian diformulasikan dengan ekstrak etanol seledri (Apium graveolus L.) dengan konsentrasi 0,5%, 1% dan 2,5%. Setelah itu dilakukan evaluasi yang meliputi uji organoleptis, uji pH, uji viskositas, uji ketinggian busa, uji ketahanan busa seta uji kesukaan (hedonic). Pengujian aktivitas antijamur dilakukan dengan metode difusi cakram untuk melihat zona hambat. Hasil uji menunjukan sampo antiketombe ekstrak etanol seledri (Apium graveolus L.) menghasilkan diameter rata-rata area hambat masing-masing untuk F4a sebesar 4,3 mm, F4b 4,6 mm, dan F4c sebesar 6,6 mm. Hasil uji aktivitas antijamur diolah dengan metode One Way Anova dengan taraf kepercayaan 99% (α=0,01). Hasil penelitian menunjukkan bahwa sampo dengan ekstrak etanol seledri 0,5%, 1% dan 2,5% aktif dalam menghambat jamur Malassezia furfur dengan hasil analisis One Way Anova menunjukkan p=0,000 (sigα).
Formulasi Dan Evaluasi Mikroemulsi Gel Minyak Chamomile Serta Uji Aktivitas Antioksidan Sri Sulistiana; Sasanti Tarini Darijanto
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11231

Abstract

Chamomile essential oil contains various kinds of chemical compounds that was useful for skin. One of them was capable to provided good protection against free radicals. The aim of this study was to develop topical antioxidant formulation in the form of microemulsion gel that had good stability and safe for skin. This study began with determined oil concentration to incorporated into microemulsion formula.Furthermore, optimization of the surfactant, cosurfactant and carrier oil concentration to produced clear microemulsion. The evaluation of microemulsion include of organoleptic, pH, viscosity, oil droplet size, oil droplet morphology, freeze thaw test and antioxidant activity test for 28 days. Then microemulsion was incorporated into gel base to form microemulsion gel. The evaluation of microemulsion gel include of organoleptic, pH, viscosity, freeze thaw test, antioxidant activity test and irritation test. Optimization results of surfactant, cosurfactant and carrier oil which can produced clear microemulsion were Tween 80 30%, PEG 400 10% and Virgin Coconut Oil (VCO) 5%. Microemulsion had good stability indicated by pH range of 5 during stored at room temperature and climatic chamber with 75% Relative Humidity, viscosity range from 11 to 12 cps, stable droplets size below 50 nm, and no phase separation observed in centrifugation and freeze thaw test. Chamomile oil microemulsion IC50value of 84.223 ppm. Chamomile oil microemulsion gel was also had good stability indicated by pH value was remain in neutral pH range (7), viscosity from 903 to 967 cps, and no phase separation in freeze thaw test. microemulsion gel IC50 value of 80,785 ppm. Chamomile oil microemulsion gel was not irritated the skin with primary irritation index 0. The results in this study showed that Chamomile oil microemulsion gel had good stability, had antioxidant activity and does not irritated.
Analisis Manajemen Pengelolaan Logistik Sediaan Farmasi dan Perbekalan Kesehatan di Instalasi Farmasi Widy Susanti Abdulkadir; Madania Madania; Teti S. Tuloli; Nur Rasdianah; Juliyanty Akuba
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11399

Abstract

Drug management is a set of optimally conducted activities related to the aspects of drug planning, procurement, storing, distribution, and extermination. This was done to achieve the proper drug amount, types, supply, maintenance, and medication. Earlier observstion revealed problems in managing pharmaceutical stock and consumables, where some of the stocks are empty. This qualitative descriptive research focus on identifying pharmaceutical logistic stock and health supplies comprising drug planning, procurement, storing, distribution, and extermination in the pharmaceutical unit of Gorontalo. The primary data were obtained from questionnaires based on technical guidance by the health ministry while the secondary were obtained from related documents. Based on the findings, the pharmaceutical stock planning and storing process at the pharmacy unit did not meet the health ministry standards, which is opposite to the procurement, distribution, and extermination process.
Karakterisasi Senyawa Minyak Atsiri Ekstrak Etil Asetat Bawang Putih (allium sativum l.) Muhammad Taupik; A. Mu’thi Andy Suryadi; Faramita Hiola; Jumriani Rannu
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.11767

Abstract

Garlic (Allium sativum L.) is one of tuber vegetable crops that is widely grown in various countries in the word and is often used as food spices and medicines. The purpose of this study was to characterize the volatile oil compound ethyl acetate extract of garlic (Allium sativum L.) using Uv-Vis and IR spectrophotometric metods. Several methods used in this research included extraction, identification of compounds, fractionation, thin layer chromatography, prepative thin layer chromatography, and characterization of compounds using Uv-Vis spectrophotometry and IR spectrophotometry. A total of 3000 grams od garlic was macerated using 70% ethanol, then evaporated and obtained a thick extract of 421.5 grams. The results of thin layer chromatography used an eluent ratio of Methanol : Ethyl Acetate (4:2) obtained stains with an Rf value of 0,55. The optimizion result of maximum wavelength of garlic isolated (Allium sativum L.) is 232 nm wich indicated  the presence of an electron transition  n→σ*.The results of IR  spectrophotometry had fuctional groups at wave numbers 3231.530 cm-1 (N-H), 1637.48 cm-1 (C=O), 1014.65 cm-1(C-N). 

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