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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 372 Documents
 2   3   4   5   6 
PENGARUH PEMBERIAN PELEMBAP TERHADAP HASIL TES DISKRIMINASI DUA TITIK PADA PENGHUNI PANTI WREDHA ABIYOSO YOGYAKARTA Asyahidatul Muchlisah Fitriana; Titis Nurmasitoh; Rosmelia Malik
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 4, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss4.art6

Abstract

Latar Belakang Proses penuaan yang terjadi pada lansia  mengakibatkan perubahan pada sistem organ, terutama kulit yang dapat mengalami penurunan fungsi  sensoris. Fungsi  sensoris  dapat dideteksi secara sederhana menggunakan tes diskriminasi dua titik. Sementara itu, pemakaian pelembap dapat memperbaiki tampilan dan fungsi kulit pada lansia.  Tujuan Untuk mengetahui perbedaan hasil tes diskriminasi dua titik pada lansia di Panti Wredha Abiyoso Yogyakarta sebelum dan sesudah pemberian pelembap.  Metode Penelitian ini merupakan penelitian eksperimen yang menggunakan rancangan pre-test and post-test control group dan melibatkan 32 subjek penelitian yang terbagi pada kelompok kontrol dan kelompok eksperimen.  Hasil Analisis dengan uji T tidak berpasangan menunjukkan bahwa secara statistik terdapat perbedaan hasil tes diskriminasi dua titik yang signifikan antara  kelompok kontrol dan kelompok eksperimen  (p=0,001). Pada kelompok eksperimen, terdapat perbedaan nilai pre-test  dan  posttest  yang bermakna setelah pemberian pelembap  (p=0,007), sedangkan pada kelompok kontrol tidak terdapat perbedaan nilai yang signifikan antara hasil pre-test dan post-test (p=0,344).  Kesimpulan Terdapat perbedaan hasil tes diskriminasi dua titik yang bermakna pada lansia di Panti Wredha Abiyoso Yogyakarta antara kelompok kontrol dan kelompok eksperimen.  Kata Kunci: pelembap, tes diskriminasi dua titik, lansia
TUMOR ocular surface squamosa TINJAUAN PUSTAKA MENGENAI ETIOPATOGENESIS, DIAGNOSIS KLINIS, DAN HISTOPATOLOGIS Esti Mahanani; Artati Sri Redjeki
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 4, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss4.art7

Abstract

Tumor  ocular surface  squamosa  neoplasia  (OSSN) merupakan salah satu tumor terbanyak di bidang mata dengan angka rekurensi dan morbiditas yang tinggi. Tumor ini memiliki gambaran klinis bervariasi. Diagnosis ditegakkan melalui histopatologi dari hasil eksisi biopsi. Istilah OSSN meliputi displasia ringan  dalam bentuk  conjunctival intraepithelial neoplasia    dan  carcinoma in situ  serta dalam bentuk metastasis yaitu karsinoma sel skuamosa invasif.  Tumor  ini memiliki etiologi multi-faktorial dengan interaksi  beberapa faktor seperti paparan radiasi ultraviolet,  karsinogen  kimia, kondisi kekurangan vitamin A  dan infeksi dari beberapa virus  tetapi kondisi individual memang belum  jelas.  Infeksi  human immunodeficiency virus  (HIV)  dan  human papilloma virus (HPV) diduga paling berperan dalam kondisi ini. Tren perubahan terlihat dalam presentasi klinis dan prognosis yang memburuk pada pasien dengan OSSN dengan infeksi HIV yaitu munculnya  bentuk  karsinoma  mucoepidermoid  dan  karsinoma  sel spindle  yang  sangat agresif.  Pemeriksaan  oftalmologi umum wajib dilakukan untuk diagnosis klinis dengan slitlamp, sedangkan pemeriksaan penunjang seperti gonioskopi, visualisasi dengan anterior optical coherence tomography (OCT) dan confocal microscopy mungkin diperlukan pada beberapa kasus. Penanganan utama adalah diagnosis tepat dan penanganan sedini mungkin untuk prognosis yang baik  sehingga peran dokter pada pelayanan primer sangat penting. Operasi  pengambilan tumor, kemoterapi  topikal,  brachytherapi  dan imunoterapi adalah berbagai  modalitas pengobatan yang dikombinasikan  dan  menunjukkan hasil yang menjanjikan pada kasus yang agresif rekurent dan besar.  Keyword  : Ocular surface squamous neoplasia, conjunctival intra epithelial neoplasia, carcinoma in situ, etiopatogenesis, diagnosis klinis, histopatologi
Efek Pemaparan Ekstrak Etanol dan Ekstrak Air Sirih Merah (Piper crocatum) terhadap Hidrofobisitas Permukaan Sel Staphylococcus aureus Farida Rachmawaty
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 2, No 5, (2010)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Red betel vine has been proved having the benefit as antibacterial toward Staphylococcus aureus1 While bacteria infected usually hydrophobic interaction before. The purpose of the research is to know the ethanol extr&ct and water extract effect toward Staphylococcus  ureus surface hydrophobicity and to know the different effect between ethanol extract and water extract. The research is laboratory experimental. Ethanol extract and water extract consentration was made with dilution method so the concentration extracts were 25%, 12.5%, 6.25%, 3.13%, 1.57%, 0.84% and 0.42%. The method was used for determine cell surface hydrophobicity is based on Koga et a/ modification. 2 Cell surface hidrophobicity of bacteria was compared between before and after exposure with ethanol and water extract. The measuring used spectrophotometer The result was analyzed using Mann-Whitney test with SPSS programme. Hydrophobicity of Staphylococcus aureus cell surface was decreased on the exposure of ethanol extract or water extract of red betel vine. The first extract addition sharply decreased the hydrophobicity and the decrease became lower. This result is appropriate with the research of Razak et a/. 3 The decreasing hydrophobicity of Staphylococcus aureus cell surface is not significantly different between ethanol extract and water extract of red betel vine (p>O. 05). Ethanol extract and water extract of red betel vme (Piper crocatum) have decreasing effect for Staphylococcus aureus A TCC 25923 cell surface. The exposure etahnol ectract and water extract of red betel vine is not significantly different. 
Effects of methanol extracts of insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats Raden Edi Fitriyanto; Sugiarto Sugiarto; Dwi Tonang Ardiyanto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art11

Abstract

Background: Obesity can lead to insulin resistance contributing to diabetes mellitus (DM). Empirically, insulin leaves of Tithonia diversifolia (Hems.) A. Gray (Td) can be used as a traditional DM medicine.Objective: This study aims to determine effects of Td methanol extracts on insulin resistance and secretion in DM rats induced by a high-fat diet and alloxan.Methods: This study was a randomized pre and post-test control group. Its research subjects were divided into five groups: a normal group, an obese group with diabetes without therapy (KN), an obese group with DM treated by the Td extracts with a dose 50 mg/kg, 250 mg/kg, and 500 mg/kg. The DM obesity was induced by a high-fat diet followed by administration of alloxan with a dose of 135 mg/kg intraperitoneally. The Td extracts was administered after 7 days of DM induction by using gastric swabs. Insulin resistance in the rats was measured based on HOMA-IR index values, while their insulin secretion was based on HOMA-B values. A statistical analysis was conducted by a 95% confidence level.Results: Blood glucose levels decreased to normal levels in all the groups administered by the Td extracts, except in the KN group. The HOMA-IR index values in all groups treated by the Td extracts did not increase except in the KN group. The HOMA-B index values in groups with doses of 50 and 250 mg/kgBW experienced a higher increase and significantly differed with the KN group.Conclusion: The administration of the Td extracts with doses of 50 and 250 mg/ kgBW in the DM rats could decrease blood glucose levels, could prevent insulin resistance and could increase insulin secretion. 
MITOKONDRIA SEBAGAI TARGET TERAPI KANKER Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 1, (2014)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss1.Art2

Abstract

ABSTRAKSel kanker merupakan sel yang memiliki karakteristik yang khas, yang mampu bertahan terhadap induksi apoptosis sel. Mitokondria merupakan organela yang berperan penting dalam induksi apoptosis sel pada jalur endogen.Pelepasan sitokrom C dan berbagai protein proapoptosis dari mitokondria ke sitoplasma dihambat oleh sel kanker melalui mekanisme stabilisasi permeabilitas mitokondria dan metabolic reprogramming.Dewasa ini telah dikembangkan berbagai terapi sel kanker berdasarkan target spesifik. Mitokondria merupakan salah satu target yang poten dalam terapi sel kanker. Dengan mengetahui karakteristik alamiah sel kanker terhadap mitokondria, diharapkan dapat dikembangkan terapi sel kanker berbasis organela spesifik (mitokondria) yang mampu meningkatkan apoptosis sel kanker tanpa mengakibatkan apoptosis pada sel normal.Naskah ini bertujuan untuk memahami lebih jauh bagaimana mekanisme sel kanker dalam memodulasi aktivitas mitokondria untuk dapat menghindari respon apoptosis sel, serta untuk mempelajari mekanisme terapi sel kanker berbasis mitokondria. Kata kunci : sel kanker, permeabilitas mitokondria, metabolic reprogramming, apoptosis sel, sitokrom C, protein proapoptosis. ABSTRACTCancer cells have distinct characteristics from normal cells, which able to withstand to cell apoptosis induction. Mitochondria are organelles that play an important role in the endogenous pathway of cells apoptosis. Release of cytochrome C and other proapoptosis proteins from the mitochondria to the cytoplasm were inhibit by cancer cells through mitochondrial permeability stabilization mechanism and metabolic reprogramming. Today various cancer cell therapies were developed on a specific targets. Mitochondria is a potent target in the treatment of cancer cells. By knowing the natural characteristics of mitochondrial cancer cells, a development of cell based cancer therapies by specific organelles were expected to increase cancer cells apoptosis without causing normal cells apoptosis. Aims of this manuscripstare to further understand about cancer cells mechanism in modulating mitochondrial activity to avoid mitochondrial apoptotic cells response, as well as to study the mechanism of cell based cancer therapies by mitokondria.Keywords :cancer cells, mitochondrial permeability, metabolic reprogramming, cells apoptosis, cytocrome C, proapoptotic cells
PENGARUH SALEP EKSTRAK ETANOL DAUN SIRIH (Piper betle) TERHADAP PENYEMBUHAN LUKA IRIS PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Muhammad Zuhdan Fannani; Taufiq Nugroho
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 1, (2014)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss1.Art4

Abstract

ABSTRAKLatar Belakang Tanaman obat yang banyak digunakan oleh masyarakat untuk mengobati luka adalah daun sirih (Piper betle). Daun sirih juga banyak dimanfaatkan untuk mengobati sariawan.Tujuan Penelitian ini bertujuan untuk menguji pengaruh salep ekstrak etanol daun sirih terhadap penyembuhan luka iris pada tikus putih jantan (Rattus norvegicus).Metode Penelitian ini menggunakan rancang penelitian eksperimental. Subjek penelitian dikelompokkan secara acak menjadi 3 kelompok. Masing-masing kelompok terdiri dari 10 ekor tikus, kemudian dilukai sepanjang 2 cm kedalaman 0,5 cm dan diberi perlakuan yang berbeda. Kelompok I merupakan kelompok perlakuan dengan pemberian salep ekstrak etanol daun sirih. Kelompok II merupakan kontrol positif dengan pemberian povidon iodine 10%, dan kelompok III adalah kontrol negatif dengan pemberian vaselin album. Panjang luka masing-masing kelompok diukur dan diamati setiap hari hingga hari ke-14, kemudian data yang didapatkan dianalisis menggunakan Oneway Anova.Hasil Lama penyembuhan luka iris kelompok uji dengan salep ekstrak etanol daun sirih, kelompok uji dengan povidon iodin dan kelompok uji dengan vaselin album berturut turut adalah 10,8±0,422; 11,9±0,316; 13,8±0,422 (p=0,000).Kesimpulan Penelitian pada tikus putih jantan (Rattus norvegicus) menunjukkan bahwa salep ekstrak etanol daun sirih mampu mempercepat proses penyembuhan luka. Salep daun sirih dapat dimanfaatkan dan menjadi alternatif terapi baru untuk penyambuhan luka.Kata Kunci : Salep daun sirih (Piper betle), Penyembuhan luka iris. ABSTRACTBackgroundOne of the medicinal plants used to treat wounds is betel leaf. Betel leaf (Piper betle) is also used by Indonesian since the first medication to treat ulcers. However, there is currently no scientific evidence of the effects of betel leaf to accelerate incision wound healing in experimental animals or in humans. Objective The study aims to assess the ethanol extract of Piper betle leaf ointment on the healing of incised wounds in the rats Methods This type of study was purely experimental design. Research subjects were randomly divided into three groups and each group consisted of 10 rats. The incision wound were made 2-cm long and 0.5-cm deep and were given different treatments. Group I was treated with the ointment of betel leaf extract. Group II was a positive control by administering povidone-iodine 10%, and group III was a negative control with the provision of Vaseline-album. The length of incision wound in each group were measured and observed every day until the 14th day, then the data obtained were analyzed using Oneway Anova. Results Wound healing at the ethanol extract of betel leaf group, the povidone-iodine group and the vaseline-album groupwere 10,8±0,422; 11,9±0,316; 13,8±0,422, respectively (p=0,000). ConclusionThis study showed that the ointment of betel leaf had the shortest healing times. Later, Ointment betel leaf can be utilized and become a new therapeutic alternative for wound healing. Keywords : Piper betle leaf ointment, incision wound   
Knowing Cholesterol Effects on Alzheimer’s Disease Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art1

Abstract

No Abstract
Standardization of leaf extract of red betel(Piper crocatum) leaves using ethanol Heni Sundari; M. Hatta Prabowo; Farida Juliantina Rachmawaty; Hady Anshory Tamhid
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art2

Abstract

Background: Red betel vine (Piper crocatum Ruiz & Pav) is known empirically to have properties to cure various kinds of diseases. It contains flavonoids, alkaloids, polifenolat compounds, tannins and essential oil compounds. Standardization in the pharmacy is required to ensure the level of quality, fulfill the standard requirement of chemical, biological, and pharmaceutical, including the guarantee of stability as pharmaceutical products generally.Objective: To investigate the standard specific and non-specific parameters set by Food and Drug Supervisory Agency (FDSA) of ethanol leaf extract of red betel leaves.Methods: The study began with sample preparation, then extracted by maceration method to get the active compounds in the lumpy extract. Extract was analyzed with standard specific and non-specific parameters set by FDSA. Results were analyzed with descriptive analysis method.Results: The features of leaf extract of red betel vine leaves using are organolepticly viscous, dark green,and has a distinctive odor with a bitter spicy taste. The yield, water content, ash content, and specific gravity of extract were 14.8%, 0.353%, 0.16%, 0.729 respectively. Total mold contamination of extract satisfied the standard criteria that was below the limit of a maximum of 10 colonies/gram. Metal contamination of lead (Pb) was 1. 404 mg/kg and Cadmium (Cd) was 0. 223 mg/kg. Chromatographic profile of the Gas Chromatography-Mass Spectrometry (GC-MS) red betel vine leaves ethanol extract contains compounds caryophyllene, germacrene-D and some other compounds with low similiaritas index, and has a marker compound which is suspected possibly trimethoxyallyl benzen.Conclusion : The ethanol extract of red betel vine (Piper crocatum Ruiz & Pav) leaves is an extract of the organolepticly viscous, dark green color, distinctive smell, bitter taste, and spicy. The ethanol extract of red betel vine leaves satisfies the standard level set by FDSA and has the marker compound which is expected likely Trimethoxyallyl benzen.
Solid waste management at the RS Jogja and RS PKU Muhammadiyah in jogja Muchsin Maulana; Hari Kusnanto; Agus Suwarni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art3

Abstract

Background: In daily activities, the hospital produces significant amount of waste which, if not properly discharged or burned, may cause adverse effect on workers as well as the surrounding area. So it is needed to explore the treatment process of waste at the RS PKU Muhammadiyah Jogja and RS Jogja.Objective: The aim of this study was to get a clear picture or description on waste management techniques at the RS PKU Muhammadiyah Jogja and RS Jogja. Methods: This study used a qualitative descriptive case study. Data were obtained through observation, document studies, in-depth interviews with the head of Environmental Health Installation and Waste Management Staffs, as well as data in the form photos and recordings. Result: Extermination of waste is executed by entering one by one parcel of medical solid waste into incinerator. The range of temperatures inside the incinerator is 600°C - 800°C. Combustion is performed approximately six hours. During the culling takes place, incinerator operators supervise the combustion process from a room that is close to the incinerator directly. Combustion process of infectious solid waste is carried out in RS PKU by PT Jasa medivest whereas hazardous and toxic waste by PT Arah. Conclusion: Each Hospital, RS PKU Muhammadiyah Jogja and RS Jogja already has a clear Standard Operating Procedure (SOP), but RS Jogja has better SOP and Implementation and Technical Guidelines in comparison with RS PKU Muhammadiyah Jogja.
Relation between temperature and wards humidity with air germs number in inpatient unit of RS PKU Muhammadiyah Jogjakarta Ichtiarini Nurullita Santri; Dyah Suryani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art4

Abstract

Background: The prevalence of nosocomial infections in Yogyakarta is quiet high, which is around 5,9%. Hospitalize patients are more prone to nosocomial infections. One of the non medical factor of nosocomial infections is environmental factor, such as temperatures and humidity, which enhance bacterial growth.Objective: The purpose of this study is to determine the correlation between temperature and wards humidity with air germs number in inpatients unit class I, II, and III of RS PKU Muhammadiyah Jogjakarta.Methods: This study was conducted as analitical study, in which laboratory tests and cross sectional approach was used. The sampling technique used was saturated sampling. The samples were 30 wards in inpatient unit of RS PKU Muhammadiyah Jogjakarta. VIP wards were excluded. Data were analyzed by chi-square test. Results: Bivariate analysis found that there is a significant correlation between temperature and wards humidity with air germs number in inpatients unit class I, II, and III of RS PKU Muhammadiyah Jogjakarta; with p=0.007, which is less than alpha (á=0.05), RP=2.25, CI=1.039-4.874 for temperature; and p=0.028, which is less than alpha (á=0.05), RP=1.968, CI=1.039-4.874 for humidity. Conclusion: There is a significant correlation between temperature and wards humidity with air germs number in inpatient units class I, II, and III of RS PKU Muhammadiyah Jogjakarta.

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