JAF (Jurnal Analis Farmasi)
Jurnal ini berisikan hasil penelitian di bidang analisa obat, obat tradisional, makanan, minuman, kosmetik. Jurnal ini diharapkan dapat bermanfaat bagi dunia pendidikan dan masyarakat umum yang ingin mengetahui mengenai informasi mengenai keamanan obat, bahan pangan, kosmetik,serta informasi nilai gizi pangan dan informasi terkait lainnya
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<![CDATA[IDENTIFIKASI HIDROKUINON DALAM SABUN PEMUTIH PEMBERSIH WAJAH DI TIGA KLINIK KECANTIKAN DENGAN METODE KROMATOGRAFI LAPIS TIPIS DAN SPEKTROFOTOMETRI UV-Vis ]]>
<![CDATA[Risna Agustin]]>;
<![CDATA[Destiana Eka Oktaviantari]]>;
<![CDATA[Niken Feladita]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.2236
<![CDATA[Sabun cair merupakan sediaan pembersih kulit berbentuk cair yang terbuat dari bahan sabun dengan penambahan bahan-bahan yang diinginkan. Hidrokuinon yang ditambahkan secara berlebih dalam sabun cair seperti sabun pemutih pembersih wajah dapat menyebabkan hiperpigmentasi pada kulit. Penggunaan hidrokuinon menurut peraturan BPOM termasuk golongan obat keras yang hanya dapat digunakan berdasarkan resep dokter. Tujuan penelitian ini untuk mengetahui apakah terdapat hidrokuinon pada sabun pemutih pembersih wajah yang dijual pada tiga klinik kecantikan di Bandar Lampung. Teknik pengambilan sampel dilakukan secara purposive sampling.Sampel diuji secara kualitatif dengan metode kromatografi lapis tipis dan spektrofotometri UV-Vis. Prinsip Kromatografi Lapis Tipis yaitu pemisahan senyawa multi komponen dengan menggunakan dua fase yaitu fase diam dan fase gerak.Fase diam yang digunakan yaitu silika gel GF 254 nm dan fase gerak yang digunakan yaitu toluen dan asam asetat glasial (8:2). Hasil nilai selisih Rf dinyatakan positif jika ≤ 0,05 dan dinyatakan negatif jika hasil nilai Rf ˃ 0,05. Diperoleh hasil dari ketiga sampel tersebut ketiganya negatif mengandung zat hidrokuinon dikarenakan nilai selisih Rf ≥ 0,05 dengan hasil Rf baku 0, 07 dan selisih Rf masing-masing sampel A = 0,185 B = 0,185 C = 0, Kemudian dilanjutkan dengan metode Spektrofotometri UV-Vis dengan membandingkan spektrum larutan baku dengan sampel, diperoleh hasil negatif pada ketiga sampel karena gambar spektrum larutan baku dan sampel tidak identik.Kata Kunci : Sabun Pemutih Pembersih Wajah, Hidrokuinon, Klinik Kecantikan, Kromatografi Lapis Tipis, Spektrofotometri UV-Vis.]]>
<![CDATA[PENETAPAN KADAR ALKALI BEBAS PADA SABUN CUCI KRIM YANG DIJUAL DI MINI MARKET SECARA ASIDIMETRI ]]>
<![CDATA[Puput Kusuma Dipaningrum]]>;
<![CDATA[Ade Maria Ulfa]]>;
<![CDATA[Sudewi Mukaromah Khoirunnisa]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5956
<![CDATA[Laundry soap cream is one PKRT (Household Health) which is used to clean equipment and to wash clothes. The main constituent component of fat and soap is alkaline, where if there is excess base does not react with the excess fat there will be alkali-free. If in the soap containing alkali-free high, it can cause skin irritations such as rough skin, flushed, sometimes there are small spots of water and cause itching. Limit allowed in the free alkali soap cream by the Indonesian National Standard 06-2048-1990 ie a maximum of 0.1%. This study aims to determine the levels of free alkaline detergent contained in the cream is sold in the mini market of Bandar Lampung. The method used is acidimetry, where the principle is the determination of free alkaline by neutralizing acids and bases. In this study HCl titrant used is a strong base that is titrated by using a strong acid, an indicator used is phenolpthalien with stretch pH 8.2 to 9.6 and endpoint occurring from pink to white. From the results obtained with the sample five different brands the average level of alkali-free for sample A: 3.06% B: 2.86%, C: 1.08%, D: 0.40%, E: 1.11 %. Based on the research results obtained showed that the alkali-free in all samples of soap cream does not meet the requirements of the maximum levels of Indonesian National Standard 06-2048-1990 ie 0.1%.]]>
<![CDATA[UJI DAYA HAMBAT EKSTRAK DAUN SIRSAK (Annona muricata L) TERHADAP BAKTERI Escherichia Coli DAN Staphylococcus Aureus DENGAN METODE DIFUSI CAKRAM ]]>
<![CDATA[Marantika Komalasari]]>;
<![CDATA[Radho Alkausar]]>;
<![CDATA[Agustina Retnaningsih]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5938
<![CDATA[This study aims to determine the antibacterial inhibition of soursop leaf extract against Escherichia coli and Staphylococcus aureus bacteria. Antibacterial test against Escherichia coli and Staphylococcus aureus bacteria using disc diffusion method. The concentration of soursop leaf extract used was 25%, 50%, 75% and 100% with Tetracycline antibiotics as a positive control. The results of this study showed soursop leaf extract against Escherichia coli bacteria at a concentration of 25%, namely 0.00 mm, at a concentration of 50%, namely 8.30 mm, at a concentration of 75%, namely 8.80 mm, and at a concentration of 100%, namely 9.90 mm. While soursop leaf extract against Staphylococcus aureus bacteria at concentrations of 25%, 50%, 75% and 100% did not get inhibition zones in each repetition. The results of testing the inhibitory power of soursop leaf extract were more effective on Escherichia coli bacteria which are gram- negative bacteria.]]>
<![CDATA[PERBANDINGAN KADAR BESI (Fe) PADA DAUN KELOR (Moringa oleifera) YANG TUMBUH DI DATARAN TINGGI DAN DATARAN RENDAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) ]]>
<![CDATA[Amelia Wilda Pratiwi]]>;
<![CDATA[Nofita Nofita]]>;
<![CDATA[Diah Astika Winahyu]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5945
<![CDATA[Moringa leaves are a multipurpose medicinal plants commonly consumed as vegetables. Moringa leaves are rich in nutrients, one of which is iron (Fe) as much as 7 mg / 100g. Iron is useful for preventing anemia. Moringa grows in the highlands and lowlands with different soil conditions, so this allows for differences in iron levels in the leaves. This study aims to determine whether there are significant differences between Moringa leaves that grow in the highlands and lowlands. Samples were obtained from one of the residents' yards in kec. Gisting (highland) and kec. Teluk Betung (lowland). The sampling technique was carried out by purposive sampling. The tools used for iron analysis are Atomic Absorption Spectrophotometry at a wavelength of 248.40 nm. Linear regression line equation is obtained, which is y = 0.010483 + 0.09074x with a correlation coefficient (r) that is 0.9985. The average level of iron from Moringa leaves that grew in the highlands and lowlands respectively 6.26 mg / 100g and 6.16 mg / 100g. The results of the calculation of the t test found that tcount = 1.06. This tcount value will be compared with ttable with a 99% confidence level of 4.60. If tcount is smaller than ttable then Ho is accepted and Ha is rejected so that there is no significant difference between iron in moringa leaves that grow in the highlands and lowlands.]]>
<![CDATA[PERBANDINGAN KADAR AIR DAN KADAR MINYAK ATSIRI PADA RIMPANG KENCUR (Kaempferia galangal L.) DENGAN PERBEDAAN PERLAKUAN PENGERINGAN ]]>
<![CDATA[Mita Anggraini]]>;
<![CDATA[Gusti Ayu Rai Saputri]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5940
<![CDATA[Kencur rhizome (Kaempferia galangal L.) is widely used as a health drink and traditional medicine in Indonesia. Kencur rhizome is widely used as a medicine for colds, indigestion, analgesic and antipyretic, and beauty because it has the content of essential oils. This research has made simplicia rhizome kencur. The purpose of this study was to determine the ratio of water content and essential oil content in kencur rhizome with different drying treatment. The method used is simple distillation. With the sample treatment is a fresh kencur rhizome after being washed and cleaned of impurities, thinly sliced more or less with a thickness of 3-4 mm. Then each shredded result is dried in two ways, ie with sunlight and oven temperature 50oC. Drying done until dry with moisture content below 10%. Simplicia rhizome kencur, then analyzed water kadai and essential oil content. The results showed that the drying method had significant effect on water content and essential oil content. To get simplicia with relative high volatile oil content can be done by drying using sunlight.]]>
<![CDATA[POTENSI KEBERADAAN SENYAWA AKRILAMIDA DALAM MAKANAN ]]>
<![CDATA[Oktaf Rina]]>;
<![CDATA[Abdi Dharma]]>;
<![CDATA[Afrizal Afrizal]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5949
<![CDATA[This of the study was to examine the potential presence of acrylamide compounds in foods containing the amino acid asparagine and reducing sugars that are processed at high temperatures. The initial research was carried out to determine the levels of precursors in the raw material and then analyzed the amount of acrylamide using HPLC-RP LC-6A Shimadzu with a C18 column and sterile aqueous mobile phase. The optimization condition of the instrument was achieved with a column temperature of 35oC, a wavelength of 254 nm and a flow rate of 0.8 mL/min. The retention time of acrylamide was observed at 3.8 min. The food sample tested was banana chips. The results showed that banana chips with a moisture content of 7.74% (w/w) ± 0.01 contained acrylamide 115.5 to 565 g/kg. Acrylamide content is influenced by the amount of precursor, temperature and duration of food processing.]]>
<![CDATA[UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN PATIKAN KEBO (Euphorbia hirta L) TERHADAP Staphylococcus aureus dengan METODE DIFUSI CAKRAM ]]>
<![CDATA[Habib Abdul Muiz]]>;
<![CDATA[Shinta Wulandari]]>;
<![CDATA[Annisa Primadiamanti]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5942
<![CDATA[Patikan kebo (Euphorbia hirta L) is a grass-shaped plant and is often used as a traditional medicine by the community. The people of Pasir Sakti use patikan kebo as a medicine for skin infections. Skin infection is the most common disease caused by Staphylococcus aureus bacteria. Based on research by Harlis 2010 patikan kebo leaves has active compounds of flavonoids and tannins that can inhibit bacterial growth. This study aimed to examine the potential of patikan kebo leaf extract in inhibiting the growth of Staphylococcus aureus bacteria using variants of the concentration of patikan kebo leaf extract, namely 30%, 40%, 50%, and 60%. Tetracyline as positive control and sterile distilled water as negative control. Antibacterial activity test was carried out by disc diffusion method. Based on the results of the inhibition test with three repetitions, the consentration of 30% has inhibition zone of 10.48 mm, the concentration of 40% has inhibition zone 12.26 mm, the concentration of 50% has inhibition zone 14.32 mm, and the concentration of 60% has inhibition zone of 15.26 mm. The conclusion of this study, patikan kebo leaf extract has antibacterial activity against the growth of Staphylococcus aureus bacteria.]]>
<![CDATA[AKTIVITAS INFUSA KULIT DAUN LIDAH BUAYA (ALOE VERA L.) SEBAGAI PENGOBATAN INFEKSI JAMUR ]]>
<![CDATA[Rafika Sari]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5950
<![CDATA[Dermatophytosis is an infection of tissue containing horny substances, such as the stratum corneum in the epidermis, hair, and nails. The infection is caused by the fungus of the genus Trichophyton, one of which is Trichophyton mentagrophytes. Aloe vera leaves contain saponins and flavonoids which are known to have an antimicrobial effect and inhibit fungi. Antifungal products can be processed in various dosage forms, one of which is spray. This study aims to determine the ability of the preparation of aloe vera L. leaf spray in killing T. mentagrophytes. Aloe vera leaves are made using the infusion method with concentrations of 20%, 40%, 60%, 80%, and 100%. Evaluation of preparations made included organoleptic examination and determination of pH values. Testing of antifungal activity was carried out using the diffusion method. The results showed that the spray produced had a liquid texture with sediment, cloudy yellow, menthol odor, pH on days 0, 7, and 14 had a range of values from 4.5 to 4.7. Aloe vera leaf peel spray preparations have antifungal activity against Trichophyton mentagrophytes with a maximum concentration of 100%. ]]>
<![CDATA[PENETAPAN KADAR PROTEIN JAMUR TIRAM PUTIH (Pleurotus ostreatus) DAN JAMUR MERANG (Volvariella volvaceae) DENGAN METODE KJELDAHL ]]>
<![CDATA[Dara Callista Dinda Amelia]]>;
<![CDATA[Diah Astika Winahyu]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5944
<![CDATA[Mushrooms are plants that contain high levels of vitamin B complex and are the only non- animal foods with vitamin D content that are used for bone health.White oyster mushrooms and straw mushrooms have a lot of nutritional content, one of which is protein. Proteins are complex organic compounds of high molecular weight. Quantitative testing with the Kjedahl method has three stages, namely destruction, distillation, and titration. The results of the quantitative test using the Kjedahl method showed that oyster mushrooms had a protein content of 2.39% and straw mushrooms were 1.46%.]]>
<![CDATA[UJI DAYA HAMBAT KRIM KULIT APEL MANALAGI (Malus sylvestris Mill) TERHADAP BAKTERI PROPIONIBACTERIUM ACNE PENYEBAB JERAWAT DENGAN METODE DIFUSI SUMURAN ]]>
<![CDATA[Liana Fajriah]]>;
<![CDATA[Robby Candra Purnama]]>
<![CDATA[ Jurnal Analis Farmasi Vol 6, No 2 (2021) ]]>
Publisher : <![CDATA[Program Studi Analisis Farmasi dan Makanan Universitas Malahayati ]]>
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DOI: 10.33024/jaf.v6i2.5951
<![CDATA[Manalagi apple (Malus sylvestris Mill) is one type of poor apple that has been widely consumed by the people of Indonesia because it has a sweet, delicious taste, and is easy to obtain. This study aimed to test the effectiveness of the anti-acne cream of Manalagi Apple (Malus sylvestris Mill) peel extract against Propionibacterium acnes bacteria. The extract obtained by maceration using 96% ethanol solvent was made into two formulations of cream concentration, namely 5% and 10% then tested on Propionibacterium acne bacteria using MHA media. The method used is the well diffusion method. Manalagi Apple peel extract was declared to meet the requirements for a good cream preparation. The 5% cream formulation has shown an inhibitory effect on Propionibacterium acne bacteria with an average diameter of 19.72 mm (intermedied), a concentration of 10% with a value of 20.11 mm (sensitive). From the results obtained it can be concluded that the preparation of Manalagi apple peel extract cream (Malus sylvestris Mill) is effective in inhibiting the growth of Propionibacterium acne bacteria. The most effective cream is in cream preparations with an extract concentration of 10%.]]>
