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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 16 Documents
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Search results for , issue "Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )" : 16 Documents clear
THE CORRELATION BETWEEN CELL OF ORIGIN SUBTYPE WITH OVERALL SURVIVAL OF DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS IN KARIADI GENERAL HOSPITAL SEMARANG Jenifer Marsela Tarius; Hermawan Istiadi; Ika Pawitra Miranti; Intan Rahmania Eka Dini
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (520.406 KB) | DOI: 10.14710/dmj.v9i3.27504

Abstract

Background: DLBCL is the most common type of NHL in the world. DLBCL based on cell of origin is divided into GCB and non-GCB. The diagnosis of DLBCL has not been routinely done to its cell of origin, and there have not been many studies that discuss the DLBCL subtype and the overall survival of the patients, especially in Kariadi General Hospital. This study aims to determine the correlation of DLBCL cell of origin with the 2-year overall survival of DLBCL patients in Kariadi General Hospital. Methods: This is an observational analytic study of 40 DLBCL patients in Kariadi General Hospital from January to August 2017. The data collection including: age of diagnosis, location, stage and 2-year overall survival. Data analysis used chi square test and Kaplan Meier curve. Results: GCB patients had higher 2-year overall survival than non-GCB subtype significantly (p: 0.047), with a 2-year survival rate of GCB subtype was 66.7% and non-GCB subtype was 31.6%. GCB patients tend to have early stage than non-GCB subtype significantly (p:0.028). Conclusion: DLBCL GCB subtype patients had significantly higher 2-year overall survival therefore it has better prognosis than non-GCB subtype.
THE DIFFERENCE OF NEUTROPHIL LYMPHOCYTE RATIO (NLR) IN CONVENTIONAL AND ELECTRIC SMOKERS Sarah, Diah Ayu Siti; Naftali, Zulfikar; Yusmawan, Willy; Suprihati, Suprihati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.527 KB)

Abstract

Background: Smoking is an unhealthy lifestyle causing health problems that may lead to high morbidity and mortality rates. One way to stop smoking habit is by replacing conventional cigarettes with electric cigarettes. Cigarette smoke exposure can trigger an inflammatory reaction that can be measured using Neutrophil Lymphocyte Ratio (NLR). Aim: Proving of NLR in electric smoker are higher than conventional smoker. Method: The research used descriptive analytic design. The number of samples were 34 people, divided into 17 people each group (conventional smoker and electric smoker). The subjects were asked to fill out a questionnaire and their blood samples were taken by 3 cc. Then, the blood samples were tested in a laboratory to obtain NLR values. The data was then analyzed using unpaired T-test.  Result: NLR mean in the conventional smoker group is 1,364 ± 0,28 and 1,791 ± 0,49 in the electric smoker group. The unpaired T-test indicates there is significant difference in the value of NLR between conventional smoker and electric smoker (p=0,005).  Conclusion: NLR in electric smoker are higher than conventional smoke.
THE IMPACT OF BODY MASS INDEX TO ACUTE MYOCARDIAL INFARCTION IN-HOSPITAL PATIENTS MORTALITY RATE IN DR. KARIADI HOSPITAL Indra Adhim Karunia Aji; Andreas Arie Setiawan; Ariosta Ariosta; Setyo Gundi Pramudo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.454 KB) | DOI: 10.14710/dmj.v9i3.27497

Abstract

Introduction. Populations with high BMI are at risk for cardiovascular disease because these populations usually have high levels of fat in the body. In contrast, there are several studies that prove that body weight below normal BMI also increases cardiovascular disease risk and death. The aim of this study was to determine the impact of BMI on mortality rates of in-hospital patients with acute myocardial infarction at dr. Kariadi Hospital. Methods. This research is a retrospective analytic observational study with cross sectional design. The sample of this study was acute myocardial infarction patients who were undergoing treatment at the RSUP dr. Kariadi between January 2013 - December 2018 complete data on body weight, height, and status of death or survival. Data comparisons were made using fisher exact test with statistical significant p value was less than 0.05. Results. Statistical analysis using fisher exact test showed association between body mass index and mortality rate is not significant (p = 0,258). Age is the only one confounding variable that showed significant association with mortality rate (p =0,032). Relative risk of age is 1.8 with a cutoff at 60 years. Conclusions. Body mass index (BMI) did not have a significant impact on the mortality rate of AMI in-hospital patients at dr. Kariadi Hospital.Keywords: body mass index, acute myocardial infarction, mortality 
CORRELATIONS BETWEEN SUCCESSFUL THERAPY AND ANXIETY LEVEL OF POST OPERATIVE GLAUCOMA PATIENTS Singgih Pratama; Arief Wildan; Riski Prihatningtias; Fifin Luthfia Rahmi
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.145 KB) | DOI: 10.14710/dmj.v9i3.27505

Abstract

Background : Glaucoma is a disease that can cause damage to the optic nerve. High intraocular pressure is a major risk factor for glaucoma. The main goal of treating glaucoma is to control the disease progression by reducing intraocular pressure to the normal range or in accordance with the target pressure, and unsuccessful treatment can lead to anxiety. Aims : Identifying the correlation between therapeutic success and anxiety levels in post-operative glaucoma patients. Methods : This research used observational analytic method with a cross-sectional design. A total of 34 post-operative glaucoma patients were collected by consecutive sampling at the Eye Outpatient Installation of Dr. Kariadi Hospital Semarang. The anxiety level was assessed using the Taylor Manifest Anxiety Scale (TMAS) questionnaire. Data analysis in the study used the Contingency Coefficient test. Results : A total of 34 glaucoma patients consisted of 17 patients who successfully achieved the target pressure and 17 patients who failed to achieve the target pressure. There was a significant correlation between the success of glaucoma therapy with anxiety levels (p = 0.008) and there was a weak relationship between the two variables (r = 0.471). Conclusion : There is a correlation between therapeutic success and anxiety levels in post-operative glaucoma patients.
THE EFFECT OF TURMERIC EXTRACT (Curcuma longa) ON THE IMPROVEMENT OF MUSCLE MASS IN SWISS DIABETES MELITUS MICE SKELETAL MUSCLE INDUCED BY STREPTOZOTOCIN Alfin Ihza Trimahendra; Yora Nindita; Vega Karlowee; Muhamad Thohar Arifin; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.964 KB) | DOI: 10.14710/dmj.v9i3.27510

Abstract

Backgrounds. Diabetes mellitus is a degenerative disease that has various complications. One of neglected diabetes mellitus complication is skeletal muscle atrophy. Turmeric and java turmeric extracts were need to be clarified due to those effect as antihyperglycemic agent which might affected muscle atrophy as one of diabetes mellitus complication. Aim. To compared the efficacy of turmeric and java turmeric extract on reducing the progression of skeletal muscle atrophy in streptozotocin-induced diabetes mellitus. Methods. We conducted experimental animal studies with a post test only control group design using 25-30 grams male Swiss mice aged 12 weeks. Diabetes mellitus was induced by streptozotocin (STZ) administration. All 28 samples were randomly divided into 4 groups : control + PBS, control + STZ, STZ + turmeric, and STZ + java turmeric groups. Before treatment, blood glucose and body weight were examined on 3rd day. Blood glucose, body weight, hindlimb muscle weight, and muscle diameter results were examined after treatment (on 21st day). Data was analyzed with statistical software after all procedures were done. Results. STZ + turmeric group showed insignificant decreased in blood sugar levels (p=0.107). Control + STZ group showed significantly reduced hindlimb muscle weight compared to other groups. Hindlimb muscle weight was significantly ameliorated by STZ + turmeric extract (p=0.048). There were no significant improvement on skeletal muscle diameter among groups. Conclusion. The administration of turmeric extract improved hindlimb muscle weight but may not mediated by glucose lowering effect in streptozotocin induced diabetic mice.
RIGHT VENTRICULAR AND PULMONARY HYPERTENSION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND RESTRICTIVE LUNG DISEASE Valencia Fabiana; Dwi Lestari Partiningrum; Bernardus Parish Budiono; Fathur Nur Kholis
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.557 KB) | DOI: 10.14710/dmj.v9i3.27498

Abstract

Background: Chronic lung disease is frequently associated with lung vascular lesion. We evaluated the structural-functional related changes of right ventricle under CLD with or without PH at RSUP dr. Kariadi, Semarang. Methods: We studied patients at RSUP dr. Kariadi who underwent routine evaluation that included resting spirometry and echocardiography. Patients with either COPD or RLD were studied, exclusion were made for patients with valvular heart disease and congestive heart disease. This study was performed during May through June of 2019 (n = 20). PASP, RVD, RVWT, TAPSE and spirometry values were analyzed for the association between PASP and RVD, RVWT, TAPSE, TAPSE/PASP ratio and FVC, FEV1, FEV1/FVC. Results: Thirteen (65%) of 20 patients who underwent echocardiography and spirometry evaluation were male and their average age were 55 years old. Mean PASP was 49.30 mmHg (range 2–111 mmHg). Ninety five percents patients had restrictive spirometry and 5% patients had moderate-severe mixed spirometry. The majority of the population of the study sample is dominated by a very severe degree of restriction spirometry. Out of the 20 subjects, 15 subjects (75%) had a diagnosis of COPD and 10 subjects (50%) had a history of pulmonary TB. In this study, 75% subjects had right ventricular dilatation, 85% subjects had right ventricular hypertrophy, and 15% subjects had decreased right ventricular systolic function (low TAPSE). The majority of structural and functional abnormalities of the right heart are found on patients with very severe degree of restriction spirometry. There were 13 subjects (65%) pulmonary hypertension, with the most findings being severe pulmonary hypertension as many as 8 subjects (40%). As many as 14 subjects (70%) had high TAPSE / PASP ratio.Conclusions: PH prevalence in patients with CLD is significantly associated with spirometry values. PH severity degree in patients with CLD is not significantly associated with spirometry values.Key words: spirometry; pulmonary hypertension; right heart echocardiography.

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