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Erna Fitriany
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INDONESIA
Jurnal AFAMEDIS
Published by Akademi Farmasi Mitra Sehat Mandiri Sidoarjo
ISSN : -     EISSN : 27213269     DOI : https://doi.org/10.61609/afamedis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia AFAMEDIS (ISSN: 2721-3269) adalah jurnal akses terbuka dan peer-review yang diterbitkan oleh Akademi Farmasi Mitra Sehat Mandiri Sidoarjo. Jurnal ini diterbitkan dua kali per tahun pada bulan Februari dan Agustus. Jurnal Farmasi Indonesia AFAMEDIS menerbitkan artikel penelitian di bidang Farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 76 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK BUAH TOMAT (Solanum lycopersicum L.) TERHADAP BAKTERI Propionibacterium acnes Elly Purwati
AFAMEDIS Vol. 2 No. 2 (2021): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Acne is a skin infection disease, one of which is caused by bacteria. Treatment with antibiotics can cause resistance, so it is needed alternative treatment of natural ingredients and tomatoes (Solanum lycopersicum L.) is one of the natural ingredients that contain alkaloid compounds, flavonoids, saponins and tannins that are known to have an antibacterial effect. The purpose of this study was to find out the antibacterial activity of tomato extract against the growth of Propionibacterium acnes bacteria. Tomato fruit extract is divided into 3 concentration series (20%, 40% and 60%). Testing the taste of Propionibacterium acnes using diffusion method (Kirby and Bauer diffusion) by disc diffusion. Clindamycin is used as a positive control, and Aquadest as a negative control. The results of the study showed that the concentration of inhibition zone was 20% with an average of 1.08 mm, a concentration of 40% with an average of 3.74 mm, a concentration of 60% with an average of 5.14 mm, and clindamycin (positive control) with an averageof 9.15 mm and test data Kruskall-wallis obtained a value of 0.00 less than 0.05, it can be concluded that tomato fruit extract (Solanum lycopersicum L.) can inhibit the growth of Propionibacterium acnes bacteria with a significant difference andit is known that tomato fruit extract (Solanum lycopersicum L.) concentration of 60 % the most influential in inhibiting the growth of Propionibacterium acnes bacteria. Keywords : Acne, Tomato (Solanum lycopersicum L.), Propionibacterium acnes, Antibacteria
COST-EFFECTIVENESS ANALYSIS BIAYA PENGOBATAN EPILEPSI JENIS GRAND MAL DENGAN BEBERAPA OBAT ANTI EPILEPSI DI RAWAT INAP RSUD SIDOARJO Andri Priyoherianto; Ismu dwi supangkat
AFAMEDIS Vol. 2 No. 2 (2021): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Epilepsy is a neurological disoder that arises suddenly and periodically, ussualy with change in consciousesness. Different use of anti-epileptic drugs by patients results in patient’s medical cost increase. The use expensive anti-epileptic drugs does not guarantee the effectiveness of patient care, therefore a research needs to be done to determine which anti-epileptic drugs therapy is more cost-effective between Valproic Acid, Na Fenitoin, and combination Na Fenitoin + Valproic Acid in hospitalized epileptic patients in RSUD Sidoarjo. The Research was a retrospective observational study with retrospective data retrieval. The research was conducted a medical Record retrieval at SIM RS from January 2020- December 2020. The samples in this study were 30 patients with 7 patients using Valproic Acid, 6 patients using Na Fenitoin, and 17 patient using combination Na Fenitoin + Valproic Acid. The results showed that the more cost- effective therapy between Valproic Acid, Na Fenitoin and combination Na Fenitoin + Valproic Acid in the treatment of epileptic in RSUD Sidoarjo was therapy with combination Na Fenitoin + Valproic Acid, which can be seen from ACER ( Average Cost-Effectiveness Ratio) combination Na Fenitoin + Valproic Acid Rp Rp. 880.854 /effectiveness compared with Valproic Acid ACER value of Rp. 977.307/effectiveness and Na Fenitoin Rp. 979.546/effectiveness. The lowest ICER value on combination Na Fenitoin + Valproic Acid was Rp.-994.290. Keywords : Cost-effectiveness analysis, Combination Na Fenitoin + Valproic Acid, Epileptic
UJI EFEK TONIKUM EKSTRAK ETANOL DAUN KAMBOJA (Plumeria sp.) PADA MENCIT (Mus muscullus) Panji Ratih Suci
AFAMEDIS Vol. 2 No. 2 (2021): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Indonesia, which is famous for its rich flora, stores various plants that can be used as medicine or decoration. Flavonoid compounds in several studies have been reported to trigger stimulants in the heart, allowing the flavonoid compounds in frangipani leaves to be used as a tonic effect. Objective: This study aims to determine what is the most effective dose of either 3.5g/KgBW, 5.25g/KgBW and 7g/KgBW of frangipani leaf extract (Plumeria sp.) when used as a tonic in male mice (Mus muscullus). ), and to find out how the effect of giving the dose variant compared to the positive control (caffeine) and negative (CMC 0.5%) gave a tonic effect on the length of time swimming in male mice (Mus muscullus). Methods: This study used the swimming test method which was carried out on male mice treated with 0.5% CMC as a negative control and caffeine as a positive control. Then look at the time on the swimming endurance of mice. Results: This study showed that the treatment group of frangipani leaf ethanol extract at a dose of 3.5 g/Kg BW, 5.25 g/KgBW, and 7 g/KgBW had an increase in the swimming survival time of male mice from before the test solution was administered. The most effective dose is 7g/KgBW which has an average swimming time of 8 minutes 9 seconds which is almost close to the average swimming time of caffeine as a positive control of 10 minutes 5 seconds. Strengthened by the SPSS test which has a significance of 0.00 which indicates the effect of dosing on the swimming time of male mice (Mus muscullus).
PENGARUH KONSENTRASI CROSPOVIDONE TERHADAP MUTU FISIK SEDIAAN ORAL FAST DISSOLVING TABLETS LORATADINE HCl Deny Budi Legowo
AFAMEDIS Vol. 2 No. 2 (2021): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Oral Fast Dissolving Tablet (OFDT) is a solid dosage form, containing an active substance which disintegrates rapidly within a few seconds when it is placed on the tongue, and generally will dissolve in less than 60 seconds. The manufacture of OFDT loratadine HCl in this formulation is to find out which results are more optimal from the different concentrations of Crospovidone disintegrants with 2%, 3%, and 4% concentrations. In this study, the method used is wet granulation, which can improve the comparability of loratadine HCl, as medicine formulations. This study aims to determine the effect of the physical quality of the Oral Fast Dissolving Tablet loratadine HCl preparation on the concentration of crospovidone as a disintegrant and to determine concentration of crospovidone that can provide results fulfilling the requirements in the manufacture of Oral Fast Dissolving Tablets. In the first formulation the average disintegration time is 0.34 minute, the second formulation disintegration time is 1.16 minute, the third formulation disintegrated time is 0.50 minute. The results of the three formulations state that only the first and third formulations accomplish the requirements, the second formulation does not accomplish the requirements. In the manufacture of OFDT preparations with different concentrations of Crospovidone, it is very influential on the disintegration time, and in this formulation, the better result is a concentration of 2% because it has a faster disintegration time and physical quality that fulfill the requirements
Pengaruh Perbandingan Konsentrasi Crospovidone Dengan Amilum Oryzae Sebagai Bahan Penghancur Pada Oral Fast Dissolving Tablet Domperidone Base Deny Budi Legowo
AFAMEDIS Vol. 3 No. 1 (2022): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

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PENGARUH GELLING AGENT PADA SEDIAAN SERUM JERAWAT KOMBINASI EKSTRAK DAUN SIRIH HIJAU DAN BUAH BELIMBING WULUH Dara Tilarso
AFAMEDIS Vol. 3 No. 1 (2022): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Abstract Serums with low viscosity can deliver active substances through the skin surface by forming a film layer. The physical properties of a good serum depend on the use of a gelling agent as a base. This study aims to determine the effect of the type and concentration of gelling agent on the physical characteristics of the combination of ethanol extract of green betel leaf (Piper betle) and wuluh starfruit (Averrhoa bilimbi L.) as an anti-acne. Serum preparations were made in 6 formulas with variations and concentrations of gel base, namely FI (Na-CMC 2%), FII (Na-CMC 3%), FIII (Na-CMC 4%), FIV (Carbopol 0.5%), FV (Carbopol 1%), and FVI (Carbopol 2%). Evaluation of the preparation is carried out to determine the optimum formula that meets the requirements criteria. The evaluations carried out included organoleptic homogeneity, dispersion, adhesion, pH, and viscosity. The analysis performed statistically using ANOVA with a 95% confidence level to see differences between groups of formulas to determine the effect of type and concentration of gelling agent on serum characteristics. The formulation of serum preparations on the concentration of gelling agent affects the physical stability for 28 days. The results of the antibacterial activity test of FV and FVI (Karbopol 1% and 2%) had inhibition zones of 8.8 mm and 9.3 mm in P. acnes, and 9 and 9.8 mm in S. aureus which were included in the inhibition zone category currently.
GAMBARAN PENGETAHUAN PENGGUNAAN SALEP MATA DITINJAU DARI PROSEDUR PENGGUNAAN YANG BENAR DI APOTEK MEDIC WONOAYU fahmi ardianti
AFAMEDIS Vol. 3 No. 1 (2022): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Salep mata adalah salep steril untuk pengobatan mata yang mengandung basis salep yangcocok dan dimasukkan secara aseptis kedalam tube steril. Penelitian ini bertujuan untukmengetahui pemahaman masyarakat tentang penggunaan obat salep mata sesuai prosedur yangbenar. Metode yang digunakan dalam penelitian ini adalah Purposive Sampling, dengan instrumenpenelitian kuesioner. Populasi yang digunakan seluruh pasien yang membeli obat di Apoteksehingga mendapatkan jumlah sampel sebanyak 370 responden. Hasil yang di dapat 2% orangyang memperoleh hasil tidak paham, 9% orang dengan hasil kurang paham, 34% orang yangmemperoleh hasil paham, dan 55% orang yang memperoleh hasil sangat paham, sehingga dapatdisimpulkan bahwa masyarakat sudah paham tentang penggunaan sediaan salep mata sesuaidengan prosedur penggunaan yang benar.
PENGARUH VARIASI KONSENTRASI MALTODEKSTRIN SEBAGAI FILM FORMING TERHADAP MUTU FISIK ORAL FAST DISSOLVING SALBUTAMOL SULFATE valiandri puspadina
AFAMEDIS Vol. 3 No. 1 (2022): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Oral Fast Dissolving Film (OFDF) merupakan bentuk sediaan baru yang ketika diletakkan di dalam mulut dapat terdisintegrasi dengan cepat untuk melepaskan obat, terlarut dan terdispersi di dalam saliva. Keuntungan sediaan OFDF dibandingkan sediaan lain yaitu bentuk yang sangat tipis, ringan, fleksibel, dapat diberikan tanpa bantuan air minum, dan berpotensi meningkatkan kepatuhan pasien dalam menggunakan obat. Sediaan OFDF tersunsun dari komponen utama yang disebut film forming agent salah satunya Maltodekstrin. Pembuatan sediaan OFDF ini menggunakan bahan aktif Salbutamol sulfate yang dilakukan dengan berbagai macam formulasi, dengan penambahan konsentrasi Maltodekstrin 2% ; 4% ; 6% untuk memperoleh hasil mutu fisik yang baik. Metode yang digunakan dalam pembuatan OFDF Salbutamol sulfate ini adalah metode solvent casting. Penelitian ini bertujuan untuk eksperimental yang digunakan untuk mengetahui pengaruh variasi konsentrasi Maltodekstrin sebagai film forming terhadap mutu fisik pembuatan Oral Fast Dissolving Film. Pengumpulan data dilakukan terhadap karakteristik fisikmeliputi ketebalan, variasi bobot, daya mengembang, kekuatan tarik, pH sediaan,dan kadar. Hasil yang diperoleh ketebalan film adalah 0,2 mm, variasi bobot 0,0763 gram – 0,0776 gram, daya mengembang 98,25 % - 98,27 %, kekuatan tarik 3,3-3,8 gram/mm2 , pH 6,4 – 6,5, keseragaman kandungan 98,18 % - 102,36 %. Hasil yang di dapat semakin bertambah konsentrasi maka semakin besar elastisitas oral fast dissolving film.
STUDI PEMILIHAN KONTRASEPSI ORAL DI ASRAMA YON ARHANUD 8/MBC DUSUN SERUNI KABUPATEN SIDOARJO PADA BULAN APRIL SAMPAI JUNI 2021 novia ariani
AFAMEDIS Vol. 3 No. 1 (2022): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Abstract The Family Planning Program (KB) is one of the Indonesian government's programs, which is held to limit births and reduce population growth and reduce the rate of Indonesia's population. Efforts are being made by the government to reduce the Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR). Family planning is one of the strategies to reduce maternal mortality, especially mothers with 4T conditions, namely giving birth too young (under the age of 20), giving birth too often, giving birth too close apart, and giving birth too old (above 35 years old). The design of this research is descriptive. Descriptive research method is a research conducted to describe or describe phenomena that occur in society. This research was carried out at the Yon Arhanud 8/MBC in Seruni, Sidoarjo district from April to June 2021. The tool used in this study was a questionnaire. Based on the results of research conducted by researchers, it can be concluded that from 45 respondents who were examined in the selection of oral contraceptives, 39 people (87%) were using the combined contraceptive pill and 6 (13%) were lactating contraceptive pills. Keywords: Family Planning Program, Family Planning Pills, Seruni Hamlet , Sidoarjo Regency
GAMBARAN PELAKSANAAN UPAYA PENCEGAHAN PENYEBARAN COVID-19 MELALUI PROTOKOL KESEHATAN DI DESA KEDUNG WONOKERTO RW.04 KECAMATAN PRAMBON KAB. SIDOARJO PERIODE MARET 2021 merry patrinila
AFAMEDIS Vol. 3 No. 1 (2022): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Abstrack At the end of 2019 the world having a slump because emergence of a new virus called COVID-19. Limiting activities outside the home is also carried out to anticipate and reduce of amount patients with COVID-19 in the Indonesia. the purpose of this research is to know how to prevention the spread of the virus COVID-19 in the Kedungwonokerto village of hamlet 4 Sub-district Prambon District Sidoarjo. This types of the research use research method descriptive qualitative on 291 people through random sampling. This research use questionnaire for submit the data and for qualitative analysis with present the variable frequency distribution. The result of the analysis is implementation to prevention the spread of the virus COVID-19 includeing category quite well with category presentation 67%. Implementation distribution prevention the spread of society have done implement prevention the spread of virus COVID-19 appropriate with health protocol for purpose to breaking the virus COVID-19. Keywords: Prevention, Spread, COVID-19

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