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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 372 Documents
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The benefit and risk of misoprostol use: in obstetrics and gynecology Sufi Desrini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art5

Abstract

Misoprostol is licensed to treat gastric ulcers but now it is widely used for a variety of indications in osbtetrics and gynecology. This is called ‘off-label’ use. Misoprostol is cheap, stable at room temperature and easily to access it. Available in tablet form, it can be administred vaginally, rectally, sublingually and bucally. This review explains benefit and risk of misoprostol in obstetric and gynecology field.
Effect of giving ethanol multistep doses to level of SGPT and SGOT in wistar rats (Rattus norvegicus) Istiqomah Kurniawati; Titis Nurmasitoh; Taufik Nur Yahya
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art6

Abstract

Background: Ethanol is one types of alcohol used in beverages. Excessive use of ethanol causes damage to organs, especially in the liver. Liver, which is an organ in the body, serves as the metabolism of various substances including ethanol. Liver damage that occurs can be known with one of these liver function examination, which check the levels of SGPT and SGOT.Objective: This research aims to look for the difference of SGPT’s and SGOT’s levels between ethanol multistep doses group and control group in Wistar rats (Rattus norvegicus) SGPT and SGOT levels.Methods: This study used an experimental research design with post test only control group design. The sample consisted of 21 male Wistar rats, which were divided into 3 groups. Each group consisted of 7 rats. The first group (K1) was the control group, which was given aquades. The second group (K2) were given ethanol 20% as 2 g/kg pe roral. And the third group (K3) were given with 25% ethanol as 2.5g/kg peroral. The treatment was given for 4 weeks. At the 31st day blood was taken from orbitalis sinus as much as 1 ml for check the level of SGPT and SGOT.Results: The results are the average increase of SGPT and SGOT levels in K2 compared to the K1. While on K3 showed that the average levels of SGPT and SGOT were lower than K1. SGPT levels showed a significant difference (p0.05 ). Conclusion: There is significant differences in the levels of SGPT treatment group in comparison with the control group, but there is no significant differences in the level of SGOT.
Comparison of communication skill of medical students between activist and non activist Mahdea Kasyiva; Warenda Wisnu Aulia Rakhman; Syaefudin Ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art7

Abstract

Background: In Globalization era, the advancement in communication affects human included medical profession. It is crucial for a doctor to practice good communication in order to interact with patients and non-patients. Communication skill can be gained either in class or outside class by joining organization.Objective: The aim of this research is to compare communication skill between activist students (ASs) and non-activist students (NASs) in Medical Faculty of UII.Methods: This study methods was using a simulation of practical communication between a doctor and patients through observation method. This research uses non-specific patients and secondary data as result of Objective Structured Clinical Examination (OSCE), communication skill between activist students and non-activist students. The subjects are all ASs and all NASs.Result: There are summary of the difference between communication ability used by ASs and NASs. The number of ASs is equal with NASs. The highlights are ability in sense of connectivity, coherent information, sequence of questioning, non-verbal language such as eye-contact, and gestures.Conclusion: Involvement of student in organization does not significantly support the success in medical skill examination, in this case for Medicine Faculty students in UII batch 2013.
Advantage of Antioxidants Asri Hendrawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art1

Abstract

No Abstract
Effect of aspirin resistance with dyslipidemia against VerifyNOW® measurement in Bethesda hospital Yogyakarta Hardi astuti witasari; Rizaldy Taslim Pinzon; Erna Kristin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art2

Abstract

Background: Aspirin is first line drug of choice to prevent ischemic stroke. However, some cases are found occuring of aspirin resistance. Objective: This study was to examine the effect of dyslipidemia on the risk of antiplatelet resistance with VerifyNOW ® at Bethesda Hospital Yogyakarta. Method: This research was observational analysis using a nested casecontrol study design. The subjects were ischemic stroke patients who underwent tests of platelet function by VerifyNOW® (Accumetrics, San Diego, CA, USA). The Case group was ischemic stroke patients who has history of aspirin resistance. The control group was ischemic stroke patients who response on aspirin therapy. Both groups were analyzed and compared to the state of dyslipidemia. Results: Bivariate analysis on the incidence of aspirin resistance indicate that dyslipidemia had OR = 0.979 (95% CI; 0.378 to 2.531), p = 0.572. Hypercholesterolemia had OR = 0,909 (CI 95%; 0,377-2,190) p = 0,500; hypertrigliceride had OR = 0,838 (CI 95%; 0,331-2,119) p = 0,409; abnormal HDL had OR = 1,468 (CI 95% 0,564-3,817) p = 0,238; abnormal LDL had OR = 0,937 (CI 95% 0,374-2,345) p = 0,500. Patient factors such as age >55 years (p = 0.168) and female gender (p = 0.226) showed a nonsignificant results. Conclusion: Ischemic stroke patients at Bethesda Hospital Yogyakarta who had dyslipidemia were not evident to have a greater risk of aspirin resistance than ischemic stroke patients who did not undergo dyslipidemia.
A comparison between the effectiveness of the ethanol based extract of pomegranate peel (Punica granatum) and simvastatin drug for lowering blood LDL level in hypercholesterolemic male rats (Rattus novergicus) Pitra Mukhlis Wardani; Putrya Hawa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art3

Abstract

Background: Hypercholesterolemia is one of the major risk factors for coronary heart disease. Drugs of natural pomegranate peel extract using ethanol can be used as an alternative of simvastatin as standard drugs. Preclinical trials are needed before clinical trials in humans to ensure the efficacy of the drug from the nature. Objective: To compare effectiveness of pomegranate peel extract using ethanol (Punica granatum) with simvastatin for lowering LDL level in hypercholesterolemia white rats (Rattus novergicus). Methods: This study used an experimental research design with pretestposttest control group. We use 27 male hypercholesterolemia wistar strain rats were used as samples. The samples were divided into 3 groups. Group I as a negative control was given DMSO 2% 2ml/300gramBW, group II was given simvastatine 0.18 mg/200gramBB/day, group III was given ethanol extract of pomegranate peel 30mg/200gramBB/day for 15 days. Results: Results of paired t-test showed that the group treated with simvastatin decreased LDL levels significantly. The group treated with ethanol extract of pomegranate peel decreased LDL levels significantly. The group given the ethanol extract did not decrease LDL levels significantly. Conclusion: Extract of pomegranate peel using ethanol is not effective for lowering LDL levels in hypercholesterolemia white rats (Rattus novergicus) compared to simvastatin.
Physical activities, exercises, and their effects to the immune system Titis Nurmasitoh
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art4

Abstract

Every systems in human body correlate to maintain homeostasis. One of those systems which contribute to maintain homeostasis is the immune system. The immune system defends physiological functions against foreign substances and cancer cells through a complex and multilayered mechanism. The ability to defend against foreign substances and abnormal cells is done by two types of immune system, which are Innate immune system and adaptive/acquired immune system. There are also certain factors that affect the immune system, for instance physiological factor, nutrition, psychological factor, environental factor, and exercise or physical activities. Regular exercises and physical activities with moderate intensity will boost the immune system. Sedentary lifestyle and minimal physical activity will increase the risk of infectious diseases. While exercises and physical activity with high intensity will suppress the immune system hence increase the risk of infection.
The expression of multidrug resistance protein 5 and thymydilate synthase on fluorouracil resistance WiDr colon cancer cell line Yolanda Dyah Kartika; Indwiani Astuti; Woro Rukmi Pratiwi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art5

Abstract

Background: Colorectal cancer becomes one of the most common cancer in Indonesia. Fluorouracil is an essential drug in colorectal cancer therapy as it has been supplemented in about 69% of current regiments of chemotherapy. However, drug resistance has reduced its clinical applications. Many factors that contribute to fluorouracil resistance have been investigated including overexpression of Multidrug Resistance Protein 5 (MRP 5) and high level expression of Thymidylate Synthase (TS). Therefore, the expression of those proteins may become key indicators to predict the presence of resistance in the model of fluorouracil-resistance-WiDr colon cancer cell line. Objective: The aim of this study is to characterize a 5-FU acquired resistance WiDr colon cancer cell line, focus on the expression of MRP5 and TS. Methods: This study was a post test controlled group design. The expression of MRP5 and TS were analyzed using immunocytochemistry method. Before protein expression analysis, 4 groups of WiDr colon cancer cell line, group 1, 2, 3, and 4 (control) were treated with 4 different concentration of fluorouracil 12.3 μM, 6.15 μM, 3.08 μM, and 0 μM respectively. Previous study showed that a significant increased level of IC50 value is observed in group induced with fluorouracil 3.08 μM (group 3). Statistical tests for protein expression performed with SPSS version 19 using Kruskall Wallis with 95% confidence level (p<0.05). Results: The expression of MRP5 and TS in the group developed fluorouracil resistance (group 3) were significantly increased compared to control group (p<0.05). In contrast, the other group exposed with higher dose of fluorouracil did not show both significant increased level of IC50 nor significant different of MRP5 and TS expression compared with the control group. Conclusion: The model of fluorouracil-acquired resistant WiDr cell line expresses Thymidilate Synthase and Multidrug Resistance Protein 5. The expressions of these proteins are in accordance with the profile of fluorouracil resistancy.
The effect of centella asiatica ethanolic extract on caspase-3 expression in prefrontal cortex of chronic restraint stress induced sprague dawley rat Kuswati Kuswati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art6

Abstract

Introduction: Stress cause changes in the structure and function of the prefrontal cortex. Chronic restraint stress causes the shortening of dendrites in the medial prefrontal cortex. Centella asiatica is an herb that has antioxidant and neuroprotective effects. The purpose of this study is to understand the effect of Centella asiatica on the active protein caspase-3 apoptosis executor expression in the prefrontal cortex. Methods: This study was a laboratory experimental using posttest only control group design. The study used 25 pieces of stored biological material sample in the form of rat brain tissue paraffin blocks. These brain tissues came from 25 rats that were divided into groups of P1, P2, P3, P4 and P5. P1 group treated with restraint stress. Group P2, P3 and P4 were subjected to restraint stress and Centella asiatica ethanolic extract with therapeutic dose of 150, 300 and 600 mg/kg/day. P5 group received stress treatment and fluoxetine with therapeutic dose of 10 mg/kg/day. On the 23rd day, termination, perfusion and brain tissues sampling were executed. Furthermore, the brain tissues were made into paraffin blocks, cut into specimen, immunohistochemical stained, and count the cells which were expressing active caspase-3. Results: There were significant differences in the expression of active caspase-3 between P1 to P2, P3, P4 and P5 groups (p = 0.00). There were no significant differences between P2, P3, P4 and P5 groups. Conclusion: Centella asiatica ethanolic extract can inhibit active caspase-3 expression in the prefrontal cortex of Sprague Dawley rats that were induced with chronic restraint stress.
Models of Assignment on Endocrine and Reproduction Block (1.5), Faculty of Medicine, Islamic University of Indonesia (FM IUI) Alin Julda Qonita; Syaefudin ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art7

Abstract

Background: Doctor’s competency in Indonesia covers seven pillars namely noble professionalism and ethics, self-development and selfcontrol, effective communication, information management, scientificfoundation of medicine, clinical skills, and problem management on public health. One of the efforts to achieve the competency especially on ethics, self development and information management competency, FM IUI has used assignment model in Block of 1.5.Objective: The study was conducted to describe the models of assignment to increase the ability of writing skill citation and bibliography using Mendeley, to avoid plagiarism using VIPER and to access journal using Clinical Key.Methods: This descriptive study focused on all students following Block 1.5 which consists of 45 male students and 95 female students. The research instrument was questionnaire for collecting data from all respondents after assignment finished.Results: Three models of assignment is used to increase the ability in writing using Mendeley, to avoid plagiarism using VIPER and to increase in accessing electronic journal (ClinicalKey). First week on Block of 1.5 was to introduce the assignment and practical work using CinicalKey, Mendeley and VIPER. The comparison between before and after assignment to use Mendeley, VIPER and ClinicalKey analyzed from questionnaire.Conclusion: The percentage of students in using Mendeley, ClinicalKey and VIPER has increased up to 90 %.

Page 5 of 38 | Total Record : 372

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