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INDONESIA
Indonesian Journal of Science and Pharmacy
Published by Pustaka Media Publishing
ISSN : -     EISSN : 30255244     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Science and Pharmacy (IJSP) accepts scientific articles as original research articles, short communication, reviews, and mini-reviews from anyone without any discrimination, as long as they submit articles that meet scientific principles. Indonesian Journal of Science and Pharmacy publishes various scientific articles covering Science and Pharmacy, Pharmaceutical Sciences. The following are the field within the scope of Indonesian Journal of Science and Pharmacy: Chemistry, Biology, Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceuticals, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Management Pharmacy, Clinical-Community Pharmacy, Microbiology Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 17 Documents
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Determination of Total Alkaloid Content of Raru (Cotylelobium lanceolatum Craib) Bark Extract Using UV-ViS Spectrophotometry Method cici andriani; Anny Sartika Daulay; Ridwanto Ridwanto; Haris Munandar Nasution
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

The raru plant (Cotylelobium  lanceolatum Craib) comes from the Dipterocarpaceae family. Raru bark is usually added to the wine to enhance the taste of the wine. raru bark has antidiabetic compounds as a lowering of sugar levels in the blood. The purpose of this study was to determine the alkaloids in the Raru plant (Cotylelobium   lanceolatum  Craib) and to determine the total alkaloid content found in the Raru plant (Cotylelobium  lanceolatum  Craib). The extraction method used is the maceration extraction method using methanol solvent with various concentrations which is then evaporated with a rotary evaporator. Whereas the quantitative test was carried out by means of the viscous extract obtained by adding 2 mL of Phosphate buffer with a pH of 4.7, 2 mL of bromocresol green (BCG), and measured at a wavelength of 272.705 nm. The yield of the extract from a concentration of 95% was 23.0779%, a concentration of 70% was 21.2144%, a concentration of 50% was 20.3274%. The correlation equation obtained from the caffeine curve is y = 0.0508X + 0.008 and the value of r = 0.999, and the levels of alkaloids with different extract concentrations. Actual alkaloid content in raru bark methanol extract 95% was 14.9094 ± 0.3697 mg/g, actual alkaloid content in raru bark methanol extract 70% was 10.0472 ± 0.4594 mg/g, actual alkaloid content in extract 50% raru bark methanol was 6.6260 ± 0.803.
Effectiveness Test of Sidaguri Leaf Ethanol Extract Gel (Sida rhombifolia L.) on the Cealing of Degree IIA Burn in Male Rabbits Bazlina Adani; Gabena Indrayani Dalimunthe; Minda Sari Lubis; D Elysa Putri Mambang
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

Burns are one of the incidents that often occur in society. Currently, the use of burn medicine is very limited, in terms of the cost of treatment and healing is relatively expensive. In this case, the use of natural plants is needed as a treatment for burns on the skin, namely sidaguri leaves. Researchers want to take advantage of secondary metabolites contained in sidaguri leaves and formulate them into pharmaceutical preparations in the form of a gel. The purpose of this study was to determine the content of secondary metabolites in the ethanolic extract of sidaguri leaf and to determine the effectiveness of the gel preparation of the ethanolic extract of sidaguri leaf (Sida rhombifolia L.) on the healing of burns. This research includes simplicia characterization, phytochemical screening, gel evaluation and test the effectiveness of sidaguri leaf extract gel. HPMC negative control group, 1% EEDS, 3% EEDS, 5% EEDS and bioplacenton positive control group. The parameters tested were the diameter of the burn for 14 days. The research data were analyzed using the One-Way ANOVA (Analysis of Variance) method followed by the Tukey test. The results of this study obtained EEDS 5% and bioplacenton did not have a significant difference in the healing of burns in male rabbits on day 14.  It can be concluded that the ethanolic extract gel of sidaguri leaves has effectiveness on healing burns with a dose of 5% EEDS concentration.
Simplicia Characteristics and Phytochemical Screening of Buni Fruit (Antidesma bunius L. Spreng) Anggitha Ningtias; Zulmai Rani
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

ABSTRACT Buni fruit is a plant that produces secondary and antibacterial metabolites. The purpose of this study was to identify the characteristics of the berry simplicia and the content of phytochemical compounds in the berry fruit. Starting with the maceration method using 96% ethanol, this study carried out phytochemical screening and characterization tests. The results of the phytochemical screening study showed that compounds such as flavonoids, tannins, saponins, alkaloids, and steroids were found in the ethanol extract of buni fruit. Due to the simplicia characterization, we found a water content of 9.3%, a water-soluble extract of 11.51%, an ethanol-soluble extract of 17.19%, a total ash content of 8.1%, and an acid-insoluble ash content (0.7 %).        
Level of Patient Satisfaction with Pharmaceutical Services in Pasar Ujungbatu Padang Lawas Health Center in 2023 Hasni Yaturramadhan Harahap; Debi Meilani
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

Quality pharmaceutical services are health services that can satisfy every service user in accordance with the level of patient satisfaction and the administration is in accordance with the established code of ethics and service standards. The purpose of this study was to determine the level of patient satisfaction with pharmaceutical services at the Pasar Ujungbatu Health Center, Padang Lawas Regency, Padang Lawas Regency in 2023. The research method included a descriptive method, namely using a quantitative approach to determine the level of patient satisfaction with pharmaceutical services at the Ujungbatu Market Health Center, Padang Lawas Regency. The results showed the level of patient satisfaction with pharmaceutical services at Pasar Ujungbatu Padang Lawas Health Center in 2023 with a total of 240 respondents, namely 2 people were very dissatisfied (0.83%), 4 people were dissatisfied (1.66%), 34 people were quite satisfied (14.16), 162 people were satisfied (67.5%), and 38 people were very satisfied (15.85%).
Analysis of Sodium Benzoate Content in the Market Soft Beverages Using Uv-Vis Spectrophotometry Method Windi Hari Akbar; Ainil Fithri Pulungan; Ridwanto Ridwanto; Anny Sartika Daulay
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

Sodium benzoate is one of the preservatives that are permitted to be used in food and beverages. Research has been carried out with the aim of knowing that carbonated drinks contain the preservative sodium benzoate, knowing the amount of sodium benzoate in soft drinks and to find out the levels of sodium benzoate in soft drinks fulfilling the maximum usage requirements according to BPOM RI Head Regulation No. 36 of 2013. This study used the uv-vis spectrophotometry method. To determine the preservative content of sodium benzoate, a qualitative test was first carried out on the sample using the color reaction method and esterification test. To determine the levels using a UV-Vis spectrophotometer at a wavelength of 269 nm with ethanol p.a as a solvent. The results of the qualitative test using the color reaction method showed that the three samples of soft drinks positively contained the preservative sodium benzoate. To validate this, an esterification test was carried out on the three samples and they produced the smell of Ambon bananas which proved that the three samples positively contained sodium benzoate. For the quantitative test using the Uv-Vis spectrophotometry method at a wavelength of 269 nm using ethanol p.a as a solvent. The results of the analysis showed that the preservative content of sodium benzoate which was calculated for each sample was for a soft drink sample a: 244.93 ± 19.9349 mg/kg. Soft drinks b: 65.3 ± 0 mg/kg, soft drinks. Soft drinks c: 78.6 ± 13.1291 mg/kg. Based on these results, it can be concluded that the levels of sodium benzoate in samples A, B, and C met the standard requirements for maximum usage limits, namely not more than 600 mg/kg.
Utilization Of Ethanol Extract Of Wungu Leaf (Graptophyllum Pictum (L) Griff) Growing In The Pamah Deli Old Area As An Anti-Inflammatory Debi Meilani; Novia Anisa Miranda; Rani Ardiani; Sofia Rahmi; Hasni Yaturramadhan
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

Wungu leaves (Graptophyllum pictum (L) Griff) are often used as traditional medicine, contain several chemical compounds, including alkaloids, glycosides, steroids, saponins, tannins and flavonoids and chemical compounds, thought to have anti-inflammatory properties. The aim of this study was to utilize the ethanol extract of Wungu leaves that grow in the Pamah Deli Tua area, North Sumatra, as an anti-inflammatory. This study included characterization of simplicia, phytochemical screening and testing of the anti-inflammatory activity of the ethanol extract of Wungu leaves (EEDW). Measurement of rat leg volume induced by 1% λ-carrageenan using a plestimometer, observations were made every 30 minutes for 6 hours. This study used 5 treatment groups, namely group I was given 0.5% CMC suspension, group II was given diclofenac sodium at a dose of 4.5 mg/kg BW, group III was given EEDW at a dose of 100 mg/kg BW, group IV was given EEDW at a dose of 200 mg /kg BW, group V was given EEDW at a dose of 400 mg/kg BW. Inflammation percentage and inflammation inhibition percentage were calculated. Data were analyzed by Duncan to see whether or not there was a difference between the groups. The results showed that there were significant differences between the doses of 100, 200 and 400 mg/kg BW, but between the doses of 400 mg/kh BW and diclofenac sodium there were no significant differences. The percentage of inflammation at a dose of 400 mg/kg BW was 3,366 and the percentage of inflammation inhibition was 86,569%. The higher the dose of EEDW the more effective it is as an anti-inflammatory, and the dose of 400 mg/KgBB in rats is the optimum dose of EEDW as an anti-inflammatory.
Antibacterial Activity of Reduced Silver Leaf Extract of Ketumpang Air (Peperomia pellucida (L.) Kunth) Against Staphylococcus aureus Tania Tiara Efendi; Dikki Miswanda; M Pandapotan Nasution; Minda Sari Lubis; Bambang Hermanto
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

Silver particles are widely applied in various medical fields, one of which is as an antibacterial. The advantage of silver particles is their small particle size, which increases their antibacterial effect. One of the environmentally friendly methods that can be used to synthesize silver particles is by utilizing extract of daun ketumpang air (Peperomia pellucida (L.) Kunth) through a reduction reaction. The aim of this research was to determine the antibacterial activity of silver particles made using water ketumpang leaf extract against Staphylococcus aureus bacteria. Silver particles were synthesized using the green synthesis method from extract of daun ketumpang air (Peperomia pellucida (L.) Kunth) which acts as a bioreductant. Silver reduction using water ketumpang leaf extract was carried out with varying concentrations of AgNO3 solution of 1 mM, 2 mM, 5 mM, and 10 mM with a ratio between the extract and AgNO3 solution of 1:40. The resulting silver particles were characterized using a Uv-Vis spectrophotometer and particle size analysis using PSA. The antibacterial activity test of the reduced silver particles was carried out against Staphylococcus aureus bacteria using the Kirby-Bauer method. The results of the research showed the formation of silver particles in the form of a change in the color of the solution from yellow to brownish. Analysis using a UV-Vis spectrophotometer showed a maximum wavelength of 423 nm, which indicated that silver particles were formed. The results of PSA analysis show the size of silver particles, where the smallest size of silver is 0.41 μm for a concentration variation of 10 mM. The antibacterial activity test showed strong antibacterial activity against Staphylococcus aureus bacteria with an average diameter of the inhibition zone of 11.48 mm. This shows that ketumpang water leaf extract can be used as a bioreductant in reducing silver particles and the silver particles produced have the potential to be antibacterial.
Effect of Extraction Method on Yellow Wood Rendement and Phenolic Content (Arcangelisia flava (L.) Merr) UV-Vis Spectrophotometry Extract of Ethanol Merida Sasnita; Anny Sartika Daulay; Ridwanto Ridwanto; Haris Munandar Nasution
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
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Abstract

Indonesia is a country rich in biodiversity. With the wealth of natural resources, there is very much that can be used from flora and fauna to treat various diseases, yellow wood is one of the plants that have medicinal properties and has not been widely studied, yellow wood is efficacious as antimicrobial, antioxidant, antihyperlipidemia, and anticancer. The objective of this study was to determine the class of chemical compounds found in simplicial and extracts of yellow wood plants and to determine the effect of extraction methods on the yield and phenolic levels of ethanol extracts of yellow wood plants. The stages of this research include processing plant materials, making maceration extracts and socletation of yellowwood plants, examination of characteristics, phytochemical screening and determination of total phenolic levels of ethanol extract 96% maceration and socleation of yellow wood (Arcangelisia flava (L.) Merr) by UV-Vis Spectrophotometry method. The highest yield research results are found in the maceration extract yield, this is because the maceration process time is shorter than the socleation process, so that the compound withdrawal process carried out by maceration is more optimal than the socleation method. In addition, the more solvent used, the more extracts produced. The determination of total phenolics is performed by determining the maximum wavelength of gallic acid using UV-Vis spectrophotometry methods. Yellowwood maceration ethanol extract has a total phenolic content of 22.0087 ± 0.8567 mg GAE/g and socleation extract has a total phenolic content of 18.2023 ± 0.1434 mg GAE/g.
Determination Of Total Alkaloid Content Of Yellow Wood (Arcangelisia flava (L.) Merr) Extract Based On Differences In Ethanol Concentration Using Uv-Vis Spectrophotometry Method Rika Yuliana; Anny Sartika Daulay; Ridwanto Ridwanto; Fathur Rahman
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

Yellow wood with its secondary metabolites is one of the plants that has the potential as a traditional medicinal plant to treat various diseases, such as cancer. The chemical compounds contained in yellow wood are alkaloids, saponins, tannins, flavonoids, steroids/triterpenoids. The objective of this research was to determine the chemical compounds contained in ethanol extract and determine the total alkaloid value of yellow wood extract. This research method is an experimental method which includes processing plant materials, making ethanol extract concentrations of 50, 70 and 96%. Characterization examination, phytochemical screening and determination of total alkaloid levels of yellow wood extract by Uv-Vis spectrophotometry method. The results of phytochemical screening on yellow wood ethanol extract contain chemical compounds such as alkaloids, saponins, tannins, flavonoids, steroids/triterpenoids. Determination of total alkaloid levels is carried out by determining the maximum wavelength of caffeine, measuring the kaffein calibration curve and calculating total alkaloid levels using the Uv-Vis spectrophotometry method. Results The determination of total alkaloid levels in ethanol solvent extract concentration of 50% is 2.9649 ± 0.1767%, ethanol solvent extract with a concentration of 70% is 6.0180 ± 0.2469% and ethanol solvent extract with a concentration of 96% is 10.92001 ± 2.7803%.
Retrospective Study Of Vitamin Purchases During The Pandemic In UMI FARMA Pharmacy Umi Chairani Manik; Muhammad Amin Nasution; Adelia Dwi Octania
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

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Abstract

In early 2020, the world was shocked by the outbreak of a new pneumonia that started in Wuhan, China, and then spread rapidly to more than 190 countries and territories. This outbreak was named coronavirus disease 2019 (COVID-19), which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SA RS-CoV-2). The spread of this disease has had a broad social and economic impact.The COVID-19 pandemic that has occurred since March 2020 has affected all aspects of life. The aim of the research is to determine the purchase of vitamins during the pandemic in July–December 2021 at the UMI FARMA Pharmacy. This research was conducted retrospectively. Data collection was obtained from recording several vitamin products purchased by patients. Data was obtained from the sales and purchases book at the UMI FARMA Pharmacy. The targeted output is purchasing vitamins during the pandemic in July–December 2021.

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