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Elmiawati Latifah
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Universitas Muhammadiyah Magelang, Jl. Mayjen Bambang Soegeng, Glagak, Sumberrejo, Kec. Mertoyudan, Magelang, Jawa Tengah 56172, Indonesia
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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 6 No 1 (2020)" : 9 Documents clear
COMPARATIVE OF REAL COST AGAINST THE PRICE OF INA-CBG’S BREAST CANCER AND ITS AFFECTING FACTORS IN JKN PROGRAM ERA Arifin Santoso; Indriyati Hadi Sulistyaningrum; Abdur Rosyid; Erwin Budi Cahyono; Ken Wirastuti; Bagus Riyanto
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.2963

Abstract

This study aims to determine differences in real cost and INA CBG's rate and to find out the factors that influence the difference between the real cost and INA CBG's rate in patient with breast cancer in JKN Era at Sultan Agung Islamic Hospital between January 2017 and October 2017. This type of research is a non-experimental (observational) study, data taken retrospectively from hospital financial data and medical records of patients. Data analysis using Mann-Whitney is used to determine the suitability of real costs with INA CBG rates. and the Kruskal-Wallis test is used to find out what factors affect real costs. There was difference between the real cost and the INA CBG's rate for class 1 of Rp (-9,861,600), class 2 of Rp (30,643,000), and class 3 of Rp (146,724,100). The factors that influence the real costs were nursing class (p = 0.014) and Length of stay (p = 0.000). The conclusion of this study is that there is a difference between the real cost in patient with breast cancer in JKN Era at Sultan Agung Islamic Hospital between January 2017 and October 2017.
CYTOTOXIC ACTIVITY OF COMBINED FIG EXTRACT AND OLIVE OIL AGAINST BREAST CANCER CELLS Naniek Widyaningrum; Atina Hussana; Reza Saeful Adi; Memi Tiastuti; Karina Misti Utami
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3016

Abstract

Figs and olive oil are plants containing flavonoids compounds. Flavonoids have antioxidant and cytotoxic activities. This study aims to find out the antioxidant and cytotoxic activities of fig extract, olive oil and combination of fig and olive oil as well. Study using a combination of tin and olive oil with a combination of extracts of 1: 0.1: 3, 1: 1, 3: 1, 0: 1. Cytotoxic and antioxidant activities were tested using MTT assay and DPPH method. Cytotoxic test results were analyzed using probit and antioxidant tests using linear regression. Test results from a single olive on T-47D cells have very strong cytotoxic and antioxidant activities (560,769 and 33.27 µg / ml). In MCF-7 cells the ratio of figs and olives 1: 1 has very strong antioxidant and cytotoxic activity (576,459 and 76.79 µg / ml), in 4T1 cells the ratio of fruitbtin and olive combination of 3: 1 has no cytotoxic activity but has antioxidant activity very strong (1733,517 and 21.81 µg / ml). The combination of fig extract and olive oil had cytotoxic activity on T-47D and MCF-7 cells, but did not have cytotoxic activity on 4T1 cells. This combination had very strong antioxidant activity in T-47D and 4T1 cells, strong in MCF-7 cells.
PHYSICAL CHARACTERISTICS OF COATING FILM COMBINATION OF CORN STARCH-CHITOSAN AND THE DETERMINATION OF VITAMIN C LEVELS IN FRUIT AND VEGETABLE I Kadek Bagiana; Bekti Nugraheni; Dyan Wigati
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3069

Abstract

Coating films is an effort to improve quality and extend the shelf life of a food ingredient. Coating film functions to coat food as well as can be consumed. The study aims to determine the best physical characteristics of the combination of corn starch-chitosan and find out the smallest % decrease in vitamin C levels from chili, tomatoes, and strawberries coated with the coating film. The materials used in this study were a combination of corn starch and chitosan 0.25%; 0.50% and 0.75%. The results showed that the coating film of 0.75% corn starch -chitosan combination has the best physical characteristics. The smallest percent decrease in vitamin C levels in chili, tomatoes, and strawberries that are dipped in coating film on a combination of corn starch-chitosan at a level of 0.75%.
SATISFACTION AND WILLINGNESS TO PAY PHARMACISTS COUNSELING SERVICES IN SURAKARTA Mariska Sri Harlianti; Khusnul Novitasari
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3173

Abstract

Satisfaction was an indicator to assess the quality of counseling services by pharmacists in pharmacies. Willingness to Pay (WTP) was an approach that can be used to measure the indirect benefits of a program. Satisfaction and WTP have a positive correlation. The increasing level of consumer satisfaction caused an increase in the value of WTP. The purpose of this study was to measure the satisfaction and WTP value of counseling services by pharmacists and the relationship between them. Non-experimental research with cross sectional design was conducted on 100 patients who visited the pharmacy and received counseling services by the pharmacist. Satisfaction was measured based on 4 dimensions, namely: tangible, reliability, assurance, and empathy. WTP value was determined using the payment card method. The relationship between the two variables was analyzed by the Pearson correlation (p-value <0.05). The results showed that the level of satisfaction and WTP of counseling services by pharmacists in the Surakarta city pharmacy was 0.93 and Rp 20,652 and there was no relationship between them (Sig. = 0.422). The high level of satisfaction showed that the quality of service was also good. However, it did not affect respondents to pay for counseling services by pharmacists in the Surakarta city area pharmacy with a relatively higher value when compared to other professions
EVALUATION OF ANTIBIOTIC IN ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS WITH FEBRILE NEUTROPENIA Ambar Yunita Nugraheni; Safira Salsabilla Rizki Rahardiani
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3192

Abstract

Patients with hematological malignancy have a high risk of experiencing febrile neutropenia (FN). Acute Lymphoblastic Leukemia (ALL) became one of the most cases as a cause of FN. Chemotherapy can also cause of neutropenia in almost 90% of cases and can increase the risk of developing febrile neutropenia. The administration of irrational antibiotics can cause problems such as increased side effects and resistance. The purpose of this study is to determine the rationality of antibiotics in ALL with FN patients at hospital X Surakarta. This study was an observational study with retrospectively. The research sample was met the inclusion criteria 31 patients with the purposive sampling method. Data were analyzed descriptively. An evaluation antibiotic of 31 patients ALL with FN was obtained the right indication 100% (31 patients), the right patient 100% (31 patients), the right medicine 83,87% (26 patients) and the right dose 51,61% (16 patients). The rationality of antibiotics was 51,61% (16 patients).
COMPARISON OF ANTI ASTHMA ACTIVITY BETWEEN EXTRACT AND OIL Nigella sativa ON HISTOPATHOLOGY OF BRONCHIAL EPITHELIAL IN ASTHMA MICE Dian Arsanti Palupi; Salwa Rahmawati; Annis Rahmawaty; Endra Pujiastuti
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3193

Abstract

Asthma is an inflammatory disease or chronic airway inflammation. Nigella sativa extract and oil are proven to be used to improve airway inflammation. This study consisted of 7 groups. The normal group (K1), negative group (K2), theophylline (K1), Nigella sativa extract (K4), Nigella sativa oil (K5). 0.9% intraperitoneally, and on the 14th day, the mice were re-sensitized intraperitoneally with a 20µg OVA + 2 mg of Alhydrogel in 1 mL of sterile NaCl 0.9%. On the 21st, 23rd, 25th day, the OVA1% was inhaled. On the 26th to 39th day, the K3 mice were given theophylline 0.338 mg/day, K4 mice were given Nigella sativa extract at a dose of 1 mL/day and K5 mice were given Nigella sativa oil at a dose of 0.1mL / day. On the 40th day, the mice were terminated for analysis of the thickness of the bronchial epithelium. Comparison between groups of Nigella sativa extract on average 15.5 ± 2.22 µm and Nigella sativa oil average of 14.05 ± 3.87 µm p-value = 0.488 means that between the Nigella sativa extract group and Nigella sativa oil there was no difference meaningful. statistically as an antiasthma in decreasing the size of the thickness of the bronchial epithelium
TOTAL FLAVONOID DETERMINATION AND ANTIOXIDANT ACTIVITY STUDY OF SPINACH (Amaranthus tricolor L.) RED GITI AND GREEN GITI VARIETY Any Guntarti; Anita Ruliyani
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3196

Abstract

Antioxidants in the form of total flavonoids are compounds that can stabilize freeradicals. The mechanism of antioxidants in stabilizing free radicals is give the lackelectron of free radicals and inhibit the formation of free radical formation thatcan damage the body. DPPH method is used to determine the activity of capturingfree radicals of ethanol extracts of Amaranthus tricolor L. red giti and green giti.As a positive control quercetin is used. The results showed that the total amount offlavonoids in red giti spinach was (5.615±0.114)% EK and green giti spinach was(4.468±0.166)% EK. The results also show that all groups have activity as freeradical scavengers. The value of ES 50 for positive control quercetin, red gitispinach extract, and green giti spinach extract are (1.375±0.085)µg/ml,(186.198±0.363)µg/ml, and (209.392± 0.607)µg/ml respectively. Based on ES 50values It can be concluded that antioxidant activity of red giti spinach extract andgreen giti spinach extract are significantly different from the positive controlquercetin. Antioxidant activity of quercetin is categorized strong antioxidantactivity, while the antioxidant activity of red giti spinach extract and green gitispinach extract is categorized as weak antioxidant activity.
COST OF ILLNESS OF INPATIENT PEDIATRIC MENINGITIS PATIENTS HOSPITALIZED IN YOGYAKARTA Ingenida Hadning; Dwi Endarti; Tri Murti Andayani; Rina Triasih
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3292

Abstract

This research to determine the average cost of illness of inpatient pediatric meningitis patients hospitalized in the hospitals in Yogyakarta. It was a pharmacoeconomic study using the cost of illness method. The calculation of the cost in the care of inpatient pediatric meningitis patients according to a societal perspective was conducted observatively with a cross sectional design. Cost of illness analysis included calculating the costs of direct medical, direct non-medical, and indirect cost. Data were collected from a type-A public hospital and a type-B privatehospital in Yogyakarta by taking medical records, detailed data on meningitis patient care costs, and interviews using questionnaires with caregivers. Analysis of cost of illness calculations applied descriptive analysis methods. In this study, 11 inpatient pediatric meningitis patients were obtained. The average cost of illness for the treatment of inpatient pediatric meningitis patients was IDR 26,224,586±12,814,789, consisting of the average direct medical cost of IDR 23,831,813±12,222,885 (90.88%), the average direct non-medical cost of IDR 1,787,955±832,353 (6.82%), and the average indirect cost of IDR 604,818±337,389 (2.31%). Components of direct medical cost with the largest percentage were drugs and medical supplies (26.46%); while the largest direct non-medical cost were the expenditure of additional needs for the patient's family (72.18%). The indirect cost component came from the reduction of the patient's parents' income while the patient is hospitalized.
OFF-LABEL PEDIATRIC DRUG USE IN INDONESIA : A SYSTEMATIC REVIEW Dewi Latifatul Ilma; Nialiana Endah Endriastuti
Jurnal Farmasi Sains dan Praktis Vol 6 No 1 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i1.3407

Abstract

The phenomenon of off-label drug use has been widely observed in the pediatric population, including in Indonesia. The major concern arising from the prevalence of off-label drug use is the increased risk of adverse drug reactions. We performed a systematic review to describe and provide insight into off-label pediatric drug use in Indonesia. The articles published using English and Indonesian language was systematically searched in five electronic databases, including Pubmed, Scopus, Google Scholar, Garuda, and Neliti. Key terms used for the search were as follows: "off-label use", "off-label”,"child", "pediatrics", "infant","adolescent", "newborn", "Indonesia". A total of one hundred sixteen studies were initially obtained from an electronic database. Further, after the references were reviewed, ten articles met all the eligibility criteria that were finally selected. The percentage of off-label pediatric drug use was 32.6-89.9%. The off-label categories in the selected studies were age, dosage, contraindication, route of administration, and indication. Among these off-label categories, age was the highest off-label with percentages ranged from 19.8 to 92.9%. Pseudoephedrine hydrochloride and triamcinolone acetonide became the most frequently used drug in that category. Thus we conclude that off-label pediatric drug use is common in Indonesia. Future research should consider the safety of off-label drugs in pediatric, primarily in Indonesia. Clinicians should be aware of off-label drugs in pediatrics and consider the risk-benefit of the drugs when prescribing to children. The authorities need to regulate off-label drug prescribing in pediatrics; therefore, it could improve medication safety and quality.

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